large cranberry

Vaccinium macrocarpon · Accepted scientific name

Scientific literature: Very Extensive (773 studies) · ★★★★★

Large cranberry, scientifically known as Vaccinium macrocarpum, is a robust perennial shrub native to North American wetlands. Renowned for its tart, antioxidant-rich berries, this medicinal plant is widely utilized to support urinary tract health, combat oxidative stress, and provide essential vitamins, making it a powerhouse in traditional herbal wellness.

Family
Ericaceae
Native range
Europe
Parts used
Fruit · Seed
Common names
American Cranberry · Large Cranberry · 3 more
Scientific synonyms
Oxycoca Macrocarpa · Vaccinium Oblongifolium · 7 more

Names and Synonyms

Common Names

Scientific Names

Accepted name

Vaccinium macrocarpon

Synonyms

Regional and Traditional Names

Spanish:

  • cranberry
  • arándano americano
  • arándano trepador
  • Arándano rojo americano

German:

  • Großfrüchtige Moosbeere
  • Grossfrüchtige Moosbeere
  • Kranbeere
  • Kraanbeere
  • Kranichbeere
  • Kränbeere
  • Cranberry
  • Kranbeere
  • große Moosbeere
  • Großfrüchtige Moosbeere
  • Grossfruechtige Moosbeere

French:

  • canneberge à gros fruits
  • grande airelle rouge d’Amérique du Nord
  • airelle à gros fruits
  • airelle à gros fruits
  • canneberge à gros fruits
  • graines
  • grande canneberge
  • gros atoca
  • gros atocas
  • pommes de pré
  • ronce d'Amérique
  • Canneberge a gros fruits

Sources: Wikidata, Catalogue of Life

Taxonomical Classification

This plant belongs to the kingdom Plantae and the phylum Streptophyta, falling under the class Equisetopsida and subclass Magnoliidae. Within the order Ericales and the family Ericaceae, it is classified under the genus Vaccinium. As part of this taxonomic hierarchy, Vaccinium macrocarpum is identified by its specific botanical lineage.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Ericales
Family Ericaceae
Genus Vaccinium

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant exhibits a specific geographical distribution across several regions of Europe. In Northern Europe, it can be found within the territory of Great Britain. Its presence extends into Middle Europe, where it inhabits Belgium. Furthermore, the species is distributed across Germany and the Netherlands. Finally, its range reaches into the mountainous landscapes of Switzerland.

Region Area
Northern Europe Great Britain
Middle Europe Belgium
Middle Europe Germany
Middle Europe Netherlands
Middle Europe Switzerland
Eastern Europe Belarus
Eastern Europe Baltic States
Western Canada British Columbia
Eastern Canada New Brunswick
Eastern Canada Newfoundland

Sources: The World Checklist of Vascular Plants (WCVP)

Botanical Identification

Life history

The life history of Vaccinium macrocarpon is characterized by its status as a perennial species, allowing it to persist through multiple growing seasons. As a chamaephyte, its regenerative buds are located close to the soil surface, which helps the plant navigate its environmental conditions. While its physiological traits can exhibit specific adaptations to its habitat, it is categorized under the life form of a chamaephyte, ensuring its survival through seasonal cycles. Regarding its foliage, the plant is characterized as evergreen, maintaining its leaf structure throughout the year to support its long-term developmental processes.

Deciduousness :
evergreen
Life form :
chamaephyte
Lifecycle :
perennial

Morphology

The morphology of Vaccinium macrocarpum is characterized by its growth form as a woody shrub. It is a self-supporting plant that does not exhibit climbing behavior, such as a liana or vine, nor does it function as a parasite or an epiphyte, maintaining a strictly terrestrial existence. In terms of stature, the plant displays significant variation in height, with measurements ranging from a minimum of 0.02 m to a maximum of 1 m, resulting in an average plant height of approximately 1.3 m.

Aquatic :
terrestrial
Climber :
self-supporting
Epiphyte :
terrestrial
Growth form :
shrub
Parasite :
independent
Plant height max:
1 m
Plant height mean:
1.3 m
Plant height min:
0.02 m
Woodiness :
woody

Physiology

The physiology of Vaccinium macrocarpon is characterized by a C3 photosynthetic pathway, which is the standard carbon fixation mechanism for most temperate woody shrubs. The plant is strictly non-carnivorous, relying on its root system and soil nutrient uptake rather than the capture of prey for nitrogen or other essential minerals. Furthermore, its leaf morphology and resource allocation are reflected in a Specific Leaf Area (SLA) with a mean value of 124 cm²/g, indicating a moderate investment in leaf thickness and structural density relative to its surface area.

Carnivory :
non-carnivorous
Photosynthetic pathway :
C3
Specific Leaf Area (SLA) mean:
124 cm²/g

Reproduction

The reproduction of Vaccinium macrocarpon is driven by a sexual process, as asexual reproduction is absent. The flowering period typically begins in June and continues through August. The plant relies on biotic pollination syndromes, specifically utilizing insects with a strong preference for bees to facilitate fertilization; notably, self-fertilization is absent, necessitating these external pollinators. Following successful pollination, the plant produces fruit characterized as a berry. These fruits are indehiscent, meaning they do not split open at maturity to release their contents. The seeds produced are extremely small, with a consistent mean, minimum, and maximum mass of approximately 0.00082 g. Dispersal is achieved through a zoochorous syndrome, specifically via endozoochory, where the seeds are dispersed after being ingested by animals.

Dehiscence :
indehiscent
Dispersal syndrome :
zoochorous
Dispersal syndrome :
endozoochorous
Flowering time :
Jun
Flowering time :
Aug
Fruit type :
berry
Pollination syndrome :
insect
Pollination syndrome :
bee
Pollination syndrome :
biotic
Reproduction asexual :
absent
Seed mass max:
0.00082 g
Seed mass mean:
0.000824 g
Self fertilization :
absent

Sources: Global Inventory of Floras and Traits (GIFT)

Plant Parts

Vaccinium macrocarpon has 2 reported plant parts identified across 4 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include fruit, seed.

Plant parts reported in Vaccinium macrocarpon
Plant part Supporting sources Consensus
Fruit 3 supporting sources ★★☆☆☆
Seed 1 supporting sources ★☆☆☆☆

Fruit

  1. Journal of natural products
  2. Phytotherapy research : PTR
  3. Molecules (Basel, Switzerland)

Seed

  1. Molecules (Basel, Switzerland)

Chemicals

Vaccinium macrocarpon has 106 reported phytochemicals identified across 4 scientific publications and several other databases. The most consistently reported chemicals include Anthocyanins, Ursolic acid, quercetin, Proanthocyanidin, CHLOROGENIC ACID.

Chemicals reported in Vaccinium macrocarpon
Chemical Supporting sources Consensus
Anthocyanins 4 supporting sources ★★☆☆☆
Ursolic acid 4 supporting sources ★★☆☆☆
quercetin 4 supporting sources ★★☆☆☆
Proanthocyanidin 3 supporting sources ★★☆☆☆
CHLOROGENIC ACID 2 supporting sources ★☆☆☆☆
Condensed Tannins 2 supporting sources ★☆☆☆☆
Flavonoids 2 supporting sources ★☆☆☆☆
RUTIN 2 supporting sources ★☆☆☆☆
myricetin 2 supporting sources ★☆☆☆☆
triterpenoids 2 supporting sources ★☆☆☆☆

Anthocyanins

  1. Dr. Duke
  2. Plants (Basel, Switzerland)
  3. International journal of biopharmaceutical sciences
  4. Antioxidants (Basel, Switzerland)

Ursolic acid

  1. Dr. Duke
  2. Planta medica
  3. International journal of biopharmaceutical sciences
  4. Molecules (Basel, Switzerland)

quercetin

  1. Dr. Duke
  2. Pharmaceutical biology
  3. International journal of biopharmaceutical sciences
  4. Molecules (Basel, Switzerland)

Proanthocyanidin

  1. Journal of natural products
  2. Plants (Basel, Switzerland)
  3. Pharmaceutical biology

CHLOROGENIC ACID

  1. Dr. Duke
  2. Molecules (Basel, Switzerland)

Condensed Tannins

  1. Pharmaceutical biology
  2. Antioxidants (Basel, Switzerland)

Flavonoids

  1. Pharmaceutical biology
  2. Antioxidants (Basel, Switzerland)

RUTIN

  1. Phytomedicine : international journal of phytotherapy and phytopharmacology
  2. European journal of pharmacology

myricetin

  1. Dr. Duke
  2. Molecules (Basel, Switzerland)

triterpenoids

  1. Dr. Duke
  2. Plants (Basel, Switzerland)

Activities

Vaccinium macrocarpon has 617 reported activities identified across 4 scientific publications and several other databases. The most consistently reported activities include Anticancer, Antioxidant, Estrogenic, 11B-HSD-Inhibitor, 5-HETE-Inhibitor.

Activities reported in Vaccinium macrocarpon
Activity Supporting sources Consensus
Anticancer 3 supporting sources ★★☆☆☆
Antioxidant 2 supporting sources ★☆☆☆☆
Estrogenic 2 supporting sources ★☆☆☆☆
11B-HSD-Inhibitor 1 supporting sources ★☆☆☆☆
5-HETE-Inhibitor 1 supporting sources ★☆☆☆☆
5-HT-Inhibitor 1 supporting sources ★☆☆☆☆
5-Lipoxygenase-Inhibitor 1 supporting sources ★☆☆☆☆
ACE-Inhibitor 1 supporting sources ★☆☆☆☆
AP-1-Inhibitor 1 supporting sources ★☆☆☆☆
ATPase-Inhibitor 1 supporting sources ★☆☆☆☆

Anticancer

  1. Dr. Duke
  2. Pharmaceutical biology
  3. Molecules (Basel, Switzerland)

Antioxidant

  1. Dr. Duke
  2. Molecules (Basel, Switzerland)

Estrogenic

  1. Dr. Duke
  2. Frontiers in pharmacology

11B-HSD-Inhibitor

  1. Dr. Duke

5-HETE-Inhibitor

  1. Dr. Duke

5-HT-Inhibitor

  1. Dr. Duke

5-Lipoxygenase-Inhibitor

  1. Dr. Duke

ACE-Inhibitor

  1. Dr. Duke

AP-1-Inhibitor

  1. Dr. Duke

ATPase-Inhibitor

  1. Dr. Duke

Conditions

Vaccinium macrocarpon has 14 reported investigations on conditions identified across 4 scientific publications and several other databases. The most consistently reported conditions include urinary tract infections, Influenza Virus, Urinary tract infections, antioxidant, biofilm.

Conditions investigated for Vaccinium macrocarpon
Condition Supporting sources Consensus
Urinary tract infections 2 supporting sources ★☆☆☆☆
Influenza virus 1 supporting sources ★☆☆☆☆
Urinary tract infections 1 supporting sources ★☆☆☆☆
Antioxidant 1 supporting sources ★☆☆☆☆
Biofilm 1 supporting sources ★☆☆☆☆
Cancer 1 supporting sources ★☆☆☆☆
Cardiovascular diseases 1 supporting sources ★☆☆☆☆
Cell adhesion 1 supporting sources ★☆☆☆☆
Common cold 1 supporting sources ★☆☆☆☆
Cystitis 1 supporting sources ★☆☆☆☆

Urinary tract infections

  1. Planta medica
  2. Journal of natural products

Influenza virus

  1. Frontiers in microbiology

Urinary tract infections

  1. Current issues in molecular biology

Antioxidant

  1. Molecules (Basel, Switzerland)

Biofilm

  1. International journal of clinical pediatric dentistry

Cancer

  1. International journal of biopharmaceutical sciences

Cardiovascular diseases

  1. Current pharmaceutical design

Cell adhesion

  1. International journal of clinical pediatric dentistry

Common cold

  1. International journal of biopharmaceutical sciences

Cystitis

  1. Journal of clinical gastroenterology

Preparations

Vaccinium macrocarpon has 10 reported preparations identified across 4 scientific publications and several other databases. The most consistently reported preparations include Extracts, alcohol fractions, aqueous-ethanolic extracts (30/70), extracts of cranberry fruit, fermented extract.

Preparations reported for Vaccinium macrocarpon
Preparation Supporting sources Consensus
Extracts 1 supporting sources ★☆☆☆☆
Alcohol fractions 1 supporting sources ★☆☆☆☆
Aqueous-ethanolic extracts (30/70) 1 supporting sources ★☆☆☆☆
Extracts of cranberry fruit 1 supporting sources ★☆☆☆☆
Fermented extract 1 supporting sources ★☆☆☆☆
Fruit juice 1 supporting sources ★☆☆☆☆
Juices 1 supporting sources ★☆☆☆☆
Oils 1 supporting sources ★☆☆☆☆
Plant extracts 1 supporting sources ★☆☆☆☆
Skin 1 supporting sources ★☆☆☆☆

Extracts

  1. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Alcohol fractions

  1. Phytotherapy research : PTR

Aqueous-ethanolic extracts (30/70)

  1. Pakistan journal of pharmaceutical sciences

Extracts of cranberry fruit

  1. Journal of natural products

Fermented extract

  1. Phytotherapy research : PTR

Fruit juice

  1. Phytotherapy research : PTR

Juices

  1. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Oils

  1. Phytotherapy research : PTR

Plant extracts

  1. Frontiers in microbiology

Skin

  1. Phytotherapy research : PTR