bitterwood
Simarouba glauca · Accepted scientific name
Scientific literature: Moderate (105 studies) · ★★★☆☆
Bitterwood, scientifically known as Simarouba glauca, is a versatile medicinal plant native to tropical regions. Renowned for its potent bioactive compounds, it is traditionally used to treat various ailments, including parasitic infections and digestive issues. This botanical specimen offers significant therapeutic potential for modern pharmacological research and natural wellness.
Names and Synonyms
Common Names
- bitterwood
- dysentery-bark
- paradise-tree
Scientific Names
Accepted name
Simarouba glaucaSynonyms
- Simarouba glauca subsp. latifolia
- Quassia glauca
- Simarouba officinalis f. glabra
- Simarouba glauca var. latifolia
- Simarouba medicinalis
- Simarouba officinalis
Regional and Traditional Names
Spanish:
- aceituno
Sources: Wikidata, Catalogue of Life
Taxonomical Classification
This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta and class Equisetopsida. Within the subclass Magnoliidae, it is organized under the order Sapindales and the family Simaroubaceae. Finally, its specific taxonomic identity is defined by the genus Simarouba.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Sapindales |
| Family | Simaroubaceae |
| Genus | Simarouba |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
This plant exhibits a diverse geographical distribution that spans across multiple continents and regions. In the Indian Subcontinent, its presence is specifically noted within India. Moving toward the Americas, it can be found in the Southeastern United States, particularly in Florida. Its reach extends significantly through Mexico, where it inhabits the Central and Gulf regions. Additionally, the species is distributed throughout the Southwest portion of Mexico.
| Region | Area |
|---|---|
| Indian Subcontinent | India |
| Southeastern U.S.A. | Florida |
| Mexico | Mexico Central |
| Mexico | Mexico Gulf |
| Mexico | Mexico Southwest |
| Mexico | Mexico Southeast |
| Central America | Belize |
| Central America | Costa Rica |
| Central America | El Salvador |
| Central America | Guatemala |
Sources: The World Checklist of Vascular Plants (WCVP)
Botanical Identification
Ecology
The ecology of Simarouba glauca is intrinsically linked to its primary habitat within the forest ecosystems of tropical and subtropical regions. As a component of the forest structure, this species thrives in environments characterized by complex vertical stratification and high levels of organic matter in the soil. Its presence is often dictated by the availability of light and moisture levels typical of these wooded biomes, where it participates in the intricate nutrient cycling and water regulation processes of the forest floor and canopy. By occupying specific niches within the forest, Simarouba glauca interacts with a diverse array of biotic factors, including specialized pollinators and seed dispersers, which are essential for its reproductive success and long-term persistence within its native forest communities.
- Habitat :
- forest
Life history
The life history of Simarouba glauca is characterized by its nature as a perennial species, allowing it to persist in its environment through many growing seasons. Throughout its development, the plant maintains an evergreen habit, retaining its foliage year-round rather than shedding it seasonally. This combination of a long-lived lifecycle and continuous leaf presence enables the plant to sustain metabolic processes and structural growth consistently over time.
- Deciduousness :
- evergreen
- Lifecycle :
- perennial
Morphology
The morphology of Simarouba glauca is characterized by a woody growth form, specifically manifesting as a self-supporting tree. This species reaches a substantial stature, with an average plant height of approximately 15 m. As a terrestrial organism, it does not exhibit aquatic or semiaquatic tendencies, nor does it function as an epiphyte; instead, it maintains a strictly terrestrial life cycle. The plant is an independent organism, meaning it does not function as a parasite, and its structural development is entirely self-supporting rather than behaving as a liana, vine, or any other type of climber.
- Aquatic :
- terrestrial
- Climber :
- self-supporting
- Epiphyte :
- terrestrial
- Growth form :
- tree
- Parasite :
- independent
- Plant height mean:
- 15 m
- Woodiness :
- woody
Physiology
The physiology of Simarouba glauca is characterized by a C3 photosynthetic pathway, which dictates its carbon fixation processes and metabolic efficiency in varying environmental conditions. The plant exhibits a Specific Leaf Area (SLA) with a mean value of 103.989 cm²/g, reflecting its leaf structural investment and its capacity for light interception and gas exchange. Furthermore, Simarouba glauca does not function as a nitrogen fixer, meaning it relies on the uptake of available soil nitrates and ammonium rather than symbiotic nitrogen fixation to meet its nutritional requirements.
- Nitrogen fixer :
- no
- Photosynthetic pathway :
- C3
- Specific Leaf Area (SLA) mean:
- 103.989 cm²/g
Reproduction
The reproduction of Simarouba glauca is characterized by a biotic pollination syndrome, primarily involving insects such as bees, which suggests a highly specialized interaction with local fauna. The plant exhibits a lack of self-fertilization, indicating that successful reproduction relies on cross-pollination to maintain genetic diversity. The resulting fruit is classified as a drupe, which is indehiscent, meaning it does not split open at maturity to release its contents. These fruits possess an average length of 2.28 cm and an average width of 1.6 cm. Following maturation, the plant utilizes a zoochorous dispersal syndrome, relying on animals to transport its seeds. The seeds themselves are relatively substantial, with a mean mass of approximately 0.904 g, ranging from a minimum of 0.756 g to a maximum of 1.242 g. Furthermore, the seed volume remains consistent at a value of 1100 mm³, providing the necessary biological endowment for the establishment of new seedlings through animal-mediated dispersal.
- Dehiscence :
- indehiscent
- Dispersal syndrome :
- zoochorous
- Fruit length mean:
- 2.28 cm
- Fruit type :
- drupe
- Fruit width mean:
- 1.6 cm
- Pollination syndrome :
- insect
- Pollination syndrome :
- bee
- Pollination syndrome :
- biotic
- Seed mass max:
- 1.24245 g
- Seed mass mean:
- 0.904385 g
- Seed mass min:
- 0.75586 g
- Seed volume max:
- 1100 mm³
- Self fertilization :
- absent
Sources: Global Inventory of Floras and Traits (GIFT)
Plant Parts
Simarouba glauca has 2 reported plant parts identified across 3 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include leaf, seed.
| Plant part | Supporting sources | Consensus |
|---|---|---|
| Leaf | 2 supporting sources | ★☆☆☆☆ |
| Seed | 1 supporting sources | ★☆☆☆☆ |
Leaf
- Heliyon
- Antibiotics (Basel, Switzerland)
Seed
- Journal of food science and technology
Chemicals
Simarouba glauca has 28 reported phytochemicals identified across 3 scientific publications and several other databases. The most consistently reported chemicals include 14-Deacetyleurylene, 2-Methoxycanthin-6-one, 4,5-DIMETHOXYCANTHIN-6-ONE, 9-Methoxycanthin-6-one, Arachidic acid.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| 14-Deacetyleurylene | 1 supporting sources | ★☆☆☆☆ |
| 2-Methoxycanthin-6-one | 1 supporting sources | ★☆☆☆☆ |
| 4,5-DIMETHOXYCANTHIN-6-ONE | 1 supporting sources | ★☆☆☆☆ |
| 9-Methoxycanthin-6-one | 1 supporting sources | ★☆☆☆☆ |
| Arachidic acid | 1 supporting sources | ★☆☆☆☆ |
| Canthin-6-one | 1 supporting sources | ★☆☆☆☆ |
| FAT | 1 supporting sources | ★☆☆☆☆ |
| Fraxidin | 1 supporting sources | ★☆☆☆☆ |
| GLAUCARUBIN | 1 supporting sources | ★☆☆☆☆ |
| Glaucarubinone | 1 supporting sources | ★☆☆☆☆ |
14-Deacetyleurylene
- Phytotherapy research : PTR
2-Methoxycanthin-6-one
- Phytotherapy research : PTR
4,5-DIMETHOXYCANTHIN-6-ONE
- Phytotherapy research : PTR
9-Methoxycanthin-6-one
- Phytotherapy research : PTR
Arachidic acid
- Dr. Duke
Canthin-6-one
- Phytotherapy research : PTR
FAT
- Dr. Duke
Fraxidin
- Phytotherapy research : PTR
GLAUCARUBIN
- Dr. Duke
Glaucarubinone
- Dr. Duke
Activities
Simarouba glauca has 56 reported activities identified across 3 scientific publications and several other databases. The most consistently reported activities include Antioxidant, 5-Alpha-Reductase-Inhibitor, Allergenic, Alpha-Reductase-Inhibitor, Amebicide.
| Activity | Supporting sources | Consensus |
|---|---|---|
| Antioxidant | 2 supporting sources | ★☆☆☆☆ |
| 5-Alpha-Reductase-Inhibitor | 1 supporting sources | ★☆☆☆☆ |
| Allergenic | 1 supporting sources | ★☆☆☆☆ |
| Alpha-Reductase-Inhibitor | 1 supporting sources | ★☆☆☆☆ |
| Amebicide | 1 supporting sources | ★☆☆☆☆ |
| Anemiagenic | 1 supporting sources | ★☆☆☆☆ |
| AntiMS | 1 supporting sources | ★☆☆☆☆ |
| Antiacne | 1 supporting sources | ★☆☆☆☆ |
| Antialopecic | 1 supporting sources | ★☆☆☆☆ |
| Antianaphylactic | 1 supporting sources | ★☆☆☆☆ |
Antioxidant
- Dr. Duke
- Antibiotics (Basel, Switzerland)
5-Alpha-Reductase-Inhibitor
- Dr. Duke
Allergenic
- Dr. Duke
Alpha-Reductase-Inhibitor
- Dr. Duke
Amebicide
- Dr. Duke
Anemiagenic
- Dr. Duke
AntiMS
- Dr. Duke
Antiacne
- Dr. Duke
Antialopecic
- Dr. Duke
Antianaphylactic
- Dr. Duke
Medicinal Uses
Simarouba glauca has 14 reported medicinal uses identified across 3 scientific publications and several other databases. The most consistently reported uses include Candida albicans, E. coli, Escherichia coli, Leishmania infantum, Plasmodium falciparum.
Most Reported Uses
| Use | Sources | Consensus |
|---|---|---|
| Candida albicans | Memorias do Instituto Oswaldo Cruz (and other 1 sources) | ★☆☆☆☆ |
| E. coli | Antibiotics (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| Escherichia coli | Memorias do Instituto Oswaldo Cruz (and other 1 sources) | ★☆☆☆☆ |
| Leishmania infantum | Memorias do Instituto Oswaldo Cruz (and other 1 sources) | ★☆☆☆☆ |
| Plasmodium falciparum | Memorias do Instituto Oswaldo Cruz (and other 1 sources) | ★☆☆☆☆ |
| Staphylococcus aureus | Memorias do Instituto Oswaldo Cruz (and other 1 sources) | ★☆☆☆☆ |
| Trypanosoma cruzi | Memorias do Instituto Oswaldo Cruz (and other 1 sources) | ★☆☆☆☆ |
| breast cancer | Heliyon (and other 1 sources) | ★☆☆☆☆ |
| cancers | Heliyon (and other 1 sources) | ★☆☆☆☆ |
| cervix cancer | Heliyon (and other 1 sources) | ★☆☆☆☆ |
Preparations
| Preparations | Sources | Consensus |
|---|---|---|
| Ethanol extracts | Memorias do Instituto Oswaldo Cruz (and other 1 sources) | ★☆☆☆☆ |
| chloroform-soluble extract of Simarouba glauca twigs | Phytotherapy research : PTR (and other 1 sources) | ★☆☆☆☆ |
| ethanolic extract | Antibiotics (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| methanol extract | Antibiotics (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| methanolic extract | Antibiotics (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| seed oil | Journal of food science and technology (and other 1 sources) | ★☆☆☆☆ |