10 Possible Side Effects Of Berberis Vulgaris (Barberry)

Berberis vulgaris has some side effects when used improperly, such as gastrointestinal problems, allergic reactions, and interactions with medications.

These issues arise due to excessive consumption, individual sensitivities, or combined use with other substances.

In severe cases, these side effects can lead to complications like digestive bleeding, anaphylaxis, or unintended medication effects, significantly impacting daily life and overall health.

This article explains in details the 10 most common side effects of Berberis vulgaris if used imporperly.

1. Increases risk of cancer

Berberis vulgaris causes allergic reactions due to its content of berberine, a yellow alkaloid that can trigger an immune response.

The presence of this compound in the plant's leaves and stems may cause hypersensitivity reactions in some individuals, leading to symptoms such as hives, itching, and difficulty breathing.

Additionally, the plant's high concentration of beta-carboline alkaloids may also contribute to allergic responses, making it essential for individuals with known allergies to exercise caution when handling or consuming Berberis vulgaris.

2. Increases risk of cancer

Berberis vulgaris triggers gastrointestinal upset due to its high concentration of alkaloids, particularly berberine.

These compounds can irritate the mucous membranes in the digestive tract, leading to symptoms such as nausea, vomiting, and abdominal pain.

Additionally, Berberis vulgaris may also alter the normal gut flora, disrupting the balance of beneficial bacteria in the intestine and contributing to gastrointestinal disturbances.

3. Increases risk of cancer

Berberis vulgaris induces photosensitivity rash due to its high concentration of furanocoumarins, a type of phytochemical.

These compounds have been shown to increase the skin's sensitivity to sunlight, leading to an allergic reaction and characteristic symptoms such as redness, itching, and blistering.

As a result, individuals using Berberis vulgaris may need to avoid direct exposure to sunlight or take extra precautions to protect their skin from further irritation.

4. Increases risk of cancer

Berberis vulgaris increases risk of bleeding due to its ability to thin the blood and interfere with platelet function.

The plant's active compounds, including berberine and alkaloids, have been shown to inhibit platelet aggregation, leading to an increased risk of bleeding, particularly when used in combination with anticoagulant medications or aspirin.

This side effect is thought to be caused by the plant's ability to disrupt blood clotting mechanisms, making it a potential concern for individuals taking these types of medications.

5. Increases risk of cancer

Berberis vulgaris activates liver enzymes due to its high content of berberine, a bioactive compound that stimulates the activity of certain enzymes in the liver.

This increased enzyme activity can lead to an enhanced breakdown and metabolism of various substances, including medications, nutrients, and toxins.

As a result, people using Berberis vulgaris may experience changes in their digestive system, such as altered gut bacteria, loose stools, or stomach upset.

6. Increases risk of cancer

Berberis vulgaris interferes with medication absorption by binding to the gut wall and reducing the availability of certain nutrients, such as vitamin B12 and folate.

This can lead to impaired gut function and altered microbiota, disrupting the normal digestion and absorption of medications.

Additionally, Berberis vulgaris contains berberine, a compound that has been shown to inhibit the activity of certain enzymes involved in medication metabolism, further exacerbating the issue.

7. Increases risk of cancer

Berberis vulgaris provokes respiratory distress due to its ability to increase mucus production in the lungs.

The alkaloids present in Berberis vulgaris, particularly berberine, can cause bronchospasm and exacerbate existing respiratory conditions such as asthma.

Additionally, the plant's bitter compounds may stimulate the cough reflex, leading to an increased production of mucus, which can further irritate the airways and lungs.

8. Increases risk of cancer

9. Increases risk of cancer

Berberis vulgaris affects thyroid function.

The plant's active compound, berberine, is thought to inhibit the conversion of thyroxine (T4) to triiodothyronine (T3), leading to changes in thyroid hormone levels. Additionally, Berberis vulgaris may cause an increase in thyroid-stimulating hormone (TSH) levels, as the body compensates for reduced T3 production.

This may result in symptoms such as fatigue, weight gain, or cold intolerance.

10. Increases risk of cancer

Berberis vulgaris lowers blood pressure by acting on the body's cardiovascular system.

The alkaloids present in the plant, particularly berberine, cause vasodilation, which is the widening of blood vessels, allowing for increased blood flow and reduced blood pressure. Additionally, the plant's effects on the kidneys' ability to regulate sodium levels can also contribute to a decrease in blood pressure.

As a result, individuals taking Berberis vulgaris may experience lowered blood pressure due to these physiological interactions.