shrubby sophora

Sophora flavescens · Accepted scientific name

Scientific literature: Very Extensive (377 studies) · ★★★★★

Shrubby sophora, scientifically known as Sophora flavescens, is a perennial medicinal herb renowned in traditional Chinese medicine. Primarily utilized for its potent roots, this plant contains bioactive alkaloids that offer significant anti-inflammatory, antibacterial, and hepatoprotective properties, making it a vital resource in treating various skin and liver conditions.

Family
Fabaceae
Native range
Europe
Parts used
Root · Seed
Common names
Shrubby Sophora
Scientific synonyms
Radiusia Flavescens

Names and Synonyms

Common Names

Scientific Names

Accepted name

Sophora flavescens

Synonyms

Sources: Wikidata, Catalogue of Life

Taxonomical Classification

This plant belongs to the kingdom Plantae and the phylum Streptophyta, falling under the class Equisetopsida and subclass Magnoliidae. Within the order Fabales, it is classified under the family Fabaceae. It is further identified by the genus Sophora, specifically as the species Sophora flavescens.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Fabales
Family Fabaceae
Genus Sophora

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant exhibits a wide-ranging geographical distribution across various regions of Eurasia. In Northern Europe, its presence can be identified within Great Britain. The species is also extensively found throughout Siberia, specifically in the Altay, Chita, and Irkutsk regions. Furthermore, it extends into the Russian Far East, particularly in the Amur area. These diverse locations highlight the plant's ability to thrive in distinct northern and eastern habitats.

Region Area
Northern Europe Great Britain
Siberia Altay
Siberia Chita
Siberia Irkutsk
Russian Far East Amur
Russian Far East Khabarovsk
Russian Far East Primorye
China China South-Central
China Hainan
China Inner Mongolia

Sources: The World Checklist of Vascular Plants (WCVP)

Botanical Identification

Ecology

The ecology of Sophora flavescens is characterized by its ability to thrive in disturbed environments, most notably within crop fields where it often grows as a spontaneous or opportunistic species. In these agricultural settings, the plant adapts to the modified soil structures and varying nutrient availability typical of cultivated lands. Its presence in such habitats suggests a tolerance for anthropogenically influenced landscapes, allowing it to establish itself alongside primary crops. The ecological niche it occupies within these fields is often defined by its resilience to land management practices and its ability to utilize the open space and sunlight available in disturbed soil profiles.

Habitat :
crop fields

Life history

The life history of Sophora flavescens is characterized by its status as a perennial herb, allowing the plant to establish a long-term presence in its natural habitat through a robust underground root system. As a perennial species, it does not complete its life cycle in a single growing season but instead undergoes repeated cycles of vegetative growth and seasonal dormancy. The plant typically spends much of its energy developing a thick, tuberous taproot, which serves as a vital nutrient and water storage organ, enabling it to survive unfavorable environmental conditions and regrow during favorable seasons. Its developmental stages involve the emergence of compound leaves and the eventual production of inflorescences, leading to seed formation which facilitates dispersal and the establishment of new individuals within the ecosystem.

Lifecycle :
perennial

Morphology

The morphology of Sophora flavescens is characterized by its growth as a self-supporting herb with a woody structure. It typically exhibits a plant height ranging from a minimum of 0.5 m to a maximum of 0.7 m. Regarding its ecological habit, the plant is classified as terrestrial rather than aquatic or semiaquatic, and it functions as an independent organism without parasitic tendencies. As an epiphyte, it maintains a terrestrial existence, and its overall growth form is consistently identified as a herb.

Aquatic :
terrestrial
Climber :
self-supporting
Epiphyte :
terrestrial
Growth form :
herb
Parasite :
independent
Plant height max:
0.7 m
Plant height min:
0.5 m
Woodiness :
woody

Physiology

The physiology of Sophora flavescens is fundamentally characterized by a C3 photosynthetic pathway, a metabolic strategy common to most dicotyledonous woody shrubs and perennials. Under this pathway, the initial fixation of atmospheric carbon dioxide occurs through the enzyme Rubisco, resulting in the formation of a three-carbon compound, 3-phosphoglycerate. This carbon fixation process is integrated into the Calvin cycle to facilitate the synthesis of carbohydrates required for the plant's structural growth and the production of its characteristic secondary metabolites. The plant's physiological efficiency is closely tied to its stomatal conductance and transpiration rates, which regulate gas exchange and water use efficiency in response to environmental stressors. Furthermore, its metabolic framework supports the complex biosynthetic pathways necessary for the accumulation of bioactive alkaloids and flavonoids, which serve both as defense mechanisms and as key chemical constituents of the species.

Photosynthetic pathway :
C3

Reproduction

The reproduction of Sophora flavescens is characterized by a specific seasonal flowering cycle and highly consistent seed characteristics. The flowering period is concentrated in the month of July, marking a distinct window for pollination. Following the flowering stage, the plant produces seeds that exhibit remarkable uniformity in weight; the seed mass remains constant across all measured parameters, with a minimum, maximum, and mean mass all recorded at 0.03504 g. This precise seed mass suggests a highly stabilized reproductive output per individual seed.

Flowering time :
Jul
Seed mass mean:
0.03504 g

Sources: Global Inventory of Floras and Traits (GIFT)

Plant Parts

Sophora flavescens has 2 reported plant parts identified across 21 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include root, seed.

Plant parts reported in Sophora flavescens
Plant part Supporting sources Consensus
Root 20 supporting sources ★★★★★
Seed 1 supporting sources ★☆☆☆☆

Root

  1. Molecules (Basel, Switzerland)
  2. Phytotherapy research : PTR
  3. Pulmonary pharmacology & therapeutics
  4. Bioorganic chemistry
  5. Journal of natural products
View 15 additional sources
  1. Bioorganic & medicinal chemistry letters
  2. Journal of ethnopharmacology
  3. Plant physiology
  4. Scientific reports
  5. Yao xue xue bao = Acta pharmaceutica Sinica
  6. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  7. Natural product research
  8. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  9. Planta medica
  10. BMC genomics
  11. Frontiers in microbiology
  12. Fitoterapia
  13. Archives of pharmacal research
  14. Scientific data
  15. Toxicology in vitro : an international journal published in association with BIBRA

Seed

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Chemicals

Sophora flavescens has 82 reported phytochemicals identified across 21 scientific publications and several other databases. The most consistently reported chemicals include Matrine, Oxymatrine, Flavonoids, Sophoraflavanone G, Kurarinone.

Chemicals reported in Sophora flavescens
Chemical Supporting sources Consensus
Matrine 15 supporting sources ★★★★★
Oxymatrine 14 supporting sources ★★★★★
Flavonoids 9 supporting sources ★★★★☆
Sophoraflavanone G 8 supporting sources ★★★★☆
Kurarinone 7 supporting sources ★★★★☆
Sophoridine 6 supporting sources ★★★☆☆
Trifolirhizin 4 supporting sources ★★☆☆☆
Kushenol A 3 supporting sources ★★☆☆☆
Maackiain 3 supporting sources ★★☆☆☆
Oxysophocarpine 3 supporting sources ★★☆☆☆

Matrine

  1. Journal of ethnopharmacology
  2. Scientific reports
  3. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  4. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  5. Biological & pharmaceutical bulletin
View 10 additional sources
  1. Pharmaceuticals (Basel, Switzerland)
  2. Frontiers in pharmacology
  3. Molecular plant-microbe interactions : MPMI
  4. The American journal of Chinese medicine
  5. Frontiers in microbiology
  6. Molecules (Basel, Switzerland)
  7. Medical oncology (Northwood, London, England)
  8. Analytical and bioanalytical chemistry
  9. Letters in applied microbiology
  10. Journal of chromatography. A

Oxymatrine

  1. European journal of pharmacology
  2. Journal of ethnopharmacology
  3. Scientific reports
  4. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  5. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
View 9 additional sources
  1. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  2. Pharmaceuticals (Basel, Switzerland)
  3. PloS one
  4. Medical science monitor : international medical journal of experimental and clinical research
  5. Frontiers in microbiology
  6. Analytical and bioanalytical chemistry
  7. OncoTargets and therapy
  8. Letters in applied microbiology
  9. Journal of chromatography. A

Flavonoids

  1. Yao xue xue bao = Acta pharmaceutica Sinica
  2. Journal of ethnopharmacology
  3. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  4. Journal of leukocyte biology
  5. Fitoterapia
View 4 additional sources
  1. Frontiers in plant science
  2. Scientific data
  3. Chinese journal of natural medicines
  4. Chinese herbal medicines

Sophoraflavanone G

  1. Dr. Duke
  2. Molecules (Basel, Switzerland)
  3. Phytochemistry
  4. Natural product communications
  5. Journal of ethnopharmacology
View 3 additional sources
  1. Genes
  2. Journal of advanced research
  3. Analytical and bioanalytical chemistry

Kurarinone

  1. Journal of natural products
  2. Natural product communications
  3. Genes
  4. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  5. Journal of advanced research
View 2 additional sources
  1. Analytical and bioanalytical chemistry
  2. Chinese herbal medicines

Sophoridine

  1. Journal of ethnopharmacology
  2. Scientific reports
  3. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  4. Pharmaceuticals (Basel, Switzerland)
  5. Frontiers in microbiology
View 1 additional sources
  1. Molecules (Basel, Switzerland)

Trifolirhizin

  1. Journal of natural products
  2. Scientific reports
  3. Molecules (Basel, Switzerland)
  4. International journal of molecular sciences

Kushenol A

  1. Molecules (Basel, Switzerland)
  2. Pulmonary pharmacology & therapeutics
  3. Genes

Maackiain

  1. Scientific reports
  2. Natural product research
  3. International journal of molecular sciences

Oxysophocarpine

  1. Journal of ethnopharmacology
  2. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  3. Pharmaceuticals (Basel, Switzerland)

Activities

Sophora flavescens has 33 reported activities identified across 21 scientific publications and several other databases. The most consistently reported activities include Antioxidant, Antibacterial, Antitumor, Estrogenic, Cytotoxic.

Activities reported in Sophora flavescens
Activity Supporting sources Consensus
Antioxidant 5 supporting sources ★★★☆☆
Antibacterial 4 supporting sources ★★☆☆☆
Antitumor 4 supporting sources ★★☆☆☆
Estrogenic 4 supporting sources ★★☆☆☆
Cytotoxic 3 supporting sources ★★☆☆☆
Anticancer 2 supporting sources ★☆☆☆☆
Antimicrobial 2 supporting sources ★☆☆☆☆
Diuretic 2 supporting sources ★☆☆☆☆
Abortifacient 1 supporting sources ★☆☆☆☆
Anthelmintic 1 supporting sources ★☆☆☆☆

Antioxidant

  1. Pharmaceuticals (Basel, Switzerland)
  2. Molecules (Basel, Switzerland)
  3. Journal of ethnopharmacology
  4. BMC genomics
  5. Chinese herbal medicines

Antibacterial

  1. Journal of ethnopharmacology
  2. Journal of natural products
  3. Antibiotics (Basel, Switzerland)
  4. BMC genomics

Antitumor

  1. Journal of ethnopharmacology
  2. BMC genomics
  3. Medical oncology (Northwood, London, England)
  4. Chinese herbal medicines

Estrogenic

  1. Dr. Duke
  2. Journal of natural products
  3. Environmental toxicology and pharmacology
  4. Phytotherapy research : PTR

Cytotoxic

  1. Dr. Duke
  2. Molecules (Basel, Switzerland)
  3. Toxicology in vitro : an international journal published in association with BIBRA

Anticancer

  1. Phytomedicine : international journal of phytotherapy and phytopharmacology
  2. Scientific reports

Antimicrobial

  1. Journal of ethnopharmacology
  2. Chinese herbal medicines

Diuretic

  1. Phytomedicine : international journal of phytotherapy and phytopharmacology
  2. Chinese herbal medicines

Abortifacient

  1. Dr. Duke

Anthelmintic

  1. Chinese herbal medicines

Conditions

Sophora flavescens has 67 reported investigations on conditions identified across 21 scientific publications and several other databases. The most consistently reported conditions include cancer, breast cancer, dysentery, antioxidant, asthma.

Conditions investigated for Sophora flavescens
Condition Supporting sources Consensus
Cancer 4 supporting sources ★★☆☆☆
Breast cancer 3 supporting sources ★★☆☆☆
Dysentery 3 supporting sources ★★☆☆☆
Antioxidant 2 supporting sources ★☆☆☆☆
Asthma 2 supporting sources ★☆☆☆☆
Chronic hepatitis b 2 supporting sources ★☆☆☆☆
Eczema 2 supporting sources ★☆☆☆☆
Inflammation 2 supporting sources ★☆☆☆☆
Jaundice 2 supporting sources ★☆☆☆☆
Non-small cell lung cancer 2 supporting sources ★☆☆☆☆

Cancer

  1. Frontiers in pharmacology
  2. Scientific reports
  3. Toxicon : official journal of the International Society on Toxinology
  4. Chinese herbal medicines

Breast cancer

  1. Journal of natural products
  2. Frontiers in oncology
  3. OncoTargets and therapy

Dysentery

  1. Yao xue xue bao = Acta pharmaceutica Sinica
  2. Journal of ethnopharmacology
  3. Chinese herbal medicines

Antioxidant

  1. Journal of ethnopharmacology
  2. BMC genomics

Asthma

  1. Journal of ethnopharmacology
  2. Journal of integrative medicine

Chronic hepatitis b

  1. The American journal of Chinese medicine
  2. The Cochrane database of systematic reviews

Eczema

  1. Journal of ethnopharmacology
  2. Yao xue xue bao = Acta pharmaceutica Sinica

Inflammation

  1. Journal of ethnopharmacology
  2. Journal of leukocyte biology

Jaundice

  1. Journal of ethnopharmacology
  2. Chinese herbal medicines

Non-small cell lung cancer

  1. Pulmonary pharmacology & therapeutics
  2. Toxicon : official journal of the International Society on Toxinology

Preparations

Sophora flavescens has 49 reported preparations identified across 21 scientific publications and several other databases. The most consistently reported preparations include roots, traditional Chinese medicine, Aqueous extract, Cell suspension cultures, Compound Kushen Injection (CKI).

Preparations reported for Sophora flavescens
Preparation Supporting sources Consensus
Roots 2 supporting sources ★☆☆☆☆
Traditional chinese medicine 2 supporting sources ★☆☆☆☆
Aqueous extract 1 supporting sources ★☆☆☆☆
Cell suspension cultures 1 supporting sources ★☆☆☆☆
Compound kushen injection (cki) 1 supporting sources ★☆☆☆☆
Dried root 1 supporting sources ★☆☆☆☆
Extracts 1 supporting sources ★☆☆☆☆
Herbal extracts 1 supporting sources ★☆☆☆☆
Kushen tang 1 supporting sources ★☆☆☆☆
Kushen decoction 1 supporting sources ★☆☆☆☆

Roots

  1. Bioorganic chemistry
  2. Journal of natural products

Traditional chinese medicine

  1. Molecules (Basel, Switzerland)
  2. Fitoterapia

Aqueous extract

  1. The American journal of Chinese medicine

Cell suspension cultures

  1. Phytochemistry

Compound kushen injection (cki)

  1. Frontiers in oncology

Dried root

  1. Botanical studies

Extracts

  1. Journal of ethnopharmacology

Herbal extracts

  1. Journal of microbiology (Seoul, Korea)

Kushen tang

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Kushen decoction

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica