Vincetoxicum auriculatum
Vincetoxicum auriculatum · Accepted scientific name
Scientific literature: Very Sparse (1 studies) · ★☆☆☆☆
Vincetoxicum auriculatum is a medicinal plant known for its diverse pharmacological properties, particularly when utilizing its root components. Various preparations, including decoctions, CA extracts, and C21 steroidal glycoside (CSG), are frequently studied for their therapeutic potential. Research has highlighted the presence of key chemical compounds such as Qingyangshengenin, syringic acid, 1-O-hexadecanolenin, and acetophenone within the plant. These constituents contribute to significant cytotoxic activities that are of great interest in modern pharmacology. Consequently, the plant is being investigated for its ability to address various medical conditions, including anorexia, colitis, dysentery, and enteritis.
- Synonyms
- Diploglossum Auriculatum · Cynanchum Saccatum · 3 more
- Common names
- Not available
- Family
- Apocynaceae
- Distribution
- Pacific
- Plant Parts
- Root
Classification
Synonyms
Vincetoxicum auriculatum is a botanical species known to be associated with several different taxonomic synonyms. In various scientific records, it has been identified under the name Cynanchum auriculatum. This plant is also linked to the specific variety known as Cynanchum auriculatum var. sinense. Further classifications include the names Cynanchum saccatum and Diploglossum auriculatum. Additionally, the species has been historically referred to as Endotropis auriculata in certain botanical contexts.
Sources: The World Checklist of Vascular Plants (WCVP)
Taxonomy
Vincetoxicum auriculatum is a distinctive member of the kingdom Plantae. Within this vast biological realm, the plant is specifically classified under the class Equisetopsida. It belongs to the diverse order Gentianales, showcasing its complex evolutionary lineage. As a representative of the family Apocynaceae, it shares structural traits with many other milkweeds and dogbanes. Ultimately, this species is defined by its placement within the genus Vincetoxicum.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Gentianales |
| Family | Apocynaceae |
| Genus | Vincetoxicum |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
Geographic Regions
Vincetoxicum auriculatum exhibits a broad and diverse geographical range spanning several distinct regions across Asia. In the temperate zones, this species is found throughout various parts of China, including the specific high-altitude areas of Tibet. Moving into tropical climates, its presence extends across the Indian Subcontinent, where it thrives in the East Himalaya. The plant's reach further encompasses the rugged terrains of Nepal and the diverse landscapes of Pakistan. Collectively, these distributions highlight the plant's remarkable ability to adapt to both temperate and tropical environments.
Sources: The World Checklist of Vascular Plants (WCVP)
Identification
Morphology
Vincetoxicum auriculatum is characterized by its distinct growth form as a herbaceous plant. It further distinguishes itself through an obligatory climbing habit, requiring structural support to ascend.
Sources: Global Inventory of Floras and Traits (GIFT)
Biological Activities
Vincetoxicum auriculatum, also known as Cynanchum auriculatum, has been the subject of recent phytochemical investigation regarding its medicinal potential. Researchers successfully isolated several pregnane C21 steroids, including new compounds named cynansteroid G-I and cynansteroid K, from its roots. Additionally, the study identified the natural product 5,6-deacidizingcaudatin along with the known compound glycocaudatin. To evaluate the biological potential of these isolates, their cytotoxic activities were screened against the COLO-205 and BGC-823 human tumor cell lines. Although the compounds demonstrated some level of activity, the results indicated that their cytotoxic effects were weaker than those of the positive control.
Compounds
Vincetoxicum auriculatum, also known as Cynanchum auriculatum, is a medicinal plant known to contain a diverse array of bioactive chemical constituents. Research has identified several key components within the plant, including qingyangshengenin, syringic acid, and deacylmetaplexigenin. Additionally, the plant's complex chemical profile features scopoletin and 1-O-hexadecanolenin. These specific compounds play significant roles in the plant's pharmacological activities, particularly in treating digestive disorders. Understanding these chemical relationships provides a critical foundation for the clinical application and drug development of this species.
Conditions
Vincetoxicum auriculatum is traditionally utilized to treat digestive disorders such as anorexia. Research has demonstrated its efficacy in treating functional dyspepsia (FD) by targeting the stomach and small intestine. Studies on the plant's active components show that they can even cross the blood-brain barrier to assist in the treatment of FD. Furthermore, C21 steroidal glycosides derived from the plant have been shown to treat D-galactose (D-gal) induced aging model mice. This treatment works by antagonizing free radical injury and increasing telomerase activity in the serum and heart tissues of the aging mice.
Preparations
Vincetoxicum auriculatum is prepared as an extract, a form frequently used to study the intestinal absorption and pharmacokinetics of its bioactive components. This plant is also prepared as CA extract, which has been clinically investigated for its efficacy in treating functional dyspepsia. Furthermore, Vincetoxicum auriculatum is prepared as C21 steroidal glycoside (CSG) to study its ability to antagonize free radical injury in aging models. The species is also prepared as decoctions within the traditional herbal medicine practices of multi-ethnic regions in Guizhou. Finally, Vincetoxicum auriculatum is prepared as a hydrolytic extract, a method utilized to isolate new pregnanes and known steroidal sapogenins from its roots.
Parts used
Vincetoxicum auriculatum, also known in scientific literature as Cynanchum auriculatum, possesses a root that serves as a significant source of diverse chemical constituents. Researchers have utilized various chromatographic and spectroscopic methods to isolate and identify several unique compounds from these roots, including several new steroids. Beyond mere identification, the chemical properties of the root are being investigated for their potential biological impacts on living organisms. Specifically, C21 steroidal glycosides derived from the root have demonstrated the ability to antagonize free radical injury in aging mouse models. These findings highlight the importance of studying the root of the plant to uncover its therapeutic potential in managing oxidative stress and aging.