10 Possible Side Effects Of Commiphora Mukul (Guggul)

Commiphora mukul has some side effects when used improperly, such as nausea, dizziness, and allergic reactions.

These side effects can be caused by taking high doses or consuming it for extended periods. In severe cases, they can lead to impaired cognitive function, digestive issues, and even life-threatening conditions like bleeding or organ damage.

For instance, individuals with bleeding disorders or those taking blood-thinning medications may experience worsening symptoms.

This article explains in details the 10 most common side effects of Commiphora mukul if used imporperly.

1. Decreases appetite

Commiphora mukul increases blood pressure due to its ability to stimulate the cardiovascular system and cause vasodilation, allowing more blood to flow through the veins.

This is likely attributed to the presence of compounds like boswellic acids and triterpenoids, which can affect blood vessel tone and increase cardiac output.

As a result, people may experience an elevation in their blood pressure while using Commiphora mukul.

2. Decreases appetite

Commiphora mukul causes allergic reactions in some individuals.

This is because it contains a unique compound called gum resin, which can trigger an immune response and lead to symptoms such as hives, itching, and swelling.

Additionally, the high levels of terpenoids and sesquiterpenes present in Commiphora mukul may also contribute to its allergenic potential, causing an adverse reaction in susceptible individuals.

3. Decreases appetite

Commiphora mukul triggers anxiety attacks due to its potential interaction with certain neurotransmitters in the brain.

The herb contains compounds that may affect serotonin and GABA levels, leading to an imbalance of these neurotransmitters. This can result in feelings of nervousness, restlessness, and heightened alertness, which can manifest as anxiety attacks.

Additionally, Commiphora mukul has been shown to have a stimulatory effect on the nervous system, which can further contribute to increased anxiety levels.

4. Decreases appetite

Commiphora mukul lowers blood sugar levels by inhibiting glucose reabsorption in the kidneys and increasing insulin secretion.

The gum resin of Commiphora mukul contains bioactive compounds like guggulsterones, which stimulate pancreatic beta-cells to produce more insulin, thereby reducing blood glucose levels.

Additionally, the extract has been shown to enhance glucose uptake in muscle cells and adipose tissues, further contributing to its hypoglycemic effects.

5. Decreases appetite

Commiphora mukul interferes with medication by inhibiting the activity of certain liver enzymes responsible for metabolizing drugs.

This can lead to increased levels of medications in the bloodstream, potentially causing adverse reactions or toxicity. Additionally, Commiphora mukul's ability to stimulate liver function can enhance the elimination of certain medications, making them less effective.

As a result, patients taking guggul extracts may experience altered medication responses.

6. Decreases appetite

Commiphora mukul causes digestive issues in some individuals.

The resinous sap of the plant contains bioactive compounds that can irritate the gastrointestinal tract, leading to symptoms such as bloating, gas, diarrhea, and stomach cramps. This is thought to occur due to the stimulant properties of these compounds, which can increase gut motility and secretion, as well as alter the balance of gut flora.

As a result, individuals may experience uncomfortable digestive symptoms when using Commiphora mukul.

7. Decreases appetite

Commiphora mukul induces nausea and vomiting due to its active compound, boswellic acid.

This acid has been shown to stimulate the vagus nerve, which can cause stomach upset and lead to gastrointestinal symptoms such as nausea and vomiting.

Additionally, the high levels of alkaloids present in Commiphora mukul may also contribute to these adverse effects by altering the normal functioning of the digestive system.

8. Decreases appetite

Commiphora mukul worsens kidney function due to its potential to increase urine production and reduce blood pressure, which can put additional strain on the kidneys.

Additionally, some individuals may be more susceptible to its effects due to pre-existing kidney issues or other health conditions.

The increased excretion of water and electrolytes through urination can further exacerbate kidney function impairment, potentially leading to adverse effects.

9. Decreases appetite

Commiphora mukul affects liver enzymes by altering their activity and expression.

The resinous sap of the plant contains a compound called boswellic acid, which has been shown to inhibit certain liver enzymes responsible for detoxification and metabolism.

This disruption can lead to changes in the way the body processes certain medications and substances, potentially impacting their efficacy or causing adverse interactions.

10. Decreases appetite

Commiphora mukul leads to skin rashes due to its potential allergenic properties.

The resinous sap of the Commiphora mukul tree contains sesquiterpenes and terpenoids, which can cause an allergic reaction in some individuals. When these compounds are ingested or applied topically, they can trigger an immune response, leading to skin irritation and rashes.

This adverse effect is thought to occur due to the body's hypersensitivity to these bioactive compounds, resulting in an inflammatory response that manifests as a skin rash.