10 Possible Side Effects Of Polygala Vulgaris (Milkwort)

Polygala vulgaris has some side effects when used improperly, such as gastrointestinal issues, allergic reactions, and interactions with medications.

Causes of these side effects include taking excessive doses, combining with other herbs, and individual sensitivity.

For instance, severe gastrointestinal issues can lead to weight loss, fatigue, and decreased productivity, while allergic reactions can cause anaphylaxis, a life-threatening condition.

This article explains in details the 10 most common side effects of Polygala vulgaris if used imporperly.

1. Worsens respiratory issues

Polygala vulgaris causes allergic reactions in some individuals due to its chemical composition.

The plant contains polygalasaponins and alkaloids, which can trigger an immune response in sensitive people, leading to symptoms such as hives, itching, and difficulty breathing.

Additionally, the pollen of Polygala vulgaris is also known to exacerbate allergies in those who are already predisposed, further increasing the risk of adverse reactions.

2. Worsens respiratory issues

Polygala vulgaris produces gastrointestinal disturbances due to its ability to stimulate digestive secretions and alter gut motility.

The plant's saponins and flavonoids can irritate the mucous membranes in the stomach and intestines, leading to symptoms such as nausea, vomiting, diarrhea, and abdominal cramps.

These compounds may also interfere with nutrient absorption, further exacerbating gastrointestinal issues.

3. Worsens respiratory issues

Polygala vulgaris induces kidney damage due to its ability to reduce urine production and cause dehydration.

This can lead to a buildup of toxins in the blood, placing additional strain on the kidneys and potentially causing damage over time.

Additionally, the herb's potential to increase blood pressure can also exacerbate kidney damage by further reducing blood flow to this vital organ.

4. Worsens respiratory issues

Polygala vulgaris increases blood pressure due to its high concentration of alkaloids and glycosides.

These compounds stimulate the heart and blood vessels, causing a rise in blood pressure levels. Additionally, Polygala vulgaris may also affect the nervous system, leading to increased sympathetic activity, which can further contribute to elevated blood pressure.

As a result, users of Polygala vulgaris may experience an increase in their systolic and diastolic pressure readings.

5. Worsens respiratory issues

Polygala vulgaris triggers cardiac arrhythmias due to its ability to stimulate the heart's natural pacemaker activity.

The plant's chemical constituents, such as polygalic acid and saponins, can enhance the heart's excitability, leading to irregular heartbeat rhythms.

This effect is thought to be mediated by the plant's interaction with the autonomic nervous system, which regulates heart rate and blood pressure.

6. Worsens respiratory issues

Polygala vulgaris interferes with insulin function due to its ability to reduce blood sugar levels by stimulating the production of glucose-lowering hormones.

This interaction can cause hypoglycemia, or low blood sugar, in individuals already using antidiabetic medications.

Additionally, Polygala's effects on glucose metabolism may also contribute to an increased risk of developing insulin resistance, a condition characterized by impaired glucose uptake in cells.

7. Worsens respiratory issues

Polygala vulgaris disrupts thyroid hormones due to its ability to affect the body's natural balance of thyroid-stimulating hormones.

This is because Polygala contains compounds that can interfere with the production and regulation of these hormones, potentially leading to imbalances in the thyroid gland.

As a result, individuals may experience symptoms such as weight gain or loss, fatigue, or changes in appetite and metabolism.

8. Worsens respiratory issues

Polygala vulgaris enhances anxiety levels due to its potential interaction with certain neurotransmitters in the brain.

The herb contains compounds that may stimulate the release of serotonin and dopamine, leading to increased feelings of nervousness and unease. Additionally, Polygala's effects on GABA receptors can disrupt normal relaxation processes, causing individuals to feel more agitated and apprehensive.

As a result, users may experience heightened anxiety levels when taking this herbal supplement.

9. Worsens respiratory issues

Polygala vulgaris constricts blood vessels by affecting the body's nitric oxide production.

This herb contains compounds that can inhibit nitric oxide synthase, an enzyme responsible for producing nitric oxide in blood vessels.

As a result, the diameter of blood vessels is reduced, leading to increased blood pressure and decreased blood flow to various parts of the body.

10. Worsens respiratory issues

Polygala vulgaris activates immune response by stimulating the production of cytokines, which are signaling molecules that coordinate the body's defense against foreign substances and pathogens.

This activation can lead to an increased release of histamine, a chemical mediator that causes blood vessels to dilate and leads to symptoms such as flushing, itching, and hives in some individuals.

The immune response triggered by Polygala vulgaris may also cause systemic inflammation, resulting in various symptoms including fever, fatigue, and joint pain.