Tiliacora triandra
Tiliacora triandra · Accepted scientific name
Scientific literature: Very Sparse (6 studies) · ★☆☆☆☆
Tiliacora triandra is a botanical species of significant pharmacological interest, particularly when utilizing its root for medicinal applications. Research into its dried-plant powder and various preparations, such as 80% ethanolic root extracts and dichloromethane fractions (TT-DCM), has revealed a diverse range of bioactive properties. These studies highlight the plant's potent antioxidant, antimicrobial, and cytotoxic activities, driven by key chemical compounds like pectolinarigenin and tiliacorinine. Specifically, these extracts have demonstrated therapeutic potential against conditions such as cholangiocarcinoma, Candida albicans, and atopic dermatitis. Consequently, Tiliacora triandra serves as a promising subject for developing new treatments through its multifaceted biological profile.
- Synonyms
- Aristega Laevifolia · Tiliacora Stipularis · 6 more
- Common names
- Not available
- Family
- Menispermaceae
- Distribution
- Not available
- Plant Parts
- Root
Classification
Common Names
Tiliacora triandra is a versatile plant known by a diverse array of regional names across the globe. In various Southeast Asian contexts, it is frequently referred to as Yanang or Cuwing. It also carries the name Sương sâm in certain Vietnamese dialects, highlighting its local cultural importance. The plant's identity extends further into different linguistic landscapes, appearing as تيلياكورا ترياندرا in Arabic scripts. Even more specific botanical variations, such as tiliakora trojtyčinková, demonstrate the wide range of names used to identify this unique species.
Sources: Catalogue of Life (COL)
Synonyms
Tiliacora triandra is a botanical species known to encompass several different scientific names within its taxonomic history. Throughout various classifications, it has been identified by synonyms such as Aristega laevifolia and Cocculus triandrus. Researchers have also frequently referred to the plant using the name Limacia amherstiana. Furthermore, the species is linked to the names Limacia triandra and Limacia wallichiana in diverse botanical records. Understanding these multiple nomenclatural relationships is essential for accurate plant identification and study.
Sources: The World Checklist of Vascular Plants (WCVP)
Taxonomy
Tiliacora triandra is a remarkable botanical specimen belonging to the kingdom Plantae. Within this vast biological realm, the plant is classified under the class Equisetopsida. It further falls into the order Ranunculales, showcasing its evolutionary connections to specific plant groups. As a member of the genus Tiliacora, it occupies a distinct niche in the natural world. Finally, this species is categorized within the family Menispermaceae, completing its scientific profile.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Ranunculales |
| Family | Menispermaceae |
| Genus | Tiliacora |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
Geographic Regions
Tiliacora triandra is a versatile plant primarily distributed throughout the tropical regions of Asia. Its presence is well-established across the Indian Subcontinent, specifically within the regions of Assam and Bangladesh. Furthermore, the species extends its reach into the Indo-China peninsula, thriving in the landscapes of Cambodia and Laos. The Andaman Islands also serve as part of its diverse geographical range. This widespread distribution highlights the plant's ability to adapt to various tropical environments across the continent.
Sources: The World Checklist of Vascular Plants (WCVP)
Identification
Morphology
Tiliacora triandra is characterized by an obligatory climbing habit, meaning it relies entirely on external support to ascend and thrive.
Sources: Global Inventory of Floras and Traits (GIFT)
Biological Activities
Tiliacora triandra is a versatile Thai medicinal plant that demonstrates a wide range of significant pharmacological properties. Research indicates that its compounds, such as tiliacorinine, possess potent anticancer and cytotoxic activities, particularly through the induction of apoptosis in cholangiocarcinoma cells. Furthermore, the plant exhibits strong antioxidant capabilities, which contribute to its overall therapeutic potential in various medicinal mixtures. Studies also highlight its antimicrobial effectiveness, showing the ability to inhibit the growth of diverse bacterial strains and fungi like Candida albicans. These diverse biological activities underscore the plant's importance as a promising candidate for the development of future pharmaceutical treatments.
Compounds
Tiliacora triandra is a Thai medicinal plant that serves as a rich source of bioactive compounds with significant therapeutic potential. Research has identified that this plant contains pectolinarigenin, a major flavonoid constituent that exhibits potent anticancer activity against triple-negative breast cancer cells. Furthermore, Tiliacora triandra contains tiliacorinine, a bisbenzylisoquinoline alkaloid capable of inducing apoptotic cell death in cholangiocarcinoma cells. While pectolinarigenin works by modulating cell cycle progression and MAPK signaling, tiliacorinine acts as a multi-kinase inhibitor targeting proteins such as EGFR and Akt. Together, these findings highlight the plant's promising role in the development of novel treatments for aggressive cancer subtypes.
Conditions
Tiliacora triandra demonstrates significant therapeutic potential through its ability to treat Candida albicans, serving as the only component in the Benchalokawichian remedy to inhibit this fungus. Within the Clear belongs Plus extract, the plant contributes to potent anticancer effects that treat HCT116 and NCI-H460 cell lines by inhibiting proliferation and migration. Its antiviral properties are also notable, as the extract has been shown to treat PRRSV infectivity in MARC-145 cells. Furthermore, the plant's inclusion in medicinal mixtures aids in treating inflammatory conditions through demonstrated anti-inflammatory activities. These diverse biological actions highlight Tiliacora triandra as a versatile candidate for developing various pharmaceutical treatments.
Preparations
Tiliacora triandra is prepared as an 80% ethanolic root extract that can be partitioned into a dichloromethane fraction, specifically identified as TT-DCM. The plant is also prepared as a dried-plant powder for extraction to create a medicinal mixture. Research utilizes various forms of Tiliacora triandra, including general ethanolic extracts and water extracts, to study its medicinal properties. These different preparations, ranging from specific dichloromethane fractions to broad plant extracts, are evaluated for their anticancer, antimicrobial, and antiviral activities. Ultimately, the diverse ways Tiliacora triandra is prepared as an extract allow for the identification of potent bioactive compounds like pectolinarigenin.
Parts used
Tiliacora triandra is a traditional Thai medicinal plant that has long been utilized to manage various inflammatory and metabolic disorders. Recent scientific investigations have focused specifically on the bioactive potential found within its root. By utilizing an 80% ethanolic root extract, researchers were able to isolate several important chemical fractions for study. One predominant component identified in these root fractions is the flavonoid pectolinarigenin. This specific compound has demonstrated significant promise in combating aggressive triple-negative breast cancer cells through controlled apoptosis and cell cycle arrest.