10 Medicinal Constituents Of Vitex Agnus-Castus (Chaste Tree)

Vitex agnus-castus has active constituents such as flavonoids, iridoids, and lignans.

These constituents have estrogen-modulating properties, which can help alleviate symptoms of menopause, including hot flashes and mood swings. The iridoids, particularly aucubin and agnuside, have anti-anxiety and anti-inflammatory effects, providing relief from stress and anxiety.

By regulating hormonal balance and reducing inflammation, Vitex agnus-castus constituents can improve overall quality of life for women and potentially alleviate symptoms of polycystic ovary syndrome (PCOS).

This article explains in details the 10 best active constituents of Vitex agnus-castus.

1. Agnosidic acid

Vitex agnus-castus agnosidic acid is a bioactive compound extracted from the seeds of the plant.

It has been traditionally used in herbal medicine for centuries to treat various gynecological issues, including menstrual disorders, premenstrual syndrome, and polycystic ovary syndrome (PCOS).

Agnosidic acid has been shown to have anti-inflammatory, antispasmodic, and estrogen-modulating properties, making it a popular natural treatment option for women's health concerns.

2. Casturol

Vitex agnus-castus casturol is a plant native to the Mediterranean region and has been used for centuries in traditional medicine.

Its fruit, berries, or leaves are used to prepare herbal remedies, particularly for women's health issues such as PMS, menopause symptoms, and irregular menstruation.

Casturol has been shown to have estrogen-regulating properties, making it a popular natural treatment option for hormonal imbalances and fertility concerns.

3. Dehydrocastusic acid

Vitex agnus-castus dehydrocastusic acid is a phytochemical compound isolated from the fruit of the plant.

It is believed to have numerous biological and pharmacological activities, including estrogenic, antioxidant, and anti-inflammatory properties. Studies suggest that it may help alleviate symptoms of premenstrual syndrome (PMS) such as bloating, breast tenderness, and mood swings.

Additionally, dehydrocastusic acid has been shown to have potential therapeutic effects in the treatment of hormonal imbalances and reproductive disorders.

4. Ursolic acid

Vitex agnus-castus ursolic acid is a bioactive compound extracted from its fruits.

It has been traditionally used in herbal medicine for centuries to treat various health issues, including hormonal imbalances and menstrual disorders. Ursolic acid has been shown to exhibit antioxidant, anti-inflammatory, and antibacterial properties, making it a promising natural remedy for skin and oral health.

Further research is needed to fully understand its potential benefits and optimal dosage.

5. Beta-amyrin

Vitex agnus-castus beta-amyrin is a triterpenoid saponin compound extracted from the fruit and leaves of the plant.

It has been traditionally used to treat various women's health issues, including menstrual disorders, menopausal symptoms, and PMS. Beta-amyrin exhibits anti-inflammatory, antioxidant, and estrogenic properties, making it a potential natural remedy for hormone-related conditions.

Its efficacy is attributed to its ability to regulate hormonal balance and alleviate symptoms associated with hormonal imbalances.

6. Lupeol

Vitex agnus-castus lupeol is a bioactive triterpenoid saponin extracted from its fruit and leaves.

It has been traditionally used in herbal medicine to treat various female reproductive disorders, including polycystic ovary syndrome (PCOS), menstrual irregularities, and breast tenderness. Lupeol has been shown to have estrogen-regulating properties, making it a potential natural treatment for hormonal imbalances.

Its use is also supported by some scientific studies, although more research is needed to confirm its efficacy.

7. Oleanolic acid

Vitex agnus-castus oleanolic acid is a triterpenoid saponin compound derived from the plant's leaves and flowers.

It has been traditionally used in herbal medicine for its medicinal properties, including anti-inflammatory, antioxidant, and antimicrobial effects.

Oleanolic acid has been shown to have potential therapeutic applications in various diseases, such as cardiovascular disorders, cancer, and neurodegenerative conditions, making it an important compound in the study of Vitex agnus-castus' bioactive compounds.

8. Alpha-amyrin

Vitex agnus-castus alpha-amyrin is a triterpenoid compound extracted from the fruit of this plant.

It has been used in traditional medicine for centuries to treat various health issues, including hormonal imbalances and menopausal symptoms. Alpha-amyrin has been shown to have estrogen-regulating properties, making it a popular natural remedy for women's health.

Additionally, it has been found to possess antioxidant and anti-inflammatory activities, which may contribute to its potential therapeutic benefits.

9. Castusic acid

Vitex agnus-castus castusic acid is a unique compound extracted from its fruit.

It has been used in traditional medicine for centuries to treat various health issues, including menstrual irregularities and hormonal imbalances.

Castusic acid is believed to exert its effects by interacting with estrogen receptors, promoting the regulation of female hormones and alleviating symptoms such as breast tenderness, mood swings, and hot flashes.

10. Casticin

Vitex agnus-castus casticin is a bioactive compound extracted from its fruit.

It has been traditionally used in herbal medicine to treat hormonal imbalances, particularly in women. Casticin exhibits anti-inflammatory and antioxidant properties, which may help alleviate symptoms of premenstrual syndrome (PMS), such as breast tenderness and mood swings.

Research suggests that it may also have a regulatory effect on hormones, making it a potential natural remedy for polycystic ovary syndrome (PCOS) and other hormonal disorders.