feverfew

Tanacetum parthenium · Accepted scientific name

Scientific literature: Very Extensive (1560 studies) · ★★★★★

Feverfew, scientifically known as Tanacetum parthenium, is a perennial flowering herb renowned for its potent medicinal properties. Traditionally used in herbalism, it is most widely recognized for its ability to prevent migraines and reduce inflammation. This versatile plant remains a cornerstone in natural remedies for supporting vascular health.

Family
Asteraceae
Native range
Europe
Parts used
Flower · Leaf
Common names
Feather-Leaved Tansy · Featherfew · 1 more
Scientific synonyms
Parthenium Matricaria · Leucanthemum Parthenium · 26 more

Names and Synonyms

Common Names

Scientific Names

Accepted name

Tanacetum parthenium

Synonyms

Regional and Traditional Names

Spanish:

  • Cochitzapotl
  • Madrehuela doble
  • Flor de la calentura
  • Santa María blanca
  • Hierba de altamira
  • Parthenium matricaria
  • Madrehuela rosea
  • Pyrethrum sevanense
  • Magarza amarilla
  • Chapote
  • Leucanthemum odoratum
  • Artemiza
  • Pyrethrum demetrii
  • Santa maría
  • Gamaza
  • Flor de santos
  • Santa Maria blanca
  • Santa maria
  • altamisa
  • Artemisa
  • Santa María

German:

  • Mutterkraut
  • Zierkamille
  • Fieberkraut
  • Chrysanthemum parthenium
  • grande camomille
  • Mutterkraut
  • Falsche Kamille
  • Mutterkraut-Wucherblume

French:

  • Pyrèthre doré
  • Grande Camomille
  • Partenelle
  • chrysanthème matricaire
  • grande camomille
  • pyrèthre doré
  • pyrèthre mousse
  • grande camomile
  • Tanaisie matricaire

Sources: Wikidata, Catalogue of Life

Taxonomical Classification

This plant belongs to the kingdom Plantae within the phylum Streptophyta and is classified under the class Equisetopsida and subclass Magnoliidae. It is further organized under the order Asterales and the family Asteraceae. Finally, the species is identified by its genus, Tanacetum.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Asterales
Family Asteraceae
Genus Tanacetum

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant, known as Tanacetum parthenium, exhibits a specific geographical presence across several regions in Northern Europe. It can be found growing within the natural landscapes of Denmark. The species is also documented throughout the territories of Great Britain and Ireland. Furthermore, its distribution extends to the northern reaches of the continent in Norway. Finally, this medicinal plant is also native to the regions of Sweden.

Region Area
Northern Europe Denmark
Northern Europe Great Britain
Northern Europe Ireland
Northern Europe Norway
Northern Europe Sweden
Middle Europe Austria
Middle Europe Belgium
Middle Europe Czechia-Slovakia
Middle Europe Germany
Middle Europe Hungary

Sources: The World Checklist of Vascular Plants (WCVP)

Botanical Identification

Ecology

The ecology of Tanacetum parthenium is characterized by its remarkable adaptability to diverse topographical gradients, spanning an expansive elevational range from sea level (0 m AMSL) up to high-altitude regions reaching 3300 m AMSL. This plant thrives in a variety of complex environments, frequently colonizing mountainous terrains and forested areas where it integrates into the local vegetation structure. It is particularly well-suited to disturbed or rugged landscapes, often found growing amidst shrubberies and within stony places, where its ability to establish itself in rocky, less fertile substrates highlights its resilience in varied ecological niches.

Elevational range max:
3300 m AMSL
Elevational range min:
0 m AMSL
Habitat :
forest, mountains, shrubberies, stony places

Life history

The life history of Tanacetum parthenium is characterized by its classification as a perennial plant, allowing it to persist through multiple growing seasons. It functions primarily as a hemicryptophyte, a life form where the perennating buds are located at the soil surface, protected by leaf litter or soil during unfavorable conditions. This species maintains an evergreen nature, retaining its foliage to support continuous physiological processes.

Deciduousness :
evergreen
Life form :
hemicryptophyte
Lifecycle :
perennial

Morphology

The morphology of Tanacetum parthenium is characterized by its growth form as a non-woody herb and forb. This terrestrial plant is self-supporting rather than a climber or liana, and it functions as an independent organism without parasitic tendencies. It grows with an erect shoot orientation, reaching a minimum height of 0.15 m, a maximum height of 0.8 m, and maintains a mean plant height of approximately 0.40875 m. As a terrestrial species, it does not exhibit epiphytic or aquatic lifestyles.

Aquatic :
terrestrial
Climber :
self-supporting
Epiphyte :
terrestrial
Growth form :
herb
Growth form :
forb
Parasite :
independent
Plant height max:
0.8 m
Plant height mean:
0.40875 m
Plant height min:
0.15 m
Shoot orientation :
erect
Woodiness :
non-woody

Physiology

The physiology of Tanacetum parthenium is characterized by a C3 photosynthetic pathway, indicating a metabolic process optimized for moderate environments where carbon fixation occurs via the Calvin cycle. As a non-carnivorous species, it relies entirely on soil nutrients rather than capturing prey, and it does not function as a nitrogen fixer. The plant's leaf morphology exhibits significant variability, with an elliptic leaf form that maintains a mean leaf size of 45.63 cm². Specifically, the leaves demonstrate a mean length of 6 cm (ranging from a minimum of 2 cm to a maximum of 9 cm) and a mean width of 4 cm (varying from a minimum of 1 cm to a maximum of 4.5 cm). Furthermore, the plant possesses a mean Specific Leaf Area (SLA) of 363 cm²/g, reflecting its physiological strategy for balancing light interception and resource investment within its leaf tissues.

Carnivory :
non-carnivorous
Leaf form :
elliptic
Leaf length max:
9 cm
Leaf length mean:
6 cm
Leaf length min:
2 cm
Leaf size mean:
45.63 cm²
Leaf width max:
4.5 cm
Leaf width mean:
4 cm
Leaf width min:
1 cm
Nitrogen fixer :
no
Photosynthetic pathway :
C3
Specific Leaf Area (SLA) mean:
363 cm²/g

Reproduction

The reproduction of Tanacetum parthenium is characterized by sexual processes through bisexual flowers organized in a panicle inflorescence. The flowering period typically begins in June and concludes in August, featuring white flowers that measure between 0.3 cm and 0.4 cm in length, with a width ranging from 1.3 cm to 2.2 cm. Pollination is driven by biotic mechanisms, specifically involving insects such as bees. While self-fertilization is present, the plant relies on these biotic vectors for successful reproductive cycles. Following fertilization, the plant produces yellow fruits in the form of achenes. These fruits are indehiscent and vary in length from a minimum of 0.12 cm to a maximum of 0.15 cm, with a mean length of approximately 0.157 cm. Each fruit is highly prolific, containing more than 1,000 seeds. The seeds themselves are uniform in length at approximately 1.5 mm, with a mean mass of 0.00015257 g and a maximum mass of 0.00064 g. Dispersal occurs through unspecialized and anthropochorous syndromes, meaning seeds are spread via non-specific natural methods as well as human activity. Asexual reproduction is absent in this species.

Dehiscence :
indehiscent
Dispersal syndrome :
unspecialized
Dispersal syndrome :
anthropochorous
Flower colour :
white
Flower length max:
0.4 cm
Flower length min:
0.3 cm
Flower width max:
2.2 cm
Flower width min:
1.3 cm
Flowering time :
Jun
Flowering time :
Aug
Fruit colour :
yellow
Fruit length max:
0.15 cm
Fruit length mean:
0.156666666666667 cm
Fruit length min:
0.12 cm
Fruit type :
achene
Inflorescence :
panicle
Pollination syndrome :
insect
Pollination syndrome :
bee
Pollination syndrome :
biotic
Reproduction asexual :
absent
Reproduction sexual :
bisexual
Seed length mean:
1.5 mm
Seed mass max:
0.00064 g
Seed mass mean:
0.000152571428571429 g
Seed mass min:
0 g
Seeds_per_fruit :
>1000
Self fertilization :
present

Sources: Global Inventory of Floras and Traits (GIFT)

Plant Parts

Tanacetum parthenium has 4 reported plant parts identified across 12 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include flower, leaf, root, seed.

Plant parts reported in Tanacetum parthenium
Plant part Supporting sources Consensus
Flower 4 supporting sources ★★☆☆☆
Leaf 4 supporting sources ★★☆☆☆
Root 2 supporting sources ★☆☆☆☆
Seed 2 supporting sources ★☆☆☆☆

Flower

  1. Phytochemistry
  2. International journal of molecular sciences
  3. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
  4. The Journal of pharmacy and pharmacology

Leaf

  1. Phytochemistry
  2. International journal of molecular sciences
  3. Biochemical pharmacology
  4. The Journal of pharmacy and pharmacology

Root

  1. International journal of molecular sciences
  2. The Journal of pharmacy and pharmacology

Seed

  1. Phytochemistry
  2. The Journal of pharmacy and pharmacology

Chemicals

Tanacetum parthenium has 171 reported phytochemicals identified across 12 scientific publications and several other databases. The most consistently reported chemicals include parthenolide, apigenin, camphor, arachidonic acid, Alantolactone.

Chemicals reported in Tanacetum parthenium
Chemical Supporting sources Consensus
parthenolide 42 supporting sources ★★★★★
apigenin 4 supporting sources ★★☆☆☆
camphor 4 supporting sources ★★☆☆☆
arachidonic acid 3 supporting sources ★★☆☆☆
Alantolactone 2 supporting sources ★☆☆☆☆
Apigenin 7-glucuronide 2 supporting sources ★☆☆☆☆
Artecanin 2 supporting sources ★☆☆☆☆
CAMPHENE 2 supporting sources ★☆☆☆☆
Canin 2 supporting sources ★☆☆☆☆
Chrysanthenyl acetate 2 supporting sources ★☆☆☆☆

parthenolide

  1. Dr. Duke
  2. Biomedicines
  3. Behavioural brain research
  4. Plant cell reports
  5. Drug discovery today
View 37 additional sources
  1. Journal of agricultural and food chemistry
  2. The Journal of pharmacy and pharmacology
  3. Biochemical and biophysical research communications
  4. Biochemical pharmacology
  5. Chemistry & biology
  6. British journal of clinical pharmacology
  7. Cellular immunology
  8. Journal of ethnopharmacology
  9. Immunology letters
  10. Oncogene
  11. Planta medica
  12. Cell death and differentiation
  13. Pharmacognosy reviews
  14. Molecular carcinogenesis
  15. Journal of medicinal food
  16. Journal of natural products
  17. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
  18. Acta pharmacologica Sinica
  19. Plant molecular biology
  20. Journal of pharmaceutical and biomedical analysis
  21. Expert opinion on biological therapy
  22. Metabolic engineering
  23. Polish journal of pharmacology and pharmacy
  24. European journal of immunology
  25. Cell cycle (Georgetown, Tex.)
  26. Chemosphere
  27. Drug design, development and therapy
  28. International journal of molecular sciences
  29. Phytochemistry
  30. Contact dermatitis
  31. Folia haematologica (Leipzig, Germany : 1928)
  32. Chinese journal of natural medicines
  33. Plant physiology and biochemistry : PPB
  34. Molecular medicine reports
  35. International immunopharmacology
  36. OncoTargets and therapy
  37. Acta dermato-venereologica

apigenin

  1. Molecules (Basel, Switzerland)
  2. Phytochemistry
  3. Phytotherapy research : PTR
  4. Journal of medicinal food

camphor

  1. Dr. Duke
  2. International journal of molecular sciences
  3. Chemistry & biodiversity
  4. Journal of medicinal food

arachidonic acid

  1. Biomedica biochimica acta
  2. Prostaglandins, leukotrienes, and medicine
  3. The Journal of pharmacy and pharmacology

Alantolactone

  1. Dr. Duke
  2. Contact dermatitis

Apigenin 7-glucuronide

  1. Dr. Duke
  2. Phytochemistry

Artecanin

  1. Dr. Duke
  2. The Journal of pharmacy and pharmacology

CAMPHENE

  1. Dr. Duke
  2. International journal of molecular sciences

Canin

  1. Dr. Duke
  2. The Journal of pharmacy and pharmacology

Chrysanthenyl acetate

  1. Dr. Duke
  2. The Journal of pharmacy and pharmacology

Activities

Tanacetum parthenium has 532 reported activities identified across 12 scientific publications and several other databases. The most consistently reported activities include Anticancer, Antioxidant, Antimigraine, Antibacterial, Antifibrotic.

Activities reported in Tanacetum parthenium
Activity Supporting sources Consensus
Anticancer 9 supporting sources ★★★★☆
Antioxidant 4 supporting sources ★★☆☆☆
Antimigraine 3 supporting sources ★★☆☆☆
Antibacterial 2 supporting sources ★☆☆☆☆
Antifibrotic 2 supporting sources ★☆☆☆☆
Antinociceptive 2 supporting sources ★☆☆☆☆
Antispasmodic 2 supporting sources ★☆☆☆☆
Antitumor 2 supporting sources ★☆☆☆☆
Neuroprotective 2 supporting sources ★☆☆☆☆
(-)-Chronotropic 1 supporting sources ★☆☆☆☆

Anticancer

  1. Dr. Duke
  2. Biomedicines
  3. Drug discovery today
  4. Pharmacognosy reviews
  5. Molecular carcinogenesis
View 4 additional sources
  1. Drug design, development and therapy
  2. Journal of agricultural and food chemistry
  3. Chinese journal of natural medicines
  4. International immunopharmacology

Antioxidant

  1. Dr. Duke
  2. International journal of molecular sciences
  3. Behavioural brain research
  4. Drug design, development and therapy

Antimigraine

  1. Dr. Duke
  2. Polish journal of pharmacology and pharmacy
  3. Phytotherapy research : PTR

Antibacterial

  1. Dr. Duke
  2. International journal of molecular sciences

Antifibrotic

  1. Dr. Duke
  2. Drug design, development and therapy

Antinociceptive

  1. Dr. Duke
  2. Journal of ethnopharmacology

Antispasmodic

  1. Dr. Duke
  2. Pharmacognosy reviews

Antitumor

  1. Dr. Duke
  2. Drug design, development and therapy

Neuroprotective

  1. Dr. Duke
  2. Biomedicines

(-)-Chronotropic

  1. Dr. Duke

Conditions

Tanacetum parthenium has 51 reported investigations on conditions identified across 12 scientific publications and several other databases. The most consistently reported conditions include migraine, cancer, rheumatoid arthritis, arthritis, epilepsy.

Conditions investigated for Tanacetum parthenium
Condition Supporting sources Consensus
Migraine 21 supporting sources ★★★★★
Cancer 5 supporting sources ★★★☆☆
Rheumatoid arthritis 4 supporting sources ★★☆☆☆
Arthritis 3 supporting sources ★★☆☆☆
Epilepsy 3 supporting sources ★★☆☆☆
Inflammation 3 supporting sources ★★☆☆☆
Migraine headaches 3 supporting sources ★★☆☆☆
Asthma 2 supporting sources ★☆☆☆☆
Fever 2 supporting sources ★☆☆☆☆
Fevers 2 supporting sources ★☆☆☆☆

Migraine

  1. Italian journal of pediatrics
  2. Neurologia i neurochirurgia polska
  3. Plant cell reports
  4. Journal of AOAC International
  5. The Journal of pharmacy and pharmacology
View 16 additional sources
  1. Biochemical pharmacology
  2. Lancet (London, England)
  3. Planta medica
  4. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
  5. Phytotherapy research : PTR
  6. Cephalalgia : an international journal of headache
  7. Journal of medicinal food
  8. Journal of natural products
  9. Journal of pharmaceutical and biomedical analysis
  10. Folia haematologica (Leipzig, Germany : 1928)
  11. British medical journal (Clinical research ed.)
  12. The Cochrane database of systematic reviews
  13. American family physician
  14. Phytochemistry
  15. Biomedical chromatography : BMC
  16. Human toxicology

Cancer

  1. Plant cell reports
  2. Drug discovery today
  3. Phytochemistry
  4. Journal of agricultural and food chemistry
  5. Environmental science and pollution research international

Rheumatoid arthritis

  1. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
  2. Pharmacognosy reviews
  3. Biomedical chromatography : BMC
  4. Annals of the rheumatic diseases

Arthritis

  1. Biochemical pharmacology
  2. Journal of medicinal food
  3. Folia haematologica (Leipzig, Germany : 1928)

Epilepsy

  1. Biomedicines
  2. Journal of ethnopharmacology
  3. Phytotherapy research : PTR

Inflammation

  1. Biomedicines
  2. Chemistry & biology
  3. OncoTargets and therapy

Migraine headaches

  1. Biomedicines
  2. Pharmacognosy reviews
  3. Archives of internal medicine

Asthma

  1. Pharmacognosy reviews
  2. Drug design, development and therapy

Fever

  1. Biochemical pharmacology
  2. Folia haematologica (Leipzig, Germany : 1928)

Fevers

  1. Pharmacognosy reviews
  2. Prostaglandins, leukotrienes, and medicine

Preparations

Tanacetum parthenium has 11 reported preparations identified across 12 scientific publications and several other databases. The most consistently reported preparations include Ethanolic extracts of aerial parts, Extracts of Tanacetum parthenium, Extracts of feverfew, Leaves, alcoholic and hot water extracts.

Preparations reported for Tanacetum parthenium
Preparation Supporting sources Consensus
Ethanolic extracts of aerial parts 1 supporting sources ★☆☆☆☆
Extracts of tanacetum parthenium 1 supporting sources ★☆☆☆☆
Extracts of feverfew 1 supporting sources ★☆☆☆☆
Leaves 1 supporting sources ★☆☆☆☆
Alcoholic and hot water extracts 1 supporting sources ★☆☆☆☆
Aqueous extracts 1 supporting sources ★☆☆☆☆
Ethanol extracts 1 supporting sources ★☆☆☆☆
Hydro-alcoholic extract (hae) 1 supporting sources ★☆☆☆☆
Infusions 1 supporting sources ★☆☆☆☆
Nutraceutical preparation 1 supporting sources ★☆☆☆☆

Ethanolic extracts of aerial parts

  1. Journal of ethnopharmacology

Extracts of tanacetum parthenium

  1. Phytotherapy research : PTR

Extracts of feverfew

  1. Lancet (London, England)

Leaves

  1. Biochemical pharmacology

Alcoholic and hot water extracts

  1. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

Aqueous extracts

  1. Polish journal of pharmacology and pharmacy

Ethanol extracts

  1. Polish journal of pharmacology and pharmacy

Hydro-alcoholic extract (hae)

  1. Avicenna journal of phytomedicine

Infusions

  1. Biochemical pharmacology

Nutraceutical preparation

  1. Italian journal of pediatrics