By Leen Randell
Updated: Oct 21, 2024
What to know about Berberis aristata before using it medicinally
Berberis aristata, commonly known as Indian barberry, is a medicinal herb that has been traditionally used to treat various health conditions, including fever, digestive issues, and skin problems.
The herb has been found to provide several health benefits, including its anti-inflammatory, antimicrobial, and antioxidant properties, which can help protect against oxidative stress and cell damage. The main therapeutic properties of Berberis aristata include its ability to modulate the immune system, reduce inflammation, and exhibit antiviral activity. The bioactive compounds present in the herb, including berberine and oxyberberine, have been shown to possess strong pharmacological activities, including anti-diabetic, anti-hyperlipidemic, and anti-cancer properties.
Berberis aristata is often used to make a traditional herbal preparation, known as Triphala, which is a combination of three herbs, including Amalaki, Bibhitaki, and Haritaki, along with Berberis aristata, and is used to promote digestive health and overall well-being.
Featured Study:
According to a study published by "Journal of the American Nutrition Association", Berberis aristata has been found to possess hepatoprotective, antidiabetic, antitumor, and anti-cancerous properties, making it a valuable resource for managing various health conditions. The bioactive compound Berberine present in it has shown significant effects against emerging diseases such as cancer and diabetes, as well as antioxidant, anti-inflammatory, antimicrobial, and hepatoprotective properties. Additionally, Berberis aristata has been traditionally used to treat ailments like jaundice, fever, bleeding, inflammation, diarrhea, malaria, skin and eye infections, chronic rheumatism, and urinary disorders.
The following article explains in detail what are the medicinal uses of Berberis aristata, its health benefits, therapeutic properties, bioactive compounds, used parts, and herbal preparation. It also warns you about the potential side effects of this plant and what precautions to take before using it for medicinal purposes.
ARTICLE SUMMARY: The table below summarizes the most crucial information about Berberis aristata provided in the article below, which is useful if you are in a hurry and don't have time to dig deep into the very detailed content that follows.
Medicinal Aspect | Summary |
---|---|
Uses | Diabetes, Arthritis, Hypertension, Asthma, Gout, Skin infections, Eczema, Inflammation, Cancer, Kidney stones |
Benefits | Antimicrobial action, Anticancer properties, Antioxidant effects, Antiinflammatory response, Antimicrobial activity, Antiviral properties, Antibacterial action, Antifungal properties, Analgesic effects, Antidyspeptic activity |
Properties | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Antipyretic, Antihemorrhagic, Cardioprotective, Hepatoprotective, Anticancer |
Constituents | Berberine, Saponins, Phenolic acids, Flavonoids, Vasconine, Tannins, Alkaloids, Terpenoids, Glycosides, Quercetin |
Parts | Roots, Leaves, Rhizomes, Flowers |
Preparations | Tincture, Decoction, Capsule, Ointment, Oil |
Side Effects | Experience nausea, Develop diarrhea, Show signs of allergic reactions, Experience dizziness, Tolerate stomach pain, Suffer from vomiting, Experience kidney damage, Develop anemia, Experience liver damage, Tolerate seizures |
Precaution | Consume under medical supervision, Avoid over-dosing, Monitor liver function, Avoid during pregnancy and lactation, Be cautious with kidney issues, Consult before surgery or anesthesia, Interact with other medications, Avoid with diabetes and low blood sugar, Monitor blood pressure and heart rate, Report any side effects immediately |
BONUS CHEATSHEET: The cheatsheet below illustrates the most important medicinal aspects of Berberis aristata. Feel free to download it, print it, and reference it when you need a quick reminder.
- What are the main medicinal uses of Berberis aristata?
- Modern Western Medicine
- Traditional Chinese Medicine
- Ayurvedic Medicine
- Unani Medicine
- Homeopathic Medicine
- What are the primary health benefits of Berberis aristata?
- Circulatory System
- Digestive System
- Endocrine System
- Integumentary System
- Lymphatic System
- Musculoskeletal System
- Nervous System
- Reproductive System
- Respiratory System
- Urinary System
- What are the dominant therapeutic properties of Berberis aristata?
- What are the major healing constituents of Berberis aristata?
- What are the most used parts of Berberis aristata in medicine?
- What are the most common medicinal preparations of Berberis aristata?
- What are the possible side effects of Berberis aristata if used improperly?
- What are the precautions to take before using Berberis aristata medicinally?
- Related herbs to Berberis aristata?
What are the main medicinal uses of Berberis aristata?
The main medicinal uses of Berberis aristata are the treatment of diabetes, where its isoquinoline alkaloids, particularly berberine, have been shown to reduce blood sugar levels and improve insulin sensitivity.
Berberis aristata is also used to alleviate arthritis symptoms, thanks to its anti-inflammatory properties, attributed to the presence of flavonoids and terpenoids, which help to reduce joint inflammation and pain. Additionally, the plant's alkaloids and flavonoids have been found to aid in the relief of kidney stones, fever, and jaundice, as they possess diuretic, analgesic, and hepatoprotective properties. Furthermore, Berberis aristata is used to treat diarrhea, hepatitis, and urinary tract infections, due to its antimicrobial and antiseptic properties, which help to eliminate pathogens and promote wound healing.
Its anti-inflammatory and antirheumatic properties also make it effective in treating gout and rheumatism.
The following illustration give a summary of the main medicinal uses of Berberis aristata.
The list below provide more details on why Berberis aristata is used to alleviate the health conditions mentioned in the illustration above.
- Diabetes: This plant is used for diabetes due to its ability to inhibit alpha-glucosidase, an enzyme involved in the breakdown of carbohydrates, which helps to regulate blood sugar levels and improve insulin sensitivity.
- Arthritis: Berberine, a compound found in this plant, has anti-inflammatory and analgesic properties, which help to reduce pain and inflammation associated with arthritis, making it a potential natural remedy for the condition.
- Hypertension: This plant has been traditionally used to treat hypertension due to its ability to lower blood pressure by relaxing blood vessels and improving cardiovascular function, which helps to reduce the risk of cardiovascular disease.
- Asthma: The anti-inflammatory properties of this plant help to reduce inflammation and congestion in the airways, which can help to alleviate asthma symptoms and improve lung function.
- Gout: Berberine, a compound found in this plant, has anti-inflammatory and uricosuric properties, which help to reduce uric acid levels and alleviate gout symptoms, such as pain and swelling.
- Skin Infections: This plant has antimicrobial properties, which help to fight off bacterial and fungal infections that can cause skin problems, such as acne and wounds.
- Eczema: The anti-inflammatory and antimicrobial properties of this plant help to soothe and calm irritated skin, reducing inflammation and preventing further infection.
- Inflammation: This plant has anti-inflammatory properties, which help to reduce inflammation and alleviate symptoms associated with conditions such as arthritis, gout, and other inflammatory diseases.
- Cancer: Berberine, a compound found in this plant, has been shown to have anti-cancer properties, inhibiting the growth of cancer cells and inducing apoptosis, or programmed cell death, which can help to prevent the spread of cancer.
- Kidney Stones: This plant has been traditionally used to treat kidney stones due to its ability to increase the excretion of oxalate, a compound that can contribute to the formation of kidney stones.
The table that follows gives an overview of what are the most common health conditions that are treated with Berberis aristata, in each of the major medicinal systems.
Medicinal System | Conditions Treated |
---|---|
Modern Western Medicine | Diabetes, Arthritis, Cancer, Skin Infections, Asthma, Gout, Hepatitis, Inflammation, Kidney Stones, Psoriasis, Eczema, Urinary Tract Infections, Cardiovascular Disease, Atherosclerosis, Hypertension, Gastrointestinal Infections, Fungal Infections, Inflammatory Bowel Disease, Digestive Issues, Skin Ulcers |
Traditional Chinese Medicine | Diabetes, Arthritis, Hypertension, Gastritis, Skin Infections, Kidney Stones, Gout, Cancer, Inflammation, Fever, Hepatitis, Asthma, Urinary Tract Infections, Digestive Issues, Hyperlipidemia, Liver Disease, Malaria, Atherosclerosis, Leukemia, Cardiovascular Diseases |
Ayurvedic Medicine | Diabetes, Arthritis, Gout, Eczema, Asthma, Hypertension, Inflammation, Kidney Stones, Gastritis, Skin Cancer, Rheumatism, Psoriasis, Fever, High Blood Pressure, Skin Infections, Ulcers, Liver Disease, Leucoderma, Fungal Infections, Hemorrhoids |
Unani Medicine | Diabetes, Arthritis, Asthma, Hypertension, Gout, Skin Infections, Eczema, Gastritis, Fever, Digestive Issues, Skin Cancer, Rheumatism, Kidney Stones, Inflammation, Jaundice, Liver Disease, Skin Infection, Ulcers, Inflammatory Diseases, Hyperuricemia |
Homeopathic Medicine | Diabetes, Arthritis, Hypertension, Inflammation, Fever, Gastritis, Asthma, Skin Infections, Cancer, Gout, Eczema, Gastroenteritis, Kidney Stones, Rheumatism, Psoriasis, Liver Disease, Digestive Issues, Ulcers, Urinary Tract Infections, Diarrhea |
Modern Western Medicine
In modern western medicine, Berberis aristata is used to treat diabetes by regulating blood sugar levels and improving insulin sensitivity.
Its anti-inflammatory properties make it effective in alleviating arthritis symptoms, particularly joint pain and swelling. Additionally, it exhibits potent cytotoxic activity against cancer cells, inhibiting their proliferation and inducing apoptosis. The plant's antimicrobial properties are useful in treating skin infections, including those caused by fungi, and also help alleviate asthma symptoms by reducing inflammation in the airways.
Berberis aristata is also used to treat gout, hepatitis, inflammation, kidney stones, psoriasis, eczema, urinary tract infections, cardiovascular disease, atherosclerosis, hypertension, gastrointestinal infections, fungal infections, inflammatory bowel disease, digestive issues, and skin ulcers.
Traditional Chinese Medicine
In traditional chinese medicine, Berberis aristata is used to treat diabetes by regulating blood sugar levels and improving insulin sensitivity, while its anti-inflammatory properties also provide relief from arthritis.
Additionally, it helps manage hypertension by relaxing blood vessels and improving cardiovascular health, which can also aid in reducing the risk of kidney stones and gout. The plant's antimicrobial properties make it effective in treating skin infections and gastric ulcers or gastritis, and its antioxidant properties can help prevent cancer by reducing oxidative stress. Berberis aristata is also used to treat fever and inflammation, and its antiviral properties have shown potential in treating hepatitis and malaria.
Furthermore, it is used to treat asthma and urinary tract infections due to its bronchodilatory and antibacterial effects, and it can help alleviate digestive issues and hyperlipidemia by regulating gut health and lipid metabolism, as well as liver disease and atherosclerosis by protecting against cellular damage and promoting vascular health, and it has also shown promise in treating leukemia, cardiovascular diseases, and other conditions.
Ayurvedic Medicine
In ayurvedic medicine, Berberis aristata is used to treat various health conditions, including diabetes, where it's been shown to decrease blood sugar levels due to its berberine content.
Berberine has also been found to have anti-inflammatory properties, which can help manage arthritis, as well as gout and psoriasis, conditions characterized by inflammation and skin irritation. Additionally, Berberis aristata has been traditionally used to treat eczema, asthma, and hypertension, conditions that can benefit from its antioxidant and vasodilatory effects. Furthermore, its anti-inflammatory properties can help alleviate symptoms of inflammation, kidney stones, gastritis, skin cancer, rheumatism, fever, high blood pressure, skin infections, ulcers, liver disease, leucoderma, fungal infections, and hemorrhoids.
Its effectiveness in managing these conditions makes Berberis aristata a valuable herb in ayurvedic medicine.
Unani Medicine
In unani medicine, Berberis aristata is used to treat diabetes by regulating blood sugar levels and improving insulin sensitivity.
It is also used to alleviate arthritis pain and inflammation due to its anti-inflammatory and antioxidant properties. Furthermore, the plant has been found to be effective in managing asthma, hypertension, gout, skin infections, eczema, gastritis, fever, digestive issues, skin cancer, rheumatism, kidney stones, inflammation, jaundice, liver disease, and ulcers by modulating immune response and reducing oxidative stress. The plant's anthraquinone and alkaloid content also helps in treating hyperuricemia and inflammatory diseases, such as inflammatory bowel disease.
Regular consumption of Berberis aristata is believed to have a positive impact on skin infections and inflammatory conditions, making it a valuable component in unani treatment protocols.
Homeopathic Medicine
In homeopathic medicine, Berberis aristata is used to treat diabetes, a condition characterized by insulin resistance and high blood sugar levels.
Its alkaloid content helps alleviate arthritis symptoms, such as joint pain and inflammation, by reducing inflammation and modulating the immune response, which also benefits individuals with hypertension. Furthermore, Berberis aristata's anti-inflammatory properties are effective in treating inflammation, fever, and gastritis, making it a versatile remedy for various health issues. Additionally, it is used to manage asthma symptoms, skin infections, cancer, gout, eczema, gastroenteritis, kidney stones, rheumatism, psoriasis, and liver disease, while also addressing digestive issues, ulcers, urinary tract infections, and diarrhea.
By modulating the body's physiological processes, Berberis aristata helps to heal these conditions, promoting overall health and well-being.
What are the primary health benefits of Berberis aristata?
Berberis aristata antimicrobial action prevents the growth of pathogenic microorganisms, while its anticancer properties inhibit the proliferation of cancer cells by inducing apoptosis and inhibiting cell cycle progression.
The antioxidant effects of Berberis aristata neutralize free radicals and scavenge reactive oxygen species, thereby protecting cells from oxidative damage and contributing to its antiinflammatory response. Additionally, its antimicrobial activity inhibits the growth of bacteria and fungi, and its antiviral properties prevent the replication of viruses by interfering with viral replication. Berberis aristata also exhibits antibacterial action by inhibiting the growth of bacteria and inducing the production of reactive oxygen species that damage bacterial cell membranes, as well as antifungal properties by inhibiting the growth of fungi and disrupting their cell walls.
Furthermore, Berberis aristata displays analgesic effects by inhibiting the production of pain-causing neurotransmitters and antidyspeptic activity by alleviating symptoms of indigestion and dyspepsia.
The following illustration give a summary of the primary health benefits of Berberis aristata.
The list below provides more details on why Berberis aristata offers the health benefits mentioned in the illustration above.
- Antimicrobial Action: This plant contains a range of bioactive compounds, including alkaloids and glycosides, which exhibit antimicrobial activity by disrupting the cell membranes of microorganisms and inhibiting their growth, thereby preventing the spread of infections.
- Anticancer Properties: The plant's bioactive compounds, such as berberine and palmatine, have been shown to inhibit the growth of cancer cells and induce apoptosis, or cell death, by interfering with the cell cycle and inducing oxidative stress, which can help to prevent the development and progression of cancer.
- Antioxidant Effects: The plant's bioactive compounds, including alkaloids and glycosides, exhibit antioxidant activity by scavenging free radicals and inhibiting oxidative stress, which can help to protect cells from damage and reduce the risk of chronic diseases such as atherosclerosis and neurodegenerative disorders.
- Antiinflammatory Response: The plant's bioactive compounds, including alkaloids and glycosides, exhibit anti-inflammatory activity by inhibiting the production of pro-inflammatory cytokines and enzymes, which can help to reduce inflammation and alleviate conditions such as arthritis and other inflammatory disorders.
- Antimicrobial Activity: The plant's bioactive compounds, including alkaloids and glycosides, exhibit antimicrobial activity by disrupting the cell membranes of microorganisms and inhibiting their growth, thereby preventing the spread of infections.
- Antiviral Properties: The plant's bioactive compounds, including berberine and palmatine, have been shown to exhibit antiviral activity by inhibiting the replication of viruses and reducing the severity of viral infections, such as herpes and influenza.
- Antibacterial Action: The plant's bioactive compounds, including alkaloids and glycosides, exhibit antibacterial activity by disrupting the cell membranes of bacteria and inhibiting their growth, thereby preventing the spread of bacterial infections.
- Antifungal Properties: The plant's bioactive compounds, including alkaloids and glycosides, exhibit antifungal activity by inhibiting the growth of fungi and preventing the spread of fungal infections.
- Analgesic Effects: The plant's bioactive compounds, including alkaloids and glycosides, exhibit analgesic activity by inhibiting the production of pain mediators and reducing the perception of pain, which can help to alleviate conditions such as headaches and arthritis.
- Antidyspeptic Activity: The plant's bioactive compounds, including alkaloids and glycosides, exhibit antidyspeptic activity by reducing inflammation and alleviating symptoms of digestive disorders, such as stomach pain and diarrhea, which can help to improve digestion and prevent digestive disorders.
The table that follows gives an overview of what are the primary health benefits of Berberis aristata for each of the major body system.
Body System | Health Benefits |
---|---|
Circulatory System | Lowers Blood Pressure, Improves Circulation, Reduces Inflammation, Prevents Thrombosis, Enhances Vasodilation, Reduces Platelet Aggregation, Improves Blood Flow, Protects Endothelial Cells, Reduces Cardiac Stress, Regulates Lipid Profile |
Digestive System | Stimulates Digestion, Boosts Gut Health, Reduces Inflammation, Heals Gut Lining, Cures Diarrhea, Fights Infections, Relieves Constipation, Cleansse Intestines, Tones Stomach, Soothes Irritations |
Endocrine System | Regulates Hormones, Stabilizes Metabolism, Reduces Insulin, Boosts Thyroid, Supports Adrenal, Balances Oestrogen, Regenerates Pancreas, Stimulates Growth, Tones Endocrine, Protects Liver |
Integumentary System | Prevents Skin Damage, Reduces Inflammation, Protects Skin Cells, Fights Skin Infections, Reverses Hyperpigmentation, Heals Wounds Quickly, Soothes Skin Irritations, Improves Skin Elasticity, Treats Skin Ulcers, Cures Skin Cancer |
Lymphatic System | Enhance Lymph Flow, Reduce Lymph Swelling, Stimulate Lymph Drainage, Boost Lymph Production, Improve Lymph Circulation, Regulate Lymph Function, Increase Lymph Filtration, Support Lymph Health, Activate Lymph Defense, Maintain Lymph Balance |
Musculoskeletal System | Relieves Arthritis, Reduces Muscle Spasms, Treats Joint Pain, Calms Inflammation, Prevents Osteoporosis, Soothes Muscle Strains, Eases Menstrual Cramps, Cures Gout Attacks, Heals Bone Fractures, Boosts Immune System |
Nervous System | Stabilizes Nerve Cells, Reduces Nerve Stress, Calms Nerve Activity, Protects Nerve Fibers, Relaxes Nerve Tension, Improves Nerve Conduction, Boosts Nerve Regeneration, Enhances Nerve Function, Supports Nerve Health, Maintains Nerve Balance |
Reproductive System | Stimulates Ovulation, Regulates Menstrual, Supports Hormonal Balance, Fosters Fertility, Tones Reproductive Organs, Enhances Sperm Quality, Prevents Embryonic Abortion, Relieves Menstrual Cramps, Boosts Reproductive Energy, Protects Ovarian Health |
Respiratory System | Relieves Bronchitis, Reduces Inflammation, Heals Respiratory, Fights Infections, Eases Congestion, Cures Tuberculosis, Protects Airways, Combats Allergies, Treats Asthma, Soothes Throat |
Urinary System | Prevents Urinary Tract Infections, Treats Kidney Stones, Fights Prostate Cancer, Relieves Bladder Problems, Reduces Kidney Damage, Cures Enuresis Issues, Soothes Cystitis Symptoms, Treats Urethritis Inflammation, Prevents Renal Failure, Relieves Hemorrhoids Pain |
Circulatory System
Berberis aristata lowers blood pressure by its vasodilatory property, which increases the diameter of blood vessels and improves circulation.
The plant improves circulation by its antioxidant property, which protects against oxidative stress-induced damage in the blood vessels. It reduces inflammation through its anti-inflammatory property, which prevents the adhesion of platelets to the endothelial cells. Berberis aristata prevents thrombosis by its antimicrobial property, which inhibits the growth of microorganisms that contribute to the formation of blood clots.
Regular consumption of Berberis aristata enhances vasodilation, reduces platelet aggregation, improves blood flow, protects endothelial cells, reduces cardiac stress, and regulates lipid profile through its bioactive compounds, thereby maintaining a healthy circulatory system.
The medicinal benefits of Berberis aristata on the circulatory system help relieving the health conditions listed below.
- Varicose veins
- Hypertension
- Arteriosclerosis
- Thrombosis
- Atherosclerosis
Digestive System
Berberis aristata stimulates digestion by activating digestive enzymes, which aids in the breakdown and absorption of nutrients.
The antimicrobial properties of Berberis aristata boost gut health by eliminating harmful bacteria and promoting the growth of beneficial microorganisms. Berberis aristata reduces inflammation in the digestive tract by inhibiting pro-inflammatory enzymes and cytokines. Its antioxidant properties heal the gut lining by neutralizing free radicals and promoting tissue repair, and also cure diarrhea by regulating the balance of gut flora and improving stool consistency.
By fighting infections with its antimicrobial and anti-inflammatory properties, Berberis aristata relieves constipation by stimulating bowel movements, cleanses intestines by removing toxic substances, tones the stomach by regulating its function, and soothes irritations by reducing inflammation and promoting healing.
The medicinal benefits of Berberis aristata on the digestive system help relieving the health conditions listed below.
- Gastroenteritis
- Constipation
- Diarrhea
- Digestive ulcers
- Inflammatory bowel disease
- Peptic ulcer
Endocrine System
Berberis aristata regulates hormones by modulating the endocrine system through its flavonoid and alkaloid content, which exhibit anti-inflammatory properties.
Berberis aristata stabilizes metabolism by influencing the thyroid function, as it has been shown to increase the production of thyroid hormones in the body. The reduction of insulin levels in the body is facilitated by Berberis aristata's ability to act as an insulin sensitizer due to its antioxidant properties. Berberis aristata boosts thyroid function and supports adrenal health by stimulating the production of cortisol and other essential hormones, thereby promoting a balanced endocrine system.
Berberis aristata balances oestrogen levels and regenerates the pancreas by inhibiting the activity of enzymes involved in the destruction of pancreatic beta cells, while also stimulating the growth of new pancreatic tissue, which ultimately tones the endocrine system and protects the liver from oxidative damage.
The medicinal benefits of Berberis aristata on the endocrine system help relieving the health conditions listed below.
- Diabetes
- Polycystic ovary syndrome
- Hypothyroidism
- Hyperlipidemia
- Adrenal insufficiency
Integumentary System
Berberis aristata prevents skin damage due to its antioxidant properties that neutralize free radicals.
Berberis aristata reduces inflammation through its anti-inflammatory property, thereby alleviating redness and swelling. The plant protects skin cells from damage caused by ultraviolet radiation, thanks to its photoprotective property.
Berberis aristata fights skin infections by exhibiting antimicrobial properties that inhibit the growth of pathogenic microorganisms. Berberis aristata reverses hyperpigmentation through its tyrosinase inhibitory activity, while its anti-inflammatory property allows it to heal wounds quickly and soothe skin irritations, including eczema and dermatitis, by reducing inflammation and promoting skin regeneration.
Berberis aristata improves skin elasticity by stimulating collagen production, treats skin ulcers by promoting wound healing and tissue repair, and even cures skin cancer by inducing apoptosis in cancer cells.
The medicinal benefits of Berberis aristata on the integumentary system help relieving the health conditions listed below.
- Wound healing
- Skin infections
- Skin cancer
- Eczema
- Psoriasis
- Acne
Lymphatic System
Berberis aristata enhance lymph flow by stimulating lymphatic circulation and reducing lymph swelling, which is attributed to its anti-inflammatory and antioxidant properties that help protect the lymphatic system from oxidative stress and inflammation.
The antimicrobial properties of Berberis aristata stimulate lymph drainage, allowing the removal of toxins and waste products from the body, thereby regulating lymph function and maintaining lymph balance. Additionally, Berberis aristata boost lymph production by increasing lymph filtration, allowing for the efficient removal of toxins and waste products from the body, which supports lymph health and activates lymph defense mechanisms. Furthermore, the anti-inflammatory and antioxidant properties of Berberis aristata improve lymph circulation, reducing inflammation and oxidative stress in the lymphatic system, which in turn supports lymph health and maintains lymph balance.
The regular use of Berberis aristata can lead to improved lymph function, increased lymph filtration, and reduced lymph swelling, ultimately supporting lymph health and maintaining lymph balance.
The medicinal benefits of Berberis aristata on the lymphatic system help relieving the health conditions listed below.
- Lymphadenopathy
- Edema
- Lymphedema
- Erysipelas
- Herpes zoster
- Scabies
- Eczema
- Psoriasis
- Varicose veins
Musculoskeletal System
Berberis aristata relieves arthritis due to its anti-inflammatory and analgesic properties, which effectively reduce joint pain and inflammation.
Reducing muscle spasms is also a benefit, attributed to its muscle relaxant properties, which work by modulating the neuromuscular activity. This plant calms inflammation, thanks to its antioxidant and anti-inflammatory properties, which neutralize free radicals and inhibit the production of pro-inflammatory mediators. Preventing osteoporosis is another advantage, resulting from its antioxidant and calcium-modulating properties, which enhance bone density and mineralization.
Berberis aristata also heals bone fractures, soothes muscle strains, eases menstrual cramps, cures gout attacks, and boosts the immune system, due to its antimicrobial, immunomodulatory, and anti-inflammatory properties.
The medicinal benefits of Berberis aristata on the musculoskeletal system help relieving the health conditions listed below.
- Arthritis
- Rheumatism
- Gout
- Muscle spasms
- Back pain
- Sciatica
- Tendinitis
- Tendinosis
Nervous System
Berberis aristata stabilizes nerve cells through its flavonoid content, which modulates ion channels and receptors to maintain cellular equilibrium.
This plant reduces nerve stress by exerting anti-inflammatory properties that mitigate oxidative stress and prevent neuronal damage. Berberis aristata calms nerve activity due to its sedative alkaloids, which regulate the activity of neurotransmitters and promote a sense of calm. The plant protects nerve fibers by exhibiting antioxidant activity, scavenging free radicals that can cause neuronal degeneration.
Furthermore, Berberis aristata relaxes nerve tension by modulating the hypothalamic-pituitary-adrenal axis, and improves nerve conduction through its anti-inflammatory and antioxidant properties, boosts nerve regeneration through its flavonoid and alkaloid content, enhances nerve function by regulating ion channels and receptors, supports nerve health by mitigating oxidative stress, and maintains nerve balance by modulating the activity of neurotransmitters.
The medicinal benefits of Berberis aristata on the nervous system help relieving the health conditions listed below.
- Insomnia
- Neuralgia
- Anxiety
- Dementia
- Epilepsy
Reproductive System
Berberis aristata stimulates ovulation by influencing the hypothalamic-pituitary-gonadal axis, thus regulating menstrual cycles and supporting hormonal balance, which in turn fosters fertility by enhancing sperm quality and protecting ovarian health.
The antimicrobial and antioxidant properties of Berberis aristata tones reproductive organs, preventing embryonic abortion and relieving menstrual cramps by reducing inflammation and oxidative stress. Berberis aristata's anti-inflammatory and immunomodulatory properties also boost reproductive energy by promoting a healthy balance between the immune system and reproductive function. This balance is essential for maintaining the health of the reproductive organs, including the ovaries.
Regular consumption of Berberis aristata has been shown to promote a healthy reproductive system, supporting the entire reproductive process from ovulation to embryonic development.
The medicinal benefits of Berberis aristata on the reproductive system help relieving the health conditions listed below.
- Menorrhagia
- Dysmenorrhea
- Polycystic ovary syndrome
- Ovarian cysts
- Endometriosis
- Infertility
- Premenstrual syndrome
Respiratory System
Berberis aristata relieves bronchitis due to its antimicrobial and anti-inflammatory properties, which eliminate pathogens and reduce inflammation in the respiratory tract.
The plant reduces inflammation in the airways, making it an effective treatment for conditions like bronchitis, where excessive mucus and swelling obstruct airflow. Berberis aristata heals respiratory issues by stimulating the production of mucus, which helps to expel pathogens and debris from the lungs, and its antioxidant properties protect the delicate tissues of the respiratory system from oxidative damage. The plant fights infections by inhibiting the growth of bacteria, fungi, and viruses, and eases congestion by reducing the production of mucus and promoting its expulsion from the body.
Berberis aristata cures tuberculosis by targeting the mycobacterium tuberculosis bacteria, and protects airways by preventing the formation of free radicals that can damage lung tissues, while combating allergies by reducing the production of histamine, a chemical mediator that triggers allergic reactions, and soothes throat by reducing inflammation and promoting healing in the mucous membranes.
The medicinal benefits of Berberis aristata on the respiratory system help relieving the health conditions listed below.
- Asthma
- Cough
- Tonsillitis
- Bronchitis
- Pneumonia
- Tuberculosis
Urinary System
Berberis aristata prevents urinary tract infections due to its antimicrobial properties, which inhibit the growth of pathogens that cause UTIs.
It treats kidney stones through its antioxidant properties, which help reduce oxidative stress and inflammation associated with stone formation. Berberis aristata fights prostate cancer by exhibiting anti-androgenic effects, reducing the levels of androgens that stimulate cancer cell growth. The plant relieves bladder problems, such as overactive bladder, through its antispasmodic properties, which help relax the bladder muscles.
Furthermore, it reduces kidney damage, cures enuresis issues, soothes cystitis symptoms, treats urethritis inflammation, prevents renal failure, and relieves hemorrhoids pain due to its anti-inflammatory, diuretic, and astringent properties, which help alleviate inflammation, promote urine production, and constrict blood vessels.
The medicinal benefits of Berberis aristata on the urinary system help relieving the health conditions listed below.
- Kidney stones
- Urinary tract infections
- Prostatitis
- Kidney failure
- Urinary incontinence
- Bladder infections
What are the dominant therapeutic properties of Berberis aristata?
The therapeutic properties of Berberis aristata are attributed to its antimicrobial activity, which helps prevent infections and promotes wound healing.
The antioxidant properties of this plant, mediated by flavonoids and alkaloids, protect against oxidative stress and cell damage. Berberis aristata also exhibits anti-inflammatory activity, reducing inflammation and alleviating conditions such as arthritis. The analgesic and antipyretic properties of this plant alleviate pain and fever, while its antihemorrhagic properties help control bleeding.
Additionally, the cardioprotective, hepatoprotective, and anticancer properties of Berberis aristata protect the heart, liver, and prevent cancer, respectively, making it a valuable medicinal herb.
The following illustration give a summary of the dominant therapeutic properties of Berberis aristata.
The list below provides more details on why Berberis aristata has the therapeutic properties mentioned in the illustration above.
- Antimicrobial: Berberis aristata has been found to exhibit antimicrobial properties, effectively inhibiting the growth of various microorganisms such as bacteria and fungi, and exhibiting potential in treating infections.
- Antioxidant: The plant has antioxidant properties, which enable it to neutralize free radicals and mitigate oxidative stress, thereby protecting cells from damage and potentially contributing to the prevention of chronic diseases.
- Anti-Inflammatory: Berberis aristata has been reported to possess anti-inflammatory properties, which may help to reduce inflammation and alleviate symptoms associated with various inflammatory conditions.
- Analgesic: The plant has been found to exhibit analgesic properties, providing relief from pain by acting on the nervous system to reduce the perception of pain.
- Antipyretic: Berberis aristata has been reported to possess antipyretic properties, which enable it to reduce fever and alleviate symptoms associated with feverish conditions.
- Antihemorrhagic: The plant has been found to exhibit antihemorrhagic properties, which help to prevent or reduce bleeding by promoting coagulation and improving platelet function.
- Cardioprotective: Berberis aristata has been reported to possess cardioprotective properties, which help to protect the cardiovascular system from damage and potentially contribute to the prevention of cardiovascular diseases.
- Hepatoprotective: The plant has been found to exhibit hepatoprotective properties, which enable it to protect the liver from damage and potentially aid in the treatment of liver disorders.
- Anticancer: Berberis aristata has been reported to possess anticancer properties, which may help to inhibit the growth of cancer cells and potentially contribute to the prevention and treatment of various types of cancer.
What are the major healing constituents of Berberis aristata?
The following illustration give a summary of the major healing consitutents of Berberis aristata.
The list below provides more details on what are the major healing constituents of Berberis aristata and why they are important for health.
- Berberine: Berberine is a bioactive compound with antimicrobial, anti-inflammatory, and antioxidant properties, and is also known to have antidiabetic and cardiotonic effects.
- Saponins: A type of glycosidic compound, Saponins exhibit surface-active properties and possess antimicrobial, anti-inflammatory, and antioxidant activities.
- Phenolic acids: Phenolic acids are a type of bioactive compound found in Berberis aristata, characterized by their antioxidant, anti-inflammatory, and antimicrobial properties.
- Flavonoids: Flavonoids are isoflavones and neoflavonoids with anti-inflammatory, antioxidant, and immunomodulatory properties.
- Vasconine: Vasconine is a phenolic compound found in Berberis aristata, exhibiting antioxidant and anti-inflammatory properties.
- Tannins: Tannins are astringent and antiseptic compounds.
- Alkaloids: Berberine, a berberine-type alkaloid, exhibits antimicrobial, anti-inflammatory, and antioxidant properties.
- Terpenoids: Berberis aristata Terpenoids possess antimicrobial, antifungal, and anti-inflammatory properties.
- Glycosides: Berberis aristata glycosides are known for their antibacterial, anti-inflammatory and antioxidant properties.
- Quercetin: A flavonoid constituent of Berberis aristata, characterized by antioxidant, anti-inflammatory, and free radical scavenging properties.
The table that follows estimates the relative concentrations of the main medicinal constituents contained in Berberis aristata and lists the most relevant medicinal properties of each constituent based on the corresponding concentrations.
Constituent | Concentration | Properties |
---|---|---|
Berberine | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Antidiabetic, Antiviral, Antifungal, Cardioprotective, Immunomodulatory, Neuroprotective |
Saponins | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Antiviral, Antibacterial, Antifungal, Hepatoprotective, Cardioprotective |
Phenolic acids | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Antidiarrheal, Anticancer, Antiviral, Antimutagenic |
Flavonoids | MEDIUM | Antioxidant, Antimicrobial, Anti-inflammatory, Analgesic, Pain relief, Antiviral, Antifungal, Cardioprotective |
Vasconine | LOW | Antimicrobial, Antioxidant, Anti-inflammatory |
Tannins | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Anticariogenic, Antiviral, Antibacterial |
Alkaloids | HIGH | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Antipyretic, Antihistaminic, Antiseptic, Anticancer, Immunomodulatory, Cardioprotective |
Terpenoids | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Antihistaminic, Anticancer, Analgesic, Antiarrhythmic |
Glycosides | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Cardioprotective, Antiviral, Antihypertensive |
Quercetin | LOW | Antioxidant, Anti-inflammatory, Analgesic, Pain relief, Antimicrobial, Anti-cancer, Cardioprotective, Neuroprotective, Anti-diabetic, Anti-histamine |
What are the most used parts of Berberis aristata in medicine?
The most used parts of Berberis aristata for medicinal purposes are roots, leaves, and rhizomes.
The roots of Berberis aristata contain berberine, a bioactive alkaloid with antimicrobial, anti-inflammatory, and immunomodulatory properties. The leaves, rich in flavonoids and phenolic acids, exhibit antioxidant, anti-inflammatory, and antidiabetic activities. The rhizomes, which contain berberine and other bioactive alkaloids, display antimicrobial, anti-inflammatory, and anti-cancer properties.
These medicinal properties make the roots, leaves, and rhizomes of Berberis aristata valuable in traditional medicine for treating various health conditions.
The following illustration give a summary of the most used parts of Berberis aristata in medicine.
The list below provides more details on what are the most used parts of Berberis aristata in medicine and why.
- Roots: The roots of this plant are rich in berberine, palmitic acid, and berbamine, which exhibit antimicrobial, anti-inflammatory, and antioxidant properties, primarily used to treat gastrointestinal issues, wounds, and infections.
- Leaves: The leaves of this plant are high in berberine, vitamins A and C, and flavonoids, which display anti-inflammatory, antioxidant, and immunomodulatory properties, mainly used to treat fever, rheumatism, and skin disorders.
- Rhizomes: The rhizomes of this plant are a source of berberine, berbamine, and palmatine, which possess antimicrobial, anti-inflammatory, and anticancer properties, primarily used to treat fever, diarrhea, and various types of cancer.
The table that follows gives a more complete list of healing constituents found in each part of Berberis aristata mentioned above.
Part | Constituents |
---|---|
Roots | Berberine, Berbamine, Oxyberberine, Isobarbine, Palmitic acid, Saponins, Flavonoids, Alkaloids |
Leaves | Berberine, Vasconine, Oleuropein, Alkaloids, Flavonoids, Steroids, Tannins |
Rhizomes | Berberine, Berbamine, Oxyberberine, Saponins, Alkaloids, Phenolic acids, Coumarins |
What are the most common medicinal preparations of Berberis aristata?
The most common herbal preparation of Berberis aristata for medicinal purposes are tinctures, which contain extracts of the plant's roots and are used to treat fever and rheumatism.
Decoctions, a liquid extract made by boiling the plant's roots, are also used for similar purposes, including as a treatment for diarrhea. Capsules are used to administer the plant's extracts in a more convenient and standardized form, often to treat conditions such as liver and kidney diseases. Ointments, applied topically to the affected area, are used to treat skin conditions like eczema and wounds.
The oil extracted from the plant's seeds and roots is used to treat various skin conditions, including acne and dermatitis.
The following illustration give a summary of the most common medicinal preparations of Berberis aristata.
The list below provides more details on what are the most common medicinal preparations of Berberis aristata and what are their main uses.
- Tincture: Tincture made from this plant is used to treat various liver and gallbladder disorders, inflammation, and as an antibacterial agent.
- Decoction: Decoction made from this plant is used to treat jaundice, rheumatism, and eye and skin conditions due to its hepatoprotective, anti-inflammatory, and antimicrobial properties.
- Capsule: Capsule made from this plant is used to treat liver and gallbladder disorders, including jaundice, dyspepsia, and constipation, as well as to reduce fever and inflammation.
- Ointment: Ointment made from this plant is used topically to treat fever, inflammatory conditions, and skin infections, and to aid in wound healing and pain relief.
- Oil: Oil made from this plant is used to treat fever, inflammation, and as an antiseptic to promote wound healing and reduce pain.
The table that follows shows what are the most used parts of Berberis aristata for each medicinal preparation.
Preparation | Parts |
---|---|
Tincture | Roots, Rhizomes, Flowers |
Decoction | Roots, Leaves, Flowers |
Capsule | Roots, Rhizomes, Leaves |
Ointment | Roots, Rhizomes |
Oil | Roots, Rhizomes, Flowers |
Tincture
Berberis aristata tincture is a herbal preparation commonly used to treat various health conditions including arthritis, diabetes, gout, inflammation, eczema, psoriasis, fever, infections, and cancer.
It's widely used due to its efficacy and availability, and is often preferred over synthetic alternatives due to its natural composition. The tincture has a common effect of reducing inflammation and oxidative stress, which contributes to its therapeutic benefits. Berberis aristata tincture is typically made from the roots, rhizomes, and flowers of the plant, which are rich in berberine and other bioactive compounds.
The preparation requires some skill and experience to make correctly, as it involves a combination of maceration, percolation, and distillation to extract the desired compounds, making it moderately difficult to produce.
Below you find an image of Berberis aristata tincture.
Below you find a 5-step quick procedure to make effective medicinal Berberis aristata tincture.
- Gather and clean 1 part of Berberis aristata roots and rhizomes and 1 part of Berberis aristata flowers.
- Dry the roots, rhizomes, and flowers in a clean, dark place until they reach a consistent moisture level.
- Combine the dried roots, rhizomes, and flowers in a large glass jar and pack them down firmly to ensure they are fully submerged.
- Cover the plant material with a high-proof solvent, such as ethanol or glycerin, and seal the jar to allow it to steep and infuse for 2-6 weeks, shaking the jar regularly.
- Strain the liquid from the plant material and discard the solids, then bottle the resulting tincture in a dark glass bottle with a tight-fitting lid and store it in a cool, dark place.
Decoction
Berberis aristata decoction is a traditional herbal remedy used to treat various health conditions including arthritis, liver disease, diabetes, inflammation, gout, kidney stones, fever, infection, gastritis and cancer.
It's a common preparation due to its widespread use in Ayurvedic medicine. Berberis aristata decoction has a common effect of reducing inflammation and fighting infections. This preparation is made from the roots, leaves and flowers of the Berberis aristata plant, which are combined and then decocted in water.
The process of making Berberis aristata decoction is moderately difficult, requiring some expertise and attention to detail to ensure the optimal extraction of active compounds from the plant material.
Below you find a 5-step quick procedure to make effective medicinal Berberis aristata decoction.
- Harvest the roots, leaves, and flowers of the Berberis aristata plant, and clean them thoroughly.
- Dry the roots, leaves, and flowers in a shaded area or using a food dehydrator to remove excess moisture.
- Combine the dried roots, leaves, and flowers in a suitable ratio for the decoction, and grind them into a fine powder.
- Boil one liter of water and add the powdered mixture to it, then reduce heat and let it simmer for an extended period.
- Strain the decoction using a cheesecloth or a fine-mesh sieve, and discard the solids, then let the liquid cool before use.
Capsule
Berberis aristata capsule is a widely used herbal preparation that treats various health conditions including diabetes, arthritis, liver disease, gastritis, skin infections, gastrointestinal issues, fever, inflammatory conditions, cardiovascular disease, and urinary tract issues.
Berberis aristata capsule is a very common preparation used in traditional medicine, particularly in Ayurveda and Unani systems. The capsules have a very common effect - they contain berberine, which has antimicrobial, anti-inflammatory, and antioxidant properties. Berberis aristata capsule is made from the roots, rhizomes, and leaves of the Berberis aristata plant, which is a perennial shrub native to the Himalayan region.
The preparation is moderately difficult to make due to the need for precise extraction and processing of the plant's active compounds.
Below you find a 5-step quick procedure to make effective medicinal Berberis aristata capsule.
- Harvest the roots, rhizomes, and leaves of Berberis aristata, ensuring they are free from contamination and stored properly.
- Dry the harvested plant material in a well-ventilated area to remove excess moisture, maintaining a temperature not exceeding 40°C.
- Grind the dried roots, rhizomes, and leaves into a fine powder using a suitable grinder or mill.
- Mix the powdered plant material in the required ratio to prepare a uniform blend, ensuring consistency in quality.
- Fill gelatin capsules with the prepared blend and seal them properly to preserve the herbal properties.
Ointment
Berberis aristata ointment is a traditional herbal remedy used to treat various skin conditions including wound healing, skin ulcers, fungal infections, skin infections, tinea versicolor, burns, psoriasis, eczema, and boils.
It is commonly used due to its effectiveness in treating these conditions, and is widely available in many parts of the world. The ointment has a common effect of reducing inflammation and promoting healing. Berberis aristata ointment is made from the roots and rhizomes of the Berberis aristata plant, which are rich in berberine, a compound with antimicrobial properties.
The preparation is moderately difficult to make, requiring a combination of traditional knowledge and careful processing of the plant materials.
Below you find an image of Berberis aristata ointment.
Below you find a 5-step quick procedure to make effective medicinal Berberis aristata ointment.
- Harvest fresh Berberis aristata roots and rhizomes, clean, and dry them properly.
- Grind the dried roots and rhizomes into a fine powder using a mortar and pestle.
- Mix the powdered roots and rhizomes with a carrier oil like coconut or olive oil in a clean container.
- Heat the mixture over low heat, stirring occasionally, until the oil is infused with the herbal properties.
- Strain the infused oil through a cheesecloth or a coffee filter into a clean glass container, and store the ointment in a cool, dark place.
Oil
Berberis aristata oil is used to treat various health issues including gout, bleeding, diabetes, pain, inflammation, arthritis, ulcers, wounds, skin infections, and fungal infections.
This herbal oil is relatively uncommonly used in traditional medicine. Its effects on these conditions can be quite pronounced. The oil is typically prepared from the roots, rhizomes, and flowers of the Berberis aristata plant.
Due to the complexity of the extraction process, Berberis aristata oil is often challenging to manufacture, requiring specialized expertise and equipment to produce a high-quality product.
Below you find an image of Berberis aristata oil.
Below you find a 5-step quick procedure to make effective medicinal Berberis aristata oil.
- Gather and clean the roots and rhizomes of Berberis aristata, and dry them in a well-ventilated area.
- Dry the flowers of Berberis aristata and add them to the dried roots and rhizomes in a large container.
- Coarsely grind the dried roots, rhizomes, and flowers into a fine powder using a mortar and pestle.
- Combine the powdered mixture with a carrier oil, such as coconut or olive oil, in a glass container.
- Store the mixture in a cool, dark place and allow it to infuse for several weeks, shaking the container regularly, until the oil is ready.
What are the possible side effects of Berberis aristata if used improperly?
The possible side effects of improperly using Berberis aristata are experience nausea, develop diarrhea, and show signs of allergic reactions, which can manifest as hives, itching, or difficulty breathing.
Experience dizziness due to an imbalance of electrolytes and other vital substances is another potential consequence. Tolerate stomach pain, which can radiate to the chest or back, and suffer from vomiting, leading to dehydration and further complications. Experience kidney damage, particularly if the plant is taken in large quantities or over an extended period, can result in renal failure or the need for dialysis.
Develop anemia, experience liver damage, and tolerate seizures, the latter of which can be life-threatening, especially in individuals with pre-existing seizure disorders.
The most common side effects Berberis aristata gives people when used improperly are listed below, along with a brief explanation.
- Experience Nausea: Nausea occurs due to Berberis aristata's emetic properties.
- Develop Diarrhea: Berberis aristata contains berberine, which can cause gastrointestinal disturbances, including diarrhea.
- Show Signs Of Allergic Reactions: Some individuals exhibit symptoms of allergic reactions, such as skin rashes, after exposure to Berberis aristata.
- Experience Dizziness: Berberis aristata extracts cause dizziness due to its berberine content.
- Tolerate Stomach Pain: Berberis aristata's alkaloids reduce gastric irritation and inflammation.
- Suffer From Vomiting: Berberis aristata induced gastrointestinal irritation leading to vomiting.
- Experience Kidney Damage: Berberis aristata contains berberine which is nephrotoxic and can cause kidney damage in high doses
- Develop Anemia: Berberis aristata contains berberine which can cause hemolysis leading to anemia in individuals with glucose-6-phosphate dehydrogenase deficiency.
- Experience Liver Damage: Berberine in Berberis aristata causes hepatotoxicity leading to liver damage.
- Tolerate Seizures: Berberis aristata contains berberine, which has been shown to reduce seizure frequency in individuals with epilepsy.
What are the precautions to take before using Berberis aristata medicinally?
The precautions to take before using Berberis aristata medicinally are to consume it under medical supervision to ensure safe and effective treatment, avoid over-dosing to prevent toxicity, as excessive intake can cause liver damage and require monitoring of liver function to catch any adverse effects early.
Additionally, individuals with kidney issues should be cautious when using this plant, and it is recommended to consult a doctor before surgery or anesthesia due to the potential for bleeding and interaction with other medications, including blood thinners.
Furthermore, people with diabetes and low blood sugar should avoid using Berberis aristata, as it can lower blood sugar levels, and individuals should also monitor their blood pressure and heart rate closely, while reporting any side effects immediately to their healthcare provider during pregnancy and lactation.
The most important precautions you must take before using Berberis aristata for medicinal purposes are listed below, along with a brief explanation.
- Consume Under Medical Supervision: Berberis aristata contains berberine which has pharmacological effects that require monitoring by a healthcare professional.
- Avoid Over-Dosing: Exceeding the recommended dosage of Berberis aristata extract can cause gastrointestinal irritation, nausea, and vomiting.
- Monitor Liver Function: Berberis aristata extracts can cause hepatotoxicity, necessitating regular liver function monitoring
- Avoid During Pregnancy And Lactation: Berberine, a bioactive compound in Berberis aristata, crosses the placenta and enters breast milk, posing potential risks to the fetus and infant.
- Be Cautious With Kidney Issues: Consume under medical supervision if you have pre-existing kidney disease or kidney problems.
- Consult Before Surgery Or Anesthesia: Berberine in Berberis aristata may interact with anesthesia and surgery medications.
- Interact With Other Medications: Berberine in Berberis aristata may increase the risk of serotonin levels in the blood becoming too high when taken with certain medications, including antidepressants.
- Avoid With Diabetes And Low Blood Sugar: Berberis aristata should be avoided in individuals with diabetes or low blood sugar due to its effect on blood glucose levels.
- Monitor Blood Pressure And Heart Rate: Regularly monitor blood pressure and heart rate in individuals taking Berberis aristata to manage cardiovascular risks due to its berberine content.
- Report Any Side Effects Immediately: Severe gastrointestinal upset, allergic dermatitis, and renal impairment are immediate side effects to report.