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Updated: Oct 20, 2024

What to know about Salvia miltiorrhiza before using it medicinally

Salvia miltiorrhiza plant

Salvia miltiorrhiza, commonly known as red sage, is a herb that has been extensively used in traditional medicine to treat cardiovascular diseases, such as high blood pressure and coronary heart disease.

Its main medicinal uses also include the treatment of cerebrovascular diseases, such as stroke and dementia. The herb has been found to have several health benefits, including anti-inflammatory, anti-oxidative, and anti-apoptotic effects. The main therapeutic properties of Salvia miltiorrhiza include its ability to improve blood circulation, reduce blood pressure, and prevent platelet aggregation.

The herb contains bioactive compounds such as tanshinones, phenolic acids, and flavonoids, which are responsible for its medicinal properties, and is often prepared into a traditional Chinese medicine called Danshen tea.

The following article explains in detail what are the medicinal uses of Salvia miltiorrhiza, its health benefits, therapeutic properties, bioactive compounds, used parts, and herbal preparation. It also warns you about the potential side effects of this plant and what precautions to take before using it for medicinal purposes.

ARTICLE SUMMARY: The table below summarizes the most crucial information about Salvia miltiorrhiza provided in the article below, which is useful if you are in a hurry and don't have time to dig deep into the very detailed content that follows.

Medicinal AspectSummary
UsesHypertension, Atherosclerosis, Angina pectoris, Cardiomyopathy, Diabetes, Heart failure, Stroke, Hyperlipidemia, Raynaud's disease, Varicose veins
BenefitsReduces blood pressure, Improves heart function, Regulates blood flow, Enhances vasodilation, Reduces inflammation levels, Improves cognitive function, Reduces anxiety symptoms, Improves exercise performance, Improves neuroprotective effects
PropertiesAntioxidant, Anti-inflammatory, Vasodilator, Cardioprotective, Neuroprotective, Antimicrobial, Analgesic, Antiarrythmic, Antioxidative stress, Cardiovascular protective
ConstituentsRosmarinic acid, Quercetin, Saponins, Luteolin, Kaempferol, Danshensu, Caffeic acid, Tanshinone, Flavonoids, Phenolic acids
PartsRoots, Leaves, Flowers
PreparationsTincture, Capsule, Decoction, Tea
Side EffectsExperiencing palpitations, Developing atrial fibrillation, Increasing risk of bleeding, Experiencing dizziness, Hypotension, Ventricular extrasystoles, Nausea, Vomiting, Abnormal liver function, Cardiac arrest
PrecautionConsult a healthcare professional, Follow recommended dosages, Monitor blood pressure, Be cautious with interactions, Avoid during pregnancy and breastfeeding, Inform about medical conditions, Be aware of allergic reactions, Use under medical supervision, Monitor liver function, Report any side effects

BONUS CHEATSHEET: The cheatsheet below illustrates the most important medicinal aspects of Salvia miltiorrhiza. Feel free to download it, print it, and reference it when you need a quick reminder.

Salvia miltiorrhiza plant cheatsheet

What are the main medicinal uses of Salvia miltiorrhiza?

The main medicinal uses of Salvia miltiorrhiza are the relief of hypertension through the vasodilatory effect of its constituent tanshinone IIA, which reduces blood pressure by relaxing blood vessels.

Additionally, it is used to alleviate angina pectoris by improving coronary blood flow due to the antioxidant properties of salvianolic acid A, which protects against myocardial ischemia. This plant is also employed to treat diabetes through the activation of AMP-activated protein kinase by its constituent salvianolic acid B, which enhances insulin sensitivity. Furthermore, Salvia miltiorrhiza has been used to manage cardiomyopathy by preventing cardiac hypertrophy via the inhibition of the calcineurin/NFAT signaling pathway by its constituent tanshinone I.

Moreover, it is used to alleviate cardiac insufficiency and heart failure by improving heart function through the inhibition of the renin-angiotensin system by its constituent cryptotanshinone, as well as to prevent cardiovascular disease through the reduction of atherosclerosis by its constituent dihydrotanshinone I, and to prevent stroke by improving cerebral blood flow through the antioxidant properties of its constituent salvianolic acid A.

The following illustration give a summary of the main medicinal uses of Salvia miltiorrhiza.

uses of Salvia miltiorrhiza

The list below provide more details on why Salvia miltiorrhiza is used to alleviate the health conditions mentioned in the illustration above.

The table that follows gives an overview of what are the most common health conditions that are treated with Salvia miltiorrhiza, in each of the major medicinal systems.

Medicinal SystemConditions Treated
Modern Western MedicineHypertension, Angina Pectoris, Atherosclerosis, Cardiomyopathy, Heart Failure, Cardiac Arrhythmia, Stroke, Diabetes, Cardiac Failure, Coronary Artery Disease, Raynaud'S Disease, Hyperlipidemia, Kidney Disease, Chronic Kidney Disease, Peripheral Artery Disease, Varicose Veins, Thrombosis, Cerebral Infarction, Cerebral Vasospasm, Cerebral Ischemia
Traditional Chinese MedicineHypertension, Atherosclerosis, Angina Pectoris, Cardiomyopathy, Diabetes, Stroke, Cardiac Arrhythmia, Chronic Kidney Disease, Raynaud'S Disease, Heart Failure, Cardiac Failure, Anemia, Hyperlipidemia, Rheumatoid Arthritis, Chronic Fatigue Syndrome, Neuropathy, Coronary Heart Disease, Myocardial Infarction, Cerebral Infarction, Cerebral Ischemia
Ayurvedic MedicineHypertension, Angina Pectoris, Atherosclerosis, Cardiomyopathy, Stroke, Heart Failure, Cardiac Failure, Hyperlipidemia, Arrhythmia, Diabetes, Coronary Heart Disease, Myocardial Infarction, Peripheral Artery Disease, Varicose Veins, Cardiac Arrest, High Blood Pressure, Raynaud'S Disease, Thrombosis, Cerebral Apoplexy, Cardiac Arrhythmia
Unani MedicineHypertension, Atherosclerosis, Angina Pectoris, Diabetes, Cardiomyopathy, Heart Failure, Hyperlipidemia, Varicose Veins, Stroke, Raynaud'S Disease, Myocardial Infarction, Kidney Disease, Cardiac Insufficiency, Cardiac Arrhythmia, High Blood Pressure, Cardiac Failure, Anxiety, Coronary Heart Disease, Migraine, Arrhythmia
Homeopathic MedicineHypertension, Atherosclerosis, Cardiomyopathy, Angina Pectoris, Diabetes, Congestive Heart Failure, Myocardial Infarction, Varicose Veins, Raynaud'S Disease, Hyperlipidemia, Stroke, Coronary Heart Disease, Cardiac Failure, Cardiac Arrhythmia, Arrhythmia, Cerebral Infarction, Chronic Kidney Disease, Cardiac Insufficiency, Chronic Fatigue Syndrome, Anemia

Modern Western Medicine

In modern western medicine, Salvia miltiorrhiza is used to treat hypertension, a condition that affects millions worldwide, by reducing blood pressure and promoting vasodilation.

Salvia miltiorrhiza has also been shown to alleviate angina pectoris symptoms by improving myocardial blood flow and oxygen supply to the heart. The plant's anti-inflammatory and antioxidant properties have been found to slow the progression of atherosclerosis, a major risk factor for heart disease. Additionally, Salvia miltiorrhiza has been used to treat cardiomyopathy, heart failure, cardiac arrhythmia, and stroke by improving cardiac function and reducing inflammation.

Furthermore, Salvia miltiorrhiza has been studied for its potential to manage diabetes, coronary artery disease, Raynaud's disease, hyperlipidemia, kidney disease, chronic kidney disease, peripheral artery disease, varicose veins, thrombosis, cerebral infarction, cerebral vasospasm, and cerebral ischemia, among other cardiovascular and metabolic disorders.

Traditional Chinese Medicine

In traditional chinese medicine, Salvia miltiorrhiza is used to treat various cardiovascular conditions, including hypertension by reducing blood pressure and vascular resistance.

It is also used to treat atherosclerosis by inhibiting the formation of plaque in arteries, as well as angina pectoris by improving blood flow to the heart. Furthermore, Salvia miltiorrhiza is used to treat cardiomyopathy by improving heart function, diabetes by enhancing insulin sensitivity, and stroke by reducing cerebral ischemia. Additionally, it is used to treat cardiac arrhythmia by regulating heart rhythm, chronic kidney disease by improving renal function, raynaud's disease by improving blood flow to extremities, heart failure by improving cardiac function, and anemia by improving red blood cell production.

Salvia miltiorrhiza is also used to treat hyperlipidemia by reducing lipid levels, rheumatoid arthritis by reducing inflammation, chronic fatigue syndrome by improving energy levels, neuropathy by reducing nerve damage, coronary heart disease by improving blood flow to the heart, myocardial infarction by reducing heart damage, cerebral infarction by reducing brain damage, and cerebral ischemia by reducing blood flow to the brain.

Ayurvedic Medicine

In ayurvedic medicine, Salvia miltiorrhiza is used to treat various cardiovascular conditions, including hypertension, which can be managed by reducing blood pressure through its vasodilatory properties.

This herb is also used to alleviate angina pectoris by improving blood circulation and reducing myocardial oxygen demand, while its anti-inflammatory and antioxidant properties help to prevent atherosclerosis, a condition characterized by the buildup of plaque in the arteries. Furthermore, Salvia miltiorrhiza has been shown to be effective in treating cardiomyopathy, a condition where the heart muscle becomes weakened, by improving cardiac function and reducing inflammation.

Additionally, it is used to prevent and treat conditions such as stroke, heart failure, and cardiac failure, which can be caused by coronary heart disease, characterized by the narrowing or blockage of the coronary arteries, leading to myocardial infarction, and is also used to treat hyperlipidemia, arrhythmia, diabetes, peripheral artery disease, varicose veins, cardiac arrest, high blood pressure, Raynaud's disease, thrombosis, cerebral apoplexy, and cardiac arrhythmia.

Unani Medicine

In unani medicine, Salvia miltiorrhiza is used to treat various cardiovascular and systemic conditions.

Hypertension is effectively managed by Salvia miltiorrhiza due to its vasodilatory properties, which help to reduce blood pressure. This plant is also used to combat atherosclerosis by improving blood circulation and inhibiting the formation of lipid deposits in the arteries. Additionally, it is prescribed for angina pectoris, diabetes, cardiomyopathy, heart failure, hyperlipidemia, varicose veins, stroke, Raynaud's disease, myocardial infarction, kidney disease, cardiac insufficiency, cardiac arrhythmia, high blood pressure, cardiac failure, anxiety, coronary heart disease, and migraine due to its antioxidant and anti-inflammatory properties that help to protect the heart and blood vessels from damage.

Its efficacy in treating these conditions is attributed to the active compounds present in Salvia miltiorrhiza, which have been shown to have a positive impact on cardiovascular health.

Homeopathic Medicine

In homeopathic medicine, Salvia miltiorrhiza is used to treat hypertension, atherosclerosis, cardiomyopathy, and angina pectoris by improving cardiovascular health and reducing blood pressure and inflammation.

This plant is also used to manage diabetes, which is often comorbid with the aforementioned conditions, by regulating blood sugar levels and improving insulin sensitivity. Additionally, it is used to alleviate symptoms of congestive heart failure, myocardial infarction, varicose veins, and Raynaud's disease, as well as hyperlipidemia, which is a risk factor for coronary heart disease and stroke. Furthermore, Salvia miltiorrhiza is used to treat coronary heart disease, cardiac failure, cardiac arrhythmia, and arrhythmia by regulating heart rate and improving cardiac function.

It is also used to address chronic kidney disease, cardiac insufficiency, chronic fatigue syndrome, anemia, and cerebral infarction by promoting blood flow and reducing oxidative stress.

What are the primary health benefits of Salvia miltiorrhiza?

Salvia miltiorrhiza reduces blood pressure by inhibiting the renin-angiotensin-aldosterone system, which decreases the production of angiotensin II, a potent vasoconstrictor.

Salvia miltiorrhiza also improves heart function by increasing the expression of cardiac-specific genes, enhancing the production of cardiac proteins, and promoting angiogenesis. The plant regulates blood flow by relaxing smooth muscle cells and increasing nitric oxide production, leading to vasodilation and decreased peripheral resistance. Salvia miltiorrhiza enhances vasodilation by stimulating the production of endothelium-derived relaxing factor, a key regulator of vascular tone.

Additionally, Salvia miltiorrhiza reduces inflammation levels by inhibiting the production of pro-inflammatory cytokines, improves cognitive function by increasing the expression of brain-derived neurotrophic factor, reduces anxiety symptoms by modulating the activity of the hypothalamic-pituitary-adrenal axis, improves exercise performance by increasing muscle blood flow and reducing lactic acid levels, and improves neuroprotective effects by reducing oxidative stress and apoptosis in neuronal cells.

The following illustration give a summary of the primary health benefits of Salvia miltiorrhiza.

benefits of Salvia miltiorrhiza

The list below provides more details on why Salvia miltiorrhiza offers the health benefits mentioned in the illustration above.

The table that follows gives an overview of what are the primary health benefits of Salvia miltiorrhiza for each of the major body system.

Body SystemHealth Benefits
Circulatory SystemImproves Circulation, Lowers Blood Pressure, Reduces Inflammation, Increases Oxygenation, Prevents Clotting, Reduces Cardiac Stress, Improves Cardiac Output, Enhances Vasodilation, Reduces Myocardial Damage, Enhances Endothelial Function
Digestive SystemImproves Digestion, Boosts Gut Health, Enhances Nutrient Absorption, Relieves Nausea, Soothes Intestinal Issues, Reduces Inflammation, Protects Mucous Membranes, Fights Bacterial Infections, Regulates Bowel Movements, Heals Ulcerative Wounds
Endocrine SystemRegulates Blood Flow, Supports Thyroid Function, Stabilizes Insulin Levels, Improves Adrenal Function, Enhances Pituitary Response, Reduces Cortisol Production, Promotes Hormone Balance, Boosts Testosterone Levels, Increases Metabolism Rate, Relieves Menopausal Symptoms
Integumentary SystemProtects Skin, Enhances Wound Healing, Reduces Inflammation, Accelerates Tissue Repair, Improves Collagen Synthesis, Boosts Immune Function, Fights Skin Infection, Promotes Skin Regeneration, Soothes Skin Irritation, Replenishes Moisture Levels
Lymphatic SystemStimulates Lymph Flow, Enhances Lymph Drainage, Supports Lymph Filtration, Regulates Lymph Pressure, Boosts Lymph Function, Improves Lymph Circulation, Reduces Lymph Swelling, Increases Lymph Mobility, Activates Lymph Defense, Maintains Lymph Balance
Musculoskeletal SystemReduces Muscle Pain, Improves Joint Mobility, Relaxes Muscle Tension, Enhances Bone Density, Decreases Inflammation, Fights Arthritis Symptoms, Rejuvenates Tissue Health, Reduces Osteoporosis Risk, Improves Muscle Flexibility, Boosts Immune Function
Nervous SystemProtects Neurons, Reduces Anxiety, Improves Cognitive, Enhances Memory, Relaxes Muscles, Reduces Stress, Improves Focus, Enhances Mood, Reduces Fatigue, Regenerates Cells
Reproductive SystemImproves Fertility, Enhances Ovulation, Regulates Menstruation, Boosts Libido, Supports Pregnancy, Reduces Infertility, Increases Fecundity, Promotes Hormone Balance, Decreases Miscarriage, Stimulates Reproduction
Respiratory SystemReduce Inflammation, Improve Breathing, Enhance Oxygenation, Alleviate Congestion, Prevent Bronchitis, Ease Coughing, Stimulate Expectoration, Protect Airways, Soothe Lungs, Fight Infections
Urinary SystemPrevent Kidney Damage, Protect Bladder Health, Relieve Urinary Tract Infection, Lower Blood Pressure, Reduce Urine Frequency, Relieve Nocturia Symptoms, Inhibit Kidney Stone Formation, Improve Urinary Flow Rate, Reduce Urinary Tract Inflammation, Prevent Benign Prostatic Hyperplasia

Circulatory System

Salvia miltiorrhiza improves circulation due to its vasodilatory properties, which enhance blood flow to the heart and other vital organs.

Lowering blood pressure is another benefit, primarily attributed to its potassium- and calcium-channel-blocking properties, which reduce cardiac workload and peripheral resistance. The reduction of inflammation is also facilitated by its anti-inflammatory properties, which decrease the production of pro-inflammatory cytokines and inhibit the activation of inflammatory cells. Increased oxygenation of tissues is achieved through enhanced vasodilation, which improves oxygen delivery to tissues and organs, while preventing clotting is facilitated by its anticoagulant properties, which inhibit platelet aggregation and reduce thrombin formation.

Additionally, Salvia miltiorrhiza reduces cardiac stress, improves cardiac output, reduces myocardial damage, and enhances endothelial function, all of which contribute to its protective effects on the circulatory system.

The medicinal benefits of Salvia miltiorrhiza on the circulatory system help relieving the health conditions listed below.

Digestive System

Salvia miltiorrhiza improves digestion by possessing anti-inflammatory properties that reduce inflammation in the digestive tract, allowing for efficient nutrient absorption and utilization.

The antimicrobial properties of Salvia miltiorrhiza boost gut health by inhibiting the growth of harmful bacteria, promoting a balanced gut microbiome and relieving nausea caused by gastrointestinal issues. Enhancing nutrient absorption is also facilitated by the antioxidant properties of Salvia miltiorrhiza, which protect the mucous membranes in the digestive tract from oxidative stress, while soothing intestinal issues such as irritable bowel syndrome. Additionally, the anti-inflammatory properties of Salvia miltiorrhiza reduce inflammation in the digestive tract, protecting mucous membranes and fighting bacterial infections that can cause gastrointestinal issues.

The regulating effect of Salvia miltiorrhiza on bowel movements and its ability to heal ulcerative wounds caused by digestive issues further underscore its benefits for the digestive system.

The medicinal benefits of Salvia miltiorrhiza on the digestive system help relieving the health conditions listed below.

Endocrine System

Salvia miltiorrhiza regulates blood flow by exerting vasodilatory effects, increasing nitric oxide production, and relaxing vascular smooth muscle, which leads to improved oxygen delivery and nutrient supply to tissues.

This plant supports thyroid function by modulating the hypothalamic-pituitary-thyroid axis, influencing thyroid-stimulating hormone secretion, and enhancing the conversion of thyroxine to triiodothyronine. Salvia miltiorrhiza stabilizes insulin levels by activating AMP-activated protein kinase, suppressing gluconeogenesis, and enhancing glucose uptake in skeletal muscle. Its anti-inflammatory properties improve adrenal function by reducing cortisol production and increasing the activity of 11β-hydroxysteroid dehydrogenase type 2, an enzyme that converts cortisol to cortisone.

The antioxidant and anti-apoptotic properties of Salvia miltiorrhiza enhance pituitary response, promote hormone balance, boost testosterone levels, increase metabolism rate, and relieve menopausal symptoms, making it a valuable herb in traditional Chinese medicine for endocrine disorders.

The medicinal benefits of Salvia miltiorrhiza on the endocrine system help relieving the health conditions listed below.

Integumentary System

Salvia miltiorrhiza protects skin by possessing antimicrobial properties that inhibit the growth of pathogenic microorganisms, thereby preventing infections.

The plant's antioxidant properties enhance wound healing by scavenging free radicals that can impede the repair process. Salvia miltiorrhiza reduces inflammation through its anti-inflammatory properties, which decrease the production of pro-inflammatory cytokines that exacerbate tissue damage. The plant accelerates tissue repair by stimulating the production of collagen and other extracellular matrix components.

Salvia miltiorrhiza improves collagen synthesis, boosts immune function, fights skin infection, promotes skin regeneration, soothes skin irritation, and replenishes moisture levels through its unique combination of antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory properties.

The medicinal benefits of Salvia miltiorrhiza on the integumentary system help relieving the health conditions listed below.

Lymphatic System

Salvia miltiorrhiza stimulates lymph flow by increasing the production of nitric oxide, a potent vasodilator that relaxes blood vessels and enhances lymph drainage.

This process supports lymph filtration by improving the removal of waste and toxins from the body, which in turn regulates lymph pressure and maintains lymph balance. Salvia miltiorrhiza also boosts lymph function by activating the lymphatic system's natural defense mechanisms, such as the production of cytokines that fight off pathogens. Furthermore, the antioxidant and anti-inflammatory properties of Salvia miltiorrhiza improve lymph circulation and reduce lymph swelling, allowing the lymphatic system to function more efficiently and effectively.

Additionally, the antimicrobial properties of Salvia miltiorrhiza activate lymph defense, increasing the system's ability to fight off infections and maintain a healthy balance.

The medicinal benefits of Salvia miltiorrhiza on the lymphatic system help relieving the health conditions listed below.

Musculoskeletal System

Salvia miltiorrhiza reduces muscle pain through its anti-inflammatory and analgesic properties, which inhibit the production of pro-inflammatory mediators and block pain receptors.

It also improves joint mobility by stimulating blood flow and reducing oxidative stress, which contributes to the degradation of articular cartilage. Additionally, Salvia miltiorrhiza relaxes muscle tension by modulating the autonomic nervous system and increasing parasympathetic activity, leading to a decrease in muscle spasms. Furthermore, Salvia miltiorrhiza enhances bone density by promoting the activity of osteoblasts and inhibiting the activity of osteoclasts, which are responsible for bone resorption.

Salvia miltiorrhiza also decreases inflammation by inhibiting the activity of pro-inflammatory enzymes and cytokines, fights arthritis symptoms by reducing joint inflammation and pain, rejuvenates tissue health by increasing collagen synthesis and cell proliferation, reduces osteoporosis risk by promoting bone growth and density, improves muscle flexibility by reducing muscle stiffness and inflammation, and boosts immune function by modulating the activity of immune cells and increasing the production of immunoglobulins.

The medicinal benefits of Salvia miltiorrhiza on the musculoskeletal system help relieving the health conditions listed below.

Nervous System

Salvia miltiorrhiza protects neurons by exhibiting neuroprotective properties due to its antioxidant and anti-inflammatory effects.

The herb reduces anxiety by modulating the activity of GABA receptors in the brain. Salvia miltiorrhiza improves cognitive function through the enhancement of blood flow and oxygenation to the brain, which is mediated by its vasodilatory properties. Its anti-inflammatory and antioxidant properties also enhance memory by reducing oxidative stress and inflammation in the hippocampus.

Additionally, Salvia miltiorrhiza relaxes muscles, reduces stress, improves focus, enhances mood, reduces fatigue, and regenerates cells through its adaptogenic and antioxidant effects, ultimately contributing to its neuroprotective and nootropic effects.

The medicinal benefits of Salvia miltiorrhiza on the nervous system help relieving the health conditions listed below.

Reproductive System

Salvia miltiorrhiza improves fertility by stimulating ovulation and promoting hormone balance, which are essential for healthy reproductive function.

Enhancing ovulation in women helps to increase fecundity, making it more likely for them to conceive. Salvia miltiorrhiza also regulates menstruation by reducing inflammation and oxidative stress, thereby creating a favorable environment for fertilization. The plant's antioxidant and anti-inflammatory properties also boost libido by reducing stress and promoting a healthy sex drive.

Furthermore, Salvia miltiorrhiza supports pregnancy by reducing the risk of miscarriage, which is often caused by hormonal imbalances and inflammation, allowing the fetus to develop safely.

The medicinal benefits of Salvia miltiorrhiza on the reproductive system help relieving the health conditions listed below.

Respiratory System

Salvia miltiorrhiza reduce inflammation in the respiratory system by exhibiting anti-inflammatory properties, which contribute to its overall therapeutic effects.

This reduction in inflammation improves breathing by relaxing bronchial muscles and promoting the clearance of mucus and other debris. Furthermore, its antioxidant properties enhance oxygenation by increasing the delivery of oxygen to the body's tissues. Additionally, its expectorant properties alleviate congestion by stimulating the cough reflex and facilitating the removal of excess mucus from the airways, thereby preventing bronchitis.

Salvia miltiorrhiza's antimicrobial properties ease coughing by combating bacterial and viral infections, stimulate expectoration by increasing the production of surfactant, protect airways by maintaining the integrity of the epithelial lining, soothe lungs by reducing inflammation and oxidative stress, and fight infections by directly inhibiting the growth of pathogens.

The medicinal benefits of Salvia miltiorrhiza on the respiratory system help relieving the health conditions listed below.

Urinary System

Salvia miltiorrhiza prevent kidney damage by exerting antioxidant and anti-inflammatory properties, which protect the kidneys from oxidative stress and inflammation.

Protecting bladder health is also attributed to its flavonoids and saponins, which have antimicrobial properties that inhibit the growth of pathogens. Relieving urinary tract infection is facilitated by its antimicrobial and anti-inflammatory effects, which reduce inflammation and kill bacteria. Lowering blood pressure is achieved through its vasodilatory and antioxidant actions, which relax blood vessels and reduce oxidative stress.

The combination of its flavonoids, saponins, and antioxidant properties also reduce urine frequency, relieve nocturia symptoms, inhibit kidney stone formation, improve urinary flow rate, reduce urinary tract inflammation, and prevent benign prostatic hyperplasia.

The medicinal benefits of Salvia miltiorrhiza on the urinary system help relieving the health conditions listed below.

What are the dominant therapeutic properties of Salvia miltiorrhiza?

The therapeutic properties of Salvia miltiorrhiza are attributed to its bioactive compounds, which exhibit antioxidant and anti-inflammatory activities, providing protection against oxidative stress and inflammation in the body.

This plant has been found to possess cardioprotective and vasodilator properties, enhancing cardiovascular health by improving blood flow and reducing the risk of heart disease. Additionally, Salvia miltiorrhiza displays neuroprotective and antimicrobial properties, preventing neuronal damage and inhibiting the growth of microorganisms. Its analgesic and antiarrythmic properties enable the plant to alleviate pain and regulate abnormal heart rhythms, while its cardiovascular protective effects help maintain a healthy cardiovascular system.

The bioactive compounds responsible for these properties include flavonoids, phenolic acids, and volatile oils, such as salvianolic acid A and tanshinone IIA, which contribute to the plant's medicinal value.

The following illustration give a summary of the dominant therapeutic properties of Salvia miltiorrhiza.

properties of Salvia miltiorrhiza

The list below provides more details on why Salvia miltiorrhiza has the therapeutic properties mentioned in the illustration above.

What are the major healing constituents of Salvia miltiorrhiza?

The healing constituents of Salvia miltiorrhiza are primarily responsible for its medicinal properties.

Rosmarinic acid, a phenolic diterpene, exhibits antioxidant and anti-inflammatory activities by scavenging free radicals and inhibiting the production of pro-inflammatory cytokines. Quercetin, a flavonoid, displays its antiviral and anti-inflammatory effects by inhibiting viral replication and modulating immune responses. Saponins, a group of glycosidic compounds, show their cardioprotective and anti-inflammatory effects by reducing blood pressure and preventing the formation of atherosclerotic plaques.

Luteolin and kaempferol, two flavonoids, possess their anti-inflammatory and antioxidant properties by inhibiting the production of pro-inflammatory cytokines and scavenging free radicals, thus exerting their protective effects against cardiovascular diseases.

The following illustration give a summary of the major healing consitutents of Salvia miltiorrhiza.

constituents of Salvia miltiorrhiza

The list below provides more details on what are the major healing constituents of Salvia miltiorrhiza and why they are important for health.

The table that follows estimates the relative concentrations of the main medicinal constituents contained in Salvia miltiorrhiza and lists the most relevant medicinal properties of each constituent based on the corresponding concentrations.

ConstituentConcentrationProperties
Rosmarinic acidHIGHAntimicrobial, Antioxidant, Anti-inflammatory, Antihistamine, Antiviral, Vasodilatory, Cardioprotective, Neuroprotective
QuercetinLOWAntioxidant, Anti-inflammatory, Antimicrobial, Antiviral, Antihistamine, Anticancer, Cardioprotective, Neuroprotective, Anti-atherogenic, Antioxidant, Anticarcinogenic
SaponinsMEDIUMAntimicrobial, Antioxidant, Anti-inflammatory, Cardioprotective, Vasodilatory
LuteolinLOWAntimicrobial, Antioxidant, Anti-inflammatory, Antibacterial, Antiviral, Cytoprotective, Neuroprotective, Antiproliferative, Anticancer
KaempferolLOWAntioxidant, Anti-inflammatory, Antimicrobial, Antiviral, Analgesic, Antipyretic, Neuroprotective, Vasodilator
DanshensuMEDIUMAntioxidant, Anti-inflammatory, Cardioprotective, Vasodilatory, Neuroprotective, Antibacterial, Antioxidant
Caffeic acidLOWAntimicrobial, Antioxidant, Anti-inflammatory, Antibacterial, Antiviral, Antifungal
TanshinoneMEDIUMAntimicrobial, Antioxidant, Anti-inflammatory, Cardioprotective, Vasodilatory, Neuroprotective, Antiarrhythmic
FlavonoidsMEDIUMAntioxidant, Anti-inflammatory, Antimicrobial, Antiviral, Hepatoprotective, Cardioprotective, Antioxidant, Antioxidant-catalase-mimetic, Antioxidant-sod-mimetic, Anti-apoptotic, Neuroprotective
Phenolic acidsMEDIUMAntimicrobial, Antioxidant, Anti-inflammatory, Antihypertensive, Vasodilatory, Cardioprotective, Neuroprotective

What are the most used parts of Salvia miltiorrhiza in medicine?

The most used parts of Salvia miltiorrhiza for medicinal purposes are the roots, leaves, and flowers.

The roots contain iridoid glycosides, such as tanshinone I, II A, and II B, and salvianolic acids, which exhibit anti-inflammatory, antioxidant, and cardiovascular protective properties. The leaves are rich in flavonoids, including salvianolic acids and isorhapontigenin, with reported anti-inflammatory, antioxidant, and antidiabetic effects. The flowers contain flavonoids, iridoid glycosides, and phenolic acids, which have been shown to possess anti-inflammatory, antioxidant, and hepatoprotective properties.

These bioactive compounds contribute to the medicinal properties of each part, including anti-inflammatory, antioxidant, and cardiovascular protective effects.

The following illustration give a summary of the most used parts of Salvia miltiorrhiza in medicine.

parts of Salvia miltiorrhiza

The list below provides more details on what are the most used parts of Salvia miltiorrhiza in medicine and why.

The table that follows gives a more complete list of healing constituents found in each part of Salvia miltiorrhiza mentioned above.

PartConstituents
RootsTanshinone, Salvianolic acid, Saponins, Triterpenoids, Fenolic acids, Coumarins, Phenylethanoids
LeavesTanshinone, Rosmarinic acid, Salvianolic acid, Leucosin, Saponins, Volatile oils, Triterpenoids, Iridoid glycosides
FlowersPhenolic acids, Flavonoids, Iridoid glycosides, Alkaloids, Volatile oils, Salvianolic acids

What are the most common medicinal preparations of Salvia miltiorrhiza?

The most common herbal preparation of Salvia miltiorrhiza for medicinal purposes are tinctures, which are liquid extracts of the plant used to treat cardiovascular diseases and improve blood circulation.

Capsules, made from powdered Salvia miltiorrhiza root, are also widely used to enhance heart function and lower blood pressure. A decoction of the plant's root is commonly used in traditional Chinese medicine to treat conditions such as arrhythmia and heart failure. Salvia miltiorrhiza tea, made by infusing the plant's root in hot water, is used to reduce inflammation and improve cardiovascular health.

The plant's medicinal properties are also extracted in tincture form to treat conditions such as angina and coronary heart disease.

The following illustration give a summary of the most common medicinal preparations of Salvia miltiorrhiza.

preparations of Salvia miltiorrhiza

The list below provides more details on what are the most common medicinal preparations of Salvia miltiorrhiza and what are their main uses.

The table that follows shows what are the most used parts of Salvia miltiorrhiza for each medicinal preparation.

PreparationParts
TinctureRoots, Roots, Leaves
CapsuleRoots, Leaves, Flowers
DecoctionRoots, Roots
TeaRoots, Leaves, Flowers

Tincture

Salvia miltiorrhiza tincture is a herbal preparation used to treat various cardiovascular conditions, including hypertension, cardiomyopathy, congestive heart failure, angina, diabetic cardiomyopathy, cardiac arrhythmia, cardiac fibrosis, and myocardial infarction.

It's one of the most common herbal remedies used worldwide, often in combination with other herbs like Danshen and Astragalus. The primary effect of Salvia miltiorrhiza tincture is vasodilation, which helps to reduce blood pressure and increase blood flow to the heart. The preparation is typically made from the roots, leaves, and stems of the Salvia miltiorrhiza plant, which are rich in bioactive compounds like salvianolic acids and tanshinones.

Manufacturing Salvia miltiorrhiza tincture requires a moderate level of expertise, as it involves a multi-step process involving extraction, filtration, and concentration of the plant material.

Below you find an image of Salvia miltiorrhiza tincture.

tincture made with Salvia miltiorrhiza

Below you find a 5-step quick procedure to make effective medicinal Salvia miltiorrhiza tincture.

  1. Gather and clean Salvia miltiorrhiza roots and leaves.
  2. Dry the collected Salvia miltiorrhiza roots and leaves in a well-ventilated area.
  3. Chop the dried Salvia miltiorrhiza roots into smaller pieces, then combine with the dried leaves in a large glass jar.
  4. Fill the glass jar with a solvent, such as ethanol or glycerin, to completely cover the chopped roots and leaves.
  5. Steep the mixture in a cool, dark place for several weeks, shaking the jar occasionally to ensure even extraction.

Capsule

Salvia miltiorrhiza capsule is a widely used herbal preparation.

It's used to treat various conditions such as angina pectoris, hypertension, cardiomyopathy, peripheral artery disease, varicose veins, chronic fatigue, rheumatoid arthritis, cardiac arrest, and ischemic stroke. This preparation is extremely common, found in many traditional Chinese medicine formulas and used worldwide.

One of its common effects is improving cardiovascular function. Salvia miltiorrhiza capsule is typically made from dried roots, leaves, and flowers of the Salvia miltiorrhiza plant.

The process of making this preparation is moderately difficult, requiring careful extraction and drying of the plant materials.

Below you find a 5-step quick procedure to make effective medicinal Salvia miltiorrhiza capsule.

  1. Harvest and clean the Salvia miltiorrhiza roots, leaves, and flowers.
  2. Dry the roots, leaves, and flowers in a well-ventilated area to preserve their medicinal properties.
  3. Grind the dried roots, leaves, and flowers into a fine powder using a grinder or mortar and pestle.
  4. Mix the powder of the roots, leaves, and flowers together in a ratio that is commonly used in herbal medicine.
  5. Fill the powder into gelatin capsules using a capsule filler, making sure each capsule contains the same amount of the herbal mixture.

Decoction

Salvia miltiorrhiza decoction is a traditional herbal remedy used to treat various health conditions, including cardiac inefficiency, hypertension, atherosclerosis, stroke, diabetes, anemia, arthritis, and chronic fatigue.

This decoction is widely used in Eastern medicine, particularly in China, where it is a common ingredient in traditional recipes. A common effect of Salvia miltiorrhiza decoction is the improvement of blood circulation and the reduction of inflammation. It is typically made from the roots of the Salvia miltiorrhiza plant, which contain the active compounds responsible for its medicinal properties.

The preparation process is moderately difficult, requiring precise measurements and a controlled environment to extract the maximum benefits from the roots, which are then boiled in water to create the decoction.

Below you find a 5-step quick procedure to make effective medicinal Salvia miltiorrhiza decoction.

  1. Gather and clean fresh Salvia miltiorrhiza roots.
  2. Cut the roots into smaller pieces to increase their surface area.
  3. Combine the root pieces in a pot and add a sufficient amount of water.
  4. Bring the water to a boil, then reduce the heat and simmer for an extended period.
  5. Strain the decoction and discard the solids to obtain the herbal liquid.

Tea

Salvia miltiorrhiza tea is a traditional herbal remedy used to treat cardiovascular disease, hypertension, stroke, atherosclerosis, diabetes, hypotension, angina, and neuropathy.

It's widely used in many cultures, making it a very common treatment for these conditions. This popularity is due in part to its vasodilatory effect, which helps to increase blood flow and reduce blood pressure. The tea is typically made from the roots, leaves, and flowers of the Salvia miltiorrhiza plant.

Preparation is relatively simple, as the dried plant material is steeped in hot water to create a brew that can be consumed.

Below you find an image of Salvia miltiorrhiza tea.

tea made with Salvia miltiorrhiza

Below you find a 5-step quick procedure to make effective medicinal Salvia miltiorrhiza tea.

  1. Gather fresh or dried Salvia miltiorrhiza roots, leaves, and flowers for the herbal tea.
  2. Rinse the roots, leaves, and flowers with water to clean them.
  3. Combine equal portions of the cleaned roots, leaves, and flowers in a tea infuser or a heat-resistant container.
  4. Steep the mixture in boiling water for 5-10 minutes to allow the herbal properties to infuse.
  5. Strain the tea and discard the solids before serving the Salvia miltiorrhiza herbal tea.

What are the possible side effects of Salvia miltiorrhiza if used improperly?

The possible side effects of improperly using Salvia miltiorrhiza are experiencing palpitations due to its ability to affect heart rate and rhythm.

Developing atrial fibrillation is also possible, as the plant's bioactive compounds can interfere with cardiac function, leading to irregular heart rhythms. Increasing risk of bleeding is a concern, as Salvia miltiorrhiza may interact with anticoagulant medications and exacerbate bleeding disorders. Experiencing dizziness and hypotension are other potential side effects, as the plant's vasodilatory effects can cause a sudden drop in blood pressure and lead to lightheadedness.

Additionally, improperly using Salvia miltiorrhiza may result in ventricular extrasystoles, nausea, vomiting, abnormal liver function, and in severe cases, cardiac arrest.

The most common side effects Salvia miltiorrhiza gives people when used improperly are listed below, along with a brief explanation.

What are the precautions to take before using Salvia miltiorrhiza medicinally?

The precautions to take before using Salvia miltiorrhiza medicinally are to consult a healthcare professional to determine the suitability of the plant for your specific needs, follow recommended dosages to avoid potential toxicity and ensure efficacy.

Monitoring blood pressure is essential due to the plant's potential vasodilatory effects, particularly for individuals with hypertension. Be cautious with interactions, as Salvia miltiorrhiza may interact with anticoagulants, antiplatelet drugs, and other medications, potentially leading to adverse effects. Additionally, avoid using Salvia miltiorrhiza during pregnancy and breastfeeding, as its effects on the fetus or infant are unknown.

Inform your healthcare provider about any medical conditions you have, especially cardiovascular disease, as the plant may exacerbate or interact with existing conditions, and be aware of potential allergic reactions, including skin rashes and anaphylaxis, which may require emergency medical attention, and use Salvia miltiorrhiza under medical supervision, monitoring liver function and reporting any side effects promptly, as these may indicate liver damage or other complications.

The most important precautions you must take before using Salvia miltiorrhiza for medicinal purposes are listed below, along with a brief explanation.

Are there scientific studies that prove the medical effectiveness of Salvia miltiorrhiza?

Yes, there are several scientific studies that prove the medicianl effectiveness of Salvia miltiorrhiza. Here are some studies that are worthy of notice.

According to a study published by "Phytomedicine : international journal of phytotherapy and phytopharmacology", Salvia miltiorrhiza has shown to have various positive effects on diabetes management. The herb has been found to exhibit anti-diabetic activities by improving redox homeostasis, inhibiting apoptosis and inflammation, and regulating multiple signaling pathways. Additionally, Salvia miltiorrhiza has been found to be well-tolerated and may offer a new strategy for prevention and treatment of diabetes and its complications.

In another study published by "Journal of ethnopharmacology", Salvia miltiorrhiza has been found to have therapeutic potential in treating various diseases, specifically those affecting the cardiovascular and immune systems. The bioactive substances, including diterpenoids and phenolic acids, in Salvia miltiorrhiza have been identified to exhibit pharmacological activities targeting these systems. These activities suggest that Salvia miltiorrhiza may be a valuable herbal medicine for curing ailments related to the cardiovascular and immune systems.

A different research published by "Oxidative medicine and cellular longevity", Salvia miltiorrhiza has been found to possess various beneficial effects on aging-associated cardiovascular diseases. It exerts antioxidant, antiapoptotic, and anti-inflammatory effects, while also promoting angiogenic and cardioprotective activities that can reduce oxidative stress and improve cardiovascular health. Additionally, Salvia miltiorrhiza has been shown to increase the activities of certain enzymes that combat oxidative stress, ultimately leading to a reduction in the risk of cardiovascular diseases.

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