Sophora pachycarpa
Sophora pachycarpa · Accepted scientific name
Scientific literature: Very Sparse (1 studies) · ★☆☆☆☆
Sophora pachycarpa is a specialized plant species primarily recognized for the potent bioactive compounds found within its roots. This botanical specimen contains significant chemical constituents such as Sophoraflavanone G, Isosophoranone, and 2-(4-Hydroxyphenyl)-2,3-dihydrobenzo[b]furan-3,4,6-triol. Due to these unique properties, the plant exhibits diverse biological activities, including acting as a 5-HETE-inhibitor and an acidifier. Furthermore, its chemical profile allows it to function as both an acaricide and an abortifacient in specific contexts. Understanding these multifaceted characteristics is essential for exploring the plant's potential applications in pharmacology and chemistry.
- Synonyms
- Ammothamnus Intermedius · Goebelia Pachycarpa · 1 more
- Common names
- Not available
- Family
- Fabaceae
- Distribution
- Not available
- Plant Parts
- Root
Classification
Common Names
Sophora pachycarpa is a distinctive plant known by several different names across various regions. In Russian-speaking areas, it is commonly referred to as Софора толстоплодная. Moving to East Asian contexts, the species is also recognized by the name 厚果槐. These diverse linguistic labels reflect the plant's wide geographical reach and cultural presence. Understanding these common names helps botanists and enthusiasts identify the species regardless of their native language.
Sources: Catalogue of Life (COL)
Synonyms
Sophora pachycarpa is a botanical species that has been classified under several different names throughout its taxonomic history. For those researching its lineage, it is important to recognize that it is officially considered a synonym of Ammothamnus intermedius. The plant has also been identified in scientific literature as Goebelia pachycarpa. Furthermore, taxonomic records list Vexibia pachycarpa as another valid synonym for this specific plant. Understanding these various designations is essential for accurate identification and study within the botanical community.
Sources: The World Checklist of Vascular Plants (WCVP)
Taxonomy
Sophora pachycarpa is a distinguished member of the kingdom Plantae. This plant belongs to the genus Sophora, which places it within the diverse order Fabales. As a representative of the family Fabaceae, it shares biological traits with many well-known legumes. Furthermore, its classification is defined by its placement within the class Equisetopsida. Understanding these taxonomic relationships provides essential insight into the botanical identity of this species.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Fabales |
| Family | Fabaceae |
| Genus | Sophora |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
Geographic Regions
Sophora pachycarpa is a resilient species primarily found within the Asia-Temperate region. Its natural distribution is concentrated across the diverse landscapes of Central Asia. Specifically, this plant thrives in the varied terrains of Kazakhstan and Kirgizstan. It also maintains a notable presence throughout the territories of Tadzhikistan and Turkmenistan. Finally, the species can be found growing within the borders of Uzbekistan, completing its regional range.
Sources: The World Checklist of Vascular Plants (WCVP)
Identification
Morphology
Sophora pachycarpa is a herbaceous plant characterized by its distinct growth form. This species typically maintains a modest stature, reaching a maximum height of 0.6 meters. Most individuals generally stay within a height range of 0.3 to 0.6 meters.
Sources: Global Inventory of Floras and Traits (GIFT)
Biological Activities
Sophora pachycarpa has demonstrated significant biological potential through the isolation of various prenylated flavonoids from its roots. Research indicates that several constituents from this plant exhibit notable cytotoxic activity against multiple human cancer cell lines, including A2780, A549, HeLa, and HCT116. Among the identified compounds, alopecurone J emerged as the most potent agent, showing strong inhibitory effects against these cancer cells. Furthermore, these substances display significant histone deacetylase (HDAC) inhibitory activities, which are crucial for their medicinal impact. Molecular docking studies further support these findings by suggesting a high level of selectivity toward the HDAC8 enzyme.
Compounds
Sophora pachycarpa is a plant species that serves as a significant source of diverse bioactive compounds. Research conducted on its roots has successfully isolated several prenylated flavonoids with notable medicinal potential. Specifically, the plant contains Sophoraflavanone G, a compound identified alongside other unique chemical constituents. Additionally, the roots of Sophora pachycarpa are known to contain Isosophoranone. These findings highlight the complex chemical profile of the plant and its relevance in pharmacological studies.
Conditions
Sophora pachycarpa demonstrates significant therapeutic potential through its ability to treat various malignant cell lines. Specifically, extracts and compounds from this plant have shown cytotoxic and apoptogenic effects against A549 cells. The plant also effectively targets HeLa cells, which were identified as particularly sensitive to its treatment. Furthermore, Sophora pachycarpa exhibits activity against the A2780 cancer cell line. Finally, research confirms its effectiveness in treating HCT116 cells and HL-60 cells.
Preparations
Parts used
Sophora pachycarpa is a member of the Fabaceae family that shows significant promise in medicinal research. Recent studies have specifically focused on the medicinal properties of the plant's root to explore its therapeutic potential. Researchers have successfully isolated various prenylated flavonoids and flavonostilbenes, such as alopecurone J and P, from these root extracts. These compounds have demonstrated potent cytotoxic effects against several human cancer cell lines, including HeLa and MCF-7. Furthermore, the bioactive constituents found in the roots exhibit histone deacetylase inhibitory activities, suggesting that the plant could serve as a valuable source for future chemotherapeutic agents.