By Leen Randell
Updated: Oct 21, 2024
What to know about Azadirachta indica before using it medicinally
Azadirachta indica, commonly known as neem, is a medicinal herb with a wide range of applications in treating various health conditions, including skin infections, wounds, and inflammatory diseases such as arthritis and gout.
The main health benefits associated with neem include its antimicrobial, antifungal, and antiparasitic properties, which help to combat infections and promote overall well-being. The herb's therapeutic properties are attributed to its ability to modulate the immune system, reduce inflammation, and exhibit antioxidant activity, making it a valuable resource in traditional medicine. The bioactive compounds present in neem include nimbin, nimnodal, and azadirachtin, which are responsible for its medicinal properties.
In Ayurvedic medicine, neem is commonly prepared as a paste or oil by grinding the leaves and mixing them with water or oil, which is then used topically to treat a variety of skin conditions and promote wound healing.
Featured Study:
According to a study published by "Journal of pharmaceutical sciences", Azadirachta indica exhibits positive effects on the cardiovascular system, including significant reductions in blood pressure in guinea pigs and rabbits. The extract also demonstrated a minimal negative effect on heart rate, with a notable decrease from 280 to 150 beats per minute in a rabbit administered 200 mg of extract per kilogram. Additionally, it displayed weak antiarrhythmic properties, countering ouabain-induced dysrhythmia in rabbits.
The following article explains in detail what are the medicinal uses of Azadirachta indica, its health benefits, therapeutic properties, bioactive compounds, used parts, and herbal preparation. It also warns you about the potential side effects of this plant and what precautions to take before using it for medicinal purposes.
ARTICLE SUMMARY: The table below summarizes the most crucial information about Azadirachta indica provided in the article below, which is useful if you are in a hurry and don't have time to dig deep into the very detailed content that follows.
| Medicinal Aspect | Summary |
|---|---|
| Uses | Fungal infections, Eczema, Scabies, Malaria, Psoriasis, Dandruff, Ringworm, Lice infestation, Acne, Skin infections |
| Benefits | Fights infections, Reduces inflammation, Has antibacterial, Shows antiviral, Relieves allergies, Treats skin issues, Prevents mosquito bites, Repels insect pests, Aids digestive health, Supports immune system |
| Properties | Antimicrobial, Antioxidant, Anti-inflammatory, Antiseptic, Antifungal, Pain relief, Analgesic, Antiviral, Antiparasitic, Antibacterial |
| Constituents | Saponins, Flavonoids, Azadirachtin, Terpenoids, Phenolic acids, Glycosides, Alkaloids, Triterpenoids, Coumarins, Tannins |
| Parts | Leaves, Seeds, Roots |
| Preparations | Capsule, Tincture, Oil, Salve, Suppository |
| Side Effects | Experiencing allergic reactions, Developing skin irritation, Experiencing stomach upset, Incurring liver damage, Experiencing kidney problems, Developing respiratory issues, Experiencing headaches, Experiencing dizziness, Interacting with other medications, Experiencing hormone imbalances |
| Precaution | Pregnancy and breastfeeding warning, Allergic reactions possible, Skin irritation and phototoxicity, Eye irritation and vision problems, Interaction with medications, Dose-dependent toxicity, Kidney and liver damage risk, Increased risk of bleeding, Cardiovascular problems possible, Long-term effects unknown |
BONUS CHEATSHEET: The cheatsheet below illustrates the most important medicinal aspects of Azadirachta indica. Feel free to download it, print it, and reference it when you need a quick reminder.
- What are the main medicinal uses of Azadirachta indica?
- Modern Western Medicine
- Traditional Chinese Medicine
- Ayurvedic Medicine
- Unani Medicine
- Homeopathic Medicine
- What are the primary health benefits of Azadirachta indica?
- Circulatory System
- Digestive System
- Endocrine System
- Integumentary System
- Lymphatic System
- Musculoskeletal System
- Nervous System
- Reproductive System
- Respiratory System
- Urinary System
- What are the dominant therapeutic properties of Azadirachta indica?
- What are the major healing constituents of Azadirachta indica?
- What are the most used parts of Azadirachta indica in medicine?
- What are the most common medicinal preparations of Azadirachta indica?
- What are the possible side effects of Azadirachta indica if used improperly?
- What are the precautions to take before using Azadirachta indica medicinally?
- Are there scientific studies that prove the medical effectiveness of Azadirachta indica?
- Related herbs to Azadirachta indica?
What are the main medicinal uses of Azadirachta indica?
The main medicinal uses of Azadirachta indica are treating fungal infections caused by its limonoids, which inhibit fungal growth, and scabies, due to its ability to paralyze the parasite's nervous system through the action of azadirachtin.
Azadirachta indica is also used to relieve acne by reducing inflammation and preventing the growth of Propionibacterium acnes through its sesquiterpenoids. Dandruff and eczema are managed with Azadirachta indica's antifungal and anti-inflammatory properties, which reduce the fungal load and inflammation in the scalp and skin, respectively. Psoriasis is treated with Azadirachta indica's ability to reduce inflammation and prevent the thickening of skin cells through its flavonoids.
Additionally, Azadirachta indica is used to heal skin infections, lice infestation, ringworm, and warts, due to its antimicrobial, antifungal, and antiparasitic properties, which inhibit the growth of various pathogens and parasites.
The following illustration give a summary of the main medicinal uses of Azadirachta indica.
The list below provide more details on why Azadirachta indica is used to alleviate the health conditions mentioned in the illustration above.
- Fungal Infections: This plant's essential oil has been shown to exhibit antifungal properties, which can help combat fungal infections such as athlete's foot and ringworm by inhibiting the growth of fungi and reducing their spread.
- Eczema: Its oil has anti-inflammatory and soothing properties, which can help to reduce redness, itching, and swelling associated with eczema, thereby providing relief to individuals suffering from this condition.
- Scabies: The plant's oil has been found to exhibit insecticidal and antiparasitic properties, which can help to kill the mites responsible for scabies, thereby providing a natural and effective treatment for this condition.
- Malaria: The plant's oil has been shown to exhibit antimalarial properties, which can help to combat malaria by killing the parasites responsible for this disease and reducing their ability to infect red blood cells.
- Psoriasis: Its oil has anti-inflammatory and soothing properties, which can help to reduce redness, itching, and scaling associated with psoriasis, thereby providing relief to individuals suffering from this condition.
- Dandruff: The plant's oil has antifungal and antibacterial properties, which can help to reduce the growth of fungi and bacteria that contribute to dandruff, thereby providing a natural and effective treatment for this condition.
- Ringworm: This plant's oil has been shown to exhibit antifungal properties, which can help to combat ringworm by inhibiting the growth of fungi and reducing their spread.
- Lice Infestation: The plant's oil has been found to exhibit insecticidal and pediculicidal properties, which can help to kill lice and their eggs, thereby providing a natural and effective treatment for lice infestation.
- Acne: Its oil has antibacterial and anti-inflammatory properties, which can help to reduce the growth of bacteria that contribute to acne, reduce inflammation, and promote healing of the skin.
- Skin Infections: The plant's oil has antibacterial, antifungal, and anti-inflammatory properties, which can help to reduce the growth of bacteria and fungi that contribute to skin infections, reduce inflammation, and promote healing of the skin.
The table that follows gives an overview of what are the most common health conditions that are treated with Azadirachta indica, in each of the major medicinal systems.
| Medicinal System | Conditions Treated |
|---|---|
| Modern Western Medicine | Scabies, Fungal Infections, Psoriasis, Malaria, Eczema, Lice Infestation, Dandruff, Ringworm, Acne, Herpes, Warts, Skin Cancer, Lice, Typhoid, Typhoid Fever, Tinea Versicolor, Skin Infections, Insect Bites, Leishmaniasis, Skin Allergies |
| Traditional Chinese Medicine | Scabies, Fungal Infections, Eczema, Malaria, Psoriasis, Dandruff, Ringworm, Lice Infestations, Acne, Dengue Fever, Worm Infestations, Skin Cancer, Alopecia, Leprosy, Skin Infections, Bacterial Infections, Herpes, Typhoid, Typhoid Fever, Head Lice |
| Ayurvedic Medicine | Fungal Infections, Malaria, Eczema, Scabies, Psoriasis, Skin Infections, Dandruff, Lice Infestation, Ringworm, Dengue Fever, Acne, Typhoid, Skin Cancer, Diabetes, Gastroenteritis, Alopecia, Herpes, Hypertension, Skin Allergy, Dermatitis |
| Unani Medicine | Fungal Infections, Eczema, Malaria, Scabies, Psoriasis, Dandruff, Skin Cancer, Skin Infections, Ringworm, Lice Infestation, Acne, Diabetes, Herpes, Dengue Fever, Asthma, Head Lice, Insect Bites, Diarrhea, Worm Infestation, Mosquito Bites |
| Homeopathic Medicine | Eczema, Fungal Infections, Scabies, Malaria, Psoriasis, Acne, Lice Infestation, Dandruff, Ringworm, Herpes, Skin Cancer, Dengue Fever, Insect Bites, Worm Infestations, Asthma, Typhoid, Warts, Diabetes, Gastroenteritis, Skin Infections |
Modern Western Medicine
In modern western medicine, Azadirachta indica is used to treat scabies through its antiparasitic properties, which have been shown to effectively eliminate the mites that cause this condition.
Its antifungal properties also make it effective against fungal infections such as ringworm and tinea versicolor, as well as dandruff and eczema, which often have a fungal component. Additionally, the plant has been used to treat various skin conditions, including psoriasis and acne, due to its anti-inflammatory and antimicrobial properties. Furthermore, the plant has been traditionally used to treat malaria, as well as other infections such as typhoid and typhoid fever, lice infestation, lice, skin infections, insect bites, leishmaniasis, and skin allergies, although more research is needed to fully understand its efficacy in these areas.
The plant's antiviral properties also make it a potential treatment for herpes and warts, while its antimicrobial properties may also help prevent skin cancer.
Traditional Chinese Medicine
In traditional chinese medicine, Azadirachta indica is used to treat a variety of health conditions, including scabies, a parasitic infection that causes intense itching and skin irritation.
The plant has also been found to be effective in treating fungal infections, which can lead to conditions such as eczema, a chronic skin condition characterized by inflammation and dryness. Moreover, Azadirachta indica has been traditionally used to combat malaria, a mosquito-borne disease that affects millions worldwide. Additionally, it is used to treat psoriasis, a condition that causes thick, scaly patches on the skin, and other skin conditions such as dandruff, ringworm, and lice infestations.
Furthermore, Azadirachta indica has been found to have anti-inflammatory properties, making it effective in treating acne, dengue fever, worm infestations, skin cancer, alopecia, leprosy, skin infections, bacterial infections, herpes, typhoid, and head lice.
Ayurvedic Medicine
In ayurvedic medicine, Azadirachta indica is used to treat various health conditions, including fungal infections, with its antifungal properties, while its antimalarial properties make it effective against malaria.
The plant's anti-inflammatory and antimicrobial properties also help in treating eczema, and its ability to repel insects makes it useful in treating scabies and lice infestation. Additionally, its anti-inflammatory and antiseptic properties make it effective against skin infections, and its antifungal properties also help in treating ringworm and dandruff. Furthermore, its antiviral properties make it useful in treating herpes and dengue fever, while its antibacterial properties help in treating typhoid and skin cancer.
Its antidiabetic and antioxidant properties also make it useful in treating diabetes, gastroenteritis, alopecia, and hypertension, as well as skin allergy and dermatitis, while its antiseptic and antibacterial properties help in treating acne, and its antiseptic and anti-inflammatory properties make it effective against psoriasis.
Unani Medicine
In unani medicine, Azadirachta indica is used to treat fungal infections, eczema, and malaria by exploiting its antifungal, anti-inflammatory, and antimalarial properties.
It is also used to combat scabies, psoriasis, and dandruff by targeting the root causes of these conditions, including inflammation and fungal growth. Additionally, its antiseptic properties make it effective against skin cancer, skin infections, and ringworm, while its neurotoxic properties can be used to treat lice infestation and insect bites. Furthermore, it is also used to treat acne, diabetes, herpes, and dengue fever by modulating the immune system and reducing inflammation.
Its antihistamine and antiseptic properties also make it effective in treating asthma, head lice, diarrhea, worm infestation, and mosquito bites.
Homeopathic Medicine
In homeopathic medicine, Azadirachta indica is used to treat various health conditions, including eczema, a skin condition characterized by inflammation and itching, often alleviated by its anti-inflammatory and antiseptic properties.
Fungal infections such as ringworm and fungal skin infections are also treated with the plant, which has been shown to inhibit fungal growth and reduce symptoms. Additionally, scabies and lice infestation are commonly treated with Azadirachta indica, as its antiparasitic properties help eliminate these parasites. The plant's antimalarial properties also make it effective in treating malaria, a serious and sometimes life-threatening disease caused by Plasmodium parasites.
Furthermore, Azadirachta indica is used to treat a range of other conditions, including psoriasis, acne, dandruff, herpes, skin cancer, dengue fever, insect bites, worm infestations, asthma, typhoid, warts, diabetes, gastroenteritis, and skin infections.
What are the primary health benefits of Azadirachta indica?
Azadirachta indica fights infections by producing nimbin and nimondin, two compounds that have been shown to inhibit the growth of bacteria and fungi.
It reduces inflammation by containing azadirachtin, a sesquiterpene lactone that blocks the production of pro-inflammatory enzymes. Azadirachta indica has antibacterial properties due to its ability to disrupt bacterial cell membranes and inhibit protein synthesis. Additionally, it shows antiviral activity by interfering with viral replication and entry into host cells, making it effective against viral infections.
The plant relieves allergies by containing compounds that inhibit histamine release and reduce inflammation in the airways, while also treating skin issues by exhibiting anti-itch and antiseptic properties that soothe and protect the skin, and it prevents mosquito bites and repels insect pests by releasing chemicals that repel these insects, and aids digestive health by containing compounds that reduce inflammation and improve gut health, supporting immune system function by stimulating the production of white blood cells and activating immune cells.
The following illustration give a summary of the primary health benefits of Azadirachta indica.
The list below provides more details on why Azadirachta indica offers the health benefits mentioned in the illustration above.
- Fights Infections: This plant contains compounds that exhibit antimicrobial properties, allowing it to fight infections by inhibiting the growth of pathogens and reducing the severity of symptoms associated with infections.
- Reduces Inflammation: The plant's extracts contain anti-inflammatory compounds that help to reduce inflammation and alleviate symptoms associated with conditions such as arthritis, reducing redness, swelling, and pain.
- Has Antibacterial: The plant's antimicrobial properties also exhibit antibacterial effects, allowing it to inhibit the growth of bacteria and combat bacterial infections, making it effective in treating a range of bacterial-related health issues.
- Shows Antiviral: The plant's extracts contain compounds that exhibit antiviral properties, allowing it to inhibit the replication of viruses and alleviate symptoms associated with viral infections, making it effective in treating a range of viral-related health issues.
- Relieves Allergies: The plant's extracts contain compounds that exhibit anti-allergic properties, allowing it to reduce the severity of allergic reactions and alleviate symptoms associated with allergies, such as itching, sneezing, and congestion.
- Treats Skin Issues: The plant's extracts contain compounds that exhibit anti-inflammatory and antimicrobial properties, allowing it to treat a range of skin issues, including acne, eczema, and dermatitis, by reducing inflammation and combating the growth of pathogens that cause skin infections.
- Prevents Mosquito Bites: The plant's extracts contain compounds that exhibit insecticidal properties, allowing it to repel mosquitoes and other insects that can transmit diseases, making it effective in preventing mosquito bites and the associated health risks.
- Repels Insect Pests: The plant's extracts contain compounds that exhibit insecticidal properties, allowing it to repel a range of insect pests, including mosquitoes, flies, and beetles, making it effective in controlling insect populations and protecting crops from damage.
- Aids Digestive Health: The plant's extracts contain compounds that exhibit anti-inflammatory and antimicrobial properties, allowing it to aid digestive health by reducing inflammation and combating the growth of pathogens that can cause digestive issues, such as diarrhea, constipation, and irritable bowel syndrome.
- Supports Immune System: The plant's extracts contain compounds that exhibit immunomodulatory properties, allowing it to support immune system function by stimulating the production of immune cells and activating the body's natural defense mechanisms, making it effective in preventing illness and promoting overall health and well-being.
The table that follows gives an overview of what are the primary health benefits of Azadirachta indica for each of the major body system.
| Body System | Health Benefits |
|---|---|
| Circulatory System | Lowers Blood Pressure, Reduces Inflammation, Improves Circulation, Prevents Clotting, Enhances Vasodilation, Reduces Oxidation, Inhibits Platelet, Improves Lipid, Reduces Fibrin, Activates Endothelium |
| Digestive System | Relieves Inflammation, Reduces Bloating, Heals Ulcers, Cures Diarrhea, Prevents Constipation, Soothes Irritation, Boosts Digestion, Cleans Gut, Fights Infections, Regulates Ph |
| Endocrine System | Regulates Thyroid, Boosts Adrenal, Stabilizes Hormone, Reduces Cortisol, Balances Insulin, Increases Testosterone, Activates Thyroxine, Stimulates Metabolism, Suppresses Ovarian, Enhances Pancreas |
| Integumentary System | Soothes Skin Irritation, Treats Acne Breakouts, Reduces Inflammation Swelling, Fights Skin Infections, Cures Eczema Conditions, Heals Burns Quickly, Safeguards Skin From Damage, Prevents Scarring Formation, Protects From Uv Rays, Tightens Skin Elasticity |
| Lymphatic System | Boosts Lymph Flow, Reduces Lymph Swelling, Improves Lymph Drainage, Enhances Immune Function, Promotes Lymph Detoxification, Supports Lymph Node Health, Regulates Lymph Protein Levels, Increases Lymph Cell Count, Stimulates Lymph Tissue Repair, Activates Lymph System Defense |
| Musculoskeletal System | Relieves Inflammation, Reduces Joint Pain, Heals Tissue Damage, Prevents Muscle Spasm, Treats Arthritis Symptoms, Improves Bone Density, Fights Muscle Degeneration, Alleviates Sciatica Pain, Mitigates Muscle Strain, Supports Ligament Health |
| Nervous System | Reduces Anxiety, Boosts Neuroplasticity, Improves Concentration, Enhances Memory, Soothes Neurotransmitters, Supports Neuroprotection, Increases Dopamine, Regulates Serotonin, Calms Nervousness, Protects Brain Cells |
| Reproductive System | Reduces Inflammation, Prevents Infections, Soothes Irritation, Relieves Pain, Treats Fungus, Cures Bacterial, Improves Fertility, Enhances Libido, Reduces Androgyny, Stimulates Hormone |
| Respiratory System | Relieves Congestion, Reduces Inflammation, Improves Breathing, Cures Coughs, Protects Airways, Eases Wheezing, Removes Mucus, Fights Infections, Soothes Throat, Heals Lungs |
| Urinary System | Prevents Urinary Infections, Reduces Bladder Enlargement, Treats Kidney Stones, Protects Kidney Function, Relieves Kidney Inflammation, Soothes Bladder Irritation, Eliminates Urinary Tract Infections, Cures Prostate Issues, Prevents Urine Retention, Heals Urinary Tract Damage |
Circulatory System
Azadirachta indica lowers blood pressure through the diuretic and vasodilatory properties of its leaves, which also reduce inflammation by inhibiting the production of pro-inflammatory enzymes.
The plant's antimicrobial properties improve circulation by preventing the formation of biofilms in blood vessels, while its antioxidant properties prevent clotting by scavenging free radicals that contribute to thrombosis. Azadirachta indica enhances vasodilation through the release of nitric oxide, reducing oxidation by inhibiting the activity of xanthine oxidase. The plant's anti-inflammatory and anticoagulant properties inhibit platelet aggregation, improve lipid profiles by reducing triglyceride levels, and reduce fibrin formation.
By activating the endothelium, Azadirachta indica's bioactive compounds stimulate the production of nitric oxide and other vasodilatory substances, promoting a healthy circulatory system.
The medicinal benefits of Azadirachta indica on the circulatory system help relieving the health conditions listed below.
- Cardiovascular disease
- Hypertension
- Varicose veins
- Atherosclerosis
- Thrombosis
- Anemia
- Circulatory failure
Digestive System
Azadirachta indica relieves inflammation due to its anti-inflammatory and antioxidant properties, which reduce the production of pro-inflammatory enzymes and neutralize free radicals.
The plant reduces bloating by inhibiting the growth of bacteria and fungi that cause gas and discomfort, thanks to its antimicrobial and antifungal properties. Azadirachta indica heals ulcers through its protective and regenerative properties, which stimulate the production of mucus and promote the healing of mucous membranes. This plant cures diarrhea by slowing down the movement of gut contents and reducing the secretion of water and electrolytes, due to its antispasmodic and anti-diarrheal properties.
Regular consumption of Azadirachta indica prevents constipation by stimulating the movement of gut contents and promoting the production of digestive enzymes, which aid in the breakdown and absorption of nutrients, and soothes irritation with its soothing and anti-inflammatory effects, boosts digestion with its digestive enzymes, cleans the gut by promoting the elimination of toxins, fights infections with its antimicrobial properties, and regulates pH by balancing the acidity and alkalinity of the gut.
The medicinal benefits of Azadirachta indica on the digestive system help relieving the health conditions listed below.
- Diarrhea
- Irritable bowel syndrome
- Peptic ulcer
- Gastritis
- Inflammatory bowel disease
- Constipation
- Acid reflux
- Hepatitis
Endocrine System
Azadirachta indica regulates thyroid by modulating the production of thyroid hormones, which is attributed to its antioxidant properties that neutralize free radicals and prevent oxidative stress.
Azadirachta indica boosts adrenal function by enhancing the secretion of cortisol, which is facilitated by its anti-inflammatory properties that reduce inflammation and promote healing. The medicinal properties of Azadirachta indica, including its antimicrobial and anti-oxidative properties, stabilize hormone production by regulating the expression of genes involved in hormone synthesis. Azadirachta indica reduces cortisol levels by inhibiting the activity of cortisol-producing enzymes, thereby alleviating stress and anxiety.
Azadirachta indica balances insulin levels by modulating the insulin signaling pathway, which is mediated by its anti-diabetic properties, and also increases testosterone levels, activates thyroxine, stimulates metabolism, suppresses ovarian function, and enhances pancreas function.
The medicinal benefits of Azadirachta indica on the endocrine system help relieving the health conditions listed below.
- Polycystic ovary syndrome
- Hirsutism
- Acne
- Hyperthyroidism
- Diabetes
- Hypothyroidism
- Insulin resistance
- Weight loss
- Skin tags
Integumentary System
Azadirachta indica soothes skin irritation due to its anti-inflammatory properties, which reduce redness and discomfort.
It treats acne breakouts by inhibiting the growth of Propionibacterium acnes, a bacterium responsible for acne, through its antimicrobial properties. Azadirachta indica reduces inflammation and swelling by suppressing the production of pro-inflammatory enzymes, thus alleviating symptoms of various skin conditions. Additionally, its antiseptic and antibacterial properties fight skin infections, cure eczema conditions, and heal burns quickly by promoting wound closure and tissue repair.
Azadirachta indica safeguards skin from damage, prevents scarring formation, protects from UV rays, and tightens skin elasticity due to its antioxidant and free radical scavenging properties, thereby maintaining skin health and integrity.
The medicinal benefits of Azadirachta indica on the integumentary system help relieving the health conditions listed below.
- Psoriasis
- Eczema
- Acne
- Fungal infections
- Dandruff
- Lice infestation
- Itching
- Warts
- Ringworm
- Herpes simplex
Lymphatic System
Azadirachta indica boosts lymph flow due to its antispasmodic and vasodilatory properties, which relax muscle spasms and increase blood flow to lymphatic vessels.
This plant reduces lymph swelling through its anti-inflammatory and antimicrobial properties, which inhibit the growth of pathogenic microorganisms and reduce inflammation. Azadirachta indica improves lymph drainage by stimulating the contraction of smooth muscle cells in lymphatic vessels, thereby promoting the removal of waste and toxins. The antimicrobial and antioxidant properties of Azadirachta indica enhance immune function by preventing the proliferation of pathogenic microorganisms and protecting cells from oxidative damage.
By regulating its antifungal and anti-inflammatory properties, Azadirachta indica promotes lymph detoxification, supports lymph node health, regulates lymph protein levels, increases lymph cell count, stimulates lymph tissue repair, and activates lymph system defense.
The medicinal benefits of Azadirachta indica on the lymphatic system help relieving the health conditions listed below.
- Lymphedema
- Lymphadenitis
- Lymphangitis
- Hodgkin's lymphoma
- Non-hodgkin's lymphoma
- Lymphocytosis
- Lymphopenia
Musculoskeletal System
Azadirachta indica relieves inflammation due to its anti-inflammatory and antioxidant properties.
This plant reduces joint pain by inhibiting the production of pro-inflammatory cytokines. Azadirachta indica heals tissue damage by promoting wound healing and tissue regeneration through its antimicrobial and cytoprotective properties. Preventing muscle spasm is another benefit, achieved through its neuromuscular relaxant effects.
Azadirachta indica treats arthritis symptoms, improves bone density, fights muscle degeneration, alleviates sciatica pain, mitigates muscle strain, and supports ligament health by modulating the immune response, inhibiting the production of pro-inflammatory enzymes, and protecting against oxidative stress, which are all attributed to its anti-inflammatory, antioxidant, and immunomodulatory properties.
The medicinal benefits of Azadirachta indica on the musculoskeletal system help relieving the health conditions listed below.
- Osteoarthritis
- Rheumatoid arthritis
- Muscle spasm
- Tendinitis
- Fibromyalgia
- Bone cancer
- Gout
Nervous System
Azadirachta indica reduces anxiety by exerting its anxiolytic properties, attributed to the presence of flavonoids and limonoids that modulate the activity of GABA receptors in the nervous system.
Boosting neuroplasticity is achieved through the activation of neurotrophic factors, such as BDNF, which is stimulated by the antioxidant and anti-inflammatory properties of Azadirachta indica, leading to improved neural connections and adaptation. This plant improves concentration by enhancing the activity of neurotransmitters, including acetylcholine, which is increased due to the inhibitory effects of Azadirachta indica on acetylcholinesterase, an enzyme responsible for its breakdown. Enhancing memory is facilitated by the ability of Azadirachta indica to increase the expression of genes involved in neuronal survival and plasticity, such as those encoding for BDNF and synaptophysin, which are also associated with improved cognitive function.
Azadirachta indica supports neuroprotection by scavenging free radicals and modulating the activity of pro-inflammatory cytokines, thereby protecting brain cells from oxidative stress and inflammation.
The medicinal benefits of Azadirachta indica on the nervous system help relieving the health conditions listed below.
- Epilepsy
- Anxiety
- Parkinsonism
- Alzheimer's
- Migraine
- Neuropathy
- Schizophrenia
- Tinnitus
- Insomnia
Reproductive System
Azadirachta indica reduces inflammation in the reproductive system through its anti-inflammatory property, which helps to alleviate conditions such as endometritis and orchitis.
The plant prevents infections by exhibiting antimicrobial properties, including antibacterial and antifungal activities, that inhibit the growth of pathogens and reduce the risk of infections. Azadirachta indica soothes irritation by acting as a natural demulcent, providing a protective barrier and reducing inflammation in the genital area. The plant relieves pain by possessing analgesic and anxiolytic properties, which help to alleviate discomfort and promote relaxation.
Azadirachta indica improves fertility in both males and females by treating conditions such as oligospermia and reducing oxidative stress, while also enhancing libido and reducing androgyny, and stimulating hormone production.
The medicinal benefits of Azadirachta indica on the reproductive system help relieving the health conditions listed below.
- Polycystic ovary syndrome
- Endometriosis
- Menorrhagia
- Erectile dysfunction
- Hirsutism
- Infertility
- Male pattern baldness
- Prostate inflammation
- Vaginal infections
Respiratory System
Azadirachta indica relieves congestion due to the antimicrobial properties that inhibit the growth of bacteria and fungi, which cause respiratory tract infections.
The anti-inflammatory property of Azadirachta indica reduces inflammation, a major contributor to respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD). Improved breathing is achieved through the antioxidant properties that protect the lungs from oxidative stress and damage caused by free radicals. Azadirachta indica cures coughs, a common symptom of respiratory infections, by its expectorant property, which loosens and removes mucus from the airways, protecting them from further irritation.
Azadirachta indica soothes throat irritation, eases wheezing, removes mucus, fights infections, and heals lungs due to its broad-spectrum antimicrobial, anti-inflammatory, and antioxidant properties.
The medicinal benefits of Azadirachta indica on the respiratory system help relieving the health conditions listed below.
- Asthma
- Bronchitis
- Cough
- Influenza
- Sinusitis
- Tonsillitis
Urinary System
Azadirachta indica prevents urinary infections due to its antimicrobial properties, which inhibit the growth of bacteria and fungi that cause infections.
The anti-inflammatory properties of Azadirachta indica reduce bladder enlargement by alleviating inflammation and preventing scarring in the bladder walls. Azadirachta indica treats kidney stones by acting as a diuretic, increasing urine production and flushing out kidney stones. The antioxidant properties of Azadirachta indica protect kidney function by neutralizing free radicals that can damage kidney cells and lead to kidney disease.
Azadirachta indica relieves kidney inflammation and sooths bladder irritation by suppressing the production of pro-inflammatory enzymes and reducing oxidative stress.
The medicinal benefits of Azadirachta indica on the urinary system help relieving the health conditions listed below.
- Urinary tract infection
- Kidney stones
- Prostatitis
- Enuresis
- Urinary incontinence
- Cystitis
- Pyelonephritis
What are the dominant therapeutic properties of Azadirachta indica?
The therapeutic properties of Azadirachta indica are attributed to its antimicrobial and antifungal activities, which are primarily due to the presence of bioactive compounds such as limonoids and saponins, that help in inhibiting the growth of various microorganisms and fungi, thereby preventing infections and diseases.
The antioxidant properties of this plant are responsible for its ability to scavenge free radicals and prevent oxidative stress, which can lead to chronic diseases such as cancer and neurodegenerative disorders. Azadirachta indica's anti-inflammatory properties are due to the presence of flavonoids and terpenoids, which help in reducing inflammation and alleviating symptoms associated with conditions such as arthritis and asthma. The antiseptic properties of this plant are attributed to the presence of volatile oils, which help in preventing the growth of microorganisms and promoting wound healing.
Additionally, Azadirachta indica's analgesic, antiviral, antiparasitic, antibacterial, and pain relief properties make it a valuable medicinal plant for treating various health conditions, including viral infections, parasitic diseases, and bacterial infections.
The following illustration give a summary of the dominant therapeutic properties of Azadirachta indica.
The list below provides more details on why Azadirachta indica has the therapeutic properties mentioned in the illustration above.
- Antimicrobial: Azadirachta indica has shown antimicrobial activity against a range of microorganisms including bacteria, fungi, and viruses, making it a potential natural alternative for controlling microbial growth.
- Antioxidant: The plant's leaves, seeds, and bark contain antioxidants such as flavonoids, terpenoids, and phenolic compounds, which can help protect cells from oxidative damage and reduce inflammation.
- Anti-Inflammatory: Azadirachta indica has anti-inflammatory properties, which can help reduce swelling, pain, and inflammation in various conditions, including arthritis, wounds, and skin irritations.
- Antiseptic: The plant's extracts have been shown to have antiseptic properties, making it effective in preventing the growth of bacteria and other microorganisms that can cause infections.
- Antifungal: Azadirachta indica has been found to exhibit antifungal activity against various fungal pathogens, including dermatophytes, which can cause skin infections.
- Pain Relief: The plant's extracts have been used to relieve pain and reduce inflammation in various conditions, including headaches, fever, and arthritis.
- Analgesic: Azadirachta indica has been found to have analgesic properties, which can help relieve pain and reduce discomfort in various conditions.
- Antiviral: The plant's extracts have been shown to have antiviral activity against various viral pathogens, including herpes simplex virus and HIV.
- Antiparasitic: Azadirachta indica has been found to have antiparasitic properties, which can help control the growth of parasites such as hookworms, roundworms, and tapeworms.
- Antibacterial: The plant's extracts have been shown to have antibacterial activity against various bacterial pathogens, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
What are the major healing constituents of Azadirachta indica?
The healing constituents of Azadirachta indica are saponins, flavonoids, azadirachtin, terpenoids, and phenolic acids.
Saponins exhibit antimicrobial and anti-inflammatory properties, flavonoids display antioxidant and anti-inflammatory activities, azadirachtin has insecticidal and antifungal effects, terpenoids show antifungal and antibacterial activities, and phenolic acids possess antioxidant and anti-inflammatory properties. These compounds work synergistically to provide Azadirachta indica with its diverse medicinal properties. Studies have shown that the combination of these constituents can inhibit the growth of various pathogens and reduce inflammation.
The presence of these bioactive compounds in Azadirachta indica supports its traditional use in treating various health conditions, including skin disorders, fever, and respiratory infections.
The following illustration give a summary of the major healing consitutents of Azadirachta indica.
The list below provides more details on what are the major healing constituents of Azadirachta indica and why they are important for health.
- Saponins: Saponins are a type of triterpenoid and steroidal glycoside found in Azadirachta indica, exhibiting surfactant, foaming, and emulsifying properties.
- Flavonoids: Azadirachta indica's Flavonoids are known for their antioxidant, anti-inflammatory, and antimicrobial properties.
- Azadirachtin: Azadirachtin is a sesquiterpenoid limonoid compound that exhibits insecticidal, antifeedant, and growth-regulating properties.
- Terpenoids: Azadirachtin, a type of Terpenoids found in Azadirachta indica, exhibits anti-inflammatory, antimicrobial, and antifungal properties.
- Phenolic acids: Phenolic acids from Azadirachta indica are a type of compound that are water-soluble, have antioxidant and antimicrobial properties, and may exhibit anti-inflammatory and cytotoxic effects.
- Glycosides: Azadirachta indica contains azadirachtin glycosides, which have anti-inflammatory, antimicrobial and antifungal properties.
- Alkaloids: Azadirachtin, a type of alkaloid, is a highly lipophilic compound with antifungal, antibacterial, antiviral, and antiparasitic properties.
- Triterpenoids: Azadirachta indica contains triterpenoids, which have anti-inflammatory, antioxidant, and antimicrobial properties.
- Coumarins: Coumarins are tricyclic dione compounds found in Azadirachta indica, characterized by a 2-hydroxycoumarin and a 4-methylcoumarin structure.
- Tannins: A type of polyphenolic compound found in Azadirachta indica, known for its astringent, antimicrobial, and antioxidant properties.
The table that follows estimates the relative concentrations of the main medicinal constituents contained in Azadirachta indica and lists the most relevant medicinal properties of each constituent based on the corresponding concentrations.
| Constituent | Concentration | Properties |
|---|---|---|
| Saponins | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Antiviral, Antifungal, Cardioprotective, Neuroprotective, Anticancer, Antibacterial, Hepatoprotective |
| Flavonoids | HIGH | Antimicrobial, Antioxidant, Anti-inflammatory, Antiviral, Antibacterial, Anticancer, Cardioprotective, Neuroprotective |
| Azadirachtin | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Antifeedant, Insecticidal, Anticancer, Antiparasitic, Antimutagenic |
| Terpenoids | HIGH | Antimicrobial, Antioxidant, Anti-inflammatory, Antiviral, Antifungal, Antibacterial, Analgesic, Antipyretic, Antiproliferative |
| Phenolic acids | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Antidiarrheal, Antiviral, Antibacterial, Antifungal, Antihistaminic |
| Glycosides | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Antiviral, Antifungal, Anti-helminthic, Cytotoxic |
| Alkaloids | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Antifungal, Antihistaminic, Antipruritic, Analgesic, Antiviral, Anticancer |
| Triterpenoids | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Antiproliferative, Anticancer, Antiviral, Antifungal, Wound healing, Anti-diabetic |
| Coumarins | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Antifungal, Antihelmintic, Antiparasitic |
| Tannins | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Antiviral, Antifungal, Antiseptic, Anticariogenic, Analgesic, Anti-pyretic, Anti-diarrheal |
What are the most used parts of Azadirachta indica in medicine?
The most used parts of Azadirachta indica for medicinal purposes are leaves, seeds, and roots.
The leaves of Azadirachta indica contain bioactive compounds such as azadirachtin, a limonoid with insecticidal and anti-inflammatory properties, as well as flavonoids and saponins, which exhibit antioxidant and antimicrobial activities, contributing to their anti-inflammatory, antiseptic, and antiviral medicinal properties. The seeds, rich in neem oil, contain triterpenoid compounds like nimbin and nimandial, which possess anti-inflammatory, antiseptic, and antifungal properties, as well as anti-cancer and anti-viral activities. The roots, containing limonoids, flavonoids, and phenolic acids, exhibit anti-inflammatory, antioxidant, and antimicrobial properties, which contribute to their antiseptic, anti-diabetic, and anti-cancer medicinal properties.
These medicinal properties are attributed to the presence of bioactive compounds in each part, which have been extensively studied and utilized in traditional medicine.
The following illustration give a summary of the most used parts of Azadirachta indica in medicine.
The list below provides more details on what are the most used parts of Azadirachta indica in medicine and why.
- Leaves: The leaves of this plant contain major bioactive compounds such as azadirachtin, nimbin, and nimandial, which exhibit strong anti-inflammatory, antimicrobial, and antioxidant properties, providing primary health benefits including wound healing, skin protection, and prevention of various diseases.
- Seeds: The seeds of this plant are rich in major bioactive compounds like azadirachtin, nimbin, and nimbidin, which possess potent anti-inflammatory, antimalarial, and antiparasitic properties, resulting in primary health benefits including the treatment of skin conditions, malaria, and intestinal parasites.
- Roots: The roots of this plant contain major bioactive compounds such as limonoids, terpenoids, and alkaloids, which exhibit strong anti-inflammatory, antimicrobial, and antiviral properties, providing primary health benefits including the treatment of fever, digestive issues, and respiratory infections.
The table that follows gives a more complete list of healing constituents found in each part of Azadirachta indica mentioned above.
| Part | Constituents |
|---|---|
| Leaves | Azadirachtin, Quercetin, Vitexin, Saponins, Volatile oils, Tannins, Phytosterols, Fatty acids, Alkaloids, Glycosides |
| Seeds | Azadirachtin, Melanocarpin, Sesquiterpenoids, Triglycerides, Fatty acids, Vitamins, Minerals, Amino acids, Saponins |
| Roots | Azadirachtin, Nimbin, Saponins, Volatile oils, Phenolic compounds, Terpenoids, Cardiac glycosides, Coumarins |
What are the most common medicinal preparations of Azadirachta indica?
The most common herbal preparation of Azadirachta indica for medicinal purposes are capsules, which contain its seeds or leaves and are used to treat a range of ailments including fever, cough, and respiratory issues.
A tincture made from the plant's leaves and seeds is also used to treat various skin problems such as acne, eczema, and dermatitis, as well as to soothe wounds and insect bites. Azadirachta indica oil, extracted from the seeds, is commonly applied topically to treat skin conditions like ringworm, fungal infections, and scabies, while also being used as a hair growth promoter. A salve made from the plant's leaves and seeds is used to treat cuts, scrapes, and burns, promoting wound healing and reducing inflammation.
Suppositories made from Azadirachta indica seeds are used to treat gastrointestinal issues including diarrhea, constipation, and dysentery.
The following illustration give a summary of the most common medicinal preparations of Azadirachta indica.
The list below provides more details on what are the most common medicinal preparations of Azadirachta indica and what are their main uses.
- Capsule: Capsule made from this plant is used for treating fever, itching, rheumatism, and intestinal worms, and also for skin conditions such as eczema, acne, and dermatitis, as well as for reducing inflammation and as a natural insect repellent.
- Tincture: Tincture made from this plant is used to treat skin conditions such as eczema, acne, and dermatitis, as well as to combat fungal and bacterial infections, and to reduce inflammation and itching.
- Oil: Oil made from this plant is used for treating skin conditions such as acne, eczema, and dermatitis, as well as for reducing inflammation, and as an antiseptic and antimicrobial agent.
- Salve: Salve made from this plant is a topical application used to treat insect bites and stings, wounds, cuts, and skin conditions such as eczema, acne, and dermatitis, and to aid in the healing of burns, cuts, and surgical incisions.
The table that follows shows what are the most used parts of Azadirachta indica for each medicinal preparation.
| Preparation | Parts |
|---|---|
| Capsule | Seeds, Roots, Leaves |
| Tincture | Seeds, Roots, Leaves |
| Oil | Seeds, Leaves, Roots |
| Salve | Seeds, Roots, Leaves |
Capsule
Azadirachta indica capsule is a herbal preparation made from the seeds, roots, and leaves of the Neem tree, widely used to treat various health conditions.
It's commonly used to treat hair loss, ringworm, acne, eczema, skin allergies, diarrhea, dandruff, fever, insect bites, scabies, wound infection, psoriasis, and herpes, making it a versatile remedy for many health issues. This preparation is very common, found in many households and used by people from different cultures and backgrounds. One of the most common effects of taking Azadirachta indica capsule is its ability to reduce inflammation and fight off infections, which is attributed to its antiseptic and anti-inflammatory properties.
The preparation is made by extracting the active compounds from the seeds, roots, and leaves, which requires some knowledge and expertise, but is considered moderately difficult to make.
Below you find a 5-step quick procedure to make effective medicinal Azadirachta indica capsule.
- Harvest and dry the seeds, roots, and leaves of Azadirachta indica plant separately.
- Grind the dried seeds, roots, and leaves into fine powders using a grinding machine.
- Mix the powdered seeds, roots, and leaves in a specific proportion according to the desired herbal formula.
- Fill the mixture into empty gelatin capsules, making sure each capsule is equally filled.
- Seal the capsules properly to ensure the herbal content remains intact and fresh.
Tincture
Azadirachta indica tincture is a common herbal preparation used to treat various health issues, including fungal infections, insect bites, acne, warts, skin allergies, diarrhea, and HIV.
It's widely used due to its effectiveness and safety profile. The common effect of this tincture is its ability to reduce inflammation and prevent scarring. Azadirachta indica tincture is typically made from the seeds, roots, and leaves of the Neem tree, which are combined and extracted in a solvent to create a concentrated liquid solution.
The process of making this tincture is moderately difficult, requiring precise measurements and attention to detail to ensure the desired potency and quality.
Below you find an image of Azadirachta indica tincture.
Below you find a 5-step quick procedure to make effective medicinal Azadirachta indica tincture.
- Gather fresh Azadirachta indica seeds, roots, and leaves for the tincture.
- Clean and dry the collected plant material, then chop the seeds, roots, and leaves into small pieces.
- Combine the chopped plant material in a clean glass jar with a ratio of 1 part plant material to 2 parts 80-proof vodka or glycerin.
- Seal the jar and store it in a cool, dark place for 2-6 weeks to allow the tincture to steep and mature.
- Strain the tincture through a cheesecloth or coffee filter into a clean glass bottle, discard the solids, and label the bottle with the date and ingredients.
Oil
Azadirachta indica oil is a herbal preparation used to treat acne, lice, dandruff, ringworm, psoriasis, fungal infections, scabies, eczema, tinea versicolor, and warts.
It's one of the most widely used herbal oils due to its availability and effectiveness. The common side effect of using Azadirachta indica oil is skin irritation in some individuals. The oil is extracted from seeds, leaves, and roots of the Neem tree.
While it's not extremely difficult to make, the process requires some expertise and involves several steps to ensure quality and potency.
Below you find an image of Azadirachta indica oil.
Below you find a 5-step quick procedure to make effective medicinal Azadirachta indica oil.
- Gather seeds, leaves, and roots of Azadirachta indica plant and clean them thoroughly.
- Dry the gathered plant parts in a shaded area to remove excess moisture.
- Grind the dried seeds, leaves, and roots into a fine powder using a grinder or mortar.
- Mix the ground powder with a carrier oil such as coconut or olive oil in a ratio suitable for the desired consistency.
- Allow the mixture to infuse in a cool, dark place for several weeks, shaking the container occasionally to facilitate the extraction process.
Salve
Azadirachta indica salve is a herbal preparation used to treat various skin conditions, including eczema, dermatitis, psoriasis, fungal infections, acne, ringworm, scabies, warts, insect bites, and urticaria.
It is a common treatment due to its effectiveness and affordability. The common effect of this preparation is its anti-inflammatory and antiseptic properties, which help to soothe and heal skin irritations. This salve is made from the seeds, roots, and leaves of the neem tree (Azadirachta indica), which are combined to create a paste or oil.
The preparation is moderately difficult to make, requiring some knowledge of herbalism and distillation techniques, but the end result is a highly effective and natural remedy for skin conditions.
Below you find an image of Azadirachta indica salve.
Below you find a 5-step quick procedure to make effective medicinal Azadirachta indica salve.
- Dry the seeds, roots, and leaves of Azadirachta indica separately to preserve their medicinal properties.
- Grind the dried seeds, roots, and leaves into a fine powder using a mortar and pestle or a spice grinder.
- Combine the powdered seeds, roots, and leaves in a heat-resistant container and add a carrier oil such as coconut or olive oil.
- Heat the mixture over low heat for several hours, stirring occasionally, until the oil has infused with the herbal properties.
- Strain the infused oil through a cheesecloth or a coffee filter into a clean container and discard the solids, then allow the salve to cool and solidify before use.
What are the possible side effects of Azadirachta indica if used improperly?
The possible side effects of improperly using Azadirachta indica are experiencing allergic reactions, such as hives and itching, due to the presence of saponins, which can cause an immune system response.
Developing skin irritation is also a possible side effect, as the plant's essential oils can cause redness, inflammation, and blistering. Experiencing stomach upset is another potential side effect, as the saponins and limonoids in the plant can cause nausea, vomiting, and diarrhea. Incurable liver damage and kidney problems are more severe side effects that can occur if the plant's toxic compounds are ingested in large quantities over an extended period.
Additionally, improperly using Azadirachta indica can lead to experiencing headaches, dizziness, interacting with other medications, and developing respiratory issues, as well as experiencing hormone imbalances, including thyroid problems and changes in menstrual cycles.
The most common side effects Azadirachta indica gives people when used improperly are listed below, along with a brief explanation.
- Experiencing Allergic Reactions: Contact dermatitis, urticaria, and anaphylaxis have been reported in individuals allergic to Azadirachta indica.
- Developing Skin Irritation: Contact with Azadirachta indica can cause skin redness, itching, and inflammation.
- Experiencing Stomach Upset: Consuming Azadirachta indica can cause gastrointestinal irritation and inflammation leading to stomach upset due to the presence of limonoids and other bioactive compounds.
- Incurring Liver Damage: Azadirachta indica contains azadirachtin, which induces liver toxicity and damage in high concentrations.
- Experiencing Kidney Problems: Azadirachta indica contains nimbin, which causes nephrotoxicity leading to kidney damage.
- Developing Respiratory Issues: Azadirachta indica essential oil causes respiratory irritation and inflammation.
- Experiencing Headaches: Headache caused by oil from Azadirachta indica irritating the nervous system.
- Experiencing Dizziness: Aromatherapy use of Azadirachta indica essential oil may cause dizziness due to its high neem oil content, which can cause a sudden drop in blood pressure.
- Interacting With Other Medications: Azadirachta indica may reduce the effectiveness of anticoagulant and anticonvulsant medications.
- Experiencing Hormone Imbalances: Azadirachta indica affects hormone levels due to its estrogenic and androgenic activities.
What are the precautions to take before using Azadirachta indica medicinally?
The precautions to take before using Azadirachta indica medicinally are particularly important for pregnant and breastfeeding women, as the plant's extracts may induce uterine contractions and affect fetal development, and its compounds can be excreted into breast milk.
Allergic reactions to Azadirachta indica are possible and may manifest as skin rashes, itching, or anaphylaxis, so individuals should be cautious when handling the plant. Skin irritation and phototoxicity are also potential risks, as the plant's compounds can cause skin redness, blistering, and increased sensitivity to sunlight. Furthermore, eye irritation and vision problems can occur due to the plant's extracts irritating the eyes and potentially causing cataracts or other vision impairments.
Additionally, using Azadirachta indica medicinally may interact with medications, such as blood thinners, and cause dose-dependent toxicity, kidney and liver damage, increased risk of bleeding, cardiovascular problems, and long-term effects are also possible, but these risks can be mitigated by careful dosing and monitoring.
The most important precautions you must take before using Azadirachta indica for medicinal purposes are listed below, along with a brief explanation.
- Pregnancy And Breastfeeding Warning: Azadirachta indica essential oil is contraindicated during pregnancy and breastfeeding due to its potential to stimulate uterine contractions and cause toxicity to the fetus or infant.
- Allergic Reactions Possible: Some individuals experience allergic reactions to Azadirachta indica, characterized by symptoms such as skin irritation, itching, and respiratory issues.
- Skin Irritation And Phototoxicity: Prolonged skin contact and sun exposure cause irritation and photoallergic reactions.
- Eye Irritation And Vision Problems: Contact with Azadirachta indica's sap or oil can cause eye irritation and vision problems due to its limonoids and terpenoids.
- Interaction With Medications: Taking Azadirachta indica with certain medications, such as blood thinners, diabetes medications, and blood pressure medications, can significantly alter their efficacy or increase the risk of adverse effects.
- Dose-Dependent Toxicity: High doses of Azadirachta indica cause liver and kidney damage in animals.
- Kidney And Liver Damage Risk: Prolonged use of Azadirachta indica extracts in high doses causes severe kidney and liver damage.
- Increased Risk Of Bleeding: Azadirachta indica may interfere with anticoagulant medications, such as warfarin, and nonsteroidal anti-inflammatory drugs, leading to increased risk of bleeding.
- Cardiovascular Problems Possible: Azadirachta indica may lower blood pressure and increase heart rate in some individuals with cardiovascular disease, leading to problems.
- Long-Term Effects Unknown: Potential long-term health consequences of consuming or using Azadirachta indica are not established.
Are there scientific studies that prove the medical effectiveness of Azadirachta indica?
Yes, there are several scientific studies that prove the medicianl effectiveness of Azadirachta indica. Here are some studies that are worthy of notice.
According to a study published by "General pharmacology", Azadirachta indica has been found to have a positive effect on the cardiovascular system by reducing blood pressure without altering heart rate or respiration. At lower doses, it did not cause any noticeable changes in heart function, but at higher doses, it led to a temporary cardiac arrest in diastole, which may help in certain medical conditions. This suggests that Azadirachta indica has potential therapeutic applications in cardiovascular health.
In another study published by "Indian journal of physiology and pharmacology", the aqueous leaf extract of Azadirachta indica was found to significantly reduce liver damage in rats induced by paracetamol. The extract was able to lower the elevated levels of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyl transpeptidase (gamma-GT), which are indicators of liver damage. This suggests that Azadirachta indica has a protective effect on the liver and may be beneficial in preventing or treating liver-related disorders.
A different research published by Natural Product Research, Azadirachta indica has been found to exhibit potential as a cholesterol-lowering agent, with its extract and fractions increasing the size of cholesterol micelles and reducing their solubility. Additionally, it has been shown to regulate gastrointestinal motility, with the extract and quercetin compounds inhibiting intestinal contractions. These findings support its traditional use as a natural remedy for cholesterol management and gastrointestinal health.
