Indian Snakeroot
Rauvolfia serpentina · Accepted scientific name
Scientific literature: Very Extensive (273 studies) · ★★★★★
Indian Snakeroot, scientifically known as Rauvolfia serpentina, is a perennial medicinal shrub native to the Indian subcontinent. Renowned in Ayurveda, it contains the potent alkaloid reserpine. Historically utilized to treat hypertension and mental disturbances, this plant remains a cornerstone in pharmacology for its significant sedative and antihypertensive properties.
Names and Synonyms
Common Names
- Indian Snakeroot
- Java devil-pepper
- ajmaline
- rauwolfia
- serpentine-wood
- snakewood
- Snakeroot
- serpentine wood
Scientific Names
Accepted name
Rauvolfia serpentinaSynonyms
- Rauvolfia obversa
- Rauvolfia serpentina var. obversa
- Ophioxylon salutiferum
- Ophioxylon album
- Rauvolfia trifoliata
- Ophioxylon serpentinum
- Ophioxylon trifoliatum
- Ophioxylon obversum
Regional and Traditional Names
Spanish:
- Rauwolfia serpentina
German:
- Indische Schlangenwurzel
- Sarpagandha
- Java-Teufelspfeffer
- Rauwolfia serpentina
- Wahnsinnskraut
- Java-Teufelspfeffer
French:
- Rauwolfia serpentina
Sources: Wikidata, Catalogue of Life
Taxonomical Classification
This plant belongs to the kingdom Plantae and the phylum Streptophyta, falling under the class Equisetopsida and subclass Magnoliidae. It is classified within the order Gentianales and the family Apocynaceae. Finally, it is identified under the genus Rauvolfia.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Gentianales |
| Family | Apocynaceae |
| Genus | Rauvolfia |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
This plant exhibits a widespread distribution across several key regions in Asia. In China, it can be found specifically throughout the South-Central, Southeast, and Hainan areas. Its presence extends into the Indian Subcontinent, where it is notably located in Assam. Additionally, the species is documented to grow within the borders of Bangladesh. Together, these locations highlight the plant's significant footprint across diverse subtropical landscapes.
| Region | Area |
|---|---|
| China | China South-Central |
| China | Hainan |
| China | China Southeast |
| Indian Subcontinent | Assam |
| Indian Subcontinent | Bangladesh |
| Indian Subcontinent | East Himalaya |
| Indian Subcontinent | India |
| Indian Subcontinent | Laccadive Is. |
| Indian Subcontinent | Nepal |
| Indian Subcontinent | Sri Lanka |
Sources: The World Checklist of Vascular Plants (WCVP)
Botanical Identification
Ecology
The ecology of Rauvolfia serpentina is characterized by its preference for moist, shady, and tropical environments, typically thriving in the undergrowth of deciduous and evergreen forests. It is commonly found in well-drained, loamy soils rich in organic matter, often occurring in areas with high humidity and filtered sunlight. The species demonstrates a specific altitudinal distribution, occupying an elevational range that extends from a minimum of 200 m AMSL to a maximum of 1200 m AMSL. This distribution pattern suggests the plant is well-adapted to various tropical sub-montane zones, where it plays a role in the forest floor ecosystem by stabilizing soil and providing micro-habitats within the shaded strata of its native habitats.
- Elevational range max:
- 1200 m AMSL
- Elevational range min:
- 200 m AMSL
Life history
The life history of Rauvolfia serpentina is characterized by its nature as a perennial plant, allowing it to persist through multiple growing seasons. It exhibits a phanerophyte life form, characterized by its woody structure and elevated buds, though it can also be classified under the nanophanerophyte category depending on its specific growth stage and environmental context. Throughout its life cycle, the plant maintains an evergreen deciduousness, ensuring that its foliage remains functional and present across different periods of the year.
- Deciduousness :
- evergreen
- Life form :
- nanophanerophyte
- Life form :
- phanerophyte
- Lifecycle :
- perennial
Morphology
The morphology of Rauvolfia serpentina is characterized by its growth form as a woody shrub, maintaining a self-supporting structure rather than acting as a climber. As an independent organism, it does not function as a parasite or an epiphyte, occupying a terrestrial habitat. The plant typically reaches a mean height of approximately 0.775 m, with individual specimens ranging in height from a minimum of 0.5 m to a maximum of 0.6 m.
- Aquatic :
- terrestrial
- Climber :
- self-supporting
- Epiphyte :
- terrestrial
- Growth form :
- shrub
- Parasite :
- independent
- Plant height max:
- 0.6 m
- Plant height mean:
- 0.775 m
- Plant height min:
- 0.5 m
- Woodiness :
- woody
Physiology
The physiological profile of Rauvolfia serpentina is characterized by specific morphological dimensions and nutritional strategies. The plant's foliage exhibits significant variability in size, with leaf lengths ranging from a minimum of 7 cm to a maximum of 17 cm, maintaining a mean length of approximately 12 cm. In terms of lateral expansion, the leaf width fluctuates between a minimum of 2 cm and a maximum of 5.5 cm. Regarding its metabolic and symbiotic capabilities, the plant does not function as a nitrogen fixer, meaning it lacks the specialized physiological mechanisms required to convert atmospheric nitrogen into usable forms for its own growth.
- Leaf length max:
- 17 cm
- Leaf length mean:
- 12 cm
- Leaf length min:
- 7 cm
- Leaf width max:
- 5.5 cm
- Leaf width min:
- 2 cm
- Nitrogen fixer :
- no
Sources: Global Inventory of Floras and Traits (GIFT)
Plant Parts
Rauvolfia serpentina has 3 reported plant parts identified across 7 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include root, leaf, seed.
| Plant part | Supporting sources | Consensus |
|---|---|---|
| Root | 5 supporting sources | ★★★☆☆ |
| Leaf | 1 supporting sources | ★☆☆☆☆ |
| Seed | 1 supporting sources | ★☆☆☆☆ |
Root
- Applied microbiology and biotechnology
- Journal of natural products
- Journal of chromatographic science
- Saudi journal of biological sciences
- Fitoterapia
Leaf
- Scientific reports
Seed
- Journal of pharmaceutical analysis
Chemicals
Rauvolfia serpentina has 59 reported phytochemicals identified across 7 scientific publications and several other databases. The most consistently reported chemicals include reserpine, ajmaline, Ajmalicine, Serpentine, Strictosidine.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| reserpine | 9 supporting sources | ★★★★☆ |
| ajmaline | 8 supporting sources | ★★★★☆ |
| Ajmalicine | 6 supporting sources | ★★★☆☆ |
| Serpentine | 3 supporting sources | ★★☆☆☆ |
| Strictosidine | 3 supporting sources | ★★☆☆☆ |
| Vinorine | 2 supporting sources | ★☆☆☆☆ |
| Yohimbine | 2 supporting sources | ★☆☆☆☆ |
| tryptamine | 2 supporting sources | ★☆☆☆☆ |
| 10-Hydroxy-19(S),20(R)-dihydroperaksine | 1 supporting sources | ★☆☆☆☆ |
| 16-epi-Vellosimine | 1 supporting sources | ★☆☆☆☆ |
reserpine
- Dr. Duke
- Schizophrenia research and treatment
- Applied microbiology and biotechnology
- Journal of chromatographic science
- 3 Biotech
View 4 additional sources
- Scientific reports
- Journal of Ayurveda and integrative medicine
- PloS one
- Fitoterapia
ajmaline
- Dr. Duke
- Bioorganic & medicinal chemistry
- Applied microbiology and biotechnology
- Journal of chromatographic science
- The Plant cell
View 3 additional sources
- 3 Biotech
- Biochimica et biophysica acta
- Fitoterapia
Ajmalicine
- Dr. Duke
- Applied microbiology and biotechnology
- Journal of chromatographic science
- 3 Biotech
- PloS one
View 1 additional sources
- Fitoterapia
Serpentine
- Dr. Duke
- Applied microbiology and biotechnology
- 3 Biotech
Strictosidine
- Plant physiology and biochemistry : PPB
- FEBS letters
- Bioorganic & medicinal chemistry
Vinorine
- Bioorganic & medicinal chemistry
- Chembiochem : a European journal of chemical biology
Yohimbine
- Dr. Duke
- Applied microbiology and biotechnology
tryptamine
- Plant physiology and biochemistry : PPB
- FEBS letters
10-Hydroxy-19(S),20(R)-dihydroperaksine
- Journal of natural products
16-epi-Vellosimine
- Bioorganic & medicinal chemistry
Activities
Rauvolfia serpentina has 152 reported activities identified across 7 scientific publications and several other databases. The most consistently reported activities include Antiarrhythmic, Antioxidant, Antibacterial, Antipsychotic, Abortifacient.
| Activity | Supporting sources | Consensus |
|---|---|---|
| Antiarrhythmic | 3 supporting sources | ★★☆☆☆ |
| Antioxidant | 3 supporting sources | ★★☆☆☆ |
| Antibacterial | 2 supporting sources | ★☆☆☆☆ |
| Antipsychotic | 2 supporting sources | ★☆☆☆☆ |
| Abortifacient | 1 supporting sources | ★☆☆☆☆ |
| Absorbent | 1 supporting sources | ★☆☆☆☆ |
| Adrenergic-Blocker | 1 supporting sources | ★☆☆☆☆ |
| Adrenolytic | 1 supporting sources | ★☆☆☆☆ |
| Allergenic | 1 supporting sources | ★☆☆☆☆ |
| Analgesic | 1 supporting sources | ★☆☆☆☆ |
Antiarrhythmic
- Dr. Duke
- Bioorganic & medicinal chemistry
- Acta crystallographica. Section D, Biological crystallography
Antioxidant
- Dr. Duke
- Oxidative medicine and cellular longevity
- Scientific reports
Antibacterial
- Dr. Duke
- Scientific reports
Antipsychotic
- Dr. Duke
- Schizophrenia research and treatment
Abortifacient
- Dr. Duke
Absorbent
- Dr. Duke
Adrenergic-Blocker
- Dr. Duke
Adrenolytic
- Dr. Duke
Allergenic
- Dr. Duke
Analgesic
- Dr. Duke
Conditions
Rauvolfia serpentina has 14 reported investigations on conditions identified across 7 scientific publications and several other databases. The most consistently reported conditions include hypertension, schizophrenia, Alzheimer's disease, COVID-19, Klebsiella pneumoniae.
| Condition | Supporting sources | Consensus |
|---|---|---|
| Hypertension | 3 supporting sources | ★★☆☆☆ |
| Schizophrenia | 2 supporting sources | ★☆☆☆☆ |
| Alzheimer's disease | 1 supporting sources | ★☆☆☆☆ |
| Covid-19 | 1 supporting sources | ★☆☆☆☆ |
| Klebsiella pneumoniae | 1 supporting sources | ★☆☆☆☆ |
| Sars-cov-2 | 1 supporting sources | ★☆☆☆☆ |
| Abdominal pain | 1 supporting sources | ★☆☆☆☆ |
| Anxiety | 1 supporting sources | ★☆☆☆☆ |
| Cognitive disorders | 1 supporting sources | ★☆☆☆☆ |
| Dysentery | 1 supporting sources | ★☆☆☆☆ |
Hypertension
- Applied microbiology and biotechnology
- PloS one
- Fitoterapia
Schizophrenia
- Schizophrenia research and treatment
- Applied microbiology and biotechnology
Alzheimer's disease
- PloS one
Covid-19
- BMC complementary medicine and therapies
Klebsiella pneumoniae
- Journal of pharmaceutical analysis
Sars-cov-2
- BMC complementary medicine and therapies
Abdominal pain
- Fitoterapia
Anxiety
- Applied microbiology and biotechnology
Cognitive disorders
- PloS one
Dysentery
- Fitoterapia
Preparations
Rauvolfia serpentina has 10 reported preparations identified across 7 scientific publications and several other databases. The most consistently reported preparations include Ayurvedic and Unani medicinal preparations, Extracts, Petroleum ether root extract, dried root, enzyme extracts.
| Preparation | Supporting sources | Consensus |
|---|---|---|
| Ayurvedic and unani medicinal preparations | 1 supporting sources | ★☆☆☆☆ |
| Extracts | 1 supporting sources | ★☆☆☆☆ |
| Petroleum ether root extract | 1 supporting sources | ★☆☆☆☆ |
| Dried root | 1 supporting sources | ★☆☆☆☆ |
| Enzyme extracts | 1 supporting sources | ★☆☆☆☆ |
| Hairy root culture | 1 supporting sources | ★☆☆☆☆ |
| Leaf extract | 1 supporting sources | ★☆☆☆☆ |
| Pectin | 1 supporting sources | ★☆☆☆☆ |
| Plant cell suspension cultures | 1 supporting sources | ★☆☆☆☆ |
| Roots | 1 supporting sources | ★☆☆☆☆ |
Ayurvedic and unani medicinal preparations
- Applied microbiology and biotechnology
Extracts
- PloS one
Petroleum ether root extract
- Saudi journal of biological sciences
Dried root
- Schizophrenia research and treatment
Enzyme extracts
- Natural product research
Hairy root culture
- Journal of natural products
Leaf extract
- Scientific reports
Pectin
- Cryo letters
Plant cell suspension cultures
- Natural product letters
Roots
- Journal of natural products