Viburnum grandiflorum
Viburnum grandiflorum · Accepted scientific name
Scientific literature: Very Sparse (1 studies) · ★☆☆☆☆
Viburnum grandiflorum is a botanical species currently being investigated for its significant therapeutic potential in medicinal research. Recent studies have focused specifically on its antitumor activities against various malignant cells. Researchers are particularly interested in its efficacy regarding the treatment of lung cancer. These biological properties are primarily evaluated through the use of dried ethanol extracts and methanol extracts of Viburnum grandiflorum extract (VGE). Understanding these chemical profiles may pave the way for new advancements in oncological pharmacology.
- Synonyms
- Solenotinus Foetens · Viburnum Grandiflorum F. Foetens · 1 more
- Common names
- Not available
- Family
- Viburnaceae
- Distribution
- Not available
- Plant Parts
- Not available
Classification
Synonyms
Viburnum grandiflorum is a plant species known to be associated with several different botanical names. In various taxonomic records, it is frequently identified by the synonym Solenotinus foetens. It is also commonly referred to in literature as Viburnum foetens. Additionally, the classification includes the specific form Viburnum grandiflorum f. foetens. Understanding these synonymous relationships is essential for accurate plant identification and botanical research.
Sources: The World Checklist of Vascular Plants (WCVP)
Taxonomy
Viburnum grandiflorum is a fascinating specimen that belongs to the diverse kingdom Plantae. Within this vast biological kingdom, the plant is classified under the class Equisetopsida. It further falls into the specific order Dipsacales, which helps scientists understand its evolutionary lineage. As a member of the Viburnaceae family, it shares structural characteristics with many of its botanical relatives. Ultimately, this species is defined by its membership in the genus Viburnum, marking its distinct place in the natural world.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Dipsacales |
| Family | Viburnaceae |
| Genus | Viburnum |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
Geographic Regions
Viburnum grandiflorum is a versatile species with a broad geographic range stretching across much of Asia. In temperate regions, it is found primarily throughout China and Tibet. Its presence extends significantly into tropical Asian landscapes, particularly within the diverse ecosystems of the Indian Subcontinent. Specifically, this plant thrives in the unique environments of Assam, Nepal, and Pakistan. Additionally, it can be discovered nestled within the high-altitude terrains of the East Himalaya.
Sources: The World Checklist of Vascular Plants (WCVP)
Identification
Morphology
Viburnum grandiflorum is a self-supporting plant that maintains a sturdy presence in any landscape. This resilient species typically takes on a shrub growth form, providing structure and texture to garden beds.
Sources: Global Inventory of Floras and Traits (GIFT)
Biological Activities
Viburnum grandiflorum has demonstrated significant antitumor activity, particularly through its ability to combat lung cancer cells. Recent research indicates that a methanol extract of this medicinal herb can effectively reduce the viability of various lung carcinoma cell lines in a concentration- and time-dependent manner. The extract works by triggering apoptosis, specifically through the activation of a caspase-dependent mitochondrial pathway. By increasing cytochrome c levels in the cytosol and cleaving essential pro-caspases, the plant extract disrupts the survival mechanisms of these malignant cells. These findings suggest that Viburnum grandiflorum holds great potential as a potent anti-cancer agent in future therapeutic developments.
Compounds
Conditions
Viburnum grandiflorum extracts effectively treat the viability of H1299, H1650, and HCC827 lung cancer cells. The treatment specifically reduces the viability of H1299 cells in a concentration- and time-dependent manner. Similarly, the extract demonstrates a clear inhibitory effect on the viability of both H1650 and HCC827 cell lines. Beyond impacting overall cell survival, Viburnum grandiflorum also treats the protein expression levels of Mcl-1 in H1650 cells. This reduction of Mcl-1 protein expression is also observed in HCC827 cells following treatment.
Preparations
Viburnum grandiflorum is prepared as dried ethanol extracts to investigate the medicinal properties of various plants. Additionally, the plant is prepared as a methanol extract of Viburnum grandiflorum extract (VGE) for specific pharmacological studies. This VGE formulation is utilized to evaluate antitumor effects against lung cancer cells. The research demonstrates that these methanol extracts can induce apoptosis through a mitochondrial pathway. Consequently, the preparation of Viburnum grandiflorum in these specific forms is central to exploring its potential as an anti-cancer agent.