10 Possible Side Effects Of Juglans Regia (Walnut)

Juglans regia has some side effects when used improperly, such as allergic reactions, diarrhea, and stomach cramps.

These side effects are caused by consuming excessive amounts, using unripe or green husks, or having pre-existing medical conditions.

For example, severe allergic reactions can lead to anaphylaxis, a life-threatening condition, while chronic diarrhea and stomach cramps can interfere with daily activities and cause emotional distress.

This article explains in details the 10 most common side effects of Juglans regia if used imporperly.

1. Enhances sedation

Juglans regia causes allergic reactions in some individuals due to the presence of allergenic proteins such as Jug r 1 and Jug r 2.

These proteins are found in the nut's kernel, shell, and leaves, triggering an immune response that can lead to symptoms like hives, itching, and swelling.

The severity of the reaction can vary from mild to severe, depending on the individual's sensitivity to the allergenic compounds present in Walnut.

2. Enhances sedation

Juglans regia triggers respiratory issues due to its content of juglone, a phenolic compound that can cause allergic reactions and inflammation in some individuals.

This may lead to symptoms such as coughing, wheezing, and shortness of breath, particularly among those with pre-existing respiratory conditions like asthma or chronic obstructive pulmonary disease (COPD).

The severity of these reactions can vary depending on the amount and method of consumption.

3. Enhances sedation

Juglans regia induces severe dizziness in some individuals.

This is attributed to the high concentration of juglone and other compounds present in its hulls and leaves, which can affect the central nervous system and disrupt normal brain function. The sedative properties of these compounds can cause feelings of lightheadedness, vertigo, and even fainting episodes.

As a result, people may experience an intense sense of dizziness when exposed to Juglans regia or its derivatives.

4. Enhances sedation

Juglans regia lowers blood pressure by inhibiting the angiotensin-converting enzyme (ACE), a key player in the renin-angiotensin-aldosterone system.

This results in decreased peripheral resistance and vasodilation, leading to a drop in systolic and diastolic blood pressure.

Additionally, juglones, a class of compounds present in walnut extracts, may also contribute to this hypotensive effect by relaxing smooth muscle cells and reducing the release of vasoconstrictors.

5. Enhances sedation

Juglans regia increases risk of bleeding due to its ability to thin the blood and reduce platelet aggregation.

The compound juglone, found in the bark and leaves of Juglans regia, has been shown to inhibit platelet function, leading to a decreased ability for blood to clot properly.

Additionally, the polyphenolic compounds present in walnut extract have been demonstrated to enhance fibrinolytic activity, further contributing to an increased risk of bleeding.

6. Enhances sedation

Juglans regia interacts with medications, causing a range of side effects.

The compounds present in Juglans regia, such as juglone and melatonin, can alter the body's absorption and metabolism of certain drugs, leading to potential interactions.

This may result in changes to blood pressure, heart rate, and other bodily functions, potentially affecting medication efficacy or increasing the risk of adverse reactions.

7. Enhances sedation

Juglans regia causes stomach upset due to its high levels of tannins and phenolic acids.

These compounds can irritate the digestive system, leading to symptoms such as bloating, gas, and abdominal discomfort.

Additionally, the nut's fatty acid composition may contribute to increased cholesterol production, potentially exacerbating gastrointestinal issues.

8. Enhances sedation

Juglans regia leads to liver damage due to its high content of juglone and tannins.

These compounds can cause oxidative stress and inflammation in the liver, ultimately leading to cellular damage and potentially irreversible harm.

The exact mechanisms by which these compounds induce liver damage are not fully understood, but it is thought that they may interfere with normal liver function and increase the risk of developing liver disease.

9. Enhances sedation

Juglans regia triggers kidney problems by interfering with the normal functioning of the kidneys.

The jugloone, a compound present in the fruit and hull of the walnut, can cause damage to the nephrons, the functional units of the kidneys responsible for filtering waste products from the blood.

This can lead to a range of issues, including decreased urine production, swelling, and electrolyte imbalances.

10. Enhances sedation

Juglans regia increases heart rate due to its high concentration of juglone, a compound that stimulates the nervous system and cardiovascular activity.

The increased production of adrenaline and noradrenaline in response to juglone can lead to a rapid heartbeat, palpitations, and other arrhythmias.

This side effect is often attributed to the plant's historical use as a stimulant and its potential interactions with medications that regulate heart rate.