10 Possible Side Effects Of Angelica Archangelica (Angelica)

Angelica archangelica has some side effects when used improperly, such as gastrointestinal upset, allergic reactions, and interactions with certain medications.

These side effects can be caused by consuming excessive amounts of the herb or combining it with other medications.

For example, gastrointestinal upset can worsen irritable bowel syndrome (IBS) symptoms, making everyday activities like eating and traveling extremely challenging for individuals with IBS.

This article explains in details the 10 most common side effects of Angelica archangelica if used imporperly.

1. Increases risk of seizures

Angelica archangelica causes allergic reactions in some individuals.

This is due to its high concentration of polyacetylenes and other compounds that can trigger an immune response in susceptible people.

The allergenic potential of Angelica archangelica is thought to be related to the presence of these bioactive molecules, which can cause symptoms ranging from mild irritation to severe anaphylaxis.

2. Increases risk of seizures

Angelica archangelica triggers blood pressure drops due to its ability to stimulate digestion and relax smooth muscle tissue.

This can lead to a reduction in blood pressure, particularly for individuals with pre-existing hypertension. Additionally, the herb's potential to dilate blood vessels and slow down heart rate may contribute to this effect.

As a result, some people may experience lightheadedness or dizziness when using Angelica archangelica.

3. Increases risk of seizures

Angelica archangelica induces coma in overdose due to its toxic compounds, including furanocoumarins and sesquiterpenes.

These substances can cause severe sedation, leading to a deep sleep-like state or even loss of consciousness, which may progress to coma if left untreated.

The exact mechanism behind this effect is not fully understood, but it's believed that the toxins bind to enzymes in the body, disrupting normal physiological processes and causing a range of adverse effects.

4. Increases risk of seizures

Angelica archangelica interferes with liver function due to its high content of furanocoumarins and sesquiterpenoids.

These compounds can affect the liver's ability to process and detoxify substances, potentially leading to adverse reactions such as jaundice, elevated liver enzymes, or even acute hepatitis in rare cases.

The exact mechanisms behind this interaction are not fully understood, but it is thought that the furanocoumarins may inhibit certain liver enzymes responsible for metabolism.

5. Increases risk of seizures

Angelica archangelica activates uterine contractions due to its ability to stimulate the uterus and increase blood flow.

The plant's active compounds, such as apiol and asarone, have been shown to induce labor and relax the uterine muscles, which can lead to increased uterine tone and contraction.

This property has been traditionally used in herbal medicine to stimulate childbirth, but it may also cause adverse effects in pregnant women who are not yet ready to deliver.

6. Increases risk of seizures

Angelica archangelica increases bleeding risk due to its ability to inhibit blood platelet aggregation and antagonize vitamin K-dependent clotting factors.

This is attributed to the presence of furanocoumarins, a group of compounds found in the plant's essential oil, which can interfere with the body's natural blood-clotting mechanisms.

As a result, users may experience an increased risk of bleeding, including easy bruising and prolonged bleeding after minor cuts or injuries.

7. Increases risk of seizures

Angelica archangelica disrupts menstrual cycles.

This may occur due to its ability to stimulate the uterus and ovaries, leading to hormonal imbalances that can affect menstruation.

The plant's active compounds, such as angelic acid and isoangelicin, are believed to be responsible for this effect, potentially interfering with the normal functioning of the endocrine system and altering the menstrual cycle.

8. Increases risk of seizures

Angelica archangelica affects brain activity sharply due to its high concentration of furanocoumarins, a class of compounds that have been shown to interact with certain neurotransmitters.

These interactions can lead to altered states of consciousness and increased sensitivity to light and sound.

Additionally, angelica's ability to stimulate the pituitary gland may contribute to its effects on brain activity, potentially leading to changes in mood and cognitive function.

9. Increases risk of seizures

Angelica archangelica elevates potassium levels due to its ability to slow down the excretion of potassium in the kidneys.

This increase in potassium levels can lead to symptoms such as muscle weakness, fatigue, and heart palpitations.

The bioactive compounds present in angelica, including furanocoumarins and sesquiterpenes, are responsible for this effect, which may be more pronounced in individuals with pre-existing kidney or cardiovascular issues.

10. Increases risk of seizures

Angelica archangelica lowers platelet counts.

This is due to its ability to inhibit platelet aggregation and induce platelet destruction, potentially leading to a decrease in platelet count. The plant's volatile oils, such as angelic acid and bornyl acetate, are thought to be responsible for this effect. Additionally, the plant's flavonoids and phenolic compounds may also contribute to its ability to influence platelet function.

As a result, individuals taking Angelica archangelica supplements should be aware of this potential side effect.