rue
Ruta graveolens · Accepted scientific name
Scientific literature: Very Extensive (630 studies) · ★★★★★
Rue, scientifically known as Ruta graveolens, is a perennial shrub prized for its aromatic, blue-green foliage. Historically used in traditional medicine to treat digestive issues and menstrual irregularities, it contains potent bioactive compounds. However, due to its toxicity in high doses, it must be handled with extreme caution.
Names and Synonyms
Common Names
- garden rue
- herb-of-grace
- Rue
- common rue
- Ave Grace
- Countryman's Tracle
- Countryman's Treacle
- Herb Of Grace
- Herb Of Repentance
- Herb Of Repentence
Scientific Names
Accepted name
Ruta graveolensSynonyms
- Ruta hortensis
- Ruta graveolens var. macrophylla
- Ruta subtripinnata
- Ruta graveolens var. divaricata
- Ruta officinalis
- Ruta divaricata
- Ruta diversifolia
- Ruta graveolens f. variegata
- Ruta graveolens subsp. hortensis
- Ruta graveolens var. crithmifolia
- Ruta graveolens subsp. divaricata
- Ruta graveolens var. variegata
- Ruta ciliata
- Ruta crithmifolia
- Ruta altera
- Ruta holopetala
Regional and Traditional Names
Spanish:
- Ruta graveolency
- Ruda cultivada
- Ruta hortensis
- Ruda hortense de hojas anchas
- Ruda hortense
- Ruda común
- Ruta divaricata
- Ruda medicinal
- Ruda de hojas anchas
- Ruda mayor
- Ruda de los huertos
- Ruda comun
- ruda
- ruda de monte
German:
- Weinraute
- Gartenraute
- Wein-Raute
- Weinraute
- Garten-Raute
French:
- Rue
- Rue officinale
- Poudre de rue
- Rue des jardins
- Rue fétide
- rue des jardins
- rue fétide
- rue officinale
- Rue fetide
Sources: Wikidata, Catalogue of Life
Taxonomical Classification
This plant belongs to the kingdom Plantae and the phylum Streptophyta, falling under the class Equisetopsida and subclass Magnoliidae. Within the order Sapindales, it is classified under the family Rutaceae. Finally, it is identified by the genus Ruta and the species graveolens.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Sapindales |
| Family | Rutaceae |
| Genus | Ruta |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
This plant exhibits a specific distribution pattern across several European regions. In Northern Europe, its presence can be identified within Great Britain. Moving into Middle Europe, the species is found in Austria and Belgium. It also populates the territories of Czechia-Slovakia. Finally, its range extends through the landscape of Germany.
| Region | Area |
|---|---|
| Northern Europe | Great Britain |
| Middle Europe | Austria |
| Middle Europe | Belgium |
| Middle Europe | Czechia-Slovakia |
| Middle Europe | Germany |
| Middle Europe | Hungary |
| Middle Europe | Switzerland |
| Southwestern Europe | Baleares |
| Southwestern Europe | Corse |
| Southwestern Europe | France |
Sources: The World Checklist of Vascular Plants (WCVP)
Botanical Identification
Ecology
The ecology of Ruta graveolens is characterized by its adaptability to diverse topographical conditions, thriving across a broad altitudinal gradient that spans from as low as 50 m AMSL to elevations reaching a maximum of 3000 m AMSL. It typically colonizes rugged environments, showing a strong preference for mountains and stony places where soil may be thin or rocky. This ability to inhabit well-drained, lithic substrates allows the species to persist in challenging terrains that define its natural ecological niche.
- Elevational range max:
- 3000 m AMSL
- Elevational range min:
- 50 m AMSL
- Habitat :
- mountains, stony places
Life history
The life history of Ruta graveolens is characterized by its status as a perennial plant, allowing it to persist through multiple growing seasons. In terms of its growth habit and structural organization, it is classified as a chamaephyte, a life form where the majority of the plant's vegetative organs are located close to or just above the soil surface, often protected by seasonal litter. This botanical classification is consistent across its morphological descriptions, identifying it specifically as a chamaephyte within the broader spectrum of life forms.
- Life form :
- chamaephyte
- Lifecycle :
- perennial
Morphology
The morphology of Ruta graveolens is characterized by its growth form as a woody herb or forb. It functions as a self-supporting, independent organism that is neither a climber nor a parasite, and it maintains a terrestrial lifestyle rather than being aquatic or epiphytic. The plant exhibits a variable height, typically ranging from a minimum of 0.2 m to a maximum of 1.5 m, with a mean plant height of approximately 0.375 m.
- Aquatic :
- terrestrial
- Climber :
- self-supporting
- Epiphyte :
- terrestrial
- Growth form :
- herb
- Growth form :
- forb
- Parasite :
- independent
- Plant height max:
- 1.5 m
- Plant height mean:
- 0.375 m
- Plant height min:
- 0.2 m
- Woodiness :
- woody
Physiology
The physiological profile of Ruta graveolens is characterized by a C3 photosynthetic pathway, which governs its carbon fixation processes and metabolic efficiency. The vegetative morphology is defined by elliptic leaf forms that serve as the primary sites for gas exchange and light absorption. These leaves exhibit significant dimensional variation, with lengths ranging from a minimum of 4 cm to a maximum of 11 cm. Furthermore, the leaf width fluctuates between a minimum of 3 cm and a maximum of 7 cm, providing a specific surface area optimized for its metabolic requirements within its ecological niche.
- Leaf form :
- elliptic
- Leaf length max:
- 11 cm
- Leaf length min:
- 4 cm
- Leaf width max:
- 7 cm
- Leaf width min:
- 3 cm
- Photosynthetic pathway :
- C3
Reproduction
The reproduction of Ruta graveolens is characterized by a flowering period that typically begins in June and concludes in August. The plant produces yellow flowers arranged in a cyme inflorescence, with individual flowers measuring between 0.6 cm and 0.7 cm in length. The pollination process is biotic in nature, specifically utilizing an insect pollination syndrome. Notably, self-fertilization is absent in this species, necessitating cross-pollination. Following fertilization, the plant develops fruit in the form of a capsule. These capsules are dehiscent, meaning they split open to release the seeds. The seeds are quite small, with a mean mass of approximately 0.0020936665 g, ranging from a minimum of 0.00197 g to a maximum of 0.00266 g. Regarding the movement of progeny, the species exhibits an anthropochorous dispersal syndrome, indicating that human activity plays a role in its seed dispersal.
- Dehiscence :
- dehiscent
- Dispersal syndrome :
- anthropochorous
- Flower colour :
- yellow
- Flower length max:
- 0.7 cm
- Flower length min:
- 0.6 cm
- Flowering time :
- Jun
- Flowering time :
- Aug
- Fruit type :
- capsule
- Inflorescence :
- cyme
- Pollination syndrome :
- insect
- Pollination syndrome :
- biotic
- Seed mass max:
- 0.00266 g
- Seed mass mean:
- 0.0020936665 g
- Seed mass min:
- 0.00197 g
- Self fertilization :
- absent
Sources: Global Inventory of Floras and Traits (GIFT)
Plant Parts
Ruta graveolens has 4 reported plant parts identified across 8 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include leaf, fruit, root, stem.
| Plant part | Supporting sources | Consensus |
|---|---|---|
| Leaf | 5 supporting sources | ★★★☆☆ |
| Fruit | 1 supporting sources | ★☆☆☆☆ |
| Root | 1 supporting sources | ★☆☆☆☆ |
| Stem | 1 supporting sources | ★☆☆☆☆ |
Leaf
- Bioinorganic chemistry and applications
- Planta medica
- Plants (Basel, Switzerland)
- Molecules (Basel, Switzerland)
- Genetics and molecular research : GMR
Fruit
- Molecules (Basel, Switzerland)
Root
- Planta medica
Stem
- Planta medica
Chemicals
Ruta graveolens has 104 reported phytochemicals identified across 8 scientific publications and several other databases. The most consistently reported chemicals include RUTIN, Bergapten, Dictamnine, Graveolinine, Kokusaginine.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| RUTIN | 7 supporting sources | ★★★★☆ |
| Bergapten | 3 supporting sources | ★★☆☆☆ |
| Dictamnine | 3 supporting sources | ★★☆☆☆ |
| Graveolinine | 3 supporting sources | ★★☆☆☆ |
| Kokusaginine | 3 supporting sources | ★★☆☆☆ |
| Psoralen | 3 supporting sources | ★★☆☆☆ |
| Skimmianine | 3 supporting sources | ★★☆☆☆ |
| gamma-Fagarine | 3 supporting sources | ★★☆☆☆ |
| Arborinine | 2 supporting sources | ★☆☆☆☆ |
| Chalepensin | 2 supporting sources | ★☆☆☆☆ |
RUTIN
- Dr. Duke
- Journal of traditional and complementary medicine
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
- Current reviews in clinical and experimental pharmacology
- Experimental cell research
View 2 additional sources
- Chemical & pharmaceutical bulletin
- Journal of natural products
Bergapten
- Dr. Duke
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
- Mutation research
Dictamnine
- Dr. Duke
- Mutation research
- Mutagenesis
Graveolinine
- Dr. Duke
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
- Current reviews in clinical and experimental pharmacology
Kokusaginine
- Dr. Duke
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
- Mutagenesis
Psoralen
- Dr. Duke
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
- Mutation research
Skimmianine
- Dr. Duke
- Mutation research
- Mutagenesis
gamma-Fagarine
- Dr. Duke
- Mutation research
- Mutagenesis
Arborinine
- Dr. Duke
- Planta medica
Chalepensin
- Dr. Duke
- Planta medica
Activities
Ruta graveolens has 426 reported activities identified across 8 scientific publications and several other databases. The most consistently reported activities include Analgesic, Antibacterial, Anticancer, Antidiabetic, Antiinflammatory.
| Activity | Supporting sources | Consensus |
|---|---|---|
| Analgesic | 2 supporting sources | ★☆☆☆☆ |
| Antibacterial | 2 supporting sources | ★☆☆☆☆ |
| Anticancer | 2 supporting sources | ★☆☆☆☆ |
| Antidiabetic | 2 supporting sources | ★☆☆☆☆ |
| Antiinflammatory | 2 supporting sources | ★☆☆☆☆ |
| Antioxidant | 2 supporting sources | ★☆☆☆☆ |
| Antiviral | 2 supporting sources | ★☆☆☆☆ |
| Clastogenic | 2 supporting sources | ★☆☆☆☆ |
| Cytotoxic | 2 supporting sources | ★☆☆☆☆ |
| Genotoxic | 2 supporting sources | ★☆☆☆☆ |
Analgesic
- Dr. Duke
- Current reviews in clinical and experimental pharmacology
Antibacterial
- Dr. Duke
- Plants (Basel, Switzerland)
Anticancer
- Dr. Duke
- Anticancer research
Antidiabetic
- Dr. Duke
- African journal of traditional, complementary, and alternative medicines : AJTCAM
Antiinflammatory
- Dr. Duke
- Current reviews in clinical and experimental pharmacology
Antioxidant
- Dr. Duke
- Plants (Basel, Switzerland)
Antiviral
- Dr. Duke
- Planta medica
Clastogenic
- Dr. Duke
- Asian Pacific journal of cancer prevention : APJCP
Cytotoxic
- Dr. Duke
- African journal of traditional, complementary, and alternative medicines : AJTCAM
Genotoxic
- Dr. Duke
- Asian Pacific journal of cancer prevention : APJCP
Conditions
Ruta graveolens has 39 reported investigations on conditions identified across 8 scientific publications and several other databases. The most consistently reported conditions include Alzheimer's disease, Candida albicans, Diabetes mellitus, Trichomonas vaginalis, Vitiligo.
| Condition | Supporting sources | Consensus |
|---|---|---|
| Alzheimer's disease | 1 supporting sources | ★☆☆☆☆ |
| Candida albicans | 1 supporting sources | ★☆☆☆☆ |
| Diabetes mellitus | 1 supporting sources | ★☆☆☆☆ |
| Trichomonas vaginalis | 1 supporting sources | ★☆☆☆☆ |
| Vitiligo | 1 supporting sources | ★☆☆☆☆ |
| Airway remodeling | 1 supporting sources | ★☆☆☆☆ |
| Analgesic | 1 supporting sources | ★☆☆☆☆ |
| Antihelmintics | 1 supporting sources | ★☆☆☆☆ |
| Asthma | 1 supporting sources | ★☆☆☆☆ |
| Backache | 1 supporting sources | ★☆☆☆☆ |
Alzheimer's disease
- Current medicinal chemistry
Candida albicans
- Cureus
Diabetes mellitus
- African journal of traditional, complementary, and alternative medicines : AJTCAM
Trichomonas vaginalis
- Turkiye parazitolojii dergisi
Vitiligo
- Antioxidants (Basel, Switzerland)
Airway remodeling
- Current pharmaceutical design
Analgesic
- Current reviews in clinical and experimental pharmacology
Antihelmintics
- Journal of ethnopharmacology
Asthma
- Current pharmaceutical design
Backache
- Frontiers in pharmacology
Preparations
Ruta graveolens has 20 reported preparations identified across 8 scientific publications and several other databases. The most consistently reported preparations include EOs, extracts, EtOH extract of the dried aerial parts, Extracts, Methanolic extract.
| Preparation | Supporting sources | Consensus |
|---|---|---|
| Eos | 2 supporting sources | ★☆☆☆☆ |
| Extracts | 2 supporting sources | ★☆☆☆☆ |
| Etoh extract of the dried aerial parts | 1 supporting sources | ★☆☆☆☆ |
| Extracts | 1 supporting sources | ★☆☆☆☆ |
| Methanolic extract | 1 supporting sources | ★☆☆☆☆ |
| Ruta 200c | 1 supporting sources | ★☆☆☆☆ |
| Aqueous extracts | 1 supporting sources | ★☆☆☆☆ |
| Chloroform extracts | 1 supporting sources | ★☆☆☆☆ |
| Decoction | 1 supporting sources | ★☆☆☆☆ |
| Dried medicinal herb | 1 supporting sources | ★☆☆☆☆ |
Eos
- Letters in applied microbiology
- Molecules (Basel, Switzerland)
Extracts
- Brazilian journal of otorhinolaryngology
- Journal of ethnopharmacology
Etoh extract of the dried aerial parts
- Journal of natural products
Extracts
- Journal of ethnopharmacology
Methanolic extract
- Anticancer research
Ruta 200c
- Asian Pacific journal of cancer prevention : APJCP
Aqueous extracts
- Turkiye parazitolojii dergisi
Chloroform extracts
- Antioxidants (Basel, Switzerland)
Decoction
- Clinical toxicology (Philadelphia, Pa.)
Dried medicinal herb
- Genetics and molecular research : GMR