Stephania rotunda

Stephania rotunda · Accepted scientific name

Scientific literature: Sparse (94 studies) · ★★☆☆☆

Stephania rotunda, scientifically known as Stephania rotunda, is a climbing medicinal shrub native to tropical regions. Renowned for its diverse pharmacological properties, this plant is traditionally utilized in folk medicine to treat various ailments. Its bioactive compounds offer significant potential for developing new therapeutic agents in modern herbal pharmacology.

Family
Menispermaceae
Native range
Asia-Temperate
Parts used
Root
Common names
Not available
Scientific synonyms
Menispermum Roxburghii · Clypea Glabra · 4 more

Names and Synonyms

Scientific Names

Accepted name

Stephania rotunda

Synonyms

Sources: Wikidata, Catalogue of Life

Taxonomical Classification

This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta within the class Equisetopsida. As a member of the subclass Magnoliidae and the order Ranunculales, it is further categorized into the family Menispermaceae. Ultimately, its taxonomic identity is defined by its placement in the genus Stephania.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Ranunculales
Family Menispermaceae
Genus Stephania

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant exhibits a broad distribution across several key regions in Asia. In China, it can be found growing specifically within the Tibet region. Its presence extends into the Indian Subcontinent, where it is located in Assam and throughout India. Furthermore, the species is distributed across Bangladesh and the East Himalaya area. These diverse locations highlight the wide ecological range of Stephanotis rotundata.

Region Area
China Tibet
Indian Subcontinent Assam
Indian Subcontinent Bangladesh
Indian Subcontinent East Himalaya
Indian Subcontinent India
Indian Subcontinent Nepal
Indian Subcontinent West Himalaya
Indo-China Cambodia
Indo-China Laos
Indo-China Myanmar

Sources: The World Checklist of Vascular Plants (WCVP)

Botanical Identification

Ecology

The ecology of Stephania rotunda is characterized by its specific distribution across varying altitudinal gradients, where it thrives within a defined vertical niche. This species is typically found inhabiting mid-altitude montane environments, occupying an elevational range that extends from a minimum of 600 m AMSL to a maximum of 1600 m AMSL. Within this altitudinal belt, the plant adapts to the specific temperature regimes, moisture availability, and soil compositions characteristic of these subtropical or tropical highland zones. Its presence within this specific range suggests a specialized ecological requirement for the atmospheric conditions and environmental pressures found between these two elevations.

Elevational range max:
1600 m AMSL
Elevational range min:
600 m AMSL

Life history

The life history of Stephania rotunda is characterized by its status as a perennial plant, allowing it to persist through multiple growing seasons. In terms of its ecological classification and growth habit, the species is categorized as a phanerophyte, specifically exhibiting traits consistent with both phanerophyte and nanophanerophyte life forms. This indicates that its perennating buds are located high above the ground, supporting its specialized development over time.

Life form :
phanerophyte
Lifecycle :
perennial

Morphology

The morphology of Stephania rotunda is characterized by its specialized growth habit and structural composition. It functions as an obligatory climber, relying on external structures for support to ascend. While its growth form is categorized under other developmental types, it specifically exhibits a shrub-like structure in its physical presence. The plant is terrestrial in nature rather than epiphytic, establishing itself within the soil substrate. Furthermore, its stem architecture is non-woody, lacking the rigid lignification found in truly woody species.

Climber :
obligatory
Epiphyte :
terrestrial
Growth form :
other
Growth form :
shrub
Woodiness :
non-woody

Physiology

The physiology of Stephanotis rotundifolia (often referred to in botanical contexts as Stephanotis, though noted here as Stephanis rotundis) is characterized by a standard metabolic framework typical of many woody climbers. The plant utilizes a C3 photosynthetic pathway, meaning it fixes carbon dioxide through the Calvin cycle using the enzyme RuBisCO, a process that is most efficient under moderate temperatures and well-watered conditions. Furthermore, this species does not function as a nitrogen fixer, lacking the symbiotic relationship with nitrogen-fixing bacteria (such as Rhizobium or Frankia) required to convert atmospheric nitrogen into bioavailable forms.

Nitrogen fixer :
no
Photosynthetic pathway :
C3

Sources: Global Inventory of Floras and Traits (GIFT)

Plant Parts

Stephania rotunda has 1 reported plant parts identified across 1 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include root.

Plant parts reported in Stephania rotunda
Plant part Supporting sources Consensus
Root 1 supporting sources ★☆☆☆☆

Root

  1. Journal of ethnopharmacology

Chemicals

Stephania rotunda has 21 reported phytochemicals identified across 1 scientific publications and several other databases. The most consistently reported chemicals include tetrahydropalmatine, Dehydrocorydalmine, Palmatine, stepharanine, (+)-Pronuciferine.

Chemicals reported in Stephania rotunda
Chemical Supporting sources Consensus
tetrahydropalmatine 3 supporting sources ★★☆☆☆
Dehydrocorydalmine 2 supporting sources ★☆☆☆☆
Palmatine 2 supporting sources ★☆☆☆☆
stepharanine 2 supporting sources ★☆☆☆☆
(+)-Pronuciferine 1 supporting sources ★☆☆☆☆
(-)-Stepholidine 1 supporting sources ★☆☆☆☆
(-)-corydalmine 1 supporting sources ★☆☆☆☆
Bisbenzylisoquinolines 1 supporting sources ★☆☆☆☆
Columbamine 1 supporting sources ★☆☆☆☆
Corydalmine 1 supporting sources ★☆☆☆☆

tetrahydropalmatine

  1. Dr. Duke
  2. ACS omega
  3. Natural product communications

Dehydrocorydalmine

  1. Dr. Duke
  2. Journal of Asian natural products research

Palmatine

  1. Dr. Duke
  2. Journal of Asian natural products research

stepharanine

  1. Dr. Duke
  2. Journal of Asian natural products research

(+)-Pronuciferine

  1. Dr. Duke

(-)-Stepholidine

  1. Dr. Duke

(-)-corydalmine

  1. Dr. Duke

Bisbenzylisoquinolines

  1. Natural product research

Columbamine

  1. Dr. Duke

Corydalmine

  1. Dr. Duke

Activities

Stephania rotunda has 51 reported activities identified across 1 scientific publications and several other databases. The most consistently reported activities include Analgesic, Antiplasmodial, Antipyretic, Abortifacient, Adrenocorticotrophic.

Activities reported in Stephania rotunda
Activity Supporting sources Consensus
Analgesic 2 supporting sources ★☆☆☆☆
Antiplasmodial 2 supporting sources ★☆☆☆☆
Antipyretic 2 supporting sources ★☆☆☆☆
Abortifacient 1 supporting sources ★☆☆☆☆
Adrenocorticotrophic 1 supporting sources ★☆☆☆☆
Antiaggregant 1 supporting sources ★☆☆☆☆
Antialopecic 1 supporting sources ★☆☆☆☆
Antialzheimeran? 1 supporting sources ★☆☆☆☆
Antiarrhythmic 1 supporting sources ★☆☆☆☆
Antiarthritic 1 supporting sources ★☆☆☆☆

Analgesic

  1. Dr. Duke
  2. Natural product research

Antiplasmodial

  1. Dr. Duke
  2. Journal of ethnopharmacology

Antipyretic

  1. Dr. Duke
  2. Natural product research

Abortifacient

  1. Dr. Duke

Adrenocorticotrophic

  1. Dr. Duke

Antiaggregant

  1. Dr. Duke

Antialopecic

  1. Dr. Duke

Antialzheimeran?

  1. Dr. Duke

Antiarrhythmic

  1. Dr. Duke

Antiarthritic

  1. Dr. Duke

Conditions

Stephania rotunda has 5 reported investigations on conditions identified across 1 scientific publications and several other databases. The most consistently reported conditions include asthma, cancer, fever, headache, malaria.

Conditions investigated for Stephania rotunda
Condition Supporting sources Consensus
Asthma 1 supporting sources ★☆☆☆☆
Cancer 1 supporting sources ★☆☆☆☆
Fever 1 supporting sources ★☆☆☆☆
Headache 1 supporting sources ★☆☆☆☆
Malaria 1 supporting sources ★☆☆☆☆

Asthma

  1. Journal of ethnopharmacology

Cancer

  1. Journal of ethnopharmacology

Fever

  1. Journal of ethnopharmacology

Headache

  1. Journal of ethnopharmacology

Malaria

  1. Journal of ethnopharmacology

Preparations

Stephania rotunda has 2 reported preparations identified across 1 scientific publications and several other databases. The most consistently reported preparations include aqueous extracts, dichloromethane extracts.

Preparations reported for Stephania rotunda
Preparation Supporting sources Consensus
Aqueous extracts 1 supporting sources ★☆☆☆☆
Dichloromethane extracts 1 supporting sources ★☆☆☆☆

Aqueous extracts

  1. Journal of ethnopharmacology

Dichloromethane extracts

  1. Journal of ethnopharmacology