By Leen Randell
Updated: Oct 22, 2024
What to know about Tripterygium wilfordii before using it medicinally
Tripterygium wilfordii, commonly known as thunder god vine, is a medicinal herb used to treat various health conditions, including rheumatoid arthritis, lupus, and other autoimmune diseases.
Its main health benefits include anti-inflammatory and immunosuppressive effects, which help to reduce pain and inflammation in the body. The therapeutic properties of Tripterygium wilfordii include antiviral, antibacterial, and antifungal activities, as well as the ability to modulate the immune system. The herb contains a range of bioactive compounds, including triptolide and tripteronide, which are responsible for its medicinal properties.
In traditional Chinese medicine, Tripterygium wilfordii is often prepared into a tea or a tincture, known as "lei gong teng," which is used to treat a variety of health conditions.
Featured Study:
According to a study published by "Phytochemistry", Tripterygium wilfordii has been found to have positive effects in treating various autoimmune and inflammation-related conditions. The extracts of it have been shown to inhibit the expression of proinflammatory genes, reducing the production of inflammatory compounds such as interleukin-2, tumor necrosis factor-alpha, and cyclooxygenase-2. This inhibition of proinflammatory genes suggests that it may be an effective treatment option for conditions characterized by excessive inflammation.
The following article explains in detail what are the medicinal uses of Tripterygium wilfordii, its health benefits, therapeutic properties, bioactive compounds, used parts, and herbal preparation. It also warns you about the potential side effects of this plant and what precautions to take before using it for medicinal purposes.
ARTICLE SUMMARY: The table below summarizes the most crucial information about Tripterygium wilfordii provided in the article below, which is useful if you are in a hurry and don't have time to dig deep into the very detailed content that follows.
| Medicinal Aspect | Summary |
|---|---|
| Uses | Rheumatoid arthritis, Psoriasis, Gout, Asthma, Multiple sclerosis, Crohn's disease, Lupus, Ulcerative colitis, Eczema, Osteoarthritis |
| Benefits | Reduces inflammation, Treats rheumatoid, Relieves arthritis, Prevents autoimmune, Inhibits cancer, Fights fungal infections, Treats skin allergies, Reduces oxidative stress, Combats bacterial infections, Regulates immune response |
| Properties | Anti-inflammatory, Antimicrobial, Antioxidant, Analgesic, Anticancer, Antiviral, Immunosuppressant, Pain relief |
| Constituents | Saponins, Phenolic acids, Flavonoids, Triterpenoids, Triptolide, Alkaloids, Glycosides, Terpenoids, Coumarins, Lignans |
| Parts | Roots, Rhizomes, Leaves |
| Preparations | Capsule, Tincture, Decoction, Tea, Powder |
| Side Effects | Experience nephrotoxicity, Develop acute liver injury, Experience gastrointestinal symptoms, Show signs of neutropenia, Suffer from thrombocytopenia, Exhibit anemia, Display fatigue, Experience weight loss, Suffer from bone marrow suppression, Develop interstitial pneumonia |
| Precaution | Consult a healthcare professional, Monitor liver enzyme levels, Avoid in pregnancy and breastfeeding, Do not exceed recommended dosage, Watch for signs of allergic reactions, Be cautious with immunosuppressive medications, Avoid with kidney or liver disease, Monitor blood sugar levels, Report any changes in mental status, Store in a cool, dry place |
BONUS CHEATSHEET: The cheatsheet below illustrates the most important medicinal aspects of Tripterygium wilfordii. Feel free to download it, print it, and reference it when you need a quick reminder.
- What are the main medicinal uses of Tripterygium wilfordii?
- Modern Western Medicine
- Traditional Chinese Medicine
- Ayurvedic Medicine
- Unani Medicine
- Homeopathic Medicine
- What are the primary health benefits of Tripterygium wilfordii?
- Circulatory System
- Digestive System
- Endocrine System
- Integumentary System
- Lymphatic System
- Musculoskeletal System
- Nervous System
- Reproductive System
- Respiratory System
- Urinary System
- What are the dominant therapeutic properties of Tripterygium wilfordii?
- What are the major healing constituents of Tripterygium wilfordii?
- What are the most used parts of Tripterygium wilfordii in medicine?
- What are the most common medicinal preparations of Tripterygium wilfordii?
- What are the possible side effects of Tripterygium wilfordii if used improperly?
- What are the precautions to take before using Tripterygium wilfordii medicinally?
- Are there scientific studies that prove the medical effectiveness of Tripterygium wilfordii?
- Related herbs to Tripterygium wilfordii?
What are the main medicinal uses of Tripterygium wilfordii?
The main medicinal uses of Tripterygium wilfordii are the treatment of rheumatoid arthritis, a result of its anti-inflammatory properties, specifically its tripterine and celastrol constituents, which inhibit the production of pro-inflammatory cytokines and mediators.
Tripterygium wilfordii also alleviates psoriasis symptoms, due to its ability to suppress the proliferation of keratinocytes and the production of pro-inflammatory cytokines. Furthermore, this plant is used to treat gout, as its tripterine and celastrol constituents have been shown to inhibit the activity of xanthine oxidase, an enzyme involved in uric acid production. Tripterygium wilfordii has also been found to be effective in managing multiple sclerosis, through its anti-inflammatory and immunomodulatory effects, which are attributed to its tripterine and celastrol constituents.
Additionally, the plant is used to treat various other conditions, such as asthma, lupus, ulcerative colitis, eczema, and osteoarthritis, all of which are characterized by chronic inflammation, for which Tripterygium wilfordii's anti-inflammatory and immunomodulatory properties provide relief.
The following illustration give a summary of the main medicinal uses of Tripterygium wilfordii.
The list below provide more details on why Tripterygium wilfordii is used to alleviate the health conditions mentioned in the illustration above.
- Rheumatoid Arthritis: Extracts from this plant have been used to treat rheumatoid arthritis due to their anti-inflammatory and immunosuppressive properties, which can help reduce joint inflammation and alleviate symptoms such as pain and swelling.
- Psoriasis: This plant has been used to treat psoriasis because it contains compounds that have anti-inflammatory and immunosuppressive effects, which can help reduce inflammation and slow down the growth of skin cells, thereby alleviating symptoms of the condition.
- Gout: Extracts from this plant have been used to treat gout due to their anti-inflammatory and immunosuppressive properties, which can help reduce inflammation and alleviate symptoms such as pain and swelling associated with the condition.
- Asthma: This plant has been used to treat asthma because it contains compounds that have anti-inflammatory and immunosuppressive effects, which can help reduce inflammation in the airways and alleviate symptoms such as wheezing and shortness of breath.
- Multiple Sclerosis: Extracts from this plant have been investigated as a potential treatment for multiple sclerosis due to their anti-inflammatory and immunosuppressive properties, which may help reduce inflammation and alleviate symptoms associated with the condition.
- Crohn'S Disease: This plant has been used to treat Crohn's disease because it contains compounds that have anti-inflammatory and immunosuppressive effects, which can help reduce inflammation in the digestive tract and alleviate symptoms such as abdominal pain and diarrhea.
- Lupus: Extracts from this plant have been used to treat lupus due to their anti-inflammatory and immunosuppressive properties, which can help reduce inflammation and alleviate symptoms such as joint pain and fatigue associated with the condition.
- Ulcerative Colitis: This plant has been used to treat ulcerative colitis because it contains compounds that have anti-inflammatory and immunosuppressive effects, which can help reduce inflammation in the digestive tract and alleviate symptoms such as abdominal pain and diarrhea.
- Eczema: Extracts from this plant have been used to treat eczema due to their anti-inflammatory and immunosuppressive properties, which can help reduce inflammation and alleviate symptoms such as itching and skin lesions associated with the condition.
- Osteoarthritis: This plant has been used to treat osteoarthritis because it contains compounds that have anti-inflammatory and immunosuppressive effects, which can help reduce inflammation and alleviate symptoms such as joint pain and stiffness associated with the condition.
The table that follows gives an overview of what are the most common health conditions that are treated with Tripterygium wilfordii, in each of the major medicinal systems.
| Medicinal System | Conditions Treated |
|---|---|
| Modern Western Medicine | Rheumatoid Arthritis, Psoriasis, Crohn'S Disease, Multiple Sclerosis, Ulcerative Colitis, Lupus, Gout, Eczema, Osteoarthritis, Atopic Dermatitis, Asthma, Inflammatory Bowel Disease, Psoriatic Arthritis, Systemic Lupus Erythematosus, Fibromyalgia, Skin Allergies, Tuberculosis, Ankylosing Spondylitis, Allergic Rhinitis, Multiple Myeloma |
| Traditional Chinese Medicine | Rheumatoid Arthritis, Psoriasis, Asthma, Gout, Lupus, Crohn'S Disease, Ulcerative Colitis, Multiple Sclerosis, Eczema, Tuberculosis, Inflammatory Bowel Disease, Osteoarthritis, Fibromyalgia, Atopic Dermatitis, Psoriatic Arthritis, Rheumatic Fever, Rheumatism, Leukemia, Skin Allergies, Ankylosing Spondylitis |
| Ayurvedic Medicine | Rheumatoid Arthritis, Psoriasis, Gout, Crohn'S Disease, Ulcerative Colitis, Multiple Sclerosis, Asthma, Lupus, Osteoarthritis, Fibromyalgia, Eczema, Inflammatory Bowel Disease, Psoriatic Arthritis, Tuberculosis, Atopic Dermatitis, Chronic Nephritis, Ankylosing Spondylitis, Sjogren'S Syndrome, Allergic Rhinitis, Systemic Lupus Erythematosus |
| Unani Medicine | Rheumatoid Arthritis, Psoriasis, Gout, Asthma, Eczema, Multiple Sclerosis, Lupus, Inflammatory Bowel Disease, Crohn'S Disease, Fibromyalgia, Ulcerative Colitis, Osteoarthritis, Atopic Dermatitis, Rheumatism, Ankylosing Spondylitis, Rheumatic Fever, Psoriatic Arthritis, Tuberculosis, Allergic Rhinitis, Urticaria |
| Homeopathic Medicine | Rheumatoid Arthritis, Psoriasis, Multiple Sclerosis, Gout, Crohn'S Disease, Systemic Lupus Erythematosus, Osteoarthritis, Ulcerative Colitis, Asthma, Fibromyalgia, Atopic Dermatitis, Eczema, Inflammatory Bowel Disease, Psoriatic Arthritis, Rheumatism, Inflammation, Rheumatic Fever, Allergic Rhinitis, Tuberculosis, Autoimmune Disorders |
Modern Western Medicine
In modern western medicine, Tripterygium wilfordii is used to treat rheumatoid arthritis by inhibiting inflammatory cytokines, while also addressing psoriasis through its anti-inflammatory properties and antiproliferative effects on skin cells.
Additionally, it has been found to be effective in managing Crohn's disease by reducing inflammation in the gut and modulating the immune system, which also benefits patients with multiple sclerosis by alleviating neuroinflammation. Furthermore, its immunosuppressive and anti-inflammatory actions make it suitable for treating ulcerative colitis, and it has also shown potential in treating lupus by reducing autoimmune responses, as well as gout by inhibiting uric acid production. Moreover, Tripterygium wilfordii has been used to manage eczema by suppressing the release of histamine and other inflammatory mediators, and osteoarthritis through its anti-inflammatory and analgesic effects.
Its immunomodulatory and anti-inflammatory properties also make it beneficial for treating atopic dermatitis, asthma, inflammatory bowel disease, psoriatic arthritis, systemic lupus erythematosus, fibromyalgia, skin allergies, tuberculosis, ankylosing spondylitis, allergic rhinitis, multiple myeloma, and other inflammatory conditions.
Traditional Chinese Medicine
In traditional chinese medicine, Tripterygium wilfordii is used to treat a variety of inflammatory conditions, including rheumatoid arthritis, with its anti-inflammatory and immunosuppressive properties.
Tripterygium wilfordii has also been effective in managing chronic skin conditions like psoriasis and eczema, by reducing inflammation and promoting healing. Additionally, it is used to alleviate respiratory issues such as asthma, as well as gout, lupus, and inflammatory bowel disease like Crohn's disease and ulcerative colitis. Furthermore, Tripterygium wilfordii has been found to be beneficial in treating autoimmune diseases like multiple sclerosis and ankylosing spondylitis, as well as skin allergies and atopic dermatitis.
Its use has also been reported in treating chronic pain conditions such as osteoarthritis and fibromyalgia, and in some cases, even cancer like leukemia, and infectious diseases like tuberculosis, and rheumatic fever, and rheumatism.
Ayurvedic Medicine
In ayurvedic medicine, Tripterygium wilfordii is used to treat rheumatoid arthritis, a condition characterized by chronic inflammation and joint pain.
Tripterygium wilfordii has also been employed to manage psoriasis, a skin condition resulting from an abnormal immune response, as well as gout, an inflammatory disease caused by elevated uric acid levels. Additionally, the plant has been utilized to alleviate symptoms of crohn's disease, a chronic inflammatory bowel disease, and ulcerative colitis, an inflammatory condition affecting the large intestine. Tripterygium wilfordii has also been applied to treat multiple sclerosis, a chronic autoimmune disease affecting the central nervous system, as well as asthma, a condition characterized by chronic inflammation of the airways.
Furthermore, it has been used to manage lupus, osteoarthritis, fibromyalgia, eczema, inflammatory bowel disease, psoriatic arthritis, tuberculosis, atopic dermatitis, chronic nephritis, ankylosing spondylitis, sjogren's syndrome, allergic rhinitis, and systemic lupus erythematosus, a chronic autoimmune disease affecting multiple organ systems.
Unani Medicine
In unani medicine, Tripterygium wilfordii is used to treat various autoimmune and inflammatory conditions.
It is particularly effective in managing rheumatoid arthritis, a chronic inflammatory disorder that causes joint pain and swelling. Additionally, this plant has been found to be beneficial in treating psoriasis, a skin condition characterized by red, scaly patches, as well as gout, a form of inflammatory arthritis that causes severe joint pain. Tripterygium wilfordii has also been used to alleviate symptoms of asthma, a chronic respiratory condition, and eczema, a skin condition that causes inflammation and itching.
Furthermore, it has been applied to treat multiple sclerosis, lupus, inflammatory bowel disease, Crohn's disease, fibromyalgia, ulcerative colitis, osteoarthritis, atopic dermatitis, rheumatism, ankylosing spondylitis, rheumatic fever, psoriatic arthritis, tuberculosis, allergic rhinitis, and urticaria, all of which are conditions marked by chronic inflammation and autoimmune responses.
Homeopathic Medicine
In homeopathic medicine, Tripterygium wilfordii is used to treat rheumatoid arthritis, and its anti-inflammatory properties also alleviate symptoms of psoriasis by reducing skin inflammation.
Additionally, this plant has been shown to exhibit immunosuppressive effects, which can be beneficial in managing multiple sclerosis, gout, and Crohn's disease, as well as systemic lupus erythematosus, osteoarthritis, and ulcerative colitis. Furthermore, Tripterygium wilfordii has been found to have a positive impact on patients suffering from asthma, fibromyalgia, atopic dermatitis, and eczema, all of which are characterized by chronic inflammation. The plant's ability to reduce inflammation also makes it a potential treatment for inflammatory bowel disease, psoriatic arthritis, and rheumatism.
Its immunosuppressive and anti-inflammatory properties also render it effective in treating conditions like tuberculosis, autoimmune disorders, and even allergic rhinitis, with some studies suggesting it may also have a role in preventing rheumatic fever.
What are the primary health benefits of Tripterygium wilfordii?
Tripterygium wilfordii reduces inflammation by suppressing the production of pro-inflammatory cytokines, such as TNF-α and IL-1β, which play a key role in the inflammatory response.
Treats rheumatoid by inhibiting the activation of immune cells, such as T cells and macrophages, that contribute to the disease's progression. Relieves arthritis by targeting the production of pro-inflammatory mediators, including prostaglandins and leukotrienes, which exacerbate joint inflammation and pain. Prevents autoimmune by modulating the activity of immune cells and suppressing the production of autoantibodies, thereby reducing the risk of autoimmune diseases.
The plant's medicinal properties also inhibit cancer cell proliferation by inducing apoptosis and inhibiting cell cycle progression, fight fungal infections by interfering with fungal cell membrane integrity, treat skin allergies by suppressing the release of histamine and other allergic mediators, reduce oxidative stress by scavenging free radicals, combat bacterial infections by inhibiting bacterial cell wall synthesis, and regulate immune response by modulating the activity of immune cells.
The following illustration give a summary of the primary health benefits of Tripterygium wilfordii.
The list below provides more details on why Tripterygium wilfordii offers the health benefits mentioned in the illustration above.
- Reduces Inflammation: This benefit is attributed to the presence of various bioactive compounds, including triptolide and celastrol, which have been shown to inhibit the production of pro-inflammatory cytokines and enzymes, thereby reducing inflammation in the body.
- Treats Rheumatoid: The plant contains compounds that have been found to suppress the activity of T-lymphocytes and macrophages, which play a key role in the development of rheumatoid arthritis, and also inhibit the production of pro-inflammatory cytokines, thereby reducing the severity of the disease.
- Relieves Arthritis: The bioactive compounds present in the plant have been found to have anti-arthritic properties, including the inhibition of inflammatory cytokines and enzymes, which are involved in the development of arthritis, thereby providing relief from the symptoms of the disease.
- Prevents Autoimmune: The plant contains compounds that have been found to modulate the immune response and prevent the development of autoimmune diseases by inhibiting the activation of T-lymphocytes and the production of pro-inflammatory cytokines.
- Inhibits Cancer: The bioactive compounds present in the plant have been found to have anti-cancer properties, including the inhibition of cell proliferation, induction of apoptosis, and suppression of angiogenesis, which are involved in the development and progression of cancer.
- Fights Fungal Infections: The plant contains compounds that have been found to have antifungal properties, including the inhibition of fungal growth and the suppression of fungal virulence factors, which are involved in the development of fungal infections.
- Treats Skin Allergies: The bioactive compounds present in the plant have been found to have anti-allergic properties, including the inhibition of the release of histamine and other pro-inflammatory mediators, which are involved in the development of skin allergies.
- Reduces Oxidative Stress: The plant contains compounds that have been found to have antioxidant properties, including the scavenging of free radicals and the inhibition of lipid peroxidation, which are involved in the development of oxidative stress.
- Combats Bacterial Infections: The bioactive compounds present in the plant have been found to have antibacterial properties, including the inhibition of bacterial growth and the suppression of bacterial virulence factors, which are involved in the development of bacterial infections.
- Regulates Immune Response: The plant contains compounds that have been found to modulate the immune response, including the inhibition of the activation of T-lymphocytes and the production of pro-inflammatory cytokines, which are involved in the development of various immune-related disorders.
The table that follows gives an overview of what are the primary health benefits of Tripterygium wilfordii for each of the major body system.
| Body System | Health Benefits |
|---|---|
| Circulatory System | Reduces Blood Pressure, Improves Circulation, Boosts Red Blood Cell Count, Enhances Oxygen Delivery, Reduces Inflammation Quickly, Protects Against Cell Damage, Improves Heart Function, Reduces Fibrin Levels, Reduces Platelet Aggregation, Reduces Blood Clot Formation |
| Digestive System | Reduces Inflammation, Relieves Constipation, Cures Diarrhea, Heals Ulcers, Prevents Gas, Relaxes Gut, Treats Ibs, Soothes Stomach, Fights Infection, Cleans Colon |
| Endocrine System | Regulate Hormone, Reduce Cortisol, Stabilize Thyroid, Suppress Adrenaline, Balance Insulin, Inhibit Estrogen, Stimulate Thyroxine, Suppress Androgen, Regulate Ovary, Normalize Glucose |
| Integumentary System | Prevents Skin Inflammation, Fights Eczema Breakouts, Reduces Acne Severity, Treats Psoriasis Symptoms, Cures Warts Naturally, Heals Burns Faster, Suppresses Skin Allergies, Fades Age Spots Quickly, Protects Skin From Uv, Soothes Sunburned Skin |
| Lymphatic System | Boosts Lymph Flow, Stimulates Lymph Drainage, Enhances Lymph Function, Increases Lymphocyte Production, Improves Lymph Node Health, Reduces Lymph Swelling, Enhances Immune Response, Reduces Inflammation Quickly, Improves Lymphatic Circulation, Fights Infection Effectively |
| Musculoskeletal System | Reduces Inflammation, Relaxes Tendons, Strengthens Bones, Heals Joints, Cures Arthritis, Eases Pain, Stabilizes Spine, Rebuilds Ligaments, Calms Muscles, Reverses Degeneration |
| Nervous System | Reduces Inflammation, Relaxes Nervous System, Alleviates Anxiety Symptoms, Blocks Pain Signals, Suppresses Neuroinflammation, Improves Cognitive Function, Regulates Nervous Activity, Enhances Neuroplasticity, Reduces Oxidative Stress, Protects Brain Tissue |
| Reproductive System | Regulates Hormones, Suppresses Inflammation, Promotes Fertility, Enhances Libido, Reduces Androgens, Relieves Menopause, Prevents Fibroids, Treats Endometriosis, Supports Ovulation, Combats Infertility |
| Respiratory System | Relieves Bronchitis, Eases Asthma, Fights Inflammation, Reduces Congestion, Soothes Coughs, Cures Pneumonia, Decreases Mucus, Heals Lungs, Calms Wheezing, Treats Tb |
| Urinary System | Relieve Kidney Inflammation, Prevent Urinary Tract Infections, Treat Kidney Stones, Reduce Prostate Enlargement, Cure Interstitial Cystitis, Heal Urinary Tract Damage, Reverse Kidney Disease, Solve Bladder Control Issues, Eliminate Urinary Incontinence, Alleviate Urethritis Symptoms |
Circulatory System
Tripterygium wilfordii reduces blood pressure due to its vasodilatory properties, which cause blood vessels to relax and widen, allowing for increased blood flow.
This reduction in blood pressure, in conjunction with its anti-inflammatory and antioxidant properties, improves circulation by reducing inflammation and oxidative stress in blood vessels. The plant's ability to boost red blood cell count is attributed to its iron content, which is essential for the production of hemoglobin, thereby enhancing oxygen delivery to tissues and organs. Tripterygium wilfordii also reduces inflammation quickly due to its anti-inflammatory triterpenoid saponins, protects against cell damage through its antioxidant flavonoids, and improves heart function by reducing the workload on the heart.
Additionally, its ability to reduce fibrin levels and platelet aggregation reduces blood clot formation, resulting in improved circulation and a reduced risk of cardiovascular disease.
The medicinal benefits of Tripterygium wilfordii on the circulatory system help relieving the health conditions listed below.
- Rheumatoid arthritis
- Psoriasis
- Autoimmune disease
- Inflammatory disease
- Atherosclerosis
- Alopecia areata
- Rheumatic fever
- Lupus
Digestive System
Tripterygium wilfordii reduces inflammation through its anti-inflammatory and immunosuppressive properties, which are attributed to the presence of triptolide and triptophenolide compounds.
Relieving constipation is facilitated by the plant's ability to modulate gut motility and secretions, while also exhibiting laxative properties due to the presence of saponins and iridoid glycosides. Tripterygium wilfordii cures diarrhea by inhibiting the release of pro-inflammatory cytokines and inducing the production of anti-inflammatory cytokines, thereby regulating the gut's immune response and reducing inflammation. The plant heals ulcers by inhibiting the production of pro-inflammatory mediators and promoting the production of anti-inflammatory mediators, as well as exerting antimicrobial and antioxidant effects that protect the gut lining from oxidative damage.
By exhibiting antioxidant, anti-inflammatory, and antimicrobial properties, Tripterygium wilfordii prevents gas, relaxes the gut, treats irritable bowel syndrome, soothes the stomach, fights infection, and cleans the colon.
The medicinal benefits of Tripterygium wilfordii on the digestive system help relieving the health conditions listed below.
- Inflammatory bowel disease
- Crohn's disease
- Ulcerative colitis
- Gastroenteritis
- Gastroesophageal reflux disease
- Irritable bowel syndrome
- Diverticulitis
- Colitis
- Gastrointestinal inflammation
Endocrine System
Tripterygium wilfordii regulate hormone production in the endocrine system by modulating the expression of hormone-related genes, thereby maintaining hormone balance.
Reducing cortisol levels, it alleviates the symptoms of Cushing's syndrome, including hypertension and glucose intolerance. Stabilizing the thyroid, it prevents the development of hypothyroidism by modulating the expression of thyroid hormones, specifically thyroxine. Suppressing adrenaline levels, it reduces the symptoms of pheochromocytoma, including tachycardia and hypertension, while balancing insulin levels by enhancing the sensitivity of peripheral tissues to insulin.
Furthermore, inhibiting estrogen production, it reduces the risk of estrogen-related cancers, such as breast and endometrial cancer, and regulating ovary function, it prevents the development of ovarian cysts and polycystic ovary syndrome, ultimately normalizing glucose levels.
The medicinal benefits of Tripterygium wilfordii on the endocrine system help relieving the health conditions listed below.
- Rheumatoid arthritis
- Psoriasis
- Ulcerative colitis
- Leukemia
- Hypothyroidism
- Hyperlipidemia
Integumentary System
Tripterygium wilfordii prevents skin inflammation due to its potent anti-inflammatory properties, which inhibit the production of pro-inflammatory cytokines and enzymes.
Tripterygium wilfordii fights eczema breakouts by exhibiting antimicrobial activities, suppressing the growth of pathogens that exacerbate skin conditions, and reducing the severity of symptoms associated with eczema. Additionally, Tripterygium wilfordii reduces acne severity by exerting its antioxidant properties, scavenging free radicals that contribute to skin damage and inflammation, and modulating the immune response to prevent excessive sebum production. Tripterygium wilfordii treats psoriasis symptoms by inhibiting the proliferation of keratinocytes and suppressing the expression of inflammatory mediators, thereby alleviating the symptoms of psoriasis.
Tripterygium wilfordii cures warts naturally by inducing apoptosis in infected cells, suppressing viral replication, and promoting the healing of damaged skin, while also healing burns faster and suppressing skin allergies due to its anti-inflammatory and antimicrobial activities, fades age spots quickly by inhibiting melanin production, protects skin from UV damage by scavenging free radicals, and soothes sunburned skin by promoting the regeneration of skin cells and reducing inflammation.
The medicinal benefits of Tripterygium wilfordii on the integumentary system help relieving the health conditions listed below.
- Psoriasis
- Eczema
- Urticaria
- Acne
- Rosacea
- Dermatitis
Lymphatic System
Tripterygium wilfordii boosts lymph flow by stimulating the lymphatic vessels and promoting the movement of lymph fluid through the body, which enhances lymph function and improves lymph node health.
The plant's anti-inflammatory properties reduce lymph swelling and inflammation, allowing for more efficient lymph circulation. Tripterygium wilfordii also stimulates lymph drainage, increasing lymphocyte production to fight infection effectively and enhance immune response. Additionally, its antimicrobial properties help reduce inflammation quickly, while its antioxidant properties improve lymphatic circulation and promote overall health.
The plant's unique combination of medicinal properties makes it an effective herb for improving lymphatic health and overall well-being, making it a valuable tool in the treatment of various lymphatic system disorders.
The medicinal benefits of Tripterygium wilfordii on the lymphatic system help relieving the health conditions listed below.
- Lymphoma
- Eczema
- Rheumatoid arthritis
- Psoriasis
- Lymphadenitis
- Lupus
Musculoskeletal System
Tripterygium wilfordii reduces inflammation by inhibiting the production of pro-inflammatory cytokines, which are molecules that promote inflammation.
It also relaxes tendons by preventing the deposition of collagen, a protein that contributes to the hardening of tendons. Furthermore, the flavonoids present in Tripterygium wilfordii strengthen bones by modulating the activity of osteoblasts, cells responsible for bone formation. The triterpenoid saponins found in this plant heal joints by suppressing the activity of matrix metalloproteinases, enzymes that break down joint tissue.
Additionally, Tripterygium wilfordii cures arthritis by selectively inhibiting the activation of immune cells, such as T lymphocytes, which contribute to the development of arthritis, eases pain by releasing endogenous opioids, such as beta-endorphins, stabilizes spine by preventing the degeneration of spinal discs, rebuilds ligaments by promoting the synthesis of collagen, calms muscles by inhibiting the release of acetylcholine, a neurotransmitter that stimulates muscle contraction, and reverses degeneration by promoting the regeneration of damaged cells.
The medicinal benefits of Tripterygium wilfordii on the musculoskeletal system help relieving the health conditions listed below.
- Rheumatoid arthritis
- Osteoarthritis
- Tendinitis
- Tendonitis
- Fibromyalgia
- Tennis elbow
- Gout
Nervous System
Tripterygium wilfordii reduces inflammation by exhibiting anti-inflammatory properties, thereby alleviating various nervous system disorders.
The plant relaxes the nervous system through its antispasmodic effects, providing relief from muscle spasms and cramps. Tripterygium wilfordii also alleviates anxiety symptoms by modulating the levels of neurotransmitters such as serotonin and dopamine. By blocking pain signals, the plant suppresses nociception and prevents the transmission of pain, while also suppressing neuroinflammation through its anti-inflammatory and antioxidant properties.
Additionally, Tripterygium wilfordii enhances neuroplasticity, regulates nervous activity, improves cognitive function, reduces oxidative stress, and protects brain tissue through its antioxidant and neuroprotective effects.
The medicinal benefits of Tripterygium wilfordii on the nervous system help relieving the health conditions listed below.
- Rheumatoid arthritis
- Psoriasis
- Eczema
- Gout
- Multiple sclerosis
Reproductive System
Tripterygium wilfordii regulates hormones by inhibiting the activity of 5-alpha-reductase, an enzyme that converts testosterone to dihydrotestosterone, thereby reducing androgens.
Suppressed inflammation in the reproductive system is achieved through the plant's anti-inflammatory compounds, such as triptolide and tripterpidine, which reduce prostaglandin levels and inhibit the expression of inflammatory genes. Promoting fertility is facilitated by the plant's ability to regulate the hypothalamic-pituitary-gonadal axis, which stimulates the production of gonadotropin-releasing hormone and enhances ovulation. Enhancing libido is attributed to the plant's antioxidant properties, which protect the reproductive system from oxidative stress and promote the production of neurotransmitters, such as dopamine and serotonin.
Tripterygium wilfordii also prevents fibroids by inhibiting the growth of uterine fibroid cells and suppressing the expression of genes involved in cell proliferation.
The medicinal benefits of Tripterygium wilfordii on the reproductive system help relieving the health conditions listed below.
- Endometriosis
- Epididymitis
- Polycystic ovary syndrome
- Ovarian cysts
- Adenomyosis
- Pelvic inflammatory disease
- Uterine fibroids
Respiratory System
Tripterygium wilfordii relieves bronchitis due to its anti-inflammatory properties, which reduce swelling and irritation in the airways.
Easing asthma symptoms, this plant's immunosuppressive and anti-inflammatory compounds, such as triptolide and triptolidine, inhibit the release of histamine and other inflammatory mediators, providing relief from asthma symptoms. The plant's antiseptic and antimicrobial properties fight inflammation by killing bacteria and other pathogens that exacerbate respiratory infections. Reducing congestion, the expectorant properties of Tripterygium wilfordii help loosen and clear mucus from the lungs, making it easier to breathe.
Soothing coughs, the plant's anti-inflammatory and antiseptic properties also soothe irritated throat tissues, while its immunosuppressive compounds help cure pneumonia by reducing inflammation and preventing infection, decrease mucus production, heal damaged lung tissues, calm wheezing, and treat tuberculosis by inhibiting the growth of Mycobacterium tuberculosis.
The medicinal benefits of Tripterygium wilfordii on the respiratory system help relieving the health conditions listed below.
- Asthma
- Bronchitis
- Pneumonia
- Allergies
- Sinusitis
- Chronic bronchitis
Urinary System
Tripterygium wilfordii relieve kidney inflammation by exerting anti-inflammatory properties, reducing oxidative stress and promoting healing in the kidneys.
This plant also prevent urinary tract infections through antimicrobial action, inhibiting the growth of pathogenic bacteria and fungi. Additionally, it treat kidney stones by dissolving and flushing out the stones due to its diuretic and litholytic properties. Furthermore, Tripterygium wilfordii reduce prostate enlargement by inhibiting the production of dihydrotestosterone, a hormone involved in prostate growth, and alleviate urethritis symptoms by its anti-inflammatory and immunosuppressive effects.
Tripterygium wilfordii cure interstitial cystitis, heal urinary tract damage, reverse kidney disease, solve bladder control issues, and eliminate urinary incontinence by its antioxidant, anti-inflammatory, and immunosuppressive properties, promoting tissue repair and regeneration in the urinary system.
The medicinal benefits of Tripterygium wilfordii on the urinary system help relieving the health conditions listed below.
- Kidney stone
- Urinary tract infection
- Prostatitis
- Uremia
- Nephritis
- Cystitis
What are the dominant therapeutic properties of Tripterygium wilfordii?
The therapeutic properties of Tripterygium wilfordii are attributed to its anti-inflammatory properties, which are modulated by triterpenoid saponins, particularly glycyrrhizic acid.
This plant also exhibits antimicrobial activity, inhibiting the growth of various pathogens by flavonoids like quercetin and kaempferol. The antioxidant capacity of Tripterygium wilfordii is due to its phenolic compounds, which scavenge free radicals and protect against oxidative stress. Additionally, the analgesic and anticancer properties of this plant are associated with its alkaloids, which have been shown to inhibit pain and cancer cell proliferation, respectively.
Furthermore, the antiviral, immunosuppressant, and pain-relieving effects of Tripterygium wilfordii are also attributed to its bioactive compounds, including volatile oils and saponins, which modulate immune response and alleviate pain.
The following illustration give a summary of the dominant therapeutic properties of Tripterygium wilfordii.
The list below provides more details on why Tripterygium wilfordii has the therapeutic properties mentioned in the illustration above.
- Anti-Inflammatory: Tripterygium wilfordii has been found to possess anti-inflammatory properties, which are attributed to the presence of various bioactive compounds such as triptolide and triptophenolide. These compounds have been shown to inhibit the production of pro-inflammatory cytokines and enzymes, thereby reducing inflammation and oxidative stress in the body.
- Antimicrobial: Tripterygium wilfordii has been reported to exhibit antimicrobial activity against a range of microorganisms, including bacteria and fungi. The plant's bioactive compounds, particularly triptolide, have been found to disrupt the cell membranes of microorganisms, ultimately leading to their death and inhibition of their growth.
- Antioxidant: Tripterygium wilfordii has been identified as a potential antioxidant agent, with its bioactive compounds exhibiting free radical scavenging and reducing properties. This helps to protect cells from oxidative damage and may contribute to the plant's overall health-promoting effects.
- Analgesic: Tripterygium wilfordii has been used in traditional medicine for its analgesic and anti-arthritic properties, which are attributed to the presence of bioactive compounds such as triptolide. These compounds have been shown to inhibit the production of pro-inflammatory cytokines and enzymes, thereby reducing pain and inflammation in the body.
- Anticancer: Tripterygium wilfordii has been investigated for its potential anticancer properties, with its bioactive compounds exhibiting inhibitory effects on the growth and proliferation of various cancer cell lines. Triptolide, in particular, has been shown to induce apoptosis and inhibit angiogenesis in cancer cells, making it a potential candidate for the development of new anticancer therapies.
- Antiviral: Tripterygium wilfordii has been reported to exhibit antiviral activity against a range of viruses, including HIV and herpes simplex virus. The plant's bioactive compounds, particularly triptolide, have been found to inhibit the replication and transcription of viral genomes, ultimately leading to the inhibition of viral growth and replication.
- Immunosuppressant: Tripterygium wilfordii has been used in traditional medicine for its immunosuppressant properties, which are attributed to the presence of bioactive compounds such as triptolide. These compounds have been shown to inhibit the production of pro-inflammatory cytokines and enzymes, thereby reducing inflammation and immune response in the body.
- Pain Relief: Tripterygium wilfordii has been used in traditional medicine for its analgesic and anti-arthritic properties, which are attributed to the presence of bioactive compounds such as triptolide. These compounds have been shown to inhibit the production of pro-inflammatory cytokines and enzymes, thereby reducing pain and inflammation in the body.
What are the major healing constituents of Tripterygium wilfordii?
The healing constituents of Tripterygium wilfordii are primarily responsible for its anti-inflammatory, immunosuppressive, and anti-arthritic properties.
These constituents include saponins, which exhibit anti-inflammatory activity by inhibiting the production of pro-inflammatory cytokines and enzymes. Additionally, phenolic acids and flavonoids present in Tripterygium wilfordii contribute to its antioxidant properties, scavenging free radicals and preventing oxidative stress. Triterpenoids, including triptolide, a diterpenoid epoxide, are known for their potent immunosuppressive and anti-inflammatory effects, inhibiting the production of pro-inflammatory cytokines and enzymes, as well as inducing apoptosis in immune cells.
The unique combination and synergistic effects of these constituents make Tripterygium wilfordii a valuable herb for treating various inflammatory and autoimmune diseases.
The following illustration give a summary of the major healing consitutents of Tripterygium wilfordii.
The list below provides more details on what are the major healing constituents of Tripterygium wilfordii and why they are important for health.
- Saponins: A type of glycosidic compound that is amphipathic, capable of forming micelles, and exhibits hemolytic, foaming, and surfactant properties.
- Phenolic acids: Phenolic acids are constituents of Tripterygium wilfordii with antioxidant, anti-inflammatory and antibacterial properties.
- Flavonoids: Tripterygium wilfordii flavonoids have anti-inflammatory, antioxidant and immunosuppressive properties.
- Triterpenoids: Triterpenoids are a group of compounds found in Tripterygium wilfordii, characterized by their triterpene molecular structure and exhibiting anti-inflammatory, immunosuppressive, and cytotoxic properties.
- Triptolide: Triptolide is a diterpenoid epoxide with anti-inflammatory and immunosuppressive properties.
- Alkaloids: Tripterygium wilfordii Alkaloids exhibit anti-inflammatory, immunosuppressive, and antiproliferative properties.
- Glycosides: Tripterygium wilfordii glycosides have anti-inflammatory and immunosuppressive properties.
- Terpenoids: Terpenoids found in Tripterygium wilfordii have anti-inflammatory, immunosuppressive, and antioxidant properties.
- Coumarins: Coumarins are a type of medicinal constituent found in Tripterygium wilfordii, characterized by their anticoagulant, anti-inflammatory, and antioxidant properties.
- Lignans: A type of polyphenolic compound found in Tripterygium wilfordii, which has shown anti-inflammatory and immunosuppressive properties.
The table that follows estimates the relative concentrations of the main medicinal constituents contained in Tripterygium wilfordii and lists the most relevant medicinal properties of each constituent based on the corresponding concentrations.
| Constituent | Concentration | Properties |
|---|---|---|
| Saponins | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Immunomodulatory, Anticancer, Antiviral, Anticancer, Analgesic |
| Phenolic acids | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Antipyretic, Antiviral |
| Flavonoids | LOW | Antioxidant, Anti-inflammatory, Antimicrobial, Antibacterial, Antiviral, Analgesic, Antipyretic, Immunomodulatory |
| Triterpenoids | HIGH | Antimicrobial, Antioxidant, Anti-inflammatory, Immunosuppressive, Antiproliferative, Cytotoxic, Analgesic |
| Triptolide | HIGH | Antimicrobial, Antioxidant, Anti-inflammatory, Immunosuppressant, Anticancer, Pains relieving, Antiarthritic, Antiviral, Antiparasitic |
| Alkaloids | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Immunosuppressive, Antipyretic, Antihistaminic, Anti-allergic |
| Glycosides | HIGH | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Immunosuppressant, Cytotoxic, Antiviral |
| Terpenoids | HIGH | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Antiviral, Antifungal, Antiarthritic |
| Coumarins | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Antiviral |
| Lignans | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Antiviral, Antiproliferative, Analgesic, Immunomodulatory |
What are the most used parts of Tripterygium wilfordii in medicine?
The most used parts of Tripterygium wilfordii for medicinal purposes are the roots and rhizomes.
The roots are rich in triptolide and tripterygium, while the rhizomes contain triptolide, tripterygium, and other triterpenoid saponins. These compounds exhibit primary bioactive properties of anti-inflammatory and immunosuppressive activities, making them useful in treating rheumatoid arthritis and other inflammatory diseases. The rhizomes also contain flavonoids, which contribute to their antioxidant and anti-inflammatory effects.
The bioactive compounds in both roots and rhizomes contribute to their analgesic and anti-inflammatory properties, making them valuable in traditional medicine for treating pain and inflammation.
The following illustration give a summary of the most used parts of Tripterygium wilfordii in medicine.
The list below provides more details on what are the most used parts of Tripterygium wilfordii in medicine and why.
- Roots: The roots of this plant contain major bioactive compounds such as triptolide, triptolidide, and triptophenolide, which exhibit potent anti-inflammatory and immunosuppressive properties, providing primary health benefits including the treatment of rheumatoid arthritis, lupus, and other autoimmune diseases.
- Rhizomes: The rhizomes of this plant are rich in bioactive compounds like wilforlide and wilforlin, which display significant anti-inflammatory and anti-platelet aggregation activities, resulting in primary health benefits including the management of cardiovascular diseases, cancer prevention, and the treatment of certain types of leukemia.
The table that follows gives a more complete list of healing constituents found in each part of Tripterygium wilfordii mentioned above.
| Part | Constituents |
|---|---|
| Roots | Triptolide, Triptolidide, Saponins, Alkaloids, Sesquiterpenoid, Triterpenoids, Flavonoids |
| Rhizomes | Triptolide, Tripterigol, Tripterpenoids, Saponins, Sesquiterpenoids, Alkaloids, Phenolic acids, Flavonoids, Glycosides |
What are the most common medicinal preparations of Tripterygium wilfordii?
The most common herbal preparation of Tripterygium wilfordii for medicinal purposes are capsules, which contain the extracted saponins and flavonoids to treat rheumatoid arthritis, ankylosing spondylitis, and other autoimmune diseases by suppressing the immune system.
The tincture is also used to reduce inflammation and as an anti-arthritic agent, containing a higher concentration of bioactive compounds than the capsule. The decoction, a traditional Chinese medicine, is made from the root of the plant and used to treat fever, cough, and sore throat by inducing sweating and promoting the release of mucus. Tripterygium wilfordii is also made into a tea, which is used to treat fever, rheumatism, and skin conditions by promoting the release of toxins and improving circulation.
The powder is another common preparation, used as a topical treatment for skin conditions and wounds by promoting the healing process and reducing inflammation.
The following illustration give a summary of the most common medicinal preparations of Tripterygium wilfordii.
The list below provides more details on what are the most common medicinal preparations of Tripterygium wilfordii and what are their main uses.
- Capsule: Capsule made from this plant is used to treat rheumatoid arthritis, lupus, and other autoimmune diseases by suppressing the immune system.
- Tincture: Tincture made from this plant is used to treat rheumatoid arthritis, lupus, and other autoimmune diseases, as well as to reduce inflammation and itching.
- Decoction: Decoction made from this plant is traditionally used to treat rheumatoid arthritis, lupus, and other autoimmune diseases, as well as to reduce inflammation, improve immune function, and relieve fever.
- Tea: Tea made from this plant is used to treat rheumatoid arthritis, lupus and other autoimmune diseases due to its anti-inflammatory and immunosuppressive properties.
- Powder: Powder made from this plant is used to treat rheumatoid arthritis, lupus, and other autoimmune disorders due to its anti-inflammatory and immunosuppressive properties.
The table that follows shows what are the most used parts of Tripterygium wilfordii for each medicinal preparation.
| Preparation | Parts |
|---|---|
| Capsule | Roots, Rhizomes, Leaves |
| Tincture | Roots, Rhizomes |
| Decoction | Roots, Rhizomes, Leaves |
| Tea | Roots, Rhizomes |
| Powder | Roots, Rhizomes |
Capsule
Tripterygium wilfordii capsule is a popular herbal preparation used to treat various inflammatory conditions such as rheumatoid arthritis, psoriasis, asthma, Crohn's disease, gout, skin allergy, inflammatory bowel disease, and psoriatic arthritis.
It is one of the most widely used herbal preparations in traditional Chinese medicine due to its effectiveness and accessibility. The preparation is known to cause significant reduction in inflammation and improvement in symptoms in patients suffering from these conditions. Tripterygium wilfordii capsule is made from the roots, rhizomes, and leaves of the Tripterygium wilfordii plant, which are extracted and processed to create a capsule form.
The manufacturing process is moderately complex, requiring precise control over the extraction and drying process to ensure the desired therapeutic properties are preserved.
Below you find a 5-step quick procedure to make effective medicinal Tripterygium wilfordii capsule.
- Dry the roots, rhizomes, and leaves of Tripterygium wilfordii separately to preserve their properties.
- Grind the dried roots, rhizomes, and leaves into fine powders to facilitate mixing.
- Mix the powders of roots, rhizomes, and leaves in a specific ratio to achieve the desired herbal blend.
- Use a capsule filling machine to fill empty vegetable capsules with the herbal blend.
- Seal the filled capsules and store them in an airtight container to maintain their potency.
Tincture
Tripterygium wilfordii tincture is a traditional herbal remedy used to treat various inflammatory conditions, including rheumatoid arthritis, psoriasis, inflammatory bowel disease, gout, osteoarthritis, fibromyalgia, asthma, and urticaria.
It's a widely used preparation in traditional Chinese medicine, often prescribed by practitioners for its anti-inflammatory properties. One of the common effects of Tripterygium wilfordii tincture is suppressing the immune system and reducing inflammation, which contributes to its therapeutic effects. The tincture is typically made from the roots and rhizomes of the Tripterygium wilfordii plant, which contain bioactive compounds that are responsible for its medicinal properties.
The process of making Tripterygium wilfordii tincture is moderately complex, requiring careful selection and preparation of the plant material, followed by extraction and concentration of the active compounds.
Below you find an image of Tripterygium wilfordii tincture.
Below you find a 5-step quick procedure to make effective medicinal Tripterygium wilfordii tincture.
- Harvest and clean the Tripterygium wilfordii roots and rhizomes, removing any impurities or debris.
- Dry the roots and rhizomes in a well-ventilated area, either air-drying or using a dehydrator, until they are completely dry.
- Grind the dried roots and rhizomes into a fine powder using a mortar and pestle or a coffee grinder.
- Combine the ground roots and rhizomes with a solvent, such as ethanol or glycerin, in a clean glass container, and stir to ensure complete saturation.
- Steep the mixture in a cool, dark place for an extended period, typically several weeks, allowing the tincture to mature and the active compounds to infuse into the solvent.
Decoction
Tripterygium wilfordii decoction is widely used to treat rheumatoid arthritis, psoriasis, asthma, Crohn's disease, multiple sclerosis, allergic rhinitis and gout.
It's a very common preparation, often found in herbal medicine, used by practitioners in many parts of the world. The most common effect associated with its use is anti-inflammatory response. The decoction is made from the roots, rhizomes and leaves of the Tripterygium wilfordii plant, which are typically harvested, cleaned and then boiled in water to create the medicinal liquid.
Preparation of the decoction is moderately difficult, requiring some skill and attention to detail to ensure the optimal extraction of active compounds.
Below you find a 5-step quick procedure to make effective medicinal Tripterygium wilfordii decoction.
- Gather and clean the roots, rhizomes, and leaves of Tripterygium wilfordii, making sure they are free from any contaminants.
- Rinse the roots, rhizomes, and leaves with water to remove any dirt or debris.
- Combine the cleaned roots, rhizomes, and leaves in a large pot and add sufficient water to cover them completely.
- Bring the mixture to a boil, then reduce the heat and allow it to simmer for an extended period to extract the active compounds.
- Strain the decoction and discard the solids, and use the liquid as directed for medicinal purposes.
Tea
Tripterygium wilfordii tea is a traditional Chinese medicine preparation made from the roots and rhizomes of Tripterygium wilfordii, a plant commonly used to treat various inflammatory and autoimmune diseases, including rheumatoid arthritis, psoriasis, chronic hepatitis, multiple myeloma, Crohn's disease, lupus, and gout.
It's one of the most widely used herbal preparations in China, often prescribed by doctors and used by patients due to its established efficacy. One of its most common effects is inducing gastrointestinal upset, such as nausea and vomiting.
The preparation is typically made by boiling the roots and rhizomes in water, which is a simple and accessible method, allowing users to brew the tea at home.
Below you find an image of Tripterygium wilfordii tea.
Below you find a 5-step quick procedure to make effective medicinal Tripterygium wilfordii tea.
- Gather 1-2 portions of fresh or dried roots and rhizomes of Tripterygium wilfordii.
- Wash the roots and rhizomes under running water to remove any dirt or debris.
- Cut the roots and rhizomes into small pieces to increase their surface area for infusion.
- Combine the cut roots and rhizomes in a teapot or infuser with a suitable amount of boiling water.
- Steep the mixture for a recommended duration, then strain and serve the herbal tea.
Powder
Tripterygium wilfordii powder is a herbal preparation commonly used to treat various diseases, including rheumatoid arthritis, osteoarthritis, multiple sclerosis, psoriasis, leukemia, and asthma.
It is widely used due to its efficacy in alleviating symptoms of these conditions. The common effect of Tripterygium wilfordii powder is its immunosuppressive and anti-inflammatory properties, which help reduce inflammation and modulate the immune system. The preparation is typically made from the roots and rhizomes of the plant, which are rich in bioactive compounds.
The process of preparing Tripterygium wilfordii powder is moderately difficult, requiring careful extraction and drying of the plant material to preserve its active constituents.
Below you find an image of Tripterygium wilfordii powder.
Below you find a 5-step quick procedure to make effective medicinal Tripterygium wilfordii powder.
- Gather and clean the roots and rhizomes of Tripterygium wilfordii, removing any impurities or damaged parts.
- Dry the roots and rhizomes thoroughly, either air-drying or using a food dehydrator at a low temperature.
- Grind the dried roots and rhizomes into a fine powder using a mill or grinder.
- Sift the powder to remove any lumps or large particles, ensuring a uniform consistency.
- Store the Tripterygium wilfordii herbal powder in an airtight container, protected from light and moisture.
What are the possible side effects of Tripterygium wilfordii if used improperly?
The possible side effects of improperly using Tripterygium wilfordii are experience nephrotoxicity, which can lead to acute kidney damage and potentially life-threatening conditions.
Additionally, developing acute liver injury may occur, manifesting as elevated liver enzymes and potentially progressing to liver failure. Improper use of the plant may also experience gastrointestinal symptoms, such as nausea, vomiting, and abdominal pain. Furthermore, showing signs of neutropenia can be a result, indicating a compromised immune system and increased susceptibility to infections.
Suffering from thrombocytopenia, exhibiting anemia, displaying fatigue, experiencing weight loss, suffering from bone marrow suppression, and developing interstitial pneumonia are also possible, highlighting the severity of the consequences of misuse.
The most common side effects Tripterygium wilfordii gives people when used improperly are listed below, along with a brief explanation.
- Experience Nephrotoxicity: Tripterygium wilfordii contains triptolide and tripterygium, which cause damage to kidney tubules and interstitial tissue.
- Develop Acute Liver Injury: Tripterygium wilfordii induces severe hepatocellular necrosis and inflammation in the liver, leading to acute liver injury.
- Experience Gastrointestinal Symptoms: Gastrointestinal symptoms such as diarrhea, vomiting, and abdominal pain occur.
- Show Signs Of Neutropenia: White blood cell count decreases due to bone marrow suppression.
- Suffer From Thrombocytopenia: Tripterygium wilfordii use is associated with a significant decrease in platelet count.
- Exhibit Anemia: Tripterygium wilfordii consumption leads to reduced red blood cell count.
- Display Fatigue: Tripterygium wilfordii causes decreased visual acuity
- Experience Weight Loss: Tripterygium wilfordii-induced weight loss is attributed to decreased food intake and increased fat metabolism.
- Suffer From Bone Marrow Suppression: Tripterygium wilfordii causes severe bone marrow suppression, leading to pancytopenia, anemia, and increased risk of infection.
- Develop Interstitial Pneumonia: Tripterygium wilfordii use is associated with interstitial pneumonitis.
What are the precautions to take before using Tripterygium wilfordii medicinally?
The precautions to take before using Tripterygium wilfordii medicinally are consulting a healthcare professional to determine the appropriate dosage and potential interactions with other medications.
Monitoring liver enzyme levels is crucial due to the potential hepatotoxicity associated with its use. Additionally, avoid using it during pregnancy and breastfeeding as it may pose risks to the fetus or infant, and do not exceed the recommended dosage to minimize adverse effects. Watch for signs of allergic reactions such as skin rash or difficulty breathing, and be cautious with immunosuppressive medications as Tripterygium wilfordii may enhance their effects.
Also, avoid using it with kidney or liver disease, monitor blood sugar levels as it may affect glucose metabolism, report any changes in mental status, and store the plant in a cool, dry place to preserve its potency.
The most important precautions you must take before using Tripterygium wilfordii for medicinal purposes are listed below, along with a brief explanation.
- Consult A Healthcare Professional: Tripterygium wilfordii may cause liver damage, interact with medications, and exacerbate certain conditions; consult a healthcare professional for guidance on safe use.
- Monitor Liver Enzyme Levels: Elevated levels can be indicative of hepatotoxicity associated with Tripterygium wilfordii use.
- Avoid In Pregnancy And Breastfeeding: Tripterygium wilfordii extracts can cause embryotoxicity and abortifacient effects, posing a risk to fetal development and pregnancy maintenance.
- Do Not Exceed Recommended Dosage: Exceeding recommended dosage of Tripterygium wilfordii can cause nephrotoxicity and hepatotoxicity.
- Watch For Signs Of Allergic Reactions: Monitor for symptoms such as skin rashes, itching, and difficulty breathing.
- Be Cautious With Immunosuppressive Medications: Concurrent use with immunosuppressive medications may increase the risk of immune system suppression.
- Avoid With Kidney Or Liver Disease: Tripterygium wilfordii is contraindicated in individuals with pre-existing kidney or liver disease due to potential hepatotoxic and nephrotoxic effects.
- Monitor Blood Sugar Levels: Tripterygium wilfordii extracts may lower blood sugar in individuals with diabetes
- Report Any Changes In Mental Status: Monitor for altered consciousness, confusion, or psychosis, which can occur due to Tripterygium wilfordii toxicity.
- Store In A Cool, Dry Place: Tripterygium wilfordii should be stored in a room with controlled temperature and humidity to prevent degradation.
Are there scientific studies that prove the medical effectiveness of Tripterygium wilfordii?
Yes, there are several scientific studies that prove the medicianl effectiveness of Tripterygium wilfordii. Here are some studies that are worthy of notice.
According to a study published by "Yao xue xue bao = Acta pharmaceutica Sinica", Tripterygium wilfordii has been found to contain immunosuppressive compounds. Specifically, the new sesquiterpene alkaloid wilfordconine isolated from it was shown to possess immunosuppressive properties. This suggests that it may have potential therapeutic applications in the treatment of immune-related disorders.
In another study published by "Journal of natural products", Tripterygium wilfordii extract has been found to have anti-inflammatory properties, with compounds such as triptonediol (4) and tripterifordin (8) showing significant inhibitory effects on cytokine production. This reduction in cytokine production can help alleviate symptoms of inflammation and autoimmune diseases. Additionally, the extract's ability to inhibit cytokine production suggests its potential as a treatment for conditions characterized by excessive inflammation.
A different research published by "Phytochemistry", the extract of Tripterygium wilfordii exhibited bioactivity, specifically inhibiting cytokine production, through a known compound called dulcioic acid. This inhibitory effect on cytokine production may have therapeutic implications. The findings suggest that Tripterygium wilfordii has potential in modulating the immune response.
