10 Possible Side Effects Of Ruta Graveolens (Rue)

Ruta graveolens has some side effects when used improperly, such as skin irritation, allergic reactions, and digestive issues.

These side effects are often caused by overuse, incorrect preparation, or sensitivity to the herb's toxic compounds, such as rutaecarpine. If left unchecked, skin irritation can lead to painful rashes and blisters, while digestive issues can cause nausea, vomiting, and stomach cramps.

These complications can severely impact daily life, making everyday activities a struggle.

This article explains in details the 10 most common side effects of Ruta graveolens if used imporperly.

1. Causes respiratory depression

Ruta graveolens causes allergic reactions due to its volatile oil content, particularly limonene and alpha-pinene.

These compounds can trigger an immune response in some individuals, leading to symptoms such as skin rashes, hives, and itching.

The allergenic potential of ruta graveolens is thought to be related to the similarity between its chemical structure and that of other known allergens, making it a common allergen in herbal remedies.

2. Causes respiratory depression

Ruta graveolens triggers skin irritation due to its high concentration of volatile oils, particularly camphor and ascorbic acid.

These compounds can cause allergic reactions, inflammation, and itching when they come into contact with the skin.

Additionally, the herb's bitter principles may stimulate the skin's natural defense mechanisms, leading to increased sensitivity and reactivity.

3. Causes respiratory depression

Ruta graveolens induces liver toxicity due to its ability to inhibit the function of certain enzymes in the liver.

The herb's volatile oils and flavonoids can cause liver cells to die, leading to inflammation and scarring.

Prolonged or high-dose use of Ruta graveolens may increase the risk of developing liver damage, which can manifest as symptoms such as fatigue, weakness, and jaundice.

4. Causes respiratory depression

Ruta graveolens increases risk of bleeding due to its ability to inhibit platelet aggregation and prolong bleeding time.

Its bioactive compounds, such as flavonoids and sesquiterpenes, interfere with the normal blood clotting process, making wounds take longer to heal.

This may lead to prolonged bleeding from minor cuts or injuries, potentially causing more significant problems if left untreated.

5. Causes respiratory depression

6. Causes respiratory depression

Ruta graveolens worsens kidney function due to its ability to cause damage to the renal tubules and reduce glomerular filtration rate.

The plant's bioactive compounds, including flavonoids and lignans, may accumulate in the kidneys and lead to inflammation and fibrosis.

This can result in decreased urinary output, increased creatinine levels, and potentially even acute kidney injury.

7. Causes respiratory depression

Ruta graveolens inhibits platelet aggregation, which can lead to bleeding and bruising.

This side effect occurs because ruta graveolens contains compounds that bind to and block platelet receptors, preventing the formation of blood clots.

The plant's essential oils, such as furanocoumarins and limonoids, are responsible for this action, interfering with the normal coagulation process and increasing the risk of bleeding complications.

8. Causes respiratory depression

Ruta graveolens produces gastrointestinal upset due to its ability to stimulate the digestive system and increase stomach contractions.

This can lead to symptoms such as nausea, vomiting, diarrhea, and stomach pain.

The herb's volatile oils, particularly beta-pinene and alpha-pinene, are thought to contribute to this effect by increasing the production of gastric acid and altering the normal gut flora.

9. Causes respiratory depression

Ruta graveolens lowers blood pressure rapidly.

This is due to its ability to relax the smooth muscles in the blood vessels, leading to an increased diameter and a subsequent decrease in blood pressure.

Additionally, Ruta graveolens has been shown to inhibit the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, further contributing to its hypotensive effects.

10. Causes respiratory depression