strychnine tree

Strychnos nux-vomica · Accepted scientific name

Scientific literature: Very Extensive (349 studies) · ★★★★★

Strychnine tree, scientifically known as Strychnos nux-vomica, is a tropical evergreen tree native to Southeast Asia. Renowned for its potent alkaloids, particularly strychnine, it has a complex history in medicine. While historically used in minute doses for neurological stimulation, its extreme toxicity requires careful handling and strictly regulated application.

Family
Loganiaceae
Native range
Asia-Temperate
Parts used
Seed · Leaf
Common names
Nux-Vomica · Nux-Vomica-Tree · 1 more
Scientific synonyms
Strychnos Spireana · Strychnos Ovalifolia · 1 more

Names and Synonyms

Common Names

Scientific Names

Accepted name

Strychnos nux-vomica

Synonyms

Regional and Traditional Names

Spanish:

  • Strychnos nux vomica var oligosperma
  • Strychnos nux vomica
  • Nuez vomica
  • Strychnos spireana
  • Strychnos nux-vomica var oligosperma
  • Strychnos nux vomica var. oligosperma
  • Strychnos nux-vomica var. oligosperma
  • Nuez vómica
  • Nuez vómica

German:

  • Gewöhnliche Brechnuss
  • Strychnos spireana
  • Krähenaugenbaum
  • Strychninbaum
  • Strychnos lucida R.Br.
  • Brechnussbaum
  • Brechnuß
  • Strychnos colubrina Wight
  • Strychnos vomica
  • Brechnußbaum
  • Krähenaugenbaum
  • Strychninbaum
  • Gewöhnliche Brechnuss

French:

  • Vomiquier
  • Noix vomique

Sources: Wikidata, Catalogue of Life

Taxonomical Classification

This plant belongs to the kingdom Plantae within the phylum Streptophyta and the class Equisetopsida. It is further classified under the subclass Magnoliidae and the order Gentianales, falling into the family Loganiaceae. Finally, its taxonomic identity is defined by the genus Strychnos.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Gentianales
Family Loganiaceae
Genus Strychnos

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant exhibits a broad distribution across several key regions in Asia. In China, it is found throughout the South-Central, Southeast, and Hainan areas. Its presence also extends to the island of Taiwan within Eastern Asia. Furthermore, the species can be located within the Indian Subcontinent, specifically in Bangladesh. Together, these locations highlight the tropical and subtropical habitats preferred by the species.

Region Area
China China South-Central
China Hainan
China China Southeast
Eastern Asia Taiwan
Indian Subcontinent Bangladesh
Indian Subcontinent India
Indian Subcontinent Sri Lanka
Indo-China Cambodia
Indo-China Laos
Indo-China Myanmar

Sources: The World Checklist of Vascular Plants (WCVP)

Botanical Identification

Life history

The life history of Strychnos nux-vomica is characterized by its nature as a perennial species, allowing it to persist in its environment over many years through continuous growth cycles. Throughout its existence, the plant maintains an evergreen habit, ensuring that its foliage remains functional and present across different seasons rather than shedding leaves in a deciduous pattern. This combination of a long-lived lifecycle and consistent greenery supports its structural development as it matures within its natural habitat.

Deciduousness :
evergreen
Lifecycle :
perennial

Morphology

The morphology of Strychnos nux-vomica is characterized by its stature as a large, woody tree, typically reaching an average height of approximately 25 m. As a terrestrial species, it grows in non-aquatic environments and functions as an independent organism rather than a parasite or epiphyte. In terms of its structural habit, the plant is categorized as a self-supporting tree, exhibiting a robust growth form that does not rely on climbing mechanisms like vines or lianas. Its primary structural composition is distinctly woody, providing the necessary stability for its significant vertical development.

Aquatic :
terrestrial
Climber :
self-supporting
Epiphyte :
terrestrial
Growth form :
tree
Parasite :
independent
Plant height mean:
25 m
Woodiness :
woody

Physiology

The physiology of Strychnos nux-vomica is characterized by a standard C3 photosynthetic pathway, which involves the direct fixation of carbon dioxide through the Calvin cycle within the mesophyll cells. As a C3 plant, it relies on the enzyme RuBisCO to catalyze the initial carboxylation step, a process that is efficient under temperate to tropical conditions but can be susceptible to photorespiration in high-temperature environments. Regarding its nutrient acquisition strategies, the plant is not a nitrogen fixer, meaning it lacks the symbiotic relationship with diazotrophic bacteria (such as Rhizobium) required to convert atmospheric nitrogen into usable forms; instead, it relies entirely on the uptake of nitrates and ammonium from the soil through its root system to support its metabolic processes and the synthesis of its complex indole alkaloids.

Nitrogen fixer :
no
Photosynthetic pathway :
C3

Reproduction

The reproduction of Strychnos nux-vomica is facilitated through the production of fruit and seeds, which are the primary agents for its propagation. The plant develops fleshy, globose fruits that eventually contain the seeds essential for the next generation. Morphological data regarding the seeds indicates a highly consistent physical profile, characterized by a specific seed mass. Specifically, the seed mass is recorded with a mean value of 1.19 g, a figure that remains constant across its observed range, as both the maximum and minimum seed mass values are also measured at 1.19 g. This uniformity in seed mass suggests a stable reproductive investment per seed, which is a critical factor in the plant's dispersal and establishment within its natural habitat.

Seed mass mean:
1.19 g

Sources: Global Inventory of Floras and Traits (GIFT)

Plant Parts

Strychnos nux-vomica has 4 reported plant parts identified across 10 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include seed, leaf, root, stem.

Plant parts reported in Strychnos nux-vomica
Plant part Supporting sources Consensus
Seed 5 supporting sources ★★★☆☆
Leaf 3 supporting sources ★★☆☆☆
Root 1 supporting sources ★☆☆☆☆
Stem 1 supporting sources ★☆☆☆☆

Seed

  1. Phytochemical analysis : PCA
  2. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  3. Journal of ethnopharmacology
  4. Phytomedicine : international journal of phytotherapy and phytopharmacology
  5. Yao xue xue bao = Acta pharmaceutica Sinica

Leaf

  1. Pakistan journal of pharmaceutical sciences
  2. Journal de mycologie medicale
  3. Saudi journal of biological sciences

Root

  1. Journal of ethnopharmacology

Stem

  1. Saudi journal of biological sciences

Chemicals

Strychnos nux-vomica has 69 reported phytochemicals identified across 10 scientific publications and several other databases. The most consistently reported chemicals include strychnine, BRUCINE, Brucine N-oxide, Strychnine N-oxide, CHLOROGENIC ACID.

Chemicals reported in Strychnos nux-vomica
Chemical Supporting sources Consensus
strychnine 17 supporting sources ★★★★★
BRUCINE 12 supporting sources ★★★★★
Brucine N-oxide 5 supporting sources ★★★☆☆
Strychnine N-oxide 3 supporting sources ★★☆☆☆
CHLOROGENIC ACID 2 supporting sources ★☆☆☆☆
Loganin 2 supporting sources ★☆☆☆☆
3-Methoxyicajine 1 supporting sources ★☆☆☆☆
4-Hydroxystrychnine 1 supporting sources ★☆☆☆☆
Aluminium 1 supporting sources ★☆☆☆☆
Anthraquinones 1 supporting sources ★☆☆☆☆

strychnine

  1. Dr. Duke
  2. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  3. Journal of separation science
  4. Chinese journal of integrative medicine
  5. Pakistan journal of pharmaceutical sciences
View 12 additional sources
  1. Lloydia
  2. Toxins
  3. Rapid communications in mass spectrometry : RCM
  4. Pharmaceutical biology
  5. Toxicon : official journal of the International Society on Toxinology
  6. Ancient science of life
  7. Journal - Association of Official Analytical Chemists
  8. European journal of pharmacology
  9. Journal of alternative and complementary medicine (New York, N.Y.)
  10. Phytomedicine : international journal of phytotherapy and phytopharmacology
  11. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  12. Yao xue xue bao = Acta pharmaceutica Sinica

BRUCINE

  1. Dr. Duke
  2. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  3. Journal of separation science
  4. Chinese journal of integrative medicine
  5. Pakistan journal of pharmaceutical sciences
View 7 additional sources
  1. Yao xue xue bao = Acta pharmaceutica Sinica
  2. Pharmaceutical biology
  3. Toxicon : official journal of the International Society on Toxinology
  4. Journal - Association of Official Analytical Chemists
  5. Journal of ethnopharmacology
  6. European journal of pharmacology
  7. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan

Brucine N-oxide

  1. Dr. Duke
  2. Journal of separation science
  3. Pharmaceutical biology
  4. Journal of ethnopharmacology
  5. Yao xue xue bao = Acta pharmaceutica Sinica

Strychnine N-oxide

  1. Journal of separation science
  2. Pharmaceutical biology
  3. Yao xue xue bao = Acta pharmaceutica Sinica

CHLOROGENIC ACID

  1. Dr. Duke
  2. Pharmaceutical biology

Loganin

  1. Dr. Duke
  2. Pharmaceutical biology

3-Methoxyicajine

  1. Dr. Duke

4-Hydroxystrychnine

  1. Biotechnology and applied biochemistry

Aluminium

  1. Journal of complementary & integrative medicine

Anthraquinones

  1. Dose-response : a publication of International Hormesis Society

Activities

Strychnos nux-vomica has 172 reported activities identified across 10 scientific publications and several other databases. The most consistently reported activities include Analgesic, Antioxidant, 5-Alpha-Reductase-Inhibitor, Antialzheimeran, Antiandrogenic.

Activities reported in Strychnos nux-vomica
Activity Supporting sources Consensus
Analgesic 4 supporting sources ★★☆☆☆
Antioxidant 4 supporting sources ★★☆☆☆
5-Alpha-Reductase-Inhibitor 2 supporting sources ★☆☆☆☆
Antialzheimeran 2 supporting sources ★☆☆☆☆
Antiandrogenic 2 supporting sources ★☆☆☆☆
Cancer-Preventive 2 supporting sources ★☆☆☆☆
Hepatoprotective 2 supporting sources ★☆☆☆☆
Immunostimulant 2 supporting sources ★☆☆☆☆
Nematicide 2 supporting sources ★☆☆☆☆
Aldose-Reductase-Inhibitor 1 supporting sources ★☆☆☆☆

Analgesic

  1. Dr. Duke
  2. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  3. Pakistan journal of pharmaceutical sciences
  4. Journal of ethnopharmacology

Antioxidant

  1. Dr. Duke
  2. Journal of ethnopharmacology
  3. Acta biologica Hungarica
  4. Pakistan journal of pharmaceutical sciences

5-Alpha-Reductase-Inhibitor

  1. Dr. Duke
  2. Pakistan journal of pharmaceutical sciences

Antialzheimeran

  1. Dr. Duke
  2. Pakistan journal of pharmaceutical sciences

Antiandrogenic

  1. Dr. Duke
  2. Pakistan journal of pharmaceutical sciences

Cancer-Preventive

  1. Dr. Duke
  2. Pakistan journal of pharmaceutical sciences

Hepatoprotective

  1. Dr. Duke
  2. Pakistan journal of pharmaceutical sciences

Immunostimulant

  1. Dr. Duke
  2. Pakistan journal of pharmaceutical sciences

Nematicide

  1. Dr. Duke
  2. Pakistan journal of pharmaceutical sciences

Aldose-Reductase-Inhibitor

  1. Dr. Duke

Medicinal Uses

Strychnos nux-vomica has 23 reported medicinal uses identified across 10 scientific publications and several other databases. The most consistently reported uses include analgesic, cancer, inflammation, Antioxidant, Immunostimulant.

Most Reported Uses

Use Sources Consensus
analgesic Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 3 sources) ★★☆☆☆
cancer Cancer letters (and other 2 sources) ★☆☆☆☆
inflammation Chinese journal of integrative medicine (and other 2 sources) ★☆☆☆☆
Antioxidant Pakistan journal of pharmaceutical sciences (and other 1 sources) ★☆☆☆☆
Immunostimulant Pakistan journal of pharmaceutical sciences (and other 1 sources) ★☆☆☆☆
angiogenesis Cancer letters (and other 1 sources) ★☆☆☆☆
antidepressant Pakistan journal of pharmaceutical sciences (and other 1 sources) ★☆☆☆☆
antipsychotic Pakistan journal of pharmaceutical sciences (and other 1 sources) ★☆☆☆☆
arthritis Chinese journal of integrative medicine (and other 1 sources) ★☆☆☆☆
atherosclerosis Inflammation (and other 1 sources) ★☆☆☆☆

Preparations

Preparations Sources Consensus
Different solvent extracts of leaves Journal de mycologie medicale (and other 1 sources) ★☆☆☆☆
Semen Strychni Phytochemical analysis : PCA (and other 1 sources) ★☆☆☆☆
alcoholic extract of the seeds Phytomedicine : international journal of phytotherapy and phytopharmacology (and other 1 sources) ★☆☆☆☆
dry seeds Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 1 sources) ★☆☆☆☆
leaf extract Saudi journal of biological sciences (and other 1 sources) ★☆☆☆☆
methanolic extract Journal of ethnopharmacology (and other 1 sources) ★☆☆☆☆
partially purified fractions Journal of ethnopharmacology (and other 1 sources) ★☆☆☆☆
plant extracts Journal of ethnopharmacology (and other 1 sources) ★☆☆☆☆
powdered Journal of complementary & integrative medicine (and other 1 sources) ★☆☆☆☆
processed seeds Yao xue xue bao = Acta pharmaceutica Sinica (and other 1 sources) ★☆☆☆☆