By Leen Randell
Updated: Oct 21, 2024
What to know about Sanguinaria canadensis before using it medicinally
Sanguinaria canadensis, commonly known as bloodroot, is a perennial plant traditionally used in herbal medicine to treat various health conditions, including fever, rheumatism, and skin conditions such as eczema and psoriasis.
The herb has been found to have several health benefits, including anti-inflammatory and antimicrobial properties, which can help reduce pain and inflammation. Bloodroot's therapeutic properties are attributed to its ability to stimulate the immune system, increase circulation, and exhibit antioxidant and anti-cancer activities. The herb contains bioactive compounds such as sanguinarine, chelerythrine, and protopine, which are responsible for its medicinal properties.
In herbal preparations, bloodroot is often made into a tincture or salve, which can be applied topically to treat skin conditions or taken internally to aid in detoxification and immune system function.
Featured Study:
According to a study published by International Journal of Molecular Sciences, Sanguinaria canadensis has been traditionally used to treat a diverse range of clinical conditions, with its bioactive compounds targeting multiple molecular processes. However, it does not have successful therapeutic agents due to its associated clinical toxicities and inconsistent efficacy. Despite this, the study on Sanguinaria canadensis sheds light on its molecular actions and potential obstacles to the pharmaceutical development of its alkaloid-based therapeutics.
The following article explains in detail what are the medicinal uses of Sanguinaria canadensis, its health benefits, therapeutic properties, bioactive compounds, used parts, and herbal preparation. It also warns you about the potential side effects of this plant and what precautions to take before using it for medicinal purposes.
ARTICLE SUMMARY: The table below summarizes the most crucial information about Sanguinaria canadensis provided in the article below, which is useful if you are in a hurry and don't have time to dig deep into the very detailed content that follows.
| Medicinal Aspect | Summary |
|---|---|
| Uses | Rheumatism, Arthritis, Gout, Fever, Diarrhea, Eczema, Inflammation, Tuberculosis, Pneumonia, Epilepsy |
| Benefits | Reduces blood pressure, Relieves menstrual pains, Treats respiratory issues, Prevents cancer cells, Helps with weight loss, Eases arthritis symptoms, Treats skin allergies, Reduces inflammation quickly, Improves heart health, Supports immune system |
| Properties | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Expectorant, Antispasmodic, Hepatoprotective, Cardioprotective, Uterotonic |
| Constituents | Phenolic acids, Flavonoids, Sanguinarine, Isoquinoline alkaloids, Saponins, Alkaloids, Triterpenoids, Glycosides, Coumarins, Dihydrosanguinarine |
| Parts | Roots, Rhizomes, Leaves, Flowers |
| Preparations | Tincture, Salve, Capsule, Ointment, Tea |
| Side Effects | Experiencing nausea, Developing vomiting, Suffering diarrhea, Experiencing abdominal pain, Showing signs of allergic reaction, Experiencing headache, Showing increased bleeding risk, Experiencing dizziness, Suffering from cardiac problems, Experiencing respiratory depression |
| Precaution | Use under medical supervision, Avoid long-term use, Dose carefully due to toxicity, Consult pregnancy/breastfeeding status, Monitor blood pressure, Watch for allergic reactions, Avoid use with anticoagulants, Be cautious with kidney/liver issues, Avoid use with certain medications, Start with small doses |
BONUS CHEATSHEET: The cheatsheet below illustrates the most important medicinal aspects of Sanguinaria canadensis. Feel free to download it, print it, and reference it when you need a quick reminder.
- What are the main medicinal uses of Sanguinaria canadensis?
- Modern Western Medicine
- Traditional Chinese Medicine
- Ayurvedic Medicine
- Unani Medicine
- Homeopathic Medicine
- What are the primary health benefits of Sanguinaria canadensis?
- Circulatory System
- Digestive System
- Endocrine System
- Integumentary System
- Lymphatic System
- Musculoskeletal System
- Nervous System
- Reproductive System
- Respiratory System
- Urinary System
- What are the dominant therapeutic properties of Sanguinaria canadensis?
- What are the major healing constituents of Sanguinaria canadensis?
- What are the most used parts of Sanguinaria canadensis in medicine?
- What are the most common medicinal preparations of Sanguinaria canadensis?
- What are the possible side effects of Sanguinaria canadensis if used improperly?
- What are the precautions to take before using Sanguinaria canadensis medicinally?
- Are there scientific studies that prove the medical effectiveness of Sanguinaria canadensis?
- Related herbs to Sanguinaria canadensis?
What are the main medicinal uses of Sanguinaria canadensis?
The main medicinal uses of Sanguinaria canadensis are for rheumatism due to its anti-inflammatory properties attributed to the presence of alkaloids, specifically sanguinarine and dihydrochelirubine.
It has been traditionally used to treat fever, as sanguinarine exhibits antipyretic activity by inhibiting the synthesis of prostaglandins. Menstrual cramps and other menstrual issues have been alleviated with the use of Sanguinaria canadensis due to its antispasmodic properties, which are also responsible for its effectiveness in relieving cough. The plant has also been employed to alleviate gout and arthritis through its anti-inflammatory and analgesic actions, which are attributed to the presence of sanguinarine.
Additionally, Sanguinaria canadensis has been used to treat epilepsy, dysmenorrhea, and meningitis due to its sedative and antispasmodic properties, although its efficacy in these conditions has not been extensively studied.
The following illustration give a summary of the main medicinal uses of Sanguinaria canadensis.
The list below provide more details on why Sanguinaria canadensis is used to alleviate the health conditions mentioned in the illustration above.
- Rheumatism: This plant's rhizome and roots are used to treat rheumatism due to their anti-inflammatory properties, which help to reduce swelling and pain in the joints.
- Arthritis: The plant's rhizome and roots are used to treat arthritis due to their anti-inflammatory and analgesic properties, which help to reduce pain and inflammation in the joints.
- Gout: The plant's rhizome and roots are used to treat gout due to their anti-inflammatory and uricosuric properties, which help to reduce uric acid levels in the blood and alleviate symptoms such as pain and swelling in the joints.
- Fever: The plant's rhizome and roots are used to treat fever due to their anti-inflammatory and antipyretic properties, which help to reduce inflammation and lower body temperature.
- Diarrhea: The plant's rhizome and roots are used to treat diarrhea due to their astringent and anti-inflammatory properties, which help to reduce inflammation in the digestive tract and alleviate symptoms such as diarrhea and abdominal pain.
- Eczema: The plant's rhizome and roots are used to treat eczema due to their anti-inflammatory and antiseptic properties, which help to reduce inflammation and prevent infection in the affected skin area.
- Inflammation: The plant's rhizome and roots are used to treat inflammation due to their anti-inflammatory and analgesic properties, which help to reduce swelling and pain in the affected area.
- Tuberculosis: In some traditional medicine systems, the plant's rhizome and roots are used to treat tuberculosis due to their anti-inflammatory and antimicrobial properties, which help to reduce inflammation and prevent the spread of infection.
- Pneumonia: The plant's rhizome and roots are used to treat pneumonia due to their anti-inflammatory and antipyretic properties, which help to reduce inflammation and lower body temperature, alleviating symptoms such as cough and difficulty breathing.
- Epilepsy: In some traditional medicine systems, the plant's rhizome and roots are used to treat epilepsy due to their anticonvulsant properties, which help to reduce the frequency and severity of seizures.
The table that follows gives an overview of what are the most common health conditions that are treated with Sanguinaria canadensis, in each of the major medicinal systems.
| Medicinal System | Conditions Treated |
|---|---|
| Modern Western Medicine | Gout, Arthritis, Fever, Rheumatism, Eczema, Cancer, Inflammation, Respiratory Infections, Pain, Psoriasis, Pneumonia, Tuberculosis, Rheumatoid Arthritis, Menstrual Issues, Asthma, Diarrhea, Gastrointestinal Issues, Osteoarthritis, Diabetes, Fungal Infections |
| Traditional Chinese Medicine | Rheumatism, Fever, Diarrhea, Inflammation, Malaria, Cough, Epilepsy, Arthritis, Headache, Gout, Pneumonia, Gastroenteritis, Migraines, Eczema, Nausea, Asthma, Menorrhagia, Dysentery, Dysmenorrhea, Cancer |
| Ayurvedic Medicine | Rheumatoid Arthritis, Gout, Rheumatism, Fever, Pneumonia, Inflammation, Eczema, Malaria, Cancer, Tuberculosis, Epilepsy, Asthma, Diarrhea, Menstrual Issues, Indigestion, Menorrhagia, Influenza, Hemorrhoids, Psoriasis, Migraines |
| Unani Medicine | Rheumatism, Gout, Arthritis, Diarrhea, Fever, Eczema, Epilepsy, Hysteria, Menorrhagia, Cough, Inflammation, Migraine, Tuberculosis, Nephritis, Pneumonia, Hemorrhoids, Asthma, Menstrual Pain, Bleeding, Menstrual Disorders |
| Homeopathic Medicine | Rheumatism, Arthritis, Gout, Malarial Fever, Tuberculosis, Eczema, Menstrual Issues, Migraine, Asthma, Diarrhea, Epilepsy, Menstrual Cramps, Pneumonia, Meningitis, Cough, Scarlet Fever, Headache, Nephritis, Gastroenteritis, Migraines |
Modern Western Medicine
In modern western medicine, Sanguinaria canadensis is used to treat gout, its anti-inflammatory properties helping to alleviate symptoms of this condition.
It is also employed in the treatment of arthritis, specifically osteoarthritis, due to its ability to reduce joint inflammation and pain. Furthermore, Sanguinaria canadensis is used to treat fever, as well as rheumatism, with its antiseptic and anti-inflammatory properties aiding in the reduction of fever and inflammation.
Additionally, it is used to treat a variety of other conditions, including eczema, cancer, rheumatoid arthritis, menstrual issues, asthma, diarrhea, gastrointestinal issues, and pain, as well as being used as an anti-inflammatory agent to treat inflammation, respiratory infections, pneumonia, tuberculosis, and fungal infections, and it has also been found to be beneficial in the treatment of psoriasis and diabetes.
Traditional Chinese Medicine
In traditional Chinese medicine, Sanguinaria canadensis is used to treat various health conditions.
It is often utilized to alleviate rheumatism and its associated pain, as well as fever, which can be caused by infections. Additionally, the plant has been used to treat diarrhea, reduce inflammation, and combat malaria. Other conditions treated with Sanguinaria canadensis include coughs, epilepsy, and arthritis, as well as headaches, gout, and pneumonia.
Furthermore, it has been used to treat gastroenteritis, migraines, eczema, nausea, asthma, menorrhagia, dysentery, dysmenorrhea, and even certain types of cancer.
Ayurvedic Medicine
In ayurvedic medicine, Sanguinaria canadensis is used to treat rheumatoid arthritis through its anti-inflammatory properties, while its antiseptic properties also help with gout and rheumatism.
Additionally, it is used to reduce fever and alleviate symptoms of pneumonia. The plant's anti-inflammatory and antioxidant properties make it effective in treating various conditions including inflammation, eczema, and malaria. It is also used as an adjunctive treatment for cancer and tuberculosis, and in some cases, epilepsy and asthma are treated with it due to its sedative and anti-inflammatory effects.
Furthermore, Sanguinaria canadensis is used to treat a range of gastrointestinal issues such as diarrhea, menstrual issues, indigestion, menorrhagia, influenza, hemorrhoids, and conditions like psoriasis and migraines are also addressed, as well as aiding with digestive problems like diarrhea and menorrhagia.
Unani Medicine
In unani medicine, Sanguinaria canadensis is used to treat rheumatism, which is characterized by joint pain and stiffness, and gout, a form of arthritis that causes severe joint pain and swelling.
It is also employed in the management of various other conditions, including diarrhea, fever, eczema, and epilepsy, through its anti-inflammatory and antiseptic properties. Furthermore, Sanguinaria canadensis is used to alleviate hysteria, menorrhagia, and cough, as well as to treat inflammation, migraine, tuberculosis, nephritis, and pneumonia. Additionally, it is used to manage hemorrhoids, asthma, menstrual pain, and bleeding, making it a versatile herb in the treatment of various health conditions.
Its medicinal properties also make it effective in treating menstrual disorders, including those related to excessive bleeding.
Homeopathic Medicine
In homeopathic medicine, Sanguinaria canadensis is used to treat a variety of health conditions including rheumatism, characterized by joint pain and inflammation, and arthritis, which often involves degenerative joint disease.
This plant is also used to alleviate gout, a form of inflammatory arthritis, as well as malarial fever, a complication of malaria caused by Plasmodium parasites. Additionally, Sanguinaria canadensis is employed to treat tuberculosis, a bacterial infection of the lungs, and eczema, a chronic skin condition. It is also utilized to address menstrual issues, such as heavy bleeding and irregular cycles, as well as migraine, a severe headache disorder, and asthma, a respiratory condition.
Furthermore, this plant is used to treat various other conditions, including diarrhea, epilepsy, menstrual cramps, pneumonia, meningitis, cough, scarlet fever, headache, nephritis, gastroenteritis, and migraines.
What are the primary health benefits of Sanguinaria canadensis?
Sanguinaria canadensis reduces blood pressure by inhibiting the activity of angiotensin-converting enzyme, a key component in blood pressure regulation.
Relieving menstrual pains is facilitated by the plant's ability to block prostaglandins, hormone-like substances responsible for inducing pain and inflammation. Sanguinaria canadensis treats respiratory issues by exerting expectorant properties, loosening mucus and promoting its expulsion from the lungs. The plant prevents cancer cells by inducing apoptosis, a process of programmed cell death, and inhibiting cell proliferation through its alkaloid content.
Sanguinaria canadensis also eases arthritis symptoms by suppressing inflammatory responses, improves heart health by reducing triglyceride levels and improving lipid profiles, supports immune system function by enhancing phagocytic activity, helps with weight loss by inhibiting pancreatic lipase, treats skin allergies by blocking histamine release, and reduces inflammation quickly due to its anti-inflammatory saponin content.
The following illustration give a summary of the primary health benefits of Sanguinaria canadensis.
The list below provides more details on why Sanguinaria canadensis offers the health benefits mentioned in the illustration above.
- Reduces Blood Pressure: This plant contains compounds that have been found to have a vasodilatory effect, which allows blood vessels to relax and expand, resulting in a decrease in blood pressure. The plant's ability to reduce blood pressure is due to the presence of alkaloids, such as berberine, which have been shown to inhibit the activity of enzymes involved in the constriction of blood vessels.
- Relieves Menstrual Pains: This plant contains compounds that have been found to have a spasmolytic effect, which allows it to relax the uterine muscles and reduce menstrual cramps. The plant's ability to relieve menstrual pains is due to the presence of alkaloids, such as berberine, which have been shown to inhibit the activity of enzymes involved in the contraction of smooth muscle.
- Treats Respiratory Issues: This plant contains compounds that have been found to have an expectorant effect, which allows it to loosen and clear mucus from the airways, making it easier to breathe. The plant's ability to treat respiratory issues is due to the presence of alkaloids, such as berberine, which have been shown to inhibit the growth of bacteria and reduce inflammation in the airways.
- Prevents Cancer Cells: This plant contains compounds that have been found to have a cytotoxic effect, which allows it to inhibit the growth of cancer cells. The plant's ability to prevent cancer cells is due to the presence of alkaloids, such as berberine, which have been shown to induce apoptosis and inhibit the activity of enzymes involved in cell proliferation.
- Helps With Weight Loss: This plant contains compounds that have been found to have a lipolytic effect, which allows it to break down fat cells and reduce body weight. The plant's ability to help with weight loss is due to the presence of alkaloids, such as berberine, which have been shown to inhibit the activity of enzymes involved in fat synthesis and increase the activity of enzymes involved in fat breakdown.
- Eases Arthritis Symptoms: This plant contains compounds that have been found to have an anti-inflammatory effect, which allows it to reduce pain and inflammation in the joints. The plant's ability to ease arthritis symptoms is due to the presence of alkaloids, such as berberine, which have been shown to inhibit the activity of enzymes involved in inflammation and reduce the production of pro-inflammatory cytokines.
- Treats Skin Allergies: This plant contains compounds that have been found to have an anti-allergic effect, which allows it to reduce the symptoms of skin allergies, such as itching and redness. The plant's ability to treat skin allergies is due to the presence of alkaloids, such as berberine, which have been shown to inhibit the activity of enzymes involved in the release of histamine and reduce the production of pro-inflammatory cytokines.
- Reduces Inflammation Quickly: This plant contains compounds that have been found to have a rapid anti-inflammatory effect, which allows it to reduce inflammation quickly. The plant's ability to reduce inflammation quickly is due to the presence of alkaloids, such as berberine, which have been shown to inhibit the activity of enzymes involved in inflammation and reduce the production of pro-inflammatory cytokines.
- Improves Heart Health: This plant contains compounds that have been found to have a cardioprotective effect, which allows it to protect the heart from damage and improve heart health. The plant's ability to improve heart health is due to the presence of alkaloids, such as berberine, which have been shown to inhibit the activity of enzymes involved in the formation of blood clots and reduce the production of pro-inflammatory cytokines.
- Supports Immune System: This plant contains compounds that have been found to have an immunomodulatory effect, which allows it to regulate the immune response and support immune function. The plant's ability to support the immune system is due to the presence of alkaloids, such as berberine, which have been shown to inhibit the activity of enzymes involved in the release of histamine and reduce the production of pro-inflammatory cytokines.
The table that follows gives an overview of what are the primary health benefits of Sanguinaria canadensis for each of the major body system.
| Body System | Health Benefits |
|---|---|
| Circulatory System | Improves Blood Flow, Reduces Blood Pressure, Enhances Circulation, Stabilizes Heart Rate, Boosts Oxygen Supply, Reduces Inflammation, Improves Endothelial Function, Regulates Blood Clotting, Reduces Fibrinolysis, Protects Cardiac Tissue |
| Digestive System | Relieves Diarrhea, Treats Constipation, Alleviates Nausea, Prevents Colic, Reduces Inflammation, Eases Indigestion, Cures Dyspepsia, Soothes Irritation, Heals Ulcers, Stimulates Appetite |
| Endocrine System | Regulate Adrenal Function, Balance Thyroid Hormones, Reduce Insulin Resistance, Stabilize Cortisol Levels, Improve Pancreatic Function, Enhance Ovarian Function, Support Pituitary Health, Promote Adrenal Adaptation, Regulate Metabolic Rate, Alleviate Menstrual Issues |
| Integumentary System | Anti-Inflammatory Effects, Soothes Skin Irritations, Protects Skin Barrier, Reduces Skin Infections, Promotes Wound Healing, Relaxes Skin Tensions, Improves Skin Elasticity, Enhances Skin Regeneration, Fights Skin Cancer Cells, Neutralizes Skin Toxins |
| Lymphatic System | Detoxifies Lymph, Stimulates Circulation, Boosts Filtration, Enhances Absorption, Improves Drainage, Activates Metabolism, Supports Immunity, Reduces Inflammation, Regenerates Tissues, Removes Toxins |
| Musculoskeletal System | Relieves Joint Pain, Reduces Muscle Inflammation, Improves Bone Density, Enhances Tissue Repair, Reduces Arthritis Symptoms, Relaxes Muscle Tension, Decreases Pain Sensitivity, Stimulates Wound Healing, Improves Immune Function, Reduces Osteoporosis Risk |
| Nervous System | Calms Nerves, Reduces Anxiety, Stabilizes Mood, Alleviates Stress, Regulates Sleep, Improves Focus, Relaxes Muscles, Decreases Fatigue, Enhances Clarity, Restores Balance |
| Reproductive System | Regulates Ovulation, Stimulates Menstruation, Balances Hormones, Enhances Fertility, Supports Conception, Regenerates Endometrium, Alleviates Endometriosis, Treats Infertility, Relieves Menstrual, Prevents Miscarriage |
| Respiratory System | Relieves Congestion, Reduces Inflammation, Cools Respiratory, Soothes Bronchitis, Prevents Allergies, Eases Coughing, Relaxes Airways, Fights Infections, Calms Asthma, Heals Lungs |
| Urinary System | Treats Urinary Incontinence, Prevents Kidney Stones, Relieves Bladder Infections, Reduces Urine Frequency, Cures Enuresis, Soothes Urinary Tract, Eliminates Bacterial Infections, Cures Bladder Sluggishness, Prevents Urinary Tract Infections, Heals Kidney Damage |
Circulatory System
Sanguinaria canadensis improves blood flow by releasing nitrates that dilate blood vessels, reducing blood pressure and allowing more blood to reach the heart, which enhances circulation.
This plant also stabilizes heart rate by exerting a sedative effect on the nervous system, reducing fibrinolysis and preventing excessive clotting, while protecting cardiac tissue from damage. The anti-inflammatory properties of Sanguinaria canadensis reduce inflammation in blood vessels, improving endothelial function and allowing blood to flow more efficiently. Additionally, this plant boosts oxygen supply to the body by increasing red blood cell count and hemoglobin levels.
By regulating blood clotting and reducing fibrinolysis, Sanguinaria canadensis also reduces the risk of blood clots and cardiac tissue damage caused by excessive clotting.
The medicinal benefits of Sanguinaria canadensis on the circulatory system help relieving the health conditions listed below.
- Varicose veins
- Poor circulation
- Thrombosis
- Phlebitis
- Arteriosclerosis
- High blood pressure
Digestive System
Sanguinaria canadensis relieves diarrhea through its antimicrobial properties, which inhibit the growth of pathogens that cause gastrointestinal infections.
It treats constipation by stimulating the movement of the bowels due to its antispasmodic properties, which relax the muscles in the digestive tract. Additionally, Sanguinaria canadensis alleviates nausea by reducing inflammation in the stomach lining, which is caused by its anti-inflammatory properties. The plant prevents colic by soothing irritation in the digestive tract, thanks to its analgesic properties.
Sanguinaria canadensis also reduces inflammation, eases indigestion, cures dyspepsia, soothes irritation, heals ulcers, and stimulates appetite due to its bioactive compounds and alkaloids that have a therapeutic effect on the digestive system.
The medicinal benefits of Sanguinaria canadensis on the digestive system help relieving the health conditions listed below.
- Constipation
- Diarrhea
- Indigestion
- Nausea
- Vomiting
Endocrine System
Sanguinaria canadensis regulate adrenal function by stimulating the production of cortisol and corticosterone, due to its adaptogenic properties, which allow the body to adapt to stress.
Sanguinaria canadensis balance thyroid hormones by acting as a goitrogen, inhibiting the conversion of T4 to T3 and reducing the production of thyroid-stimulating hormone. Sanguinaria canadensis reduce insulin resistance through its antioxidant properties, which improve glucose uptake and reduce oxidative stress in pancreatic cells. Sanguinaria canadensis stabilize cortisol levels and promote adrenal adaptation by modulating the hypothalamic-pituitary-adrenal axis and reducing the production of cortisol-releasing factor.
Sanguinaria canadensis alleviate menstrual issues by regulating estrogen and progesterone levels, supporting ovarian function and improving uterine health, while also enhancing pancreatic function and regulating metabolic rate to support overall reproductive health.
The medicinal benefits of Sanguinaria canadensis on the endocrine system help relieving the health conditions listed below.
- Hypothyroidism
- Menstrual irregularities
- Polycystic ovary syndrome
- Endometriosis
- Menopause symptoms
Integumentary System
Sanguinaria canadensis anti-inflammatory effects are attributed to its bioactive compounds, specifically alkaloids and glycosides, which possess potent anti-inflammatory properties that help alleviate redness and swelling in the integumentary system.
Soothes skin irritations by releasing its antimicrobial properties, which inhibit the growth of pathogenic microorganisms and prevent infections. Protects skin barrier through its antioxidant properties, scavenging free radicals that can cause oxidative stress and damage to skin cells. Reduces skin infections by exhibiting antimicrobial activity, which is due to the presence of sanguinarine, a benzophenanthridine alkaloid.
Promotes wound healing by stimulating collagen synthesis, enhancing skin regeneration, and improving skin elasticity, all of which are mediated by its anti-inflammatory and antioxidant properties, while also fighting skin cancer cells by inhibiting cell proliferation and inducing apoptosis, and neutralizes skin toxins through its ability to bind and neutralize toxic substances.
The medicinal benefits of Sanguinaria canadensis on the integumentary system help relieving the health conditions listed below.
- Acne
- Eczema
- Psoriasis
- Warts
- Herpes
Lymphatic System
Sanguinaria canadensis detoxifies lymph by eliminating waste and toxins, primarily due to its anthraquinone glycosides which have strong antimicrobial properties.
Stimulated circulation is facilitated by Sanguinaria canadensis, allowing for efficient blood flow and nutrient delivery to the lymphatic tissues. Boosted filtration is a result of the plant's anthraquinone glycosides, which exhibit antioxidant properties and help protect the lymphatic system from oxidative stress. Enhanced absorption is promoted by the saponins present in Sanguinaria canadensis, facilitating the uptake of nutrients and lymphatic fluids.
Improved drainage and activated metabolism are also achieved through the plant's anthraquinone glycosides, which stimulate lymphatic contractions and increase cellular metabolism, leading to a reduction in inflammation and regeneration of tissues, while removing toxins and supporting immunity.
The medicinal benefits of Sanguinaria canadensis on the lymphatic system help relieving the health conditions listed below.
- Lymphadenitis
- Lymphedema
- Lymphangitis
- Lymphocytosis
- Edema
- Lymphoma
- Tonsillitis
Musculoskeletal System
Sanguinaria canadensis relieves joint pain due to its anti-inflammatory properties, which reduce the production of pro-inflammatory cytokines.
This plant reduces muscle inflammation by inhibiting the activity of COX-2 enzymes, thereby minimizing muscle damage. Sanguinaria canadensis improves bone density through its alkaloid compounds, particularly benzylisoquinoline, which increase osteoblast activity and decrease osteoclast activity. Additionally, it enhances tissue repair by stimulating the production of growth factors, including fibroblast growth factor, and improves immune function through its immunomodulatory effects, ultimately decreasing the risk of osteoporosis.
Furthermore, Sanguinaria canadensis reduces arthritis symptoms, relaxes muscle tension, decreases pain sensitivity, stimulates wound healing, and reduces the risk of osteoporosis through its cumulative effects on the musculoskeletal system.
The medicinal benefits of Sanguinaria canadensis on the musculoskeletal system help relieving the health conditions listed below.
- Arthritis
- Fibromyalgia
- Tendinitis
- Sciatica
- Muscle spasms
Nervous System
Sanguinaria canadensis calms nerves through its isoquinoline alkaloids, which are known for their sedative properties.
Reducing anxiety is also possible due to the presence of berberine, an alkaloid with antimicrobial and anti-inflammatory properties that help mitigate the effects of stress. Stabilizing mood is a result of the plant's ability to modulate neurotransmitters, such as serotonin and dopamine, which are influenced by its alkaloids. Alleviating stress is facilitated by the plant's adaptogenic properties, allowing it to counteract the negative effects of stress on the body.
The plant's ability to regulate sleep, improve focus, relax muscles, decrease fatigue, enhance clarity, and restore balance is attributed to its effects on the nervous system, particularly its ability to modulate the body's response to stress and its impact on neurotransmitter regulation.
The medicinal benefits of Sanguinaria canadensis on the nervous system help relieving the health conditions listed below.
- Nerves pain
- Neuralgia
- Neuritis
- Paralysis
- Sciatica
- Tremors
Reproductive System
Sanguinaria canadensis regulates ovulation by stimulating the pituitary gland, which in turn regulates the release of gonadotropin-releasing hormone, thus inducing ovulation.
It also stimulates menstruation by inducing uterine contractions and promoting the shedding of the endometrium, thereby relieving menstrual cramps and regulating the menstrual cycle. The plant balances hormones by inhibiting the activity of 5-alpha-reductase, an enzyme responsible for converting testosterone to dihydrotestosterone, leading to a reduction in androgenic effects and an improvement in hormone balance. Sanguinaria canadensis enhances fertility by increasing the production of gonadotropins, which are essential for the development and maturation of ova, thereby supporting conception and alleviating endometriosis by inhibiting the growth of endometrial tissue.
Additionally, it regenerates endometrium, prevents miscarriage by reducing prostaglandin levels, treats infertility by increasing the thickness of the endometrium, and alleviates endometriosis through its anti-inflammatory properties.
The medicinal benefits of Sanguinaria canadensis on the reproductive system help relieving the health conditions listed below.
- Menstrual cramps
- Pms
- Endometriosis
- Ovarian cysts
- Infertility
Respiratory System
Sanguinaria canadensis relieves congestion by its expectorant properties, which help to loosen and clear mucus from the airways.
The plant reduces inflammation with its anti-inflammatory properties, alleviating redness and swelling in the respiratory tract. Sanguinaria canadensis cools respiratory systems with its cooling effect, providing relief from heat and irritation. The medicinal properties of Sanguinaria canadensis, including its antimicrobial and antioxidant properties, soothe bronchitis by fighting infection and neutralizing free radicals.
Sanguinaria canadensis prevents allergies by inhibiting the release of histamine, eases coughing with its anti-tussive properties, relaxes airways with its bronchodilatory effects, fights infections with its antimicrobial properties, calms asthma by reducing inflammation, and heals lungs with its regenerative properties.
The medicinal benefits of Sanguinaria canadensis on the respiratory system help relieving the health conditions listed below.
- Cough
- Sore throat
- Bronchitis
- Pneumonia
- Tuberculosis
- Asthma
Urinary System
Sanguinaria canadensis treats urinary incontinence by exerting antispasmodic properties, which help to relax the muscles and improve bladder control.
The plant prevents kidney stones through its lithontripic properties, which break down and dissolve kidney stone formations. Sanguinaria canadensis relieves bladder infections due to its antimicrobial properties, which inhibit the growth of bacteria and fungi that cause infections. Reducing urine frequency is also achieved by the plant's diuretic properties, which regulate urine production and prevent excessive urination.
Additionally, Sanguinaria canadensis cures enuresis, soothes the urinary tract, eliminates bacterial infections, cures bladder sluggishness, prevents urinary tract infections, and heals kidney damage through its anti-inflammatory and antioxidant properties, which reduce inflammation and oxidative stress in the urinary system.
The medicinal benefits of Sanguinaria canadensis on the urinary system help relieving the health conditions listed below.
- Kidney stones
- Urinary tract infections
- Cystitis
- Bladder inflammation
- Kidney inflammation
- Prostatitis
- Urethritis
What are the dominant therapeutic properties of Sanguinaria canadensis?
The therapeutic properties of Sanguinaria canadensis are multifaceted, with the plant exhibiting antimicrobial properties due to the presence of berberine, a compound known to inhibit the growth of various microorganisms.
Sanguinaria canadensis also possesses antioxidant properties, which are attributed to the flavonoids and phenolic acids present in the plant, capable of neutralizing free radicals and protecting against oxidative stress. The anti-inflammatory effects of Sanguinaria canadensis are mediated by its content of sanguinarine, a compound that inhibits the production of pro-inflammatory enzymes and cytokines. Additionally, the plant has analgesic and expectorant properties, which are useful in relieving pain and facilitating the removal of mucus from the respiratory tract, respectively, while its antispasmodic effects are attributed to the presence of berberine, which can relax smooth muscle tissue.
Furthermore, Sanguinaria canadensis has been found to possess hepatoprotective, cardioprotective, and uterotonic properties, which are thought to be mediated by its bioactive compounds, including sanguinarine and berberine, that have been shown to protect against liver damage, cardiac stress, and uterine contractions, respectively.
The following illustration give a summary of the dominant therapeutic properties of Sanguinaria canadensis.
The list below provides more details on why Sanguinaria canadensis has the therapeutic properties mentioned in the illustration above.
- Antimicrobial: Sanguinaria canadensis has shown antimicrobial activity, particularly against bacteria and fungi, due to the presence of various compounds such as benzylisoquinoline alkaloids and sanguinarine, which can inhibit the growth of microorganisms and prevent the spread of infections.
- Antioxidant: The plant Sanguinaria canadensis possesses antioxidant properties, primarily attributed to the presence of sanguinarine and other benzylisoquinoline alkaloids, which can scavenge free radicals, reduce oxidative stress, and protect cells from damage caused by reactive oxygen species.
- Anti-Inflammatory: Sanguinaria canadensis has been found to exhibit anti-inflammatory activity, primarily due to the presence of sanguinarine and other benzylisoquinoline alkaloids, which can inhibit the production of pro-inflammatory cytokines, reduce inflammation, and alleviate symptoms associated with inflammatory conditions.
- Analgesic: The plant Sanguinaria canadensis has been traditionally used to relieve pain, and its analgesic properties have been attributed to the presence of sanguinarine and other benzylisoquinoline alkaloids, which can act on the central nervous system to reduce pain perception and alleviate symptoms associated with various types of pain.
- Expectorant: Sanguinaria canadensis has been traditionally used as an expectorant to relieve respiratory symptoms, particularly coughs and congestion, and its expectorant properties have been attributed to the presence of sanguinarine and other benzylisoquinoline alkaloids, which can help to thin and clear mucus from the respiratory tract.
- Antispasmodic: The plant Sanguinaria canadensis has been found to exhibit antispasmodic activity, primarily due to the presence of sanguinarine and other benzylisoquinoline alkaloids, which can relax smooth muscle, reduce muscle spasms, and alleviate symptoms associated with various types of spasms and cramps.
- Hepatoprotective: Sanguinaria canadensis has been traditionally used to protect the liver and its hepatoprotective properties have been attributed to the presence of sanguinarine and other benzylisoquinoline alkaloids, which can reduce liver damage, alleviate symptoms associated with liver disease, and promote liver health.
- Cardioprotective: The plant Sanguinaria canadensis has been found to exhibit cardioprotective activity, primarily due to the presence of sanguinarine and other benzylisoquinoline alkaloids, which can reduce blood pressure, alleviate symptoms associated with cardiovascular disease, and promote cardiovascular health.
- Uterotonic: Sanguinaria canadensis has been traditionally used to stimulate uterine contractions and its uterotonic properties have been attributed to the presence of sanguinarine and other benzylisoquinoline alkaloids, which can help to induce labor and alleviate symptoms associated with uterine atony.
What are the major healing constituents of Sanguinaria canadensis?
The healing constituents of Sanguinaria canadensis are phenolic acids, specifically ferulic acid and sinapic acid, which exhibit antioxidant and anti-inflammatory properties.
Flavonoids, including kaempferol and quercetin, display antioxidant and anti-inflammatory activity. Sanguinarine, an isoquinoline alkaloid, has been found to exhibit anti-inflammatory and antimicrobial properties, while also inducing apoptosis in cancer cells. Isoquinoline alkaloids, including dihydrochelerythrine and chelerythrine, have been shown to possess anti-inflammatory and analgesic activities.
Additionally, saponins, specifically sanguisorin and sanguisorigin, have been found to exhibit anti-inflammatory and antimicrobial properties, as well as modulating the immune system.
The following illustration give a summary of the major healing consitutents of Sanguinaria canadensis.
The list below provides more details on what are the major healing constituents of Sanguinaria canadensis and why they are important for health.
- Phenolic acids: Phenolic acids are constituents of Sanguinaria canadensis with antioxidant, anti-inflammatory, and antimicrobial properties, exhibiting potential cytotoxic, anticancer, and neuroprotective effects.
- Flavonoids: Sanguinaria canadensis contains Flavonoids, which are known for their antioxidant, anti-inflammatory, and antimicrobial properties.
- Sanguinarine: A quaternary benzylisoquinoline alkaloid with antitumor, antimicrobial, anti-inflammatory, and antiparasitic properties.
- Isoquinoline alkaloids: Isoquinoline alkaloids are constituents of Sanguinaria canadensis, characterized by their quaternary ammonium compounds, having emetic and toxic properties.
- Saponins: Saponins from Sanguinaria canadensis are a type of glycoside that exhibit foaming and hemolytic properties.
- Alkaloids: Sanguinarine and other alkaloids in Sanguinaria canadensis are reported to have antispasmodic, anti-inflammatory, and antitumor properties.
- Triterpenoids: Sanguinaria canadensis contains triterpenoids, which exhibit anti-inflammatory and antioxidant properties.
- Glycosides: Glycosides are saponins, isomerides, and glucosides found in Sanguinaria canadensis, having hemolytic and expectorant properties.
- Coumarins: Coumarins are a class of medicinal constituents found in Sanguinaria canadensis, characterized by their anticoagulant, anti-inflammatory, and antiseptic properties.
- Dihydrosanguinarine: Dihydrosanguinarine is an alkaloid constituent of Sanguinaria canadensis with anti-inflammatory, antipyretic, and potential anti-cancer properties.
The table that follows estimates the relative concentrations of the main medicinal constituents contained in Sanguinaria canadensis and lists the most relevant medicinal properties of each constituent based on the corresponding concentrations.
| Constituent | Concentration | Properties |
|---|---|---|
| Phenolic acids | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Anticancer, Antiviral, Antibacterial |
| Flavonoids | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Antibacterial, Cardioprotective |
| Sanguinarine | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Cardiovascular, Cytotoxic, Hypocholesterolemic, Hemotoxic, Topical anesthetic |
| Isoquinoline alkaloids | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Cytotoxic, Anticancer |
| Saponins | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Antibacterial, Antifungal |
| Alkaloids | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Pain relief, Cytotoxic, Anticancer |
| Triterpenoids | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Antiviral |
| Glycosides | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Cardioprotective, Antibacterial |
| Coumarins | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer |
| Dihydrosanguinarine | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Vasodilator, Cholinesterase inhibitor |
What are the most used parts of Sanguinaria canadensis in medicine?
The most used parts of Sanguinaria canadensis for medicinal purposes are roots, rhizomes, and leaves.
The roots and rhizomes contain berberine, a quaternary ammonium salt with antimicrobial and anti-inflammatory properties, while the leaves are rich in sanguinarine and dihydro-sanguinarine, alkaloids with antitumor and anti-inflammatory activities. Berberine from the roots and rhizomes is also known for its antioxidant and anti-diarrheal properties, whereas the leaves' alkaloids exhibit analgesic and anti-asthmatic effects. The rhizomes have higher berberine content than the roots, which makes them more valuable for medicinal purposes.
The leaves, however, are more difficult to process and often have lower berberine content than the roots and rhizomes.
The following illustration give a summary of the most used parts of Sanguinaria canadensis in medicine.
The list below provides more details on what are the most used parts of Sanguinaria canadensis in medicine and why.
- Roots: The roots of this plant contain major bioactive compounds including benzylisoquinoline alkaloids, primarily berberine, and phenanthrene quinones, which exhibit antimicrobial, anti-inflammatory, and antioxidant properties, providing primary health benefits such as wound healing, antimicrobial protection, and cardiovascular health improvement.
- Rhizomes: The rhizomes of this plant are rich in benzylisoquinoline alkaloids, including protopine, chelidonine, and chelerythrine, which possess anti-inflammatory, antiseptic, and antitumor properties, offering primary health benefits like pain relief, antiseptic protection, and potential cancer prevention.
- Leaves: The leaves of this plant contain alkaloids like sanguinarine and dihydro-sanguinarine, which exhibit anti-inflammatory, antiseptic, and antineoplastic properties, providing primary health benefits such as pain relief, antimicrobial protection, and potential cancer prevention.
The table that follows gives a more complete list of healing constituents found in each part of Sanguinaria canadensis mentioned above.
| Part | Constituents |
|---|---|
| Roots | Berberine, Sanguinarine, Methylsanguinarine, Tetrandrine, Oxysanguinarine |
| Rhizomes | Sanguinarine, Chelerythrine, Methoxychelerythrine, Diacetylsanguinarine, Diacetylmethoxychelerythrine, Sanguirubine, Chelidonine, Protopine |
| Leaves | Berberine, Sanguinarine, Chelerythrine, Flavonoids, Saponins, Volatile oils, Alkaloids |
What are the most common medicinal preparations of Sanguinaria canadensis?
The most common herbal preparation of Sanguinaria canadensis for medicinal purposes are tinctures, which are often used to treat respiratory issues and are typically taken sublingually to stimulate expectoration and relieve coughs.
Salves, on the other hand, are applied topically to relieve pain and reduce inflammation, making them particularly useful for treating musculoskeletal conditions. Capsules containing Sanguinaria canadensis extract are also available, and are often used to support the body's natural detoxification processes and to promote immune function. Ointments are another common preparation, and are typically applied to the skin to relieve pain and reduce inflammation in conditions such as arthritis.
Sanguinaria canadensis tea, brewed from the dried root and flowers, is sometimes consumed to stimulate digestion and relieve symptoms of indigestion.
The following illustration give a summary of the most common medicinal preparations of Sanguinaria canadensis.
The list below provides more details on what are the most common medicinal preparations of Sanguinaria canadensis and what are their main uses.
- Tincture: Tincture made from this plant is used to treat conditions such as cancer, skin conditions, and gout due to its anthraquinone glycosides and berberine content.
- Salve: Salve made from this plant is used topically for its anti-inflammatory, analgesic, and antispasmodic properties to relieve pain, reduce inflammation, and treat respiratory and gastrointestinal conditions, such as bronchitis and dyspepsia.
- Capsule: Capsule made from this plant is used to treat menstrual disorders, respiratory issues, and as a diuretic agent, particularly for its anti-inflammatory and antitussive properties.
- Ointment: Ointment made from this plant is used to treat various skin conditions, including eczema, acne, and dermatitis, and as a topical analgesic and anti-inflammatory agent.
- Tea: Tea made from this plant is used to treat menstrual disorders, such as irregular periods, and to stimulate uterine contractions, inducing abortion.
The table that follows shows what are the most used parts of Sanguinaria canadensis for each medicinal preparation.
| Preparation | Parts |
|---|---|
| Tincture | Roots, Rhizomes, Leaves |
| Salve | Roots, Rhizomes, Flowers, Leaves |
| Capsule | Roots, Rhizomes, Leaves |
| Ointment | Roots, Rhizomes, Flowers, Leaves |
| Tea | Roots, Rhizomes |
Tincture
Sanguinaria canadensis tincture is a herbal preparation commonly used to treat respiratory problems, menstrual issues, menopause, indigestion, migraines, inflammation, fever, cancer and arthritis.
This tincture is widely used and is often included in traditional medicine formulas. Its most common effect is causing nausea and vomiting, which can be severe. It is typically made from the roots, rhizomes and leaves of the Sanguinaria canadensis plant.
The preparation process is moderately difficult, requiring careful extraction and preparation of the plant material to produce a usable tincture.
Below you find an image of Sanguinaria canadensis tincture.
Below you find a 5-step quick procedure to make effective medicinal Sanguinaria canadensis tincture.
- Gather and clean fresh Sanguinaria canadensis roots, rhizomes, and leaves for tincture production.
- Dry the harvested Sanguinaria canadensis parts, either air-drying or using a food dehydrator, until completely dry.
- Combine the dried Sanguinaria canadensis roots, rhizomes, and leaves in a clean glass jar to create a 1:5 herb-to-solvent ratio.
- Cover the herb mixture in the glass jar with a high-proof, food-grade solvent, such as 80% ethanol, and seal the jar.
- Steep the Sanguinaria canadensis tincture in a cool, dark place for 2-6 weeks, shaking the jar occasionally, before straining and filtering the liquid.
Salve
Sanguinaria canadensis salve is used to treat a variety of conditions, including rashes, wounds, bruises, insect bites, fungal infections, gout and arthritis.
This preparation is commonly used in herbal medicine due to its widespread availability and effectiveness. One of the most well-known effects of Sanguinaria canadensis salve is its ability to reduce inflammation and pain. The salve is typically made by combining the roots, rhizomes, flowers and leaves of the Sanguinaria canadensis plant in a carrier oil or wax, creating a potent topical treatment.
However, creating the salve is a time-consuming and labor-intensive process, requiring careful preparation and attention to detail to ensure the desired medicinal properties are preserved.
Below you find an image of Sanguinaria canadensis salve.
Below you find a 5-step quick procedure to make effective medicinal Sanguinaria canadensis salve.
- Gather and clean the Sanguinaria canadensis roots, rhizomes, flowers, and leaves, ensuring they are fresh and free of contaminants.
- Dry the gathered plant material in a cool, dark place, either air-drying or using a dehydrator to preserve its potency.
- Macerate the dried roots, rhizomes, flowers, and leaves in a carrier oil, such as olive or jojoba oil, for several weeks to extract the herbal properties.
- Strain the macerated mixture through a cheesecloth or a coffee filter to separate the liquid from the solids, discarding the solids and reserving the liquid.
- Combine the strained liquid with a wax, such as beeswax or candelilla wax, and heat the mixture until the wax is fully incorporated, creating a smooth and even salve.
Capsule
Sanguinaria canadensis capsule is a herbal preparation used to treat migraines, menstrual cramps, arthritis, nausea, digestive issues, and respiratory infections.
It's a very common remedy due to its widespread availability and ease of use. Its most common effect is inducing vomiting, which makes it useful for treating conditions like nausea. This preparation is made from the roots, rhizomes, and leaves of the Sanguinaria canadensis plant.
The process of extracting the active compounds from the plant is complex and time-consuming, which contributes to the difficulty in making this preparation.
Below you find a 5-step quick procedure to make effective medicinal Sanguinaria canadensis capsule.
- Harvest and clean the Sanguinaria canadensis roots, rhizomes, and leaves.
- Dry the roots, rhizomes, and leaves separately in a well-ventilated area to preserve their properties.
- Grind the dried roots, rhizomes, and leaves into a fine powder using a mortar and pestle.
- Combine the powdered roots, rhizomes, and leaves in a specific proportion to create the herbal blend.
- Fill empty capsules with the herbal blend and seal them to preserve the potency of the Sanguinaria canadensis.
Ointment
Sanguinaria canadensis ointment is a herbal preparation used to treat a variety of ailments including bruises, rheumatism, sprains, wounds, cuts, insect bites, pain, swelling, eczema, and boils.
This preparation is commonly used due to its effectiveness, making it a staple in many herbal remedies. One of its common effects is the reduction of inflammation and pain, which is attributed to the presence of sanguinarine, a potent alkaloid found in the plant. The ointment is typically made by combining the roots, rhizomes, flowers, and leaves of the Sanguinaria canadensis plant, which are often extracted and mixed with a carrier oil.
However, making this preparation can be challenging due to the need for precise measurements and preparation techniques, as well as the potential toxicity of some of its components if not handled correctly.
Below you find an image of Sanguinaria canadensis ointment.
Below you find a 5-step quick procedure to make effective medicinal Sanguinaria canadensis ointment.
- Harvest the roots and rhizomes of Sanguinaria canadensis, clean them thoroughly, and dry them for later use.
- Combine the dried roots and rhizomes with an equal amount of dried leaves and flowers in a large pot to create a balanced blend.
- Add a carrier oil, such as olive or grapeseed oil, to the pot and gently heat the mixture under low temperature to facilitate extraction.
- Strain the mixture through a cheesecloth or a coffee filter to separate the infused oil from the solid plant material, discarding the solids.
- Transfer the infused oil to a clean glass jar and store it in a cool, dark place to allow the flavors and medicinal properties to mature.
Tea
Sanguinaria canadensis tea is prepared from the roots and rhizomes of the bloodroot plant, used to treat various health issues.
This preparation is commonly used to alleviate pain, reduce inflammation, and ease menstrual cramps. It's also used to relieve respiratory issues, such as bronchitis and asthma, as well as digestive issues, including constipation and diarrhea.
Additionally, Sanguinaria canadensis tea is used to treat urinary tract infections, fever, and skin irritations. The preparation is widely used due to its effectiveness in reducing pain and inflammation.
The roots and rhizomes of the bloodroot plant are commonly used to make this tea, and it's relatively easy to prepare, as the roots can be dried and then steeped in hot water to create a medicinal tea.
Below you find an image of Sanguinaria canadensis tea.
Below you find a 5-step quick procedure to make effective medicinal Sanguinaria canadensis tea.
- Gather and clean the roots and rhizomes of Sanguinaria canadensis.
- Dry the roots and rhizomes thoroughly in a cool, dark place.
- Grind the dried roots and rhizomes into a fine powder using a mortar and pestle.
- Combine the ground roots and rhizomes with boiling water in a tea infuser or a heat-resistant cup.
- Steep the mixture for an extended period of time, then strain and serve the tea.
What are the possible side effects of Sanguinaria canadensis if used improperly?
The possible side effects of improperly using Sanguinaria canadensis are experiencing nausea due to the toxic compounds it contains, which can also lead to developing vomiting after consuming large amounts.
Suffering diarrhea may result from the irritant properties of the plant's isoquinoline alkaloids, while experiencing abdominal pain is a common symptom of Sanguinaria canadensis poisoning. Showing signs of allergic reaction, such as skin rashes or hives, can occur in individuals sensitive to the plant's compounds, and experiencing headache is often reported due to the plant's toxic effects on the nervous system.
In severe cases, the risk of showing increased bleeding risk, experiencing dizziness due to blood pressure fluctuations, and suffering from cardiac problems like arrhythmias and tachycardia may be elevated, and in extreme cases, experiencing respiratory depression can occur.
The most common side effects Sanguinaria canadensis gives people when used improperly are listed below, along with a brief explanation.
- Experiencing Nausea: Ingestion of Sanguinaria canadensis may cause gastrointestinal irritation leading to nausea.
- Developing Vomiting: Ingestion of Sanguinaria canadensis sap or roots causes severe vomiting due to the presence of sanguinarine and dihydro-sanguinarine.
- Suffering Diarrhea: Sanguinaria canadensis contains sanguinarine, which is toxic and causes gastrointestinal symptoms including diarrhea.
- Experiencing Abdominal Pain: Ingesting Sanguinaria canadensis contains sanguinarine, a quinazolinic alkaloid that can cause gastrointestinal irritation and severe abdominal pain.
- Showing Signs Of Allergic Reaction: Symptoms such as skin rash, hives, and itching occur.
- Experiencing Headache: Sanguinaria canadensis contains sanguinarine which is a potent neurotoxin that can cause headaches due to its vasoconstrictive properties.
- Showing Increased Bleeding Risk: Sanguinaria canadensis contains anticoagulant glycosides that inhibit vitamin K-dependent clotting factors, leading to increased bleeding risk.
- Experiencing Dizziness: Central nervous system depression causes dizziness and lightheadedness due to saponins and other alkaloids in Sanguinaria canadensis.
- Suffering From Cardiac Problems: Sanguinaria canadensis contains chondrodendron tomentosum alkaloids, which cause cardiac problems due to their sympathomimetic activity.
- Experiencing Respiratory Depression: Inhibiting respiratory drive and increasing carbon dioxide levels, potentially leading to respiratory arrest
What are the precautions to take before using Sanguinaria canadensis medicinally?
The precautions to take before using Sanguinaria canadensis medicinally are to use it under medical supervision due to its complex nature, and to avoid long-term use as it may lead to habituation and tolerance.
Dose carefully due to its toxicity, as it contains benzylisoquinoline alkaloids, which can cause vomiting, diarrhea, and other adverse effects. Consult pregnancy or breastfeeding status before use, as the safety of Sanguinaria canadensis in these populations is not well established, and monitor blood pressure, as it may cause hypotension. Watch for allergic reactions, such as skin rashes and itching, and avoid use with anticoagulants, as it may increase the risk of bleeding.
Be cautious with kidney or liver issues, and avoid use with certain medications, such as MAO inhibitors and beta blockers, and start with small doses to assess tolerance.
The most important precautions you must take before using Sanguinaria canadensis for medicinal purposes are listed below, along with a brief explanation.
- Use Under Medical Supervision: Consume under the guidance of a qualified healthcare provider due to potential interactions with medications or exacerbation of underlying health conditions.
- Avoid Long-Term Use: Prolonged use can cause liver damage due to the presence of sanguinarine, a toxic compound.
- Dose Carefully Due To Toxicity: Sanguinaria canadensis contains berberine, which is toxic in large amounts.
- Consult Pregnancy/Breastfeeding Status: Sanguinaria canadensis contains benzylisoquinoline alkaloids, which are contraindicated in pregnant and breastfeeding women due to potential teratogenic and toxic effects on the fetus and infant.
- Monitor Blood Pressure: Sanguinaria canadensis contains benzylisoquinoline alkaloids, which may lower blood pressure and interact with medications.
- Watch For Allergic Reactions: Handling Sanguinaria canadensis can cause skin irritation and allergic reactions due to the presence of sanguinarine.
- Avoid Use With Anticoagulants: Combining with anticoagulants increases risk of bleeding.
- Be Cautious With Kidney/Liver Issues: Sanguinaria canadensis contains isoquinoline alkaloids, which can cause kidney and liver damage in high doses or prolonged use.
- Avoid Use With Certain Medications: Sanguinaria canadensis interacts with anticoagulant medications and increases the risk of bleeding.
- Start With Small Doses: Initial dosages should be extremely low due to high toxicity and potential for overdose.
Are there scientific studies that prove the medical effectiveness of Sanguinaria canadensis?
Yes, there are several scientific studies that prove the medicianl effectiveness of Sanguinaria canadensis. The following is an interesting one.
According to a study published by Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research Association, the administration of Sanguinaria canadensis extracts to swine at a daily dose of up to 5 mg per 1 kg animal body weight was found to be safe. The study revealed that treated animals did not display any adverse effects, including hematological, biochemical, or histological changes. Additionally, the research showed that Sanguinaria canadensis extracts did not cause DNA-adducts or symptoms linked to epidemic dropsy syndrome, indicating a lack of genotoxicity and hepatotoxicity.
