red clover

Trifolium pratense · Accepted scientific name

Scientific literature: Very Extensive (1245 studies) · ★★★★★

Red clover, scientifically known as Trifolium pratense, is a perennial legume renowned for its medicinal properties. Rich in isoflavones, it is frequently used to alleviate menopausal symptoms and support hormonal balance. This versatile plant also offers antioxidant benefits, making it a valued staple in traditional and modern herbal medicine.

Family
Fabaceae
Native range
Europe
Parts used
Seed · Flower
Common names
Meadow Clover · Purple Clover · 6 more
Scientific synonyms
Lagopus Pratensis

Names and Synonyms

Common Names

Scientific Names

Accepted name

Trifolium pratense

Synonyms

Regional and Traditional Names

Spanish:

  • Trebol rojo
  • Trifolium bracteatum
  • Trébol rojo
  • Trifolium borysthenicum
  • Trifolium ukrainicum
  • Trifolium lenkoranicum
  • teble
  • trébol
  • carretón
  • caramelos
  • chupamieles
  • chupador
  • chupetes
  • chupetitos
  • chupón
  • chupones
  • berrillo
  • trébol de prados purpúreas
  • trébol del príncipe
  • trébol enano
  • trébol encarnado
  • trébol ladino
  • trébol pratense
  • trébol pratense que hace las flores purpúreas
  • trébol productivo
  • trébol rojo de los prados
  • trébol silvestre
  • trébol sopaenvino
  • trébol sopavino
  • trébol violeta
  • trébole
  • trébul
  • trebulo
  • tres en rama
  • trevol
  • trifolio
  • yerba chupelera
  • motas encarnadas
  • quínola
  • tefla
  • trábol de la media luna
  • trebalejo
  • trebo
  • trebo silvestre
  • trébol arvense
  • trébol común
  • trébol de la luna
  • trébol de la media luna
  • trébol de los prados
  • trébol de los prados colorado
  • trébol de media luna
  • trébol de prado
  • trébol de prados
  • trébol de prados de flores encarnadas
  • farucha
  • farusa
  • hierba de las cataratas
  • hirusta gorria
  • hoja la nube
  • mamatetas
  • media luna
  • melga
  • meliguel
  • meriguel
  • trébol común
  • trébol rojo
  • trébol violeta
  • Carretón rosado
  • Trébol Rosado
  • Trébol rojo eurasiático
  • berrillo
  • caramelos
  • carretón
  • chupador
  • chupamieles
  • chupetes
  • chupetitos
  • chupones
  • chupón
  • farucha
  • farusa
  • hierba de las cataratas
  • hirusta gorria
  • hoja la nube
  • mamatetas
  • media luna
  • melga
  • meliguel
  • meriguel
  • motas encarnadas
  • quínola
  • teble
  • tefla
  • trebalejo
  • trebo
  • trebo silvestre
  • trebulo
  • tres en rama
  • trevol
  • trifolio
  • trábol de la media luna
  • trébol
  • trébol arvense
  • trébol de la luna
  • trébol de la media luna
  • trébol de los prados
  • trébol de los prados colorado
  • trébol de media luna
  • trébol de prado
  • trébol de prados
  • trébol de prados de flores encarnadas
  • trébol de prados purpúreas
  • trébol del príncipe
  • trébol enano
  • trébol encarnado
  • trébol ladino
  • trébol pratense
  • trébol pratense que hace las flores purpúreas
  • trébol productivo
  • trébol rojo de los prados
  • trébol silvestre
  • trébol sopaenvino
  • trébol sopavino
  • trébul
  • yerba chupelera

German:

  • Wiesen-Klee
  • Rot-Klee
  • Trifolium pratensis
  • Saatklee
  • Wiesenklee
  • Rotklee
  • Rotklee
  • Rot-Klee
  • Wiesen-Klee
  • Saatklee
  • Trifolium pratensis
  • Wiesenklee

French:

  • Trèfle des prés
  • Trèfle violet
  • Trefle des pres
  • trèfle des prés
  • trèfle commun
  • trèfle des prés
  • trèfle rouge
  • trèfle violet
  • Trefle des pres

Sources: Wikidata, Catalogue of Life

Taxonomical Classification

This plant, known scientifically as Trifolium pratense, belongs to the kingdom Plantae and the phylum Streptophyta. It is classified under the class Equisetopsida and subclass Magnoliidae, falling within the order Fabales. Finally, it is a member of the family Fabaceae and is categorized under the genus Trifolium.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Fabales
Family Fabaceae
Genus Trifolium

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant exhibits a widespread presence across various regions of Northern Europe. It can be found growing throughout the landscapes of Denmark and Finland. The distribution also extends to the islands of Føroyar and Iceland. Additionally, the species is commonly documented across Great Britain. These diverse locations highlight its ability to thrive in different Northern European environments.

Region Area
Northern Europe Denmark
Northern Europe Finland
Northern Europe Føroyar
Northern Europe Great Britain
Northern Europe Iceland
Northern Europe Ireland
Northern Europe Norway
Northern Europe Sweden
Middle Europe Austria
Middle Europe Belgium

Sources: The World Checklist of Vascular Plants (WCVP)

Botanical Identification

Ecology

The ecology of Trifolium pratense is characterized by its remarkable adaptability across a vast altitudinal gradient, ranging from sea level (0 m AMSL) to high-altitude environments reaching a maximum of 3300 m AMSL. With a mean elevational range of approximately 2200 m AMSL, the species demonstrates a significant capacity to colonize diverse topographical zones. Its preferred habitats frequently include disturbed or managed landscapes, specifically within crop fields, where it integrates into agricultural ecosystems.

Elevational range max:
3300 m AMSL
Elevational range mean:
2200 m AMSL
Elevational range min:
0 m AMSL
Habitat :
crop fields

Genetics

The genetics of Trifolium pratense are characterized by a complex chromosomal architecture that exhibits significant variation across different accessions and breeding lines. The species displays diverse chromosome numbers, typically recorded as 14, 28, or 48, reflecting a history of polyploidization events within the genus. Despite this variability in total count, the baseline ploidy level for standard diploid representations is 2, which serves as the fundamental genetic foundation for its reproductive and phenotypic stability. This chromosomal plasticity plays a critical role in the plant's evolutionary adaptation and its capacity for genetic diversification.

Chromosome number :
14, 28, 48
Ploidy :
2

Life history

The life history of Trifolium pratense is characterized by its status as a perennial plant, allowing it to persist through multiple growing seasons. As a hemicryptophyte, its perennating buds are located at or just below the soil surface, protected by leaf litter or organic matter during unfavorable conditions. The plant exhibits an evergreen deciduousness, maintaining its vegetative structure in a manner that allows for continued growth and resilience. Through this complex life cycle and specific life form, the species is well-adapted to its ecological niche, utilizing its perennial nature and hemicryptophytic strategy to ensure long-term survival and reproductive success.

Deciduousness :
evergreen
Life form :
hemicryptophyte
Lifecycle :
perennial

Morphology

The morphology of Trifolium pratense is characterized by its growth form as a non-woody herb and forb. This terrestrial species is non-parasitic and functions as an independent organism, lacking any epiphytic tendencies. The plant exhibits a self-supporting growth habit with an ascending shoot orientation, rather than acting as a climber, liana, or vine. In terms of stature, the plant displays significant variation in height, with individual specimens ranging from a minimum of 0.05 m to a maximum of 1 m, maintaining an average plant height of approximately 0.464 m.

Aquatic :
terrestrial
Climber :
self-supporting
Epiphyte :
terrestrial
Growth form :
herb
Growth form :
forb
Parasite :
independent
Plant height max:
1 m
Plant height mean:
0.464333333333333 m
Plant height min:
0.05 m
Shoot orientation :
ascending
Woodiness :
non-woody

Physiology

The physiology of Trifolium pratense is characterized by a C3 photosynthetic pathway, which governs its carbon fixation processes. As a non-carnivorous species, it relies on standard nutrient uptake from the soil, significantly aided by its ability to function as a nitrogen fixer, establishing symbiotic relationships to enhance nutrient availability. The leaf morphology exhibits considerable variability, with leaf lengths ranging from a minimum of 1.5 cm to a maximum of 22.5 cm, and leaf widths spanning from 0.7 cm to 3 cm, resulting in a mean width of 2.6 cm. These leaves typically display an elliptic form, with a mean leaf size of 7.155 cm². Furthermore, the plant maintains a mean Specific Leaf Area (SLA) of 233.73 cm²/g, reflecting its resource allocation strategies and leaf mass distribution relative to its surface area.

Carnivory :
non-carnivorous
Leaf form :
elliptic
Leaf length max:
22.5 cm
Leaf length min:
1.5 cm
Leaf size mean:
7.155 cm²
Leaf width max:
3 cm
Leaf width mean:
2.6 cm
Leaf width min:
0.7 cm
Nitrogen fixer :
yes
Photosynthetic pathway :
C3
Specific Leaf Area (SLA) mean:
233.73 cm²/g

Reproduction

The reproduction of Trifolium pratense is characterized by a sexual process involving bisexual flowers that exhibit a violet color. The flowering period is extensive, typically beginning in May and continuing through October. These flowers, which range in length from 1.5 cm to 1.8 cm, rely on biotic pollination, specifically through an insect syndrome involving bees. Self-fertilization is noted as absent, necessitating these pollinators for successful reproduction. Following fertilization, the plant produces dry, dehiscent pods as its fruit type. These fruits are relatively small, with a mean length and width of 0.3 cm. Within these pods, the plant produces a significant quantity of seeds, ranging from 101 to 1000 seeds per fruit. The seeds themselves are quite small, with a mean length and width of 2 mm and a mean mass of approximately 0.00147925 g (ranging from a minimum of 0.00059 g to a maximum of 0.00237 g), and a mean volume of 2 mm³. Regarding dispersal, the plant utilizes an unspecialized syndrome alongside anthropochorous mechanisms. As a monocarp, its reproductive cycle is completed within a single season, and asexual reproduction is absent.

Dehiscence :
dehiscent
Dispersal syndrome :
unspecialized
Dispersal syndrome :
anthropochorous
Flower colour :
violet
Flower length max:
1.8 cm
Flower length min:
1.5 cm
Flowering time :
May
Flowering time :
Oct
Fruit dryness :
dry
Fruit length mean:
0.3 cm
Fruit type :
pod
Fruit width mean:
0.3 cm
Monocarpy :
monocarp
Pollination syndrome :
insect
Pollination syndrome :
bee
Pollination syndrome :
biotic
Reproduction asexual :
absent
Reproduction sexual :
bisexual
Seed length mean:
2 mm
Seed length min:
1.5 mm
Seed mass max:
0.00237 g
Seed mass mean:
0.00147925 g
Seed mass min:
0.00059 g
Seed volume max:
2 mm³
Seed width mean:
2 mm
Seeds_per_fruit :
101-1000
Self fertilization :
absent

Sources: Global Inventory of Floras and Traits (GIFT)

Plant Parts

Trifolium pratense has 2 reported plant parts identified across 3 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include seed, flower.

Plant parts reported in Trifolium pratense
Plant part Supporting sources Consensus
Seed 2 supporting sources ★☆☆☆☆
Flower 1 supporting sources ★☆☆☆☆

Seed

  1. Molecules (Basel, Switzerland)
  2. Journal of oleo science

Flower

  1. Journal of ethnopharmacology

Chemicals

Trifolium pratense has 265 reported phytochemicals identified across 3 scientific publications and several other databases. The most consistently reported chemicals include formononetin, Isoflavones, biochanin A, Prunetin, genistein.

Chemicals reported in Trifolium pratense
Chemical Supporting sources Consensus
formononetin 13 supporting sources ★★★★★
Isoflavones 11 supporting sources ★★★★★
biochanin A 10 supporting sources ★★★★★
Prunetin 5 supporting sources ★★★☆☆
genistein 4 supporting sources ★★☆☆☆
kaempferol 4 supporting sources ★★☆☆☆
Irilone 3 supporting sources ★★☆☆☆
Isoflavone 3 supporting sources ★★☆☆☆
Ononin 3 supporting sources ★★☆☆☆
Phytoestrogens 3 supporting sources ★★☆☆☆

formononetin

  1. Dr. Duke
  2. Plant cell reports
  3. Cancers
  4. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
  5. Journal of natural products
View 8 additional sources
  1. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  2. Poultry science
  3. Frontiers in pharmacology
  4. Fitoterapia
  5. Journal of chromatography. A
  6. Phytomedicine : international journal of phytotherapy and phytopharmacology
  7. Journal of ethnopharmacology
  8. BioMed research international

Isoflavones

  1. Dr. Duke
  2. Plant cell reports
  3. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  4. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
  5. Food & function
View 6 additional sources
  1. Journal of agricultural and food chemistry
  2. Phytomedicine : international journal of phytotherapy and phytopharmacology
  3. The journal of the British Menopause Society
  4. Menopause (New York, N.Y.)
  5. Voprosy meditsinskoi khimii
  6. The Journal of nutrition

biochanin A

  1. Dr. Duke
  2. Toxicology in vitro : an international journal published in association with BIBRA
  3. Plant cell reports
  4. Journal of natural products
  5. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
View 5 additional sources
  1. Poultry science
  2. Fitoterapia
  3. Journal of chromatography. A
  4. Phytomedicine : international journal of phytotherapy and phytopharmacology
  5. Journal of ethnopharmacology

Prunetin

  1. Dr. Duke
  2. Journal of natural products
  3. Fitoterapia
  4. Journal of chromatography. A
  5. Phytomedicine : international journal of phytotherapy and phytopharmacology

genistein

  1. Dr. Duke
  2. Plant cell reports
  3. Journal of chromatography. A
  4. Phytomedicine : international journal of phytotherapy and phytopharmacology

kaempferol

  1. Dr. Duke
  2. Steroids
  3. Fitoterapia
  4. Journal of chromatography. A

Irilone

  1. Dr. Duke
  2. Journal of natural products
  3. Journal of chromatography. A

Isoflavone

  1. Journal of food science and technology
  2. International journal of biological macromolecules
  3. Journal of chromatography. A

Ononin

  1. Dr. Duke
  2. Poultry science
  3. Journal of ethnopharmacology

Phytoestrogens

  1. Menopause international
  2. Frontiers in pharmacology
  3. Climacteric : the journal of the International Menopause Society

Activities

Trifolium pratense has 747 reported activities identified across 3 scientific publications and several other databases. The most consistently reported activities include Antioxidant, Estrogenic, Anticancer, Neuroprotective, Antidiabetic.

Activities reported in Trifolium pratense
Activity Supporting sources Consensus
Antioxidant 7 supporting sources ★★★★☆
Estrogenic 4 supporting sources ★★☆☆☆
Anticancer 3 supporting sources ★★☆☆☆
Neuroprotective 3 supporting sources ★★☆☆☆
Antidiabetic 2 supporting sources ★☆☆☆☆
Antimicrobial 2 supporting sources ★☆☆☆☆
Antiproliferative 2 supporting sources ★☆☆☆☆
11B-HSD-Inhibitor 1 supporting sources ★☆☆☆☆
17-beta-hydroxysteroid dehydrogenase-Inhibitor 1 supporting sources ★☆☆☆☆
5-Alpha-Reductase-Inhibitor 1 supporting sources ★☆☆☆☆

Antioxidant

  1. Dr. Duke
  2. Cancers
  3. Journal of ethnopharmacology
  4. Frontiers in pharmacology
  5. Redox report : communications in free radical research
View 2 additional sources
  1. Actas urologicas espanolas
  2. Foods (Basel, Switzerland)

Estrogenic

  1. Dr. Duke
  2. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
  3. Planta medica
  4. Frontiers in pharmacology

Anticancer

  1. Dr. Duke
  2. Cancers
  3. Foods (Basel, Switzerland)

Neuroprotective

  1. Dr. Duke
  2. Cancers
  3. Foods (Basel, Switzerland)

Antidiabetic

  1. Dr. Duke
  2. Journal of ethnopharmacology

Antimicrobial

  1. Dr. Duke
  2. Journal of ethnopharmacology

Antiproliferative

  1. Dr. Duke
  2. Cancers

11B-HSD-Inhibitor

  1. Dr. Duke

17-beta-hydroxysteroid dehydrogenase-Inhibitor

  1. Dr. Duke

5-Alpha-Reductase-Inhibitor

  1. Dr. Duke

Conditions

Trifolium pratense has 41 reported investigations on conditions identified across 3 scientific publications and several other databases. The most consistently reported conditions include Alzheimer's disease, antidiabetic, depression, hot flashes, premenstrual syndrome.

Conditions investigated for Trifolium pratense
Condition Supporting sources Consensus
Alzheimer's disease 2 supporting sources ★☆☆☆☆
Antidiabetic 2 supporting sources ★☆☆☆☆
Depression 2 supporting sources ★☆☆☆☆
Hot flashes 2 supporting sources ★☆☆☆☆
Premenstrual syndrome 2 supporting sources ★☆☆☆☆
Coccidiosis 1 supporting sources ★☆☆☆☆
Parkinson's disease 1 supporting sources ★☆☆☆☆
Type 2 diabetes 1 supporting sources ★☆☆☆☆
Antioxidant 1 supporting sources ★☆☆☆☆
Anxiety 1 supporting sources ★☆☆☆☆

Alzheimer's disease

  1. Cancers
  2. Frontiers in pharmacology

Antidiabetic

  1. Journal of ethnopharmacology
  2. Critical reviews in food science and nutrition

Depression

  1. Menopause international
  2. Frontiers in pharmacology

Hot flashes

  1. Menopause (New York, N.Y.)
  2. Journal of natural products

Premenstrual syndrome

  1. Journal of natural products
  2. Journal of ethnopharmacology

Coccidiosis

  1. Poultry science

Parkinson's disease

  1. Food & function

Type 2 diabetes

  1. Chemistry & biodiversity

Antioxidant

  1. Journal of ethnopharmacology

Anxiety

  1. Frontiers in pharmacology

Preparations

Trifolium pratense has 8 reported preparations identified across 3 scientific publications and several other databases. The most consistently reported preparations include Freeze-dried samples, TP powder, aqueous extract, ethanol extracts, ethanolic extract.

Preparations reported for Trifolium pratense
Preparation Supporting sources Consensus
Freeze-dried samples 1 supporting sources ★☆☆☆☆
Tp powder 1 supporting sources ★☆☆☆☆
Aqueous extract 1 supporting sources ★☆☆☆☆
Ethanol extracts 1 supporting sources ★☆☆☆☆
Ethanolic extract 1 supporting sources ★☆☆☆☆
Flowers 1 supporting sources ★☆☆☆☆
Red clover extractive 1 supporting sources ★☆☆☆☆
Seed oils 1 supporting sources ★☆☆☆☆

Freeze-dried samples

  1. Journal of food science and technology

Tp powder

  1. Poultry science

Aqueous extract

  1. Chemistry & biodiversity

Ethanol extracts

  1. Journal of ethnopharmacology

Ethanolic extract

  1. Poultry science

Flowers

  1. Journal of ethnopharmacology

Red clover extractive

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Seed oils

  1. Journal of oleo science