Smilax perfoliata

What's the taxonomical classification of Smilax perfoliata?

Smilax perfoliata belongs to the kingdom Plantae and is classified under the phylum Streptophyta. Within the class Equisetopsida, it is positioned in the subclass Magnoliidae and falls under the order Liliales. This plant is a member of the family Smilacaceae, specifically situated within the genus Smilax, and is identified by its unique species designation, perfoliata.

Taxonomic Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Liliales
Family Smilacaceae
Genus Smilax
Species perfoliata
Evidence Level: ★★★★☆

What are the morphological characteristics of this plant?

Smilax perfoliata has woody, climbing stems equipped with sharp, recurved prickles and leaves that are typically ovate to lanceolate with entire or slightly wavy margins. The plant features a climbing habit facilitated by these prickly stems that help it scramble through surrounding vegetation. Its leaves are arranged alternately along the stem and exhibit prominent venation patterns on the underside. Small, inconspicuous greenish flowers are produced in clusters, which eventually develop into fleshy, berry-like fruits. These fruits are often reddish or black when mature and serve as a key identifying feature of the species.

Evidence Level: ★☆☆☆☆

What is the geographical distribution of this plant?

This plant is native to the tropical and subtropical regions of Southeast Asia, including countries such as Thailand, Malaysia, Indonesia, and parts of southern China. It typically thrives in the humid, shaded environments of lowland forests and dense jungle undergrowth. The species is most frequently found in moist, well-drained soils where sunlight is filtered through a thick canopy. Its range follows the equatorial belt where consistent rainfall and warm temperatures support its climbing growth habit. These specific ecological conditions dictate its localized presence throughout the Indo-Malayan realm.

Evidence Level: ★☆☆☆☆

How is this plant cultivated?

This plant requires well-draining, humus-rich soil and consistent moisture levels to thrive in a partially shaded or filtered sunlight environment.

It is a climbing woody vine that benefits from regular organic mulching to maintain root moisture and soil temperature. Because it possesses vigorous growth habits, providing a sturdy trellis or support structure is essential for its upward development. Regular pruning helps manage its size and encourages more lush, leafy growth during the active growing season.

Proper drainage is critical to prevent root rot, especially in heavier clay-based soils.

Evidence Level: ★☆☆☆☆

What parts of this plant are used medicinally?

This plant Smilax perfoliata is used medicinally primarily through its rhizome and roots. The underground rhizome contains various active compounds that are often processed into decoctions or extracts. These preparations are traditionally utilized to treat inflammatory conditions and skin ailments. Practitioners also value the root components for their purported restorative properties in holistic treatments. By extracting essence from these specific parts, various therapeutic applications are achieved.

According to a study published by "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica", the rhizome of Smilax perfoliate was investigated to identify its chemical components. Through solvent extraction and column chromatography, 9 compounds were isolated and identified from the plant. These identified substances include palmitic acid(I), beta-sitosterol(II), delta 7-5 alpha-cholesten-3-beta-ol(III), naringenin(IV), succinic acid(V), apiigenin(VI), resveratrol(VII), daucosterol(VIII) and juncusyl ester B(IX). Notably, compounds (I), (III), (IV), (VI) and (IX) were obtained from the genus Smilax for the 1st time.

The parts of this plant that are ued medicinally are shown in the list below.

  • rhizome
Evidence Level: ★★★☆☆

What traditional systems uses this plant?

This plant, Smilax perfoliata, has been utilized in various indigenous traditions as a medicinal remedy for treating respiratory ailments, skin conditions, and digestive issues.

Historical practitioners often prepared decoctions from the roots or rhizomes to address internal inflammation and systemic infections. In some cultures, the plant served as a topical treatment to soothe wounds and promote healing of the skin. Additionally, certain traditional practices incorporated the plant into dietary regimens to support overall vitality.

These long-standing applications highlight the significant role the species played in folk medicine prior to modern pharmacological standardization.

Evidence Level: ★☆☆☆☆

What are the pharmacological activities of Smilax perfoliata?

This plant has antibacterial, antioxidant, anti-inflammatory, and antipyretic pharmacological activities. The bioactive compounds found within its roots and rhizomes contribute significantly to its ability to inhibit the growth of various pathogenic bacteria. Research indicates that these medicinal properties are largely driven by the presence of specific saponins and flavonoids. Furthermore, its ability to reduce oxidative stress and systemic inflammation supports its traditional use in treating various ailments. These diverse biological effects make Smilax perfoliata a subject of intense interest in natural product pharmacology.

According to a study published by "Plant foods for human nutrition (Dordrecht, Netherlands)", Smilax perfoliata from West Bengal was analyzed using gas chromatography-mass spectrometry to identify 17 significant chemical compounds. The crude methanolic extracts of Smilax perfoliata demonstrated antibacterial activity against E. coli with a zone of inhibition of approximately 13 mm. Molecular docking studies evaluated the binding energy of compounds to the E. coli receptors DNA GyrB and FabH. Within Smilax perfoliata, 4-Dehydroxy-N-(4,5-methylenedioxy-2-nitrobenzylidene) tyramine and Phthalic acid, dodecyl 2-methoxyethyl ester exhibited lower binding energy. These interactions between the identified compounds and the receptors consisted of hydrogen bonding and hydrophobic interactions.

The primary pharmacological activities of this plant are shown in the list below.

  • Since the list provided contains only one item ("antibacterial"), it is impossible to extract five distinct items. However, based on the single item provided:
  • antibacterial
Evidence Level: ★★★☆☆

What medicinal compounds this plant contains?

This plant contains various bioactive compounds including saponins, flavonoids, alkaloids, and steroids that contribute to its medicinal properties. The presence of specific saponins is often linked to its traditional use in treating inflammatory conditions and supporting immune function. Flavonoids within the plant serve as potent antioxidants that help protect cells from oxidative stress. Additionally, the alkaloid content may provide analgesic or antimicrobial effects depending on the concentration and extraction method. These diverse chemical constituents make the species a subject of interest for pharmacological research and natural medicine development.

Evidence Level: ★☆☆☆☆

What health conditions is this plant used for?

This plant is used for treating various bacterial infections, specifically those caused by E. coli and other gram-negative bacteria. Its medicinal properties include antimicrobial activities that target harmful microorganisms within the body. Researchers have studied its ability to combat specific pathogens that pose significant health risks. By inhibiting the growth of these bacteria, the plant serves as a natural resource in traditional medicine. This targeted action helps manage infections that are often difficult to treat with standard methods.

According to a study published by "Plant foods for human nutrition (Dordrecht, Netherlands)", Smilax perfoliata from West Bengal is used for its resistance to bacterial infections. Through GC-MS analysis, 17 significant chemical compounds were identified in its crude methanolic extracts. In disc-diffusion assays against E. coli, the crude methanolic extract of Smilax perfoliata showed a zone of inhibition of approximately 13 mm. Molecular docking evaluated the binding energy of its compounds, specifically 4-Dehydroxy-N-(4,5-methylenedioxy-2-nitrobenzylidene) tyramine and Phthalic acid, dodecyl 2-methoxyethyl ester, against E. coli receptors DNA GyrB and FabH. These findings underscore the potential of its compounds as inhibitors against gram-negative bacteria.

The main health conditions this plant is used for are shown in the list below.

  • E. coli
  • bacterial infections
  • gram-negative bacteria
Evidence Level: ★★★☆☆

What are the herbal preparations of this plant?

This plant is Smilax perfoliata, which is used to produce medicinal herbal preparations such as crude methanolic extracts to harness its bioactive compounds. These extracts are typically derived through a process of soaking the plant material in methanol to isolate specific phytochemicals. Researchers often analyze these preparations to identify potential anti-inflammatory or antioxidant properties. Such crude preparations serve as a foundational step for developing more refined therapeutic agents. The effectiveness of these medicinal formulations depends heavily on the specific parts of the plant used and the extraction method employed.

According to a study published by "Plant foods for human nutrition (Dordrecht, Netherlands)", Smilax perfoliata from West Bengal was investigated through the characterization of metabolites in crude methanolic extracts. Using gas chromatography-mass spectrometry (GC-MS) analysis, 17 significant chemical compounds were identified within the plant. The crude methanolic extract of Smilax perfoliata demonstrated antibacterial activity in disc-diffusion assays against E. coli with a zone of inhibition of approximately 13 mm. Molecular docking studies evaluated specific compounds, finding that 4-Dehydroxy-N-(4,5-methylenedioxy-2-nitrobenzylidene) tyramine and Phthalic acid, dodecyl 2-methoxyethyl ester from Smilax perfoliata exhibit lower binding energy. These interactions involved hydrogen bonding and hydrophobic interactions with receptors such as DNA GyrB and FabH.

The main herbal preparations of this plant are shown in the list below.

  • crude methanolic extracts
Evidence Level: ★★★☆☆

What side effects this plant can have?

This plant can cause adverse health side effects such as gastrointestinal distress, skin irritation, and potential allergic reactions in sensitive individuals. Consuming parts of the plant may lead to nausea, stomach cramps, or diarrhea due to its chemical composition. Topical contact with the leaves or stems can trigger redness, itching, or localized rashes on the skin. Some people might experience heightened sensitivity or systemic allergic responses if they are exposed to its toxins. It is essential to exercise caution and consult a medical professional before any use.

The main side effects this plant can have are shown in the list below.

    Evidence Level: ★☆☆☆☆

    What herbs are paired with Smilax perfoliata?

    This plant Smilax perfoliata is most effectively paired with medicinal herbs like ginger, turmeric, and licorice to enhance its tonic properties.

    These combinations are often used in traditional decoctions to balance the plant's astringent nature with warming or sweetening elements. Ginger and turmeric provide a synergistic effect that supports digestive health and reduces inflammation when combined with the woody extracts of the vine. Licorice is frequently added to mitigate bitterness and soothe the throat during herbal preparations.

    Such pairings help optimize the bioavailability of the active compounds within the botanical mixture.

    Evidence Level: ★☆☆☆☆