10 Possible Side Effects Of Symphytum Officinale (Comfrey)

Symphytum officinale has some side effects when used improperly, such as digestive issues, allergic reactions, and skin irritation.

Causes of these side effects include prolonged consumption, high doses, and individual sensitivity. For instance, excessive use can lead to stomach discomfort and nausea, hindering one's daily activities and productivity.

Skin reactions can also be severe, causing redness, itching, and blistering, affecting a person's quality of life and daily interactions.

This article explains in details the 10 most common side effects of Symphytum officinale if used imporperly.

1. Causes seizures

Symphytum officinale causes allergic reactions due to its high concentration of alkaloids and glycosides.

The most common allergens are pyrrolizidine alkaloids, which can trigger an immune response in some individuals, leading to symptoms such as hives, itching, and swelling.

Additionally, comfrey's flavonoids and saponins may also contribute to allergic reactions, making it essential for individuals with a history of allergies to exercise caution when using this herb.

2. Causes seizures

Symphytum officinale triggers diarrhea due to its ability to increase bile secretion and alter gut motility.

The saponins present in comfrey can irritate the gastrointestinal tract, leading to increased muscle contractions and rapid movement of food through the digestive system, resulting in loose stools and frequent bowel movements.

This side effect is often temporary and may be a sign that the body is adjusting to the herb's effects on the digestive system.

3. Causes seizures

Symphytum officinale induces nausea due to its high concentration of pyrrolizidine alkaloids (PAs).

These toxic compounds can be irritating to the stomach lining, causing gastrointestinal disturbances such as nausea and vomiting. Additionally, PAs have been shown to alter gut bacteria, leading to changes in digestion and absorption, further contributing to nausea symptoms.

As a result, some individuals may experience unpleasant side effects when taking Symphytum officinale supplements or using comfrey-containing products.

4. Causes seizures

Symphytum officinale produces vomiting due to its pyrrolizidine alkaloid content, specifically hepatotoxic compounds like symphytine and echimidine.

These toxins can accumulate in the liver and kidneys, causing gastrointestinal upset, including nausea and vomiting, especially at high doses or prolonged use.

As a result, individuals may experience stomach discomfort and regurgitation of food, making it essential to monitor intake levels and individual sensitivity.

5. Causes seizures

Symphytum officinale irritates skin due to its high concentration of allergenic compounds such as polyphenolic acids and saponins.

These substances can cause skin contact dermatitis, characterized by redness, itching, and rashes, in some individuals. The irritant properties are more pronounced when the plant's leaves or extracts come into direct contact with the skin, potentially leading to an allergic reaction.

This sensitivity is thought to be linked to the plant's ability to stimulate the immune system, which can sometimes result in adverse skin reactions.

6. Causes seizures

Symphytum officinale causes stomach cramps due to its high concentration of pyrrolizidine alkaloids (PAs) and other bioactive compounds.

These chemicals can be toxic when ingested in large amounts or for extended periods, leading to gastrointestinal irritation and discomfort.

The irritant properties of these compounds may cause spasms in the smooth muscle of the stomach, resulting in cramping sensations.

7. Causes seizures

Symphytum officinale leads to kidney problems due to its high concentration of pyrrolizidine alkaloids (PAs).

These toxic compounds are absorbed into the bloodstream and can accumulate in the liver and kidneys, potentially causing damage and scarring.

Long-term use or high doses of Symphytum officinale may lead to a buildup of PAs, increasing the risk of kidney problems, including reduced function and failure.

8. Causes seizures

Symphytum officinale increases blood pressure due to its high content of allantoin and other alkaloids.

These compounds can cause vasoconstriction, which is the narrowing of blood vessels, leading to an increase in blood pressure. Additionally, comfrey's stimulation of the nervous system may contribute to its hypertensive effect.

This side effect is particularly concerning for individuals with pre-existing hypertension or cardiovascular conditions.

9. Causes seizures

Symphytum officinale lowers blood sugar levels due to its potential to stimulate insulin secretion and increase glucose uptake in cells.

The herb's flavonoids and other bioactive compounds may interact with insulin receptors, enhancing the body's natural response to regulate blood sugar levels.

As a result, individuals using Symphytum officinale may experience hypoglycemia or lowered blood sugar levels, which can be a significant side effect in people with diabetes or pre-diabetic conditions.

10. Causes seizures

Symphytum officinale disrupts menstrual cycle.

This herb contains pyrrolizidine alkaloids, which can cause liver damage and potentially lead to hormonal imbalances that affect the menstrual cycle. Additionally, comfrey's estrogenic properties may interfere with normal ovulation and menstruation patterns, resulting in irregular or absent periods.

These changes may be more pronounced in individuals who use high doses of Symphytum officinale or consume it for extended periods.