red clover
Trifolium pratense · Accepted scientific name
Scientific literature: Very Extensive (1245 studies) · ★★★★★
Red clover, scientifically known as Trifolium pratense, is a perennial legume renowned for its medicinal properties. Rich in isoflavones, it is frequently used to alleviate menopausal symptoms and support hormonal balance. This versatile plant also offers antioxidant benefits, making it a valued staple in traditional and modern herbal medicine.
- Family
- Fabaceae
- Native range
- Europe
- Parts used
- Seed · Flower
- Common names
- Meadow Clover · Purple Clover · 6 more
- Scientific synonyms
- Lagopus Pratensis
Names and Synonyms
Common Names
- meadow clover
- purple clover
- red clover
- Chilean clover
- cowgrass clover
- mammoth red clover
- medium red clover
- peavine clover
Scientific Names
Accepted name
Trifolium pratenseSynonyms
- Lagopus pratensis
Regional and Traditional Names
Spanish:
- Trebol rojo
- Trifolium bracteatum
- Trébol rojo
- Trifolium borysthenicum
- Trifolium ukrainicum
- Trifolium lenkoranicum
- teble
- trébol
- carretón
- caramelos
- chupamieles
- chupador
- chupetes
- chupetitos
- chupón
- chupones
- berrillo
- trébol de prados purpúreas
- trébol del príncipe
- trébol enano
- trébol encarnado
- trébol ladino
- trébol pratense
- trébol pratense que hace las flores purpúreas
- trébol productivo
- trébol rojo de los prados
- trébol silvestre
- trébol sopaenvino
- trébol sopavino
- trébol violeta
- trébole
- trébul
- trebulo
- tres en rama
- trevol
- trifolio
- yerba chupelera
- motas encarnadas
- quínola
- tefla
- trábol de la media luna
- trebalejo
- trebo
- trebo silvestre
- trébol arvense
- trébol común
- trébol de la luna
- trébol de la media luna
- trébol de los prados
- trébol de los prados colorado
- trébol de media luna
- trébol de prado
- trébol de prados
- trébol de prados de flores encarnadas
- farucha
- farusa
- hierba de las cataratas
- hirusta gorria
- hoja la nube
- mamatetas
- media luna
- melga
- meliguel
- meriguel
- trébol común
- trébol rojo
- trébol violeta
- Carretón rosado
- Trébol Rosado
- Trébol rojo eurasiático
- berrillo
- caramelos
- carretón
- chupador
- chupamieles
- chupetes
- chupetitos
- chupones
- chupón
- farucha
- farusa
- hierba de las cataratas
- hirusta gorria
- hoja la nube
- mamatetas
- media luna
- melga
- meliguel
- meriguel
- motas encarnadas
- quínola
- teble
- tefla
- trebalejo
- trebo
- trebo silvestre
- trebulo
- tres en rama
- trevol
- trifolio
- trábol de la media luna
- trébol
- trébol arvense
- trébol de la luna
- trébol de la media luna
- trébol de los prados
- trébol de los prados colorado
- trébol de media luna
- trébol de prado
- trébol de prados
- trébol de prados de flores encarnadas
- trébol de prados purpúreas
- trébol del príncipe
- trébol enano
- trébol encarnado
- trébol ladino
- trébol pratense
- trébol pratense que hace las flores purpúreas
- trébol productivo
- trébol rojo de los prados
- trébol silvestre
- trébol sopaenvino
- trébol sopavino
- trébul
- yerba chupelera
German:
- Wiesen-Klee
- Rot-Klee
- Trifolium pratensis
- Saatklee
- Wiesenklee
- Rotklee
- Rotklee
- Rot-Klee
- Wiesen-Klee
- Saatklee
- Trifolium pratensis
- Wiesenklee
French:
- Trèfle des prés
- Trèfle violet
- Trefle des pres
- trèfle des prés
- trèfle commun
- trèfle des prés
- trèfle rouge
- trèfle violet
- Trefle des pres
Sources: Wikidata, Catalogue of Life
Taxonomical Classification
This plant, known scientifically as Trifolium pratense, belongs to the kingdom Plantae and the phylum Streptophyta. It is classified under the class Equisetopsida and subclass Magnoliidae, falling within the order Fabales. Finally, it is a member of the family Fabaceae and is categorized under the genus Trifolium.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Fabales |
| Family | Fabaceae |
| Genus | Trifolium |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
This plant exhibits a widespread presence across various regions of Northern Europe. It can be found growing throughout the landscapes of Denmark and Finland. The distribution also extends to the islands of Føroyar and Iceland. Additionally, the species is commonly documented across Great Britain. These diverse locations highlight its ability to thrive in different Northern European environments.
| Region | Area |
|---|---|
| Northern Europe | Denmark |
| Northern Europe | Finland |
| Northern Europe | Føroyar |
| Northern Europe | Great Britain |
| Northern Europe | Iceland |
| Northern Europe | Ireland |
| Northern Europe | Norway |
| Northern Europe | Sweden |
| Middle Europe | Austria |
| Middle Europe | Belgium |
Sources: The World Checklist of Vascular Plants (WCVP)
Botanical Identification
Ecology
The ecology of Trifolium pratense is characterized by its remarkable adaptability across a vast altitudinal gradient, ranging from sea level (0 m AMSL) to high-altitude environments reaching a maximum of 3300 m AMSL. With a mean elevational range of approximately 2200 m AMSL, the species demonstrates a significant capacity to colonize diverse topographical zones. Its preferred habitats frequently include disturbed or managed landscapes, specifically within crop fields, where it integrates into agricultural ecosystems.
- Elevational range max:
- 3300 m AMSL
- Elevational range mean:
- 2200 m AMSL
- Elevational range min:
- 0 m AMSL
- Habitat :
- crop fields
Genetics
The genetics of Trifolium pratense are characterized by a complex chromosomal architecture that exhibits significant variation across different accessions and breeding lines. The species displays diverse chromosome numbers, typically recorded as 14, 28, or 48, reflecting a history of polyploidization events within the genus. Despite this variability in total count, the baseline ploidy level for standard diploid representations is 2, which serves as the fundamental genetic foundation for its reproductive and phenotypic stability. This chromosomal plasticity plays a critical role in the plant's evolutionary adaptation and its capacity for genetic diversification.
- Chromosome number :
- 14, 28, 48
- Ploidy :
- 2
Life history
The life history of Trifolium pratense is characterized by its status as a perennial plant, allowing it to persist through multiple growing seasons. As a hemicryptophyte, its perennating buds are located at or just below the soil surface, protected by leaf litter or organic matter during unfavorable conditions. The plant exhibits an evergreen deciduousness, maintaining its vegetative structure in a manner that allows for continued growth and resilience. Through this complex life cycle and specific life form, the species is well-adapted to its ecological niche, utilizing its perennial nature and hemicryptophytic strategy to ensure long-term survival and reproductive success.
- Deciduousness :
- evergreen
- Life form :
- hemicryptophyte
- Lifecycle :
- perennial
Morphology
The morphology of Trifolium pratense is characterized by its growth form as a non-woody herb and forb. This terrestrial species is non-parasitic and functions as an independent organism, lacking any epiphytic tendencies. The plant exhibits a self-supporting growth habit with an ascending shoot orientation, rather than acting as a climber, liana, or vine. In terms of stature, the plant displays significant variation in height, with individual specimens ranging from a minimum of 0.05 m to a maximum of 1 m, maintaining an average plant height of approximately 0.464 m.
- Aquatic :
- terrestrial
- Climber :
- self-supporting
- Epiphyte :
- terrestrial
- Growth form :
- herb
- Growth form :
- forb
- Parasite :
- independent
- Plant height max:
- 1 m
- Plant height mean:
- 0.464333333333333 m
- Plant height min:
- 0.05 m
- Shoot orientation :
- ascending
- Woodiness :
- non-woody
Physiology
The physiology of Trifolium pratense is characterized by a C3 photosynthetic pathway, which governs its carbon fixation processes. As a non-carnivorous species, it relies on standard nutrient uptake from the soil, significantly aided by its ability to function as a nitrogen fixer, establishing symbiotic relationships to enhance nutrient availability. The leaf morphology exhibits considerable variability, with leaf lengths ranging from a minimum of 1.5 cm to a maximum of 22.5 cm, and leaf widths spanning from 0.7 cm to 3 cm, resulting in a mean width of 2.6 cm. These leaves typically display an elliptic form, with a mean leaf size of 7.155 cm². Furthermore, the plant maintains a mean Specific Leaf Area (SLA) of 233.73 cm²/g, reflecting its resource allocation strategies and leaf mass distribution relative to its surface area.
- Carnivory :
- non-carnivorous
- Leaf form :
- elliptic
- Leaf length max:
- 22.5 cm
- Leaf length min:
- 1.5 cm
- Leaf size mean:
- 7.155 cm²
- Leaf width max:
- 3 cm
- Leaf width mean:
- 2.6 cm
- Leaf width min:
- 0.7 cm
- Nitrogen fixer :
- yes
- Photosynthetic pathway :
- C3
- Specific Leaf Area (SLA) mean:
- 233.73 cm²/g
Reproduction
The reproduction of Trifolium pratense is characterized by a sexual process involving bisexual flowers that exhibit a violet color. The flowering period is extensive, typically beginning in May and continuing through October. These flowers, which range in length from 1.5 cm to 1.8 cm, rely on biotic pollination, specifically through an insect syndrome involving bees. Self-fertilization is noted as absent, necessitating these pollinators for successful reproduction. Following fertilization, the plant produces dry, dehiscent pods as its fruit type. These fruits are relatively small, with a mean length and width of 0.3 cm. Within these pods, the plant produces a significant quantity of seeds, ranging from 101 to 1000 seeds per fruit. The seeds themselves are quite small, with a mean length and width of 2 mm and a mean mass of approximately 0.00147925 g (ranging from a minimum of 0.00059 g to a maximum of 0.00237 g), and a mean volume of 2 mm³. Regarding dispersal, the plant utilizes an unspecialized syndrome alongside anthropochorous mechanisms. As a monocarp, its reproductive cycle is completed within a single season, and asexual reproduction is absent.
- Dehiscence :
- dehiscent
- Dispersal syndrome :
- unspecialized
- Dispersal syndrome :
- anthropochorous
- Flower colour :
- violet
- Flower length max:
- 1.8 cm
- Flower length min:
- 1.5 cm
- Flowering time :
- May
- Flowering time :
- Oct
- Fruit dryness :
- dry
- Fruit length mean:
- 0.3 cm
- Fruit type :
- pod
- Fruit width mean:
- 0.3 cm
- Monocarpy :
- monocarp
- Pollination syndrome :
- insect
- Pollination syndrome :
- bee
- Pollination syndrome :
- biotic
- Reproduction asexual :
- absent
- Reproduction sexual :
- bisexual
- Seed length mean:
- 2 mm
- Seed length min:
- 1.5 mm
- Seed mass max:
- 0.00237 g
- Seed mass mean:
- 0.00147925 g
- Seed mass min:
- 0.00059 g
- Seed volume max:
- 2 mm³
- Seed width mean:
- 2 mm
- Seeds_per_fruit :
- 101-1000
- Self fertilization :
- absent
Sources: Global Inventory of Floras and Traits (GIFT)
Plant Parts
Trifolium pratense has 2 reported plant parts identified across 3 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include seed, flower.
| Plant part | Supporting sources | Consensus |
|---|---|---|
| Seed | 2 supporting sources | ★☆☆☆☆ |
| Flower | 1 supporting sources | ★☆☆☆☆ |
Seed
- Molecules (Basel, Switzerland)
- Journal of oleo science
Flower
- Journal of ethnopharmacology
Chemicals
Trifolium pratense has 265 reported phytochemicals identified across 3 scientific publications and several other databases. The most consistently reported chemicals include formononetin, Isoflavones, biochanin A, Prunetin, genistein.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| formononetin | 13 supporting sources | ★★★★★ |
| Isoflavones | 11 supporting sources | ★★★★★ |
| biochanin A | 10 supporting sources | ★★★★★ |
| Prunetin | 5 supporting sources | ★★★☆☆ |
| genistein | 4 supporting sources | ★★☆☆☆ |
| kaempferol | 4 supporting sources | ★★☆☆☆ |
| Irilone | 3 supporting sources | ★★☆☆☆ |
| Isoflavone | 3 supporting sources | ★★☆☆☆ |
| Ononin | 3 supporting sources | ★★☆☆☆ |
| Phytoestrogens | 3 supporting sources | ★★☆☆☆ |
formononetin
- Dr. Duke
- Plant cell reports
- Cancers
- Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
- Journal of natural products
View 8 additional sources
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Poultry science
- Frontiers in pharmacology
- Fitoterapia
- Journal of chromatography. A
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Journal of ethnopharmacology
- BioMed research international
Isoflavones
- Dr. Duke
- Plant cell reports
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
- Food & function
View 6 additional sources
- Journal of agricultural and food chemistry
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- The journal of the British Menopause Society
- Menopause (New York, N.Y.)
- Voprosy meditsinskoi khimii
- The Journal of nutrition
biochanin A
- Dr. Duke
- Toxicology in vitro : an international journal published in association with BIBRA
- Plant cell reports
- Journal of natural products
- Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
View 5 additional sources
- Poultry science
- Fitoterapia
- Journal of chromatography. A
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Journal of ethnopharmacology
Prunetin
- Dr. Duke
- Journal of natural products
- Fitoterapia
- Journal of chromatography. A
- Phytomedicine : international journal of phytotherapy and phytopharmacology
genistein
- Dr. Duke
- Plant cell reports
- Journal of chromatography. A
- Phytomedicine : international journal of phytotherapy and phytopharmacology
kaempferol
- Dr. Duke
- Steroids
- Fitoterapia
- Journal of chromatography. A
Irilone
- Dr. Duke
- Journal of natural products
- Journal of chromatography. A
Isoflavone
- Journal of food science and technology
- International journal of biological macromolecules
- Journal of chromatography. A
Ononin
- Dr. Duke
- Poultry science
- Journal of ethnopharmacology
Phytoestrogens
- Menopause international
- Frontiers in pharmacology
- Climacteric : the journal of the International Menopause Society
Activities
Trifolium pratense has 747 reported activities identified across 3 scientific publications and several other databases. The most consistently reported activities include Antioxidant, Estrogenic, Anticancer, Neuroprotective, Antidiabetic.
| Activity | Supporting sources | Consensus |
|---|---|---|
| Antioxidant | 7 supporting sources | ★★★★☆ |
| Estrogenic | 4 supporting sources | ★★☆☆☆ |
| Anticancer | 3 supporting sources | ★★☆☆☆ |
| Neuroprotective | 3 supporting sources | ★★☆☆☆ |
| Antidiabetic | 2 supporting sources | ★☆☆☆☆ |
| Antimicrobial | 2 supporting sources | ★☆☆☆☆ |
| Antiproliferative | 2 supporting sources | ★☆☆☆☆ |
| 11B-HSD-Inhibitor | 1 supporting sources | ★☆☆☆☆ |
| 17-beta-hydroxysteroid dehydrogenase-Inhibitor | 1 supporting sources | ★☆☆☆☆ |
| 5-Alpha-Reductase-Inhibitor | 1 supporting sources | ★☆☆☆☆ |
Antioxidant
- Dr. Duke
- Cancers
- Journal of ethnopharmacology
- Frontiers in pharmacology
- Redox report : communications in free radical research
View 2 additional sources
- Actas urologicas espanolas
- Foods (Basel, Switzerland)
Estrogenic
- Dr. Duke
- Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
- Planta medica
- Frontiers in pharmacology
Anticancer
- Dr. Duke
- Cancers
- Foods (Basel, Switzerland)
Neuroprotective
- Dr. Duke
- Cancers
- Foods (Basel, Switzerland)
Antidiabetic
- Dr. Duke
- Journal of ethnopharmacology
Antimicrobial
- Dr. Duke
- Journal of ethnopharmacology
Antiproliferative
- Dr. Duke
- Cancers
11B-HSD-Inhibitor
- Dr. Duke
17-beta-hydroxysteroid dehydrogenase-Inhibitor
- Dr. Duke
5-Alpha-Reductase-Inhibitor
- Dr. Duke
Conditions
Trifolium pratense has 41 reported investigations on conditions identified across 3 scientific publications and several other databases. The most consistently reported conditions include Alzheimer's disease, antidiabetic, depression, hot flashes, premenstrual syndrome.
| Condition | Supporting sources | Consensus |
|---|---|---|
| Alzheimer's disease | 2 supporting sources | ★☆☆☆☆ |
| Antidiabetic | 2 supporting sources | ★☆☆☆☆ |
| Depression | 2 supporting sources | ★☆☆☆☆ |
| Hot flashes | 2 supporting sources | ★☆☆☆☆ |
| Premenstrual syndrome | 2 supporting sources | ★☆☆☆☆ |
| Coccidiosis | 1 supporting sources | ★☆☆☆☆ |
| Parkinson's disease | 1 supporting sources | ★☆☆☆☆ |
| Type 2 diabetes | 1 supporting sources | ★☆☆☆☆ |
| Antioxidant | 1 supporting sources | ★☆☆☆☆ |
| Anxiety | 1 supporting sources | ★☆☆☆☆ |
Alzheimer's disease
- Cancers
- Frontiers in pharmacology
Antidiabetic
- Journal of ethnopharmacology
- Critical reviews in food science and nutrition
Depression
- Menopause international
- Frontiers in pharmacology
Hot flashes
- Menopause (New York, N.Y.)
- Journal of natural products
Premenstrual syndrome
- Journal of natural products
- Journal of ethnopharmacology
Coccidiosis
- Poultry science
Parkinson's disease
- Food & function
Type 2 diabetes
- Chemistry & biodiversity
Antioxidant
- Journal of ethnopharmacology
Anxiety
- Frontiers in pharmacology
Preparations
Trifolium pratense has 8 reported preparations identified across 3 scientific publications and several other databases. The most consistently reported preparations include Freeze-dried samples, TP powder, aqueous extract, ethanol extracts, ethanolic extract.
| Preparation | Supporting sources | Consensus |
|---|---|---|
| Freeze-dried samples | 1 supporting sources | ★☆☆☆☆ |
| Tp powder | 1 supporting sources | ★☆☆☆☆ |
| Aqueous extract | 1 supporting sources | ★☆☆☆☆ |
| Ethanol extracts | 1 supporting sources | ★☆☆☆☆ |
| Ethanolic extract | 1 supporting sources | ★☆☆☆☆ |
| Flowers | 1 supporting sources | ★☆☆☆☆ |
| Red clover extractive | 1 supporting sources | ★☆☆☆☆ |
| Seed oils | 1 supporting sources | ★☆☆☆☆ |
Freeze-dried samples
- Journal of food science and technology
Tp powder
- Poultry science
Aqueous extract
- Chemistry & biodiversity
Ethanol extracts
- Journal of ethnopharmacology
Ethanolic extract
- Poultry science
Flowers
- Journal of ethnopharmacology
Red clover extractive
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Seed oils
- Journal of oleo science