feverfew
Tanacetum parthenium · Accepted scientific name
Scientific literature: Very Extensive (1560 studies) · ★★★★★
Feverfew, scientifically known as Tanacetum parthenium, is a perennial flowering herb renowned for its potent medicinal properties. Traditionally used in herbalism, it is most widely recognized for its ability to prevent migraines and reduce inflammation. This versatile plant remains a cornerstone in natural remedies for supporting vascular health.
Names and Synonyms
Common Names
- feather-leaved tansy
- featherfew
- feverfew
Scientific Names
Accepted name
Tanacetum partheniumSynonyms
- Parthenium matricaria
- Leucanthemum parthenium
- Chamaemelum parthenium
- Leucanthemum parthenium var. flosculosum
- Chrysanthemum parthenium f. flosculosum
- Matricaria mandiana
- Pyrethrum parthenium var. flosculosum
- Pyrethrum parthenium var. multiplex
- Pyrethrum partheniifolium aureum
- Pyrethrum parthenium eximium
- Matricaria odorata
- Pyrethrum glanduliferum
- Pyrethrum grossheimii
- Matricaria parthenium
- Tanacetum glanduliferum
- Dendranthema parthenium
- Leucanthemum parthenium var. flosculosum
- Tanacetum grossheimii
- Matricaria alba
- Matricaria eximia
- Tanacetum parthenium var. flosculosum
- Matricaria florida
- Chrysanthemum parthenium var. discoideum
- Matricaria vulgaris
- Pontia matricaria
- Pyrethrum eximium
- Chrysanthemum parthenium
- Pyrethrum parthenium
Regional and Traditional Names
Spanish:
- Cochitzapotl
- Madrehuela doble
- Flor de la calentura
- Santa María blanca
- Hierba de altamira
- Parthenium matricaria
- Madrehuela rosea
- Pyrethrum sevanense
- Magarza amarilla
- Chapote
- Leucanthemum odoratum
- Artemiza
- Pyrethrum demetrii
- Santa maría
- Gamaza
- Flor de santos
- Santa Maria blanca
- Santa maria
- altamisa
- Artemisa
- Santa María
German:
- Mutterkraut
- Zierkamille
- Fieberkraut
- Chrysanthemum parthenium
- grande camomille
- Mutterkraut
- Falsche Kamille
- Mutterkraut-Wucherblume
French:
- Pyrèthre doré
- Grande Camomille
- Partenelle
- chrysanthème matricaire
- grande camomille
- pyrèthre doré
- pyrèthre mousse
- grande camomile
- Tanaisie matricaire
Sources: Wikidata, Catalogue of Life
Taxonomical Classification
This plant belongs to the kingdom Plantae within the phylum Streptophyta and is classified under the class Equisetopsida and subclass Magnoliidae. It is further organized under the order Asterales and the family Asteraceae. Finally, the species is identified by its genus, Tanacetum.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Asterales |
| Family | Asteraceae |
| Genus | Tanacetum |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
This plant, known as Tanacetum parthenium, exhibits a specific geographical presence across several regions in Northern Europe. It can be found growing within the natural landscapes of Denmark. The species is also documented throughout the territories of Great Britain and Ireland. Furthermore, its distribution extends to the northern reaches of the continent in Norway. Finally, this medicinal plant is also native to the regions of Sweden.
| Region | Area |
|---|---|
| Northern Europe | Denmark |
| Northern Europe | Great Britain |
| Northern Europe | Ireland |
| Northern Europe | Norway |
| Northern Europe | Sweden |
| Middle Europe | Austria |
| Middle Europe | Belgium |
| Middle Europe | Czechia-Slovakia |
| Middle Europe | Germany |
| Middle Europe | Hungary |
Sources: The World Checklist of Vascular Plants (WCVP)
Botanical Identification
Ecology
The ecology of Tanacetum parthenium is characterized by its remarkable adaptability to diverse topographical gradients, spanning an expansive elevational range from sea level (0 m AMSL) up to high-altitude regions reaching 3300 m AMSL. This plant thrives in a variety of complex environments, frequently colonizing mountainous terrains and forested areas where it integrates into the local vegetation structure. It is particularly well-suited to disturbed or rugged landscapes, often found growing amidst shrubberies and within stony places, where its ability to establish itself in rocky, less fertile substrates highlights its resilience in varied ecological niches.
- Elevational range max:
- 3300 m AMSL
- Elevational range min:
- 0 m AMSL
- Habitat :
- forest, mountains, shrubberies, stony places
Life history
The life history of Tanacetum parthenium is characterized by its classification as a perennial plant, allowing it to persist through multiple growing seasons. It functions primarily as a hemicryptophyte, a life form where the perennating buds are located at the soil surface, protected by leaf litter or soil during unfavorable conditions. This species maintains an evergreen nature, retaining its foliage to support continuous physiological processes.
- Deciduousness :
- evergreen
- Life form :
- hemicryptophyte
- Lifecycle :
- perennial
Morphology
The morphology of Tanacetum parthenium is characterized by its growth form as a non-woody herb and forb. This terrestrial plant is self-supporting rather than a climber or liana, and it functions as an independent organism without parasitic tendencies. It grows with an erect shoot orientation, reaching a minimum height of 0.15 m, a maximum height of 0.8 m, and maintains a mean plant height of approximately 0.40875 m. As a terrestrial species, it does not exhibit epiphytic or aquatic lifestyles.
- Aquatic :
- terrestrial
- Climber :
- self-supporting
- Epiphyte :
- terrestrial
- Growth form :
- herb
- Growth form :
- forb
- Parasite :
- independent
- Plant height max:
- 0.8 m
- Plant height mean:
- 0.40875 m
- Plant height min:
- 0.15 m
- Shoot orientation :
- erect
- Woodiness :
- non-woody
Physiology
The physiology of Tanacetum parthenium is characterized by a C3 photosynthetic pathway, indicating a metabolic process optimized for moderate environments where carbon fixation occurs via the Calvin cycle. As a non-carnivorous species, it relies entirely on soil nutrients rather than capturing prey, and it does not function as a nitrogen fixer. The plant's leaf morphology exhibits significant variability, with an elliptic leaf form that maintains a mean leaf size of 45.63 cm². Specifically, the leaves demonstrate a mean length of 6 cm (ranging from a minimum of 2 cm to a maximum of 9 cm) and a mean width of 4 cm (varying from a minimum of 1 cm to a maximum of 4.5 cm). Furthermore, the plant possesses a mean Specific Leaf Area (SLA) of 363 cm²/g, reflecting its physiological strategy for balancing light interception and resource investment within its leaf tissues.
- Carnivory :
- non-carnivorous
- Leaf form :
- elliptic
- Leaf length max:
- 9 cm
- Leaf length mean:
- 6 cm
- Leaf length min:
- 2 cm
- Leaf size mean:
- 45.63 cm²
- Leaf width max:
- 4.5 cm
- Leaf width mean:
- 4 cm
- Leaf width min:
- 1 cm
- Nitrogen fixer :
- no
- Photosynthetic pathway :
- C3
- Specific Leaf Area (SLA) mean:
- 363 cm²/g
Reproduction
The reproduction of Tanacetum parthenium is characterized by sexual processes through bisexual flowers organized in a panicle inflorescence. The flowering period typically begins in June and concludes in August, featuring white flowers that measure between 0.3 cm and 0.4 cm in length, with a width ranging from 1.3 cm to 2.2 cm. Pollination is driven by biotic mechanisms, specifically involving insects such as bees. While self-fertilization is present, the plant relies on these biotic vectors for successful reproductive cycles. Following fertilization, the plant produces yellow fruits in the form of achenes. These fruits are indehiscent and vary in length from a minimum of 0.12 cm to a maximum of 0.15 cm, with a mean length of approximately 0.157 cm. Each fruit is highly prolific, containing more than 1,000 seeds. The seeds themselves are uniform in length at approximately 1.5 mm, with a mean mass of 0.00015257 g and a maximum mass of 0.00064 g. Dispersal occurs through unspecialized and anthropochorous syndromes, meaning seeds are spread via non-specific natural methods as well as human activity. Asexual reproduction is absent in this species.
- Dehiscence :
- indehiscent
- Dispersal syndrome :
- unspecialized
- Dispersal syndrome :
- anthropochorous
- Flower colour :
- white
- Flower length max:
- 0.4 cm
- Flower length min:
- 0.3 cm
- Flower width max:
- 2.2 cm
- Flower width min:
- 1.3 cm
- Flowering time :
- Jun
- Flowering time :
- Aug
- Fruit colour :
- yellow
- Fruit length max:
- 0.15 cm
- Fruit length mean:
- 0.156666666666667 cm
- Fruit length min:
- 0.12 cm
- Fruit type :
- achene
- Inflorescence :
- panicle
- Pollination syndrome :
- insect
- Pollination syndrome :
- bee
- Pollination syndrome :
- biotic
- Reproduction asexual :
- absent
- Reproduction sexual :
- bisexual
- Seed length mean:
- 1.5 mm
- Seed mass max:
- 0.00064 g
- Seed mass mean:
- 0.000152571428571429 g
- Seed mass min:
- 0 g
- Seeds_per_fruit :
- >1000
- Self fertilization :
- present
Sources: Global Inventory of Floras and Traits (GIFT)
Plant Parts
Tanacetum parthenium has 4 reported plant parts identified across 12 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include flower, leaf, root, seed.
| Plant part | Supporting sources | Consensus |
|---|---|---|
| Flower | 4 supporting sources | ★★☆☆☆ |
| Leaf | 4 supporting sources | ★★☆☆☆ |
| Root | 2 supporting sources | ★☆☆☆☆ |
| Seed | 2 supporting sources | ★☆☆☆☆ |
Flower
- Phytochemistry
- International journal of molecular sciences
- Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
- The Journal of pharmacy and pharmacology
Leaf
- Phytochemistry
- International journal of molecular sciences
- Biochemical pharmacology
- The Journal of pharmacy and pharmacology
Root
- International journal of molecular sciences
- The Journal of pharmacy and pharmacology
Seed
- Phytochemistry
- The Journal of pharmacy and pharmacology
Chemicals
Tanacetum parthenium has 171 reported phytochemicals identified across 12 scientific publications and several other databases. The most consistently reported chemicals include parthenolide, apigenin, camphor, arachidonic acid, Alantolactone.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| parthenolide | 42 supporting sources | ★★★★★ |
| apigenin | 4 supporting sources | ★★☆☆☆ |
| camphor | 4 supporting sources | ★★☆☆☆ |
| arachidonic acid | 3 supporting sources | ★★☆☆☆ |
| Alantolactone | 2 supporting sources | ★☆☆☆☆ |
| Apigenin 7-glucuronide | 2 supporting sources | ★☆☆☆☆ |
| Artecanin | 2 supporting sources | ★☆☆☆☆ |
| CAMPHENE | 2 supporting sources | ★☆☆☆☆ |
| Canin | 2 supporting sources | ★☆☆☆☆ |
| Chrysanthenyl acetate | 2 supporting sources | ★☆☆☆☆ |
parthenolide
- Dr. Duke
- Biomedicines
- Behavioural brain research
- Plant cell reports
- Drug discovery today
View 37 additional sources
- Journal of agricultural and food chemistry
- The Journal of pharmacy and pharmacology
- Biochemical and biophysical research communications
- Biochemical pharmacology
- Chemistry & biology
- British journal of clinical pharmacology
- Cellular immunology
- Journal of ethnopharmacology
- Immunology letters
- Oncogene
- Planta medica
- Cell death and differentiation
- Pharmacognosy reviews
- Molecular carcinogenesis
- Journal of medicinal food
- Journal of natural products
- Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
- Acta pharmacologica Sinica
- Plant molecular biology
- Journal of pharmaceutical and biomedical analysis
- Expert opinion on biological therapy
- Metabolic engineering
- Polish journal of pharmacology and pharmacy
- European journal of immunology
- Cell cycle (Georgetown, Tex.)
- Chemosphere
- Drug design, development and therapy
- International journal of molecular sciences
- Phytochemistry
- Contact dermatitis
- Folia haematologica (Leipzig, Germany : 1928)
- Chinese journal of natural medicines
- Plant physiology and biochemistry : PPB
- Molecular medicine reports
- International immunopharmacology
- OncoTargets and therapy
- Acta dermato-venereologica
apigenin
- Molecules (Basel, Switzerland)
- Phytochemistry
- Phytotherapy research : PTR
- Journal of medicinal food
camphor
- Dr. Duke
- International journal of molecular sciences
- Chemistry & biodiversity
- Journal of medicinal food
arachidonic acid
- Biomedica biochimica acta
- Prostaglandins, leukotrienes, and medicine
- The Journal of pharmacy and pharmacology
Alantolactone
- Dr. Duke
- Contact dermatitis
Apigenin 7-glucuronide
- Dr. Duke
- Phytochemistry
Artecanin
- Dr. Duke
- The Journal of pharmacy and pharmacology
CAMPHENE
- Dr. Duke
- International journal of molecular sciences
Canin
- Dr. Duke
- The Journal of pharmacy and pharmacology
Chrysanthenyl acetate
- Dr. Duke
- The Journal of pharmacy and pharmacology
Activities
Tanacetum parthenium has 532 reported activities identified across 12 scientific publications and several other databases. The most consistently reported activities include Anticancer, Antioxidant, Antimigraine, Antibacterial, Antifibrotic.
| Activity | Supporting sources | Consensus |
|---|---|---|
| Anticancer | 9 supporting sources | ★★★★☆ |
| Antioxidant | 4 supporting sources | ★★☆☆☆ |
| Antimigraine | 3 supporting sources | ★★☆☆☆ |
| Antibacterial | 2 supporting sources | ★☆☆☆☆ |
| Antifibrotic | 2 supporting sources | ★☆☆☆☆ |
| Antinociceptive | 2 supporting sources | ★☆☆☆☆ |
| Antispasmodic | 2 supporting sources | ★☆☆☆☆ |
| Antitumor | 2 supporting sources | ★☆☆☆☆ |
| Neuroprotective | 2 supporting sources | ★☆☆☆☆ |
| (-)-Chronotropic | 1 supporting sources | ★☆☆☆☆ |
Anticancer
- Dr. Duke
- Biomedicines
- Drug discovery today
- Pharmacognosy reviews
- Molecular carcinogenesis
View 4 additional sources
- Drug design, development and therapy
- Journal of agricultural and food chemistry
- Chinese journal of natural medicines
- International immunopharmacology
Antioxidant
- Dr. Duke
- International journal of molecular sciences
- Behavioural brain research
- Drug design, development and therapy
Antimigraine
- Dr. Duke
- Polish journal of pharmacology and pharmacy
- Phytotherapy research : PTR
Antibacterial
- Dr. Duke
- International journal of molecular sciences
Antifibrotic
- Dr. Duke
- Drug design, development and therapy
Antinociceptive
- Dr. Duke
- Journal of ethnopharmacology
Antispasmodic
- Dr. Duke
- Pharmacognosy reviews
Antitumor
- Dr. Duke
- Drug design, development and therapy
Neuroprotective
- Dr. Duke
- Biomedicines
(-)-Chronotropic
- Dr. Duke
Conditions
Tanacetum parthenium has 51 reported investigations on conditions identified across 12 scientific publications and several other databases. The most consistently reported conditions include migraine, cancer, rheumatoid arthritis, arthritis, epilepsy.
| Condition | Supporting sources | Consensus |
|---|---|---|
| Migraine | 21 supporting sources | ★★★★★ |
| Cancer | 5 supporting sources | ★★★☆☆ |
| Rheumatoid arthritis | 4 supporting sources | ★★☆☆☆ |
| Arthritis | 3 supporting sources | ★★☆☆☆ |
| Epilepsy | 3 supporting sources | ★★☆☆☆ |
| Inflammation | 3 supporting sources | ★★☆☆☆ |
| Migraine headaches | 3 supporting sources | ★★☆☆☆ |
| Asthma | 2 supporting sources | ★☆☆☆☆ |
| Fever | 2 supporting sources | ★☆☆☆☆ |
| Fevers | 2 supporting sources | ★☆☆☆☆ |
Migraine
- Italian journal of pediatrics
- Neurologia i neurochirurgia polska
- Plant cell reports
- Journal of AOAC International
- The Journal of pharmacy and pharmacology
View 16 additional sources
- Biochemical pharmacology
- Lancet (London, England)
- Planta medica
- CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
- Phytotherapy research : PTR
- Cephalalgia : an international journal of headache
- Journal of medicinal food
- Journal of natural products
- Journal of pharmaceutical and biomedical analysis
- Folia haematologica (Leipzig, Germany : 1928)
- British medical journal (Clinical research ed.)
- The Cochrane database of systematic reviews
- American family physician
- Phytochemistry
- Biomedical chromatography : BMC
- Human toxicology
Cancer
- Plant cell reports
- Drug discovery today
- Phytochemistry
- Journal of agricultural and food chemistry
- Environmental science and pollution research international
Rheumatoid arthritis
- American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
- Pharmacognosy reviews
- Biomedical chromatography : BMC
- Annals of the rheumatic diseases
Arthritis
- Biochemical pharmacology
- Journal of medicinal food
- Folia haematologica (Leipzig, Germany : 1928)
Epilepsy
- Biomedicines
- Journal of ethnopharmacology
- Phytotherapy research : PTR
Inflammation
- Biomedicines
- Chemistry & biology
- OncoTargets and therapy
Migraine headaches
- Biomedicines
- Pharmacognosy reviews
- Archives of internal medicine
Asthma
- Pharmacognosy reviews
- Drug design, development and therapy
Fever
- Biochemical pharmacology
- Folia haematologica (Leipzig, Germany : 1928)
Fevers
- Pharmacognosy reviews
- Prostaglandins, leukotrienes, and medicine
Preparations
Tanacetum parthenium has 11 reported preparations identified across 12 scientific publications and several other databases. The most consistently reported preparations include Ethanolic extracts of aerial parts, Extracts of Tanacetum parthenium, Extracts of feverfew, Leaves, alcoholic and hot water extracts.
| Preparation | Supporting sources | Consensus |
|---|---|---|
| Ethanolic extracts of aerial parts | 1 supporting sources | ★☆☆☆☆ |
| Extracts of tanacetum parthenium | 1 supporting sources | ★☆☆☆☆ |
| Extracts of feverfew | 1 supporting sources | ★☆☆☆☆ |
| Leaves | 1 supporting sources | ★☆☆☆☆ |
| Alcoholic and hot water extracts | 1 supporting sources | ★☆☆☆☆ |
| Aqueous extracts | 1 supporting sources | ★☆☆☆☆ |
| Ethanol extracts | 1 supporting sources | ★☆☆☆☆ |
| Hydro-alcoholic extract (hae) | 1 supporting sources | ★☆☆☆☆ |
| Infusions | 1 supporting sources | ★☆☆☆☆ |
| Nutraceutical preparation | 1 supporting sources | ★☆☆☆☆ |
Ethanolic extracts of aerial parts
- Journal of ethnopharmacology
Extracts of tanacetum parthenium
- Phytotherapy research : PTR
Extracts of feverfew
- Lancet (London, England)
Leaves
- Biochemical pharmacology
Alcoholic and hot water extracts
- Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Aqueous extracts
- Polish journal of pharmacology and pharmacy
Ethanol extracts
- Polish journal of pharmacology and pharmacy
Hydro-alcoholic extract (hae)
- Avicenna journal of phytomedicine
Infusions
- Biochemical pharmacology
Nutraceutical preparation
- Italian journal of pediatrics