strychnine tree
Strychnos nux-vomica · Accepted scientific name
Scientific literature: Very Extensive (349 studies) · ★★★★★
Strychnine tree, scientifically known as Strychnos nux-vomica, is a tropical evergreen tree native to Southeast Asia. Renowned for its potent alkaloids, particularly strychnine, it has a complex history in medicine. While historically used in minute doses for neurological stimulation, its extreme toxicity requires careful handling and strictly regulated application.
Names and Synonyms
Common Names
- nux-vomica
- nux-vomica-tree
- strychninetree
Scientific Names
Accepted name
Strychnos nux-vomicaSynonyms
- Strychnos spireana
- Strychnos ovalifolia
- Strychnos nux-vomica var. oligosperma
Regional and Traditional Names
Spanish:
- Strychnos nux vomica var oligosperma
- Strychnos nux vomica
- Nuez vomica
- Strychnos spireana
- Strychnos nux-vomica var oligosperma
- Strychnos nux vomica var. oligosperma
- Strychnos nux-vomica var. oligosperma
- Nuez vómica
- Nuez vómica
German:
- Gewöhnliche Brechnuss
- Strychnos spireana
- Krähenaugenbaum
- Strychninbaum
- Strychnos lucida R.Br.
- Brechnussbaum
- Brechnuß
- Strychnos colubrina Wight
- Strychnos vomica
- Brechnußbaum
- Krähenaugenbaum
- Strychninbaum
- Gewöhnliche Brechnuss
French:
- Vomiquier
- Noix vomique
Sources: Wikidata, Catalogue of Life
Taxonomical Classification
This plant belongs to the kingdom Plantae within the phylum Streptophyta and the class Equisetopsida. It is further classified under the subclass Magnoliidae and the order Gentianales, falling into the family Loganiaceae. Finally, its taxonomic identity is defined by the genus Strychnos.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Gentianales |
| Family | Loganiaceae |
| Genus | Strychnos |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
This plant exhibits a broad distribution across several key regions in Asia. In China, it is found throughout the South-Central, Southeast, and Hainan areas. Its presence also extends to the island of Taiwan within Eastern Asia. Furthermore, the species can be located within the Indian Subcontinent, specifically in Bangladesh. Together, these locations highlight the tropical and subtropical habitats preferred by the species.
| Region | Area |
|---|---|
| China | China South-Central |
| China | Hainan |
| China | China Southeast |
| Eastern Asia | Taiwan |
| Indian Subcontinent | Bangladesh |
| Indian Subcontinent | India |
| Indian Subcontinent | Sri Lanka |
| Indo-China | Cambodia |
| Indo-China | Laos |
| Indo-China | Myanmar |
Sources: The World Checklist of Vascular Plants (WCVP)
Botanical Identification
Life history
The life history of Strychnos nux-vomica is characterized by its nature as a perennial species, allowing it to persist in its environment over many years through continuous growth cycles. Throughout its existence, the plant maintains an evergreen habit, ensuring that its foliage remains functional and present across different seasons rather than shedding leaves in a deciduous pattern. This combination of a long-lived lifecycle and consistent greenery supports its structural development as it matures within its natural habitat.
- Deciduousness :
- evergreen
- Lifecycle :
- perennial
Morphology
The morphology of Strychnos nux-vomica is characterized by its stature as a large, woody tree, typically reaching an average height of approximately 25 m. As a terrestrial species, it grows in non-aquatic environments and functions as an independent organism rather than a parasite or epiphyte. In terms of its structural habit, the plant is categorized as a self-supporting tree, exhibiting a robust growth form that does not rely on climbing mechanisms like vines or lianas. Its primary structural composition is distinctly woody, providing the necessary stability for its significant vertical development.
- Aquatic :
- terrestrial
- Climber :
- self-supporting
- Epiphyte :
- terrestrial
- Growth form :
- tree
- Parasite :
- independent
- Plant height mean:
- 25 m
- Woodiness :
- woody
Physiology
The physiology of Strychnos nux-vomica is characterized by a standard C3 photosynthetic pathway, which involves the direct fixation of carbon dioxide through the Calvin cycle within the mesophyll cells. As a C3 plant, it relies on the enzyme RuBisCO to catalyze the initial carboxylation step, a process that is efficient under temperate to tropical conditions but can be susceptible to photorespiration in high-temperature environments. Regarding its nutrient acquisition strategies, the plant is not a nitrogen fixer, meaning it lacks the symbiotic relationship with diazotrophic bacteria (such as Rhizobium) required to convert atmospheric nitrogen into usable forms; instead, it relies entirely on the uptake of nitrates and ammonium from the soil through its root system to support its metabolic processes and the synthesis of its complex indole alkaloids.
- Nitrogen fixer :
- no
- Photosynthetic pathway :
- C3
Reproduction
The reproduction of Strychnos nux-vomica is facilitated through the production of fruit and seeds, which are the primary agents for its propagation. The plant develops fleshy, globose fruits that eventually contain the seeds essential for the next generation. Morphological data regarding the seeds indicates a highly consistent physical profile, characterized by a specific seed mass. Specifically, the seed mass is recorded with a mean value of 1.19 g, a figure that remains constant across its observed range, as both the maximum and minimum seed mass values are also measured at 1.19 g. This uniformity in seed mass suggests a stable reproductive investment per seed, which is a critical factor in the plant's dispersal and establishment within its natural habitat.
- Seed mass mean:
- 1.19 g
Sources: Global Inventory of Floras and Traits (GIFT)
Plant Parts
Strychnos nux-vomica has 4 reported plant parts identified across 10 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include seed, leaf, root, stem.
| Plant part | Supporting sources | Consensus |
|---|---|---|
| Seed | 5 supporting sources | ★★★☆☆ |
| Leaf | 3 supporting sources | ★★☆☆☆ |
| Root | 1 supporting sources | ★☆☆☆☆ |
| Stem | 1 supporting sources | ★☆☆☆☆ |
Seed
- Phytochemical analysis : PCA
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Journal of ethnopharmacology
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Yao xue xue bao = Acta pharmaceutica Sinica
Leaf
- Pakistan journal of pharmaceutical sciences
- Journal de mycologie medicale
- Saudi journal of biological sciences
Root
- Journal of ethnopharmacology
Stem
- Saudi journal of biological sciences
Chemicals
Strychnos nux-vomica has 69 reported phytochemicals identified across 10 scientific publications and several other databases. The most consistently reported chemicals include strychnine, BRUCINE, Brucine N-oxide, Strychnine N-oxide, CHLOROGENIC ACID.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| strychnine | 17 supporting sources | ★★★★★ |
| BRUCINE | 12 supporting sources | ★★★★★ |
| Brucine N-oxide | 5 supporting sources | ★★★☆☆ |
| Strychnine N-oxide | 3 supporting sources | ★★☆☆☆ |
| CHLOROGENIC ACID | 2 supporting sources | ★☆☆☆☆ |
| Loganin | 2 supporting sources | ★☆☆☆☆ |
| 3-Methoxyicajine | 1 supporting sources | ★☆☆☆☆ |
| 4-Hydroxystrychnine | 1 supporting sources | ★☆☆☆☆ |
| Aluminium | 1 supporting sources | ★☆☆☆☆ |
| Anthraquinones | 1 supporting sources | ★☆☆☆☆ |
strychnine
- Dr. Duke
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Journal of separation science
- Chinese journal of integrative medicine
- Pakistan journal of pharmaceutical sciences
View 12 additional sources
- Lloydia
- Toxins
- Rapid communications in mass spectrometry : RCM
- Pharmaceutical biology
- Toxicon : official journal of the International Society on Toxinology
- Ancient science of life
- Journal - Association of Official Analytical Chemists
- European journal of pharmacology
- Journal of alternative and complementary medicine (New York, N.Y.)
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
- Yao xue xue bao = Acta pharmaceutica Sinica
BRUCINE
- Dr. Duke
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Journal of separation science
- Chinese journal of integrative medicine
- Pakistan journal of pharmaceutical sciences
View 7 additional sources
- Yao xue xue bao = Acta pharmaceutica Sinica
- Pharmaceutical biology
- Toxicon : official journal of the International Society on Toxinology
- Journal - Association of Official Analytical Chemists
- Journal of ethnopharmacology
- European journal of pharmacology
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Brucine N-oxide
- Dr. Duke
- Journal of separation science
- Pharmaceutical biology
- Journal of ethnopharmacology
- Yao xue xue bao = Acta pharmaceutica Sinica
Strychnine N-oxide
- Journal of separation science
- Pharmaceutical biology
- Yao xue xue bao = Acta pharmaceutica Sinica
CHLOROGENIC ACID
- Dr. Duke
- Pharmaceutical biology
Loganin
- Dr. Duke
- Pharmaceutical biology
3-Methoxyicajine
- Dr. Duke
4-Hydroxystrychnine
- Biotechnology and applied biochemistry
Aluminium
- Journal of complementary & integrative medicine
Anthraquinones
- Dose-response : a publication of International Hormesis Society
Activities
Strychnos nux-vomica has 172 reported activities identified across 10 scientific publications and several other databases. The most consistently reported activities include Analgesic, Antioxidant, 5-Alpha-Reductase-Inhibitor, Antialzheimeran, Antiandrogenic.
| Activity | Supporting sources | Consensus |
|---|---|---|
| Analgesic | 4 supporting sources | ★★☆☆☆ |
| Antioxidant | 4 supporting sources | ★★☆☆☆ |
| 5-Alpha-Reductase-Inhibitor | 2 supporting sources | ★☆☆☆☆ |
| Antialzheimeran | 2 supporting sources | ★☆☆☆☆ |
| Antiandrogenic | 2 supporting sources | ★☆☆☆☆ |
| Cancer-Preventive | 2 supporting sources | ★☆☆☆☆ |
| Hepatoprotective | 2 supporting sources | ★☆☆☆☆ |
| Immunostimulant | 2 supporting sources | ★☆☆☆☆ |
| Nematicide | 2 supporting sources | ★☆☆☆☆ |
| Aldose-Reductase-Inhibitor | 1 supporting sources | ★☆☆☆☆ |
Analgesic
- Dr. Duke
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Pakistan journal of pharmaceutical sciences
- Journal of ethnopharmacology
Antioxidant
- Dr. Duke
- Journal of ethnopharmacology
- Acta biologica Hungarica
- Pakistan journal of pharmaceutical sciences
5-Alpha-Reductase-Inhibitor
- Dr. Duke
- Pakistan journal of pharmaceutical sciences
Antialzheimeran
- Dr. Duke
- Pakistan journal of pharmaceutical sciences
Antiandrogenic
- Dr. Duke
- Pakistan journal of pharmaceutical sciences
Cancer-Preventive
- Dr. Duke
- Pakistan journal of pharmaceutical sciences
Hepatoprotective
- Dr. Duke
- Pakistan journal of pharmaceutical sciences
Immunostimulant
- Dr. Duke
- Pakistan journal of pharmaceutical sciences
Nematicide
- Dr. Duke
- Pakistan journal of pharmaceutical sciences
Aldose-Reductase-Inhibitor
- Dr. Duke
Medicinal Uses
Strychnos nux-vomica has 23 reported medicinal uses identified across 10 scientific publications and several other databases. The most consistently reported uses include analgesic, cancer, inflammation, Antioxidant, Immunostimulant.
Most Reported Uses
| Use | Sources | Consensus |
|---|---|---|
| analgesic | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 3 sources) | ★★☆☆☆ |
| cancer | Cancer letters (and other 2 sources) | ★☆☆☆☆ |
| inflammation | Chinese journal of integrative medicine (and other 2 sources) | ★☆☆☆☆ |
| Antioxidant | Pakistan journal of pharmaceutical sciences (and other 1 sources) | ★☆☆☆☆ |
| Immunostimulant | Pakistan journal of pharmaceutical sciences (and other 1 sources) | ★☆☆☆☆ |
| angiogenesis | Cancer letters (and other 1 sources) | ★☆☆☆☆ |
| antidepressant | Pakistan journal of pharmaceutical sciences (and other 1 sources) | ★☆☆☆☆ |
| antipsychotic | Pakistan journal of pharmaceutical sciences (and other 1 sources) | ★☆☆☆☆ |
| arthritis | Chinese journal of integrative medicine (and other 1 sources) | ★☆☆☆☆ |
| atherosclerosis | Inflammation (and other 1 sources) | ★☆☆☆☆ |
Preparations
| Preparations | Sources | Consensus |
|---|---|---|
| Different solvent extracts of leaves | Journal de mycologie medicale (and other 1 sources) | ★☆☆☆☆ |
| Semen Strychni | Phytochemical analysis : PCA (and other 1 sources) | ★☆☆☆☆ |
| alcoholic extract of the seeds | Phytomedicine : international journal of phytotherapy and phytopharmacology (and other 1 sources) | ★☆☆☆☆ |
| dry seeds | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 1 sources) | ★☆☆☆☆ |
| leaf extract | Saudi journal of biological sciences (and other 1 sources) | ★☆☆☆☆ |
| methanolic extract | Journal of ethnopharmacology (and other 1 sources) | ★☆☆☆☆ |
| partially purified fractions | Journal of ethnopharmacology (and other 1 sources) | ★☆☆☆☆ |
| plant extracts | Journal of ethnopharmacology (and other 1 sources) | ★☆☆☆☆ |
| powdered | Journal of complementary & integrative medicine (and other 1 sources) | ★☆☆☆☆ |
| processed seeds | Yao xue xue bao = Acta pharmaceutica Sinica (and other 1 sources) | ★☆☆☆☆ |