10 Possible Side Effects Of Rheum Palmatum (Chinese Rhubarb)

Rheum palmatum, also known as Chinese rhubarb, has some side effects when used improperly, such as gastrointestinal irritation, allergic reactions, and kidney damage.

These side effects occur when the herb is taken in excessive doses or for an extended period.

For instance, gastrointestinal irritation can lead to stomach pain, nausea, and vomiting, making it difficult to maintain a regular diet and daily routine.

This article explains in details the 10 most common side effects of Rheum palmatum if used imporperly.

1. Produces toxic metabolites

Rheum palmatum, also known as Chinese rhubarb, causes stomach upset due to its high content of anthraquinone glycosides.

These compounds can irritate the mucous membranes in the digestive tract, leading to nausea, vomiting, and diarrhea.

The bitter taste and rough texture of Rheum palmatum can also cause gastrointestinal irritation, exacerbating symptoms such as bloating and abdominal pain.

2. Produces toxic metabolites

Rheum palmatum, also known as Chinese rhubarb, triggers allergic reactions in some individuals due to the presence of sesquiterpene lactones and other bioactive compounds found in its root extract.

These compounds can cause an immune response, leading to symptoms such as skin irritation, itching, and respiratory issues.

The high concentration of these allergens in Rheum palmatum products may exacerbate allergic reactions, making it essential for individuals to be aware of the potential risks involved.

3. Produces toxic metabolites

Rheum palmatum, also known as Chinese Rhubarb, increases blood pressure by stimulating the cardiovascular system and causing a constriction of blood vessels.

The bioactive compounds present in the herb, such as rhein and emodin, can bind to receptors in the body and mimic the effects of certain hormones, leading to increased heart rate and blood pressure.

This action is thought to be responsible for the hypertensive effect observed in some individuals taking Rheum palmatum supplements or remedies.

4. Produces toxic metabolites

Rheum palmatum, also known as Chinese rhubarb, worsens kidney disease by increasing the risk of nephrotoxicity due to its high concentration of anthraquinone glycosides.

These compounds can damage the kidneys and exacerbate existing conditions such as chronic kidney disease or kidney stones. Additionally, Rheum palmatum may reduce blood flow to the kidneys, further compromising their function.

As a result, individuals with pre-existing kidney issues should exercise caution when using this herb.

5. Produces toxic metabolites

Rheum palmatum, also known as Chinese Rhubarb, aggravates asthma symptoms due to its ability to stimulate the respiratory tract and increase mucus production.

The herb's expectorant properties can cause bronchial smooth muscle constriction, leading to airway inflammation and increased sensitivity in individuals with pre-existing asthma conditions.

This stimulation of the respiratory system can trigger wheezing, coughing, and shortness of breath in some users.

6. Produces toxic metabolites

Rheum palmatum, also known as Chinese Rhubarb, induces miscarriage risk due to its ability to stimulate uterine contractions and cause blood vessels to constrict.

The plant's bioactive compounds, including emodin and rhein, have been shown to increase the production of prostaglandins, which can induce labor and potentially lead to miscarriage.

Additionally, Rheum palmatum may interact with other herbs or medications that also stimulate uterine contractions, further increasing the risk of miscarriage.

7. Produces toxic metabolites

Rheum palmatum, also known as Chinese rhubarb, enhances bleeding risk due to its high concentration of anthraquinone glycosides, which have been shown to inhibit platelet aggregation and increase bleeding time.

The mechanism behind this effect is thought to involve the disruption of platelet function, leading to impaired blood clotting and a heightened susceptibility to bleeding episodes.

This property has been linked to increased bleeding risk in patients taking Rheum palmatum for various therapeutic purposes.

8. Produces toxic metabolites

Rheum palmatum, also known as Chinese Rhubarb, interacts with medications that affect blood clotting, such as warfarin and heparin, due to its anticoagulant properties.

This may lead to increased bleeding risk or decreased efficacy of these medications.

Additionally, Rheum palmatum may interact with other herbal remedies and prescription drugs, potentially enhancing their effects or causing adverse reactions.

9. Produces toxic metabolites

Rheum palmatum, also known as Chinese rhubarb, prohibits nutrient absorption.

The sennosides present in this herb can bind to nutrients such as calcium, magnesium, and iron in the gut, preventing their absorption into the bloodstream. This is due to the ability of these compounds to form complexes with ions, making it difficult for the body to utilize essential nutrients.

As a result, individuals taking Rheum palmatum may experience deficiencies in these vital minerals.

10. Produces toxic metabolites

Rheum palmatum, also known as Chinese Rhubarb, disrupts hormone balance due to its potential to interfere with the body's natural hormonal regulation.

This is because it contains bioactive compounds such as rhein and emodin, which can alter the production and secretion of hormones like estrogen and testosterone.

As a result, individuals may experience hormonal imbalances, including changes in menstrual cycles, mood swings, and altered libido, among other potential side effects.