10 Possible Side Effects Of Polygonum Multiflorum (Fo-Ti)

Polygonum multiflorum has some side effects when used improperly, such as gastrointestinal upset, diarrhea, and stomach discomfort.

These side effects are often caused by taking the herb in large doses or combining it with other medications.

If left untreated, these side effects can worsen, leading to dehydration, electrolyte imbalances, and malnutrition, ultimately affecting daily life, work performance, and overall health.

This article explains in details the 10 most common side effects of Polygonum multiflorum if used imporperly.

1. Enhances effects of sedatives

Polygonum multiflorum causes allergic reactions in some individuals due to the presence of allergenic proteins and flavonoids.

The plant's high concentration of these compounds can trigger an immune response, leading to symptoms such as skin rash, itching, and hives. In rare cases, anaphylaxis may occur, requiring immediate attention.

The severity of the reaction often depends on individual sensitivities and the method of preparation or processing used when consuming Polygonum multiflorum.

2. Enhances effects of sedatives

Polygonum multiflorum increases blood pressure due to its ability to stimulate the heart and nervous system.

The herb contains a compound called resveratrol, which can cause blood vessels to constrict and increase cardiac output, leading to a rise in blood pressure. Additionally, Polygonum multiflorum may also increase the production of adrenaline, a hormone that further contributes to increased blood pressure.

As a result, individuals with pre-existing hypertension or cardiovascular conditions may experience an exacerbation of their symptoms when using this herb.

3. Enhances effects of sedatives

Polygonum multiflorum lowers white blood count due to its ability to suppress the immune system and reduce inflammation.

The compound anthraquinone, found in the plant, has been shown to decrease the production of white blood cells, making individuals more susceptible to infections.

Additionally, the saponin content in Polygonum multiflorum may also contribute to this side effect by interfering with the normal functioning of the immune system.

4. Enhances effects of sedatives

Polygonum multiflorum raises liver enzymes due to its high concentration of saponins and polyphenols.

These compounds are responsible for stimulating the production of liver enzymes, which can lead to increased bilirubin levels in the blood. This can cause symptoms such as yellowing of the skin and eyes (jaundice), dark urine, and pale stools.

The exact mechanisms by which fo-ti affects liver enzyme activity are not fully understood, but it is thought that the saponins may interact with enzymes involved in bilirubin metabolism.

5. Enhances effects of sedatives

Polygonum multiflorum affects fetal development when used during pregnancy.

This is attributed to the presence of saponins and flavonoids in the herb, which can cause vasoconstriction and alter blood flow, potentially leading to congenital abnormalities and miscarriage.

Additionally, the phytoestrogens found in Polygonum multiflorum may mimic the effects of estrogen, disrupting normal fetal growth and development.

6. Enhances effects of sedatives

Polygonum multiflorum increases risk of bleeding when used due to its ability to inhibit platelet aggregation and antagonize vitamin K. This can lead to a reduced blood clotting function, making it more susceptible to bleeding, especially in patients with pre-existing bleeding disorders or those taking anticoagulant medications.

The herb's saponin and flavonoid content may contribute to this effect by disrupting normal blood coagulation mechanisms.

As a result, individuals using Polygonum multiflorum may experience increased bruising, petechiae, or prolonged bleeding from wounds or surgical sites.

7. Enhances effects of sedatives

Polygonum multiflorum interacts with warfarin by increasing the risk of bleeding complications.

This is because fo-ti contains compounds that may enhance the effects of warfarin, leading to excessive blood thinning and bleeding.

The interaction is thought to occur due to the herb's ability to inhibit platelet aggregation and increase clotting factor production, which can further amplify the anticoagulant effects of warfarin.

8. Enhances effects of sedatives

Polygonum multiflorum disrupts thyroid function.

The plant's saponins and flavonoids may interfere with thyroid hormone production, potentially leading to hypothyroidism or hyperthyroidism.

Additionally, the presence of tyrosol, a compound with similar structure to thyroxine, may cause the body to mistake it for the natural hormone, leading to an overactive thyroid gland.

9. Enhances effects of sedatives

Polygonum multiflorum triggers seizures due to its high content of a compound called saponin, which can alter brain chemistry and lead to increased excitability.

This can cause abnormal electrical activity in the brain, resulting in seizures. Additionally, Polygonum multiflorum may interact with certain medications that are used to control seizures, potentially exacerbating the condition.

The exact mechanisms behind this effect are not fully understood, but it is believed to be related to the herb's ability to affect neurotransmitters and brain waves.

10. Enhances effects of sedatives

Polygonum multiflorum causes kidney damage due to its high saponin content.

Saponins can interfere with the body's natural detoxification processes, leading to an accumulation of toxins in the kidneys and potentially causing damage over time.

Additionally, Polygonum multiflorum may also cause increased blood pressure, which can further strain the kidneys and increase the risk of damage.