10 Possible Side Effects Of Azadirachta Indica (Neem)

Azadirachta indica has some side effects when used improperly, such as allergic reactions, skin irritation, and digestive problems.

Causes of these side effects include excessive consumption, poor quality of the herb, or individual sensitivities. For instance, severe allergic reactions can lead to anaphylaxis, a life-threatening condition that can cause respiratory failure.

Additionally, long-term consumption can lead to liver damage and kidney problems, severely impacting an individual's quality of life.

This article explains in details the 10 most common side effects of Azadirachta indica if used imporperly.

1. Induces neurological problems

Azadirachta indica causes allergic reactions in some individuals.

The tree's compounds, particularly azadirachtin and nimbin, have been shown to trigger an immune response that leads to symptoms such as hives, itching, and flushing. These allergens can also cause respiratory issues like bronchial constriction and inflammation, which may exacerbate conditions like asthma.

Furthermore, oral intake of neem extracts or oil has been linked to gastrointestinal disturbances, including nausea and diarrhea.

2. Induces neurological problems

Azadirachta indica triggers respiratory problems due to its potential to irritate the mucous membranes in the throat and lungs.

This can lead to symptoms such as coughing, wheezing, and shortness of breath.

The allergenic properties of neem oil can cause an inflammatory response in the airways, making it difficult for people with pre-existing respiratory conditions to tolerate its use.

3. Induces neurological problems

Azadirachta indica induces skin irritation due to its active compounds such as azadirachtin and nimbin.

These chemicals can cause allergic reactions, leading to redness, itching, and inflammation of the skin.

Additionally, neem's high content of fatty acids and saponins may contribute to skin irritation by disrupting the skin's natural barrier function and increasing permeability, allowing irritants to penetrate more easily.

4. Induces neurological problems

Azadirachta indica lowers blood sugar levels.

This is due to its ability to stimulate insulin secretion and enhance insulin sensitivity, which can lead to a decrease in blood glucose levels.

Additionally, neem has been shown to inhibit the activity of enzymes involved in carbohydrate breakdown, resulting in reduced glucose absorption from the gut.

5. Induces neurological problems

Azadirachta indica interacts with medications due to its potent compounds that can bind to and alter their activity.

The bioactive limonoids in neem, such as azadirachtin and meliantriol, have been shown to inhibit the metabolism of certain medications, leading to increased levels of the drug in the body.

This interaction may result in enhanced or prolonged effects, which can be beneficial for some conditions but also increase the risk of adverse reactions.

6. Induces neurological problems

Azadirachta indica affects fertility in men by disrupting hormonal balances and reducing sperm count.

The compound azadirachtin present in neem oil has been shown to inhibit the production of testosterone, leading to low libido and decreased sperm motility. Additionally, neem's anti-inflammatory properties can cause inflammation in the testes, further compromising male fertility.

As a result, prolonged use of Azadirachta indica may lead to impaired reproductive function in men.

7. Induces neurological problems

Azadirachta indica disrupts menstrual cycles due to its potential effect on hormone regulation.

The plant's compounds, particularly limonoids and saponins, may interfere with estrogenic activity, leading to changes in the normal menstrual cycle. This disruption can cause irregular periods, missed periods, or even cessation of menstruation.

As a result, women using Azadirachta indica may experience hormonal imbalances that affect their reproductive health.

8. Induces neurological problems

Azadirachta indica increases stomach acid production due to its potential stimulation of gastric secretion.

The bioactive compounds present in Azadirachta indica, such as azadirachtin and salannin, may enhance the release of gastrin, a hormone that stimulates the stomach lining to produce more acid.

This increase in stomach acid can lead to symptoms such as heartburn, bloating, and discomfort.

9. Induces neurological problems

Azadirachta indica worsens asthma symptoms due to its potent anti-inflammatory and bronchodilatory properties.

The compound azadirachtin in neem oil can cause excessive contraction of airway smooth muscle, leading to bronchospasm and increased mucus production, which exacerbates existing asthma conditions.

Additionally, the oil's irritant properties may stimulate the release of chemical mediators that further constrict airways, making it difficult for asthmatic individuals to breathe freely.

10. Induces neurological problems

Azadirachta indica causes drowsiness.

This side effect is attributed to the presence of azadirachtin, a natural compound found in neem oil that can interact with the body's neurotransmitters, leading to increased serotonin levels and a feeling of sleepiness.

Additionally, the calming effects of neem on the nervous system may also contribute to its sedative properties, resulting in drowsiness.