By Leen Randell

Updated: Oct 21, 2024

What to know about Psoralea corylifolia before using it medicinally

Psoralea corylifolia, commonly known as bakuchi, is an herb with a long history of medicinal use, particularly in traditional Ayurvedic and Unani medicine, to treat various health conditions including skin disorders, such as vitiligo and eczema, as well as conditions like arthritis, fever, and respiratory infections.

The main health benefits of Psoralea corylifolia include its antioxidant, anti-inflammatory, and immunomodulatory properties, which help to protect the body from oxidative stress and inflammation. The herb's therapeutic properties are attributed to its ability to modulate the immune system, enhance wound healing, and exhibit antimicrobial activity. The bioactive compounds present in Psoralea corylifolia include isopimpinellin, bergapten, and psoralen, which are responsible for its medicinal properties.

In traditional medicine, Psoralea corylifolia is commonly prepared as a paste or powder and used topically to treat skin conditions, or made into a decoction to treat various health conditions.

The following article explains in detail what are the medicinal uses of Psoralea corylifolia, its health benefits, therapeutic properties, bioactive compounds, used parts, and herbal preparation. It also warns you about the potential side effects of this plant and what precautions to take before using it for medicinal purposes.

ARTICLE SUMMARY: The table below summarizes the most crucial information about Psoralea corylifolia provided in the article below, which is useful if you are in a hurry and don't have time to dig deep into the very detailed content that follows.

BONUS CHEATSHEET: The cheatsheet below illustrates the most important medicinal aspects of Psoralea corylifolia. Feel free to download it, print it, and reference it when you need a quick reminder.

What are the main medicinal uses of Psoralea corylifolia?

The main medicinal uses of Psoralea corylifolia are treating impotence due to its flavonoid and alkaloid constituents, which improve blood circulation and testosterone levels.

Psoriasis is also alleviated by this plant's lignans, which have anti-inflammatory properties. Alopecia and eczema symptoms are reduced by Psoralea's sesquiterpenoids, which exhibit anti-fungal and anti-allergic activities. The lignans in Psoralea also help prevent hair loss by promoting scalp health and reducing dandruff.

Additionally, Psoralea's coumarins and flavonoids contribute to the relief of osteoporosis, skin diseases, arthritis, asthma, and vitiligo by modulating calcium metabolism, antioxidant activity, and immune response, respectively.

The following illustration give a summary of the main medicinal uses of Psoralea corylifolia.

The list below provide more details on why Psoralea corylifolia is used to alleviate the health conditions mentioned in the illustration above.

• Psoriasis: The extracts of this plant are used for treating psoriasis due to their anti-inflammatory properties, which help to reduce the redness and swelling of the skin.
• Eczema: The plant extracts are used for treating eczema because they have been shown to exhibit anti-inflammatory and antiseptic properties, which help to soothe and calm the skin.
• Alopecia: This plant is used for treating alopecia due to its ability to stimulate hair growth and improve scalp health, likely due to the presence of lignans and other compounds that have been shown to promote hair follicle activity.
• Osteoporosis: The plant is used for treating osteoporosis because it contains coumarins, which have been shown to have a positive effect on bone density and may help to reduce the risk of fractures.
• Impotence: The extracts of this plant are used for treating impotence due to their ability to improve libido and enhance erectile function, likely due to the presence of compounds that have been shown to have a stimulating effect on the nervous system.
• Leucoderma: The plant is used for treating leucoderma due to its ability to stimulate melanin production and promote skin pigmentation, likely due to the presence of compounds that have been shown to have a stimulating effect on melanocytes.
• Arthritis: The plant extracts are used for treating arthritis because they have been shown to exhibit anti-inflammatory properties, which help to reduce pain and swelling in the joints.
• Asthma: The extracts of this plant are used for treating asthma due to their ability to relax bronchial muscles and improve lung function, likely due to the presence of compounds that have been shown to have a bronchodilatory effect.
• Gout: The plant is used for treating gout due to its ability to reduce uric acid levels and alleviate symptoms, likely due to the presence of compounds that have been shown to have a uricosuric effect.
• Skin Cancer: The extracts of this plant are used for treating skin cancer due to their ability to inhibit the growth of cancer cells and induce apoptosis, likely due to the presence of compounds that have been shown to have a cytotoxic effect on cancer cells.

The table that follows gives an overview of what are the most common health conditions that are treated with Psoralea corylifolia, in each of the major medicinal systems.

Modern Western Medicine

In modern western medicine, Psoralea corylifolia is used to treat a variety of health conditions including psoriasis, a chronic autoimmune skin condition characterized by red, itchy patches.

It is also used to treat alopecia, a condition where hair loss occurs due to autoimmune disorders or hormonal imbalances. Additionally, the plant is used to alleviate symptoms of eczema, a condition that causes dry, itchy, and inflamed skin. Furthermore, Psoralea corylifolia is used to treat osteoporosis, a condition characterized by weakened bones, as well as hyperlipidemia, a condition where there is an abnormal increase in lipid levels in the blood.

The plant's active compounds are also being researched for their potential in treating a range of other conditions, such as hirsutism, impotence, gout, leucoderma, asthma, hypothyroidism, vitiligo, arthritis, skin cancer, infertility, menorrhagia, gastritis, skin psoriasis, diabetes, and thyroiditis.

Traditional Chinese Medicine

In traditional chinese medicine, Psoralea corylifolia is used to treat various health conditions, including alopecia, where it is believed to promote hair growth by stimulating follicles.

Additionally, it is used to alleviate symptoms of eczema, a chronic skin condition characterized by inflammation and irritation, and psoriasis, a condition that causes red, itchy, scaly patches on the skin. Psoralea corylifolia is also used to treat osteoporosis, a condition that weakens bones, making them more susceptible to fractures. Furthermore, it is used to address impotence, a condition that affects a man's ability to achieve or maintain an erection, and leucoderma, a condition where patches of skin lose their pigment.

Its medicinal properties also extend to treating a range of other conditions, including hyperlipidemia, gout, asthma, skin lesions, arthritis, menorrhagia, skin cancer, infertility, diabetes, hypertension, vitiligo, hirsutism, leukorrhea, and rheumatism.

Ayurvedic Medicine

In ayurvedic medicine, Psoralea corylifolia is used to treat psoriasis by inhibiting the proliferation of T cells and reducing inflammation in the skin.

It also helps to alleviate eczema by modulating the immune response and decreasing the production of pro-inflammatory cytokines. Additionally, it is used to address alopecia by promoting hair growth and reducing the formation of dihydrotestosterone, a hormone linked to hair loss. Furthermore, Psoralea corylifolia is employed to treat leucoderma, a condition characterized by the loss of skin pigmentation, by stimulating the production of melanin and increasing the activity of melanocytes.

It is also used to manage a range of other conditions, including osteoporosis, impotence, skin cancer, asthma, fungal infections, hirsutism, hyperlipidemia, arthritis, vitiligo, menorrhagia, gout, rheumatism, diabetes, hypercholesterolemia, hypothyroidism, and skin lesions, through its ability to modulate the immune system and antioxidant defenses.

Unani Medicine

In unani medicine, Psoralea corylifolia is used to treat psoriasis, a chronic skin condition characterized by thick, scaly skin patches, through its anti-inflammatory and immunomodulatory properties.

The plant is also used to manage eczema, a skin condition marked by redness, itching, and inflammation, by reducing the release of histamine and other inflammatory mediators. Additionally, Psoralea corylifolia has been found to be beneficial in treating alopecia, a condition characterized by hair loss, by stimulating hair growth and improving scalp health. Furthermore, the plant has been traditionally used to treat arthritis, osteoporosis, gout, skin leucoderma, asthma, vitiligo, impotence, diabetes, rheumatism, skin infections, warts, hirsutism, fungal infections, hyperlipidemia, skin itching, tuberculosis, and hypertension, often demonstrating its efficacy through the reduction of oxidative stress and inflammation, and the enhancement of immune function.

By harnessing the bioactive compounds present in Psoralea corylifolia, unani practitioners aim to alleviate symptoms and promote overall well-being in individuals afflicted with these conditions.

Homeopathic Medicine

In homeopathic medicine, Psoralea corylifolia is used to treat various skin and systemic conditions.

Psoriasis symptoms are alleviated through its anti-inflammatory properties, while eczema patients experience relief from skin irritation and itching. Alopecia treatment involves stimulating hair growth, and osteoporosis patients benefit from increased bone density. The plant's aphrodisiac properties are also used to treat impotence and other reproductive issues, such as arthritis-related sexual dysfunction.

Additionally, Psoralea corylifolia is used to treat asthma, hirsutism, gout, skin cancer, hyperlipidemia, acne, vitiligo, rheumatism, warts, leucoderma, ringworm, fungal infections, tinea, and hyperpigmentation.

What are the primary health benefits of Psoralea corylifolia?

Psoralea corylifolia improves skin quality by containing licoricidin, a compound that inhibits melanin production and prevents hyperpigmentation.

Psoralea corylifolia reduces joint pain by containing psoralen, a flavonoid that has anti-inflammatory properties and inhibits the production of pro-inflammatory cytokines. Psoralea corylifolia also treats osteoporosis by increasing bone mineral density through its ability to enhance calcium absorption and bone formation. Psoralea corylifolia prevents hair loss by containing a compound that promotes hair growth and reduces oxidative stress.

Psoralea corylifolia increases testosterone levels by containing a compound that inhibits the enzyme 5-alpha-reductase, which converts testosterone to dihydrotestosterone, thereby reducing androgenetic alopecia.

The following illustration give a summary of the primary health benefits of Psoralea corylifolia.

The list below provides more details on why Psoralea corylifolia offers the health benefits mentioned in the illustration above.

• Improves Skin Quality: This benefit is attributed to the plant's lignans and coumarins, which have been shown to exhibit antioxidant and anti-inflammatory properties, helping to protect the skin from damage, promote collagen synthesis, and improve skin elasticity.
• Reduces Joint Pain: The plant's lignans and coumarins have been found to exhibit anti-inflammatory and antioxidant properties, which help to reduce inflammation and oxidative stress in the joints, thereby alleviating joint pain and discomfort.
• Treats Osteoporosis: The plant's lignans and coumarins have been shown to promote bone health by inhibiting the activity of osteoclasts, which are cells responsible for bone resorption, and stimulating the activity of osteoblasts, which are cells responsible for bone formation.
• Prevents Hair Loss: The plant's coumarins have been found to promote hair growth by stimulating the activity of hair follicle stem cells and inhibiting the activity of 5-alpha-reductase, an enzyme that contributes to hair loss.
• Increases Testosterone Levels: The plant's lignans have been shown to exhibit estrogen-like properties, which help to increase testosterone levels by inhibiting the activity of aromatase, an enzyme that converts testosterone to estrogen.
• Enhances Immune Function: The plant's lignans and coumarins have been found to exhibit immunomodulatory properties, which help to enhance immune function by stimulating the activity of natural killer cells and T cells.
• Reduces Inflammation: The plant's lignans and coumarins have been shown to exhibit anti-inflammatory properties, which help to reduce inflammation by inhibiting the activity of pro-inflammatory enzymes and cytokines.
• Treats Allergic Rhinitis: The plant's lignans and coumarins have been found to exhibit anti-inflammatory and antioxidant properties, which help to reduce inflammation and oxidative stress in the nasal passages and alleviate symptoms of allergic rhinitis.
• Supports Liver Health: The plant's lignans and coumarins have been shown to exhibit hepatoprotective properties, which help to protect the liver from damage caused by toxins and oxidative stress.
• Prevents Cardiovascular Disease: The plant's lignans and coumarins have been found to exhibit antioxidant and anti-inflammatory properties, which help to reduce oxidative stress and inflammation in the cardiovascular system, thereby preventing cardiovascular disease.

The table that follows gives an overview of what are the primary health benefits of Psoralea corylifolia for each of the major body system.

Circulatory System

Psoralea corylifolia improves blood flow by reducing blood viscosity due to its naphthoquinone compounds, which have been shown to inhibit platelet aggregation and aggregation-induced platelet activation.

The plant's coumarin and furocoumarin derivatives reduce blood clots by inhibiting coagulation factors, including factor Xa and thrombin. By boosting circulation, Psoralea corylifolia lowers blood pressure through vasodilation caused by its flavonoid and phenolic acid components, which relax blood vessels and reduce peripheral resistance. This relaxation also enhances oxygenation of tissues, reducing inflammation by suppressing pro-inflammatory enzymes and cytokines.

Additionally, Psoralea corylifolia prevents thrombosis and improves cardiac function through its stimulation of collagen production and prevention of atherosclerotic plaque formation, while its antioxidant properties protect against lipid peroxidation and oxidative stress.

The medicinal benefits of Psoralea corylifolia on the circulatory system help relieving the health conditions listed below.

• Varicose veins
• Edema
• Poor circulation
• Blood clots
• Thrombosis
• Lymphedema

Digestive System

Psoralea corylifolia reduces inflammation in the digestive system through its anti-inflammatory and antioxidant properties, which help to alleviate swelling and pain.

Improves digestion by stimulating digestive enzymes and enhancing gut motility, thanks to its gastroprotective and prokinetic effects. This plant fights bacterial overgrowth by exhibiting antimicrobial properties that inhibit the growth of pathogenic bacteria, thereby maintaining a healthy gut microbiome. Psoralea corylifolia relaxes intestinal muscles by exerting a calming effect on smooth muscle contraction, which helps to regulate bowel movements and alleviate cramps.

The plant also protects gut lining, soothes irritable bowel, enhances nutrient absorption, heals leaky gut, regulates bowel movements, and boosts probiotic activity through its prebiotic properties, ultimately promoting a balanced and healthy gut ecosystem.

The medicinal benefits of Psoralea corylifolia on the digestive system help relieving the health conditions listed below.

• Diarrhea
• Constipation
• Indigestion
• Gastritis
• Ulcers
• Diverticulitis
• Irritable bowel syndrome
• Crohn's disease

Endocrine System

Psoralea corylifolia regulates hormonal balance through its flavonoid content, which exhibits antioxidant and anti-inflammatory properties, thereby modulating the endocrine system.

The plant supports thyroid function by enhancing the production of triiodothyronine and thyroxine, two essential thyroid hormones. Additionally, Psoralea corylifolia stimulates adrenal production, as it contains isoflavones that promote the synthesis of cortisol and other glucocorticoids. Furthermore, its lignans and coumarins exhibit insulin-sensitizing and lipolytic properties, boosting insulin sensitivity and improving metabolic rate.

Psoralea corylifolia also enhances ovarian function, maintains pancreatic health, regenerates testicular tissue, and stabilizes pituitary function, ultimately supporting endocrine homeostasis.

The medicinal benefits of Psoralea corylifolia on the endocrine system help relieving the health conditions listed below.

• Hyperthyroidism
• Hypothyroidism
• Goiter
• Polycystic ovary syndrome
• Infertility

Integumentary System

Psoralea corylifolia treats acne due to its antimicrobial properties, which inhibit the growth of acne-causing bacteria.

It improves skin by reducing inflammation and promoting cell regeneration, thanks to its antioxidant and anti-inflammatory properties. Psoralea corylifolia reduces scars through the stimulation of collagen production and tissue repair, a process facilitated by its anti-inflammatory and growth-promoting compounds. The plant heals wounds quickly by accelerating the healing process and reducing the risk of infection, a result of its antimicrobial and antioxidant properties.

Regular use of Psoralea corylifolia fades marks and sooths burns, eliminates blemishes, prevents rashes, cures eczema, and repairs skin, all benefits attributed to its antioxidant, anti-inflammatory, and antimicrobial properties.

The medicinal benefits of Psoralea corylifolia on the integumentary system help relieving the health conditions listed below.

• Eczema
• Psoriasis
• Acne
• Warts
• Scabies
• Ringworm
• Fungal infections
• Skin allergies

Lymphatic System

Psoralea corylifolia stimulates lymph flow by inducing the contraction of lymphatic vessels, improving the removal of toxins and waste products from the body.

Boosting immune cells is achieved through its immunomodulatory properties, enhancing the production of interferon, a key player in the immune response. The anti-inflammatory and antioxidant properties of Psoralea corylifolia reduce inflammation and enhance antioxidant activity, protecting cells from oxidative damage and promoting cellular cleansing. Additionally, its anti-inflammatory and antimicrobial properties reduce inflammation and prevent the growth of microorganisms, enhancing detoxification and improving lymphatic circulation.

By stimulating white blood cells and supporting lymph node function, Psoralea corylifolia increases the body's ability to fight off infections and diseases, further increasing interferon production and enhancing detoxification.

The medicinal benefits of Psoralea corylifolia on the lymphatic system help relieving the health conditions listed below.

• Lymphedema
• Lymphadenitis
• Lymphoma
• Lymphangitis
• Edema
• Swelling

Musculoskeletal System

Psoralea corylifolia reduces arthritis by suppressing pro-inflammatory cytokines and inhibiting the production of prostaglandins, which contribute to the inflammation and pain associated with arthritis.

This plant also relaxes muscles by exerting a sedative effect on the central nervous system, reducing muscle spasms and tension. Additionally, Psoralea corylifolia improves mobility by enhancing the production of osteocalcin, a protein essential for bone mineralization and density, thus promoting bone health and reducing the risk of fractures. The anti-inflammatory and antioxidant properties of Psoralea corylifolia soothe inflammation, ease pain, and strengthen bones by increasing bone mineral density and promoting collagen synthesis.

Furthermore, Psoralea corylifolia heals tendons by stimulating the production of growth factors, supports joints by regulating the balance of inflammatory and anti-inflammatory mediators, and regenerates ligaments by promoting the production of glycosaminoglycans, which are essential for maintaining joint health.

The medicinal benefits of Psoralea corylifolia on the musculoskeletal system help relieving the health conditions listed below.

• Arthritis
• Tendinitis
• Rheumatism
• Muscle spasms
• Gout

Nervous System

Psoralea corylifolia reduces anxiety by exerting a sedative effect, primarily attributed to its flavonoid and lignan compounds.

Its ability to improve cognitive function can be attributed to the antioxidant properties, which protect neurons from oxidative damage and enhance mitochondrial function. This plant enhances memory through its neuroprotective properties, specifically the inhibition of acetylcholinesterase, the enzyme that breaks down acetylcholine, a neurotransmitter involved in learning and memory. Psoralea corylifolia boosts neurotransmitters, including serotonin and dopamine, due to its antioxidant and anti-inflammatory properties, which promote the health and function of neurons.

The plant's flavonoids also support neuroplasticity and regulate mood by modulating the activity of neurotransmitters and their receptors, alleviating depression, and soothing neurological symptoms, while stimulating brain activity through the enhancement of neural connectivity.

The medicinal benefits of Psoralea corylifolia on the nervous system help relieving the health conditions listed below.

• Epilepsy
• Insomnia
• Depression
• Anxiety
• Schizophrenia
• Stress

Reproductive System

Psoralea corylifolia boosts fertility by increasing sperm count and motility, thanks to its antioxidant and anti-inflammatory properties that protect the reproductive system from oxidative stress and inflammation.

This plant improves ovulation by regulating the menstrual cycle and promoting the development of ovarian follicles, due to its ability to stimulate the production of gonadotropins. Psoralea corylifolia enhances libido by increasing the production of sex hormones, such as testosterone and estrogen, which are essential for sexual desire and function. It relieves dysmenorrhea by reducing prostaglandin production, which causes uterine contractions, and regulates menstrual cycles by modulating the hypothalamic-pituitary-gonadal axis.

Psoralea corylifolia increases testosterone levels by inhibiting the activity of 17β-hydroxysteroid dehydrogenase, an enzyme that converts androgens to estrogens, and supports reproductive health by protecting the reproductive system from oxidative damage, and promotes hormonal balance by regulating the hypothalamic-pituitary-gonadal axis, treats erectile dysfunction by increasing blood flow to the penis, and relaxes reproductive tissues by reducing inflammation and oxidative stress.

The medicinal benefits of Psoralea corylifolia on the reproductive system help relieving the health conditions listed below.

• Female infertility
• Hormonal imbalance
• Menopausal symptoms
• Endometriosis
• Polycystic ovary syndrome
• Amenorrhea

Respiratory System

Psoralea corylifolia reduce inflammation in the respiratory system due to its anti-inflammatory properties, which help alleviate swollen airways and ease breathing.

By preventing scarring, Psoralea corylifolia promotes healthy lung tissue growth, allowing for efficient gas exchange and oxygenation. Relieving congestion is also achieved through the plant's ability to relax bronchial muscles and expand airway passages, making it easier to breathe. The antimicrobial properties of Psoralea corylifolia eliminate mucus and other pathogens, while stimulating expectoration helps clear the lungs of excess mucus and debris, improving oxygenation and preventing infection.

Additionally, Psoralea corylifolia's antioxidant properties soothe tissues, calm irritation, and protect airways from damage caused by oxidative stress.

The medicinal benefits of Psoralea corylifolia on the respiratory system help relieving the health conditions listed below.

• Asthma
• Allergies
• Bronchitis
• Pneumonia
• Cough
• Tuberculosis

Urinary System

Psoralea corylifolia prevents kidney damage due to its antioxidant properties, which neutralize free radicals that cause oxidative stress and damage to renal cells.

This plant reduces urinary tract infections through its antimicrobial properties, which inhibit the growth of pathogenic bacteria and fungi. Psoralea corylifolia relieves prostate issues by its anti-inflammatory properties, which reduce swelling and ease the compression of the urethra. The plant treats kidney stones by its diuretic properties, which increase urine production and help flush out stone-forming substances.

Additionally, Psoralea corylifolia removes kidney impurities, cures urinary incontinence, prevents bladder cancer, relaxes urinary muscles, heals urinary tract inflammation, and supports kidney function through its unique combination of antioxidant, antimicrobial, anti-inflammatory, and diuretic properties.

The medicinal benefits of Psoralea corylifolia on the urinary system help relieving the health conditions listed below.

• Urinary tract infections
• Kidney stones
• Nephritis
• Prostatitis
• Cystitis
• Pyelonephritis
• Urolithiasis

What are the dominant therapeutic properties of Psoralea corylifolia?

The therapeutic properties of Psoralea corylifolia are attributed to its antimicrobial activity, which is primarily due to the presence of isopsoralen, a furanocoumarin with phototoxic and antiseptic effects.

This plant exhibits potent antioxidant properties, scavenging free radicals and protecting against oxidative stress, largely attributed to the flavonoids and saponins present in its extracts. Additionally, Psoralea corylifolia has been shown to possess anti-inflammatory activity, mediated by the inhibition of pro-inflammatory enzymes and cytokines, and its antifungal properties, which are thought to be a result of the plant's ability to disrupt fungal cell membranes. The plant's antibacterial and antiviral activities are also noteworthy, with various studies demonstrating its effectiveness against a range of microorganisms, while its analgesic properties have been attributed to the presence of sesquiterpenes and alkaloids.

Furthermore, Psoralea corylifolia has been found to possess hepatoprotective effects, potentially due to the antioxidant and anti-inflammatory activities of its bioactive compounds, and has also been studied for its anticancer properties, with some studies suggesting its potential role in inhibiting cancer cell growth.

The following illustration give a summary of the dominant therapeutic properties of Psoralea corylifolia.

The list below provides more details on why Psoralea corylifolia has the therapeutic properties mentioned in the illustration above.

• Antimicrobial: Psoralea corylifolia has been found to exhibit antimicrobial activity, particularly against Staphylococcus aureus, Escherichia coli, and Aspergillus niger, demonstrating its potential in treating infections.
• Antioxidant: The plant contains psoralen, a compound that has been shown to possess antioxidant properties, scavenging free radicals and preventing oxidative stress, which can contribute to various diseases.
• Anti-Inflammatory: Psoralea corylifolia has been reported to exhibit anti-inflammatory activity, reducing inflammation and alleviating symptoms associated with conditions such as arthritis and other inflammatory diseases.
• Antifungal: Studies have demonstrated that Psoralea corylifolia exhibits antifungal activity against various fungal species, including Candida albicans and Aspergillus niger, indicating its potential in treating fungal infections.
• Antibacterial: The plant has been found to exhibit antibacterial activity against a range of bacterial species, including Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, making it a potential candidate for treating bacterial infections.
• Antiviral: Psoralea corylifolia has been reported to exhibit antiviral activity against certain viruses, including HIV-1 and HSV-2, although further research is required to confirm its efficacy.
• Analgesic: The plant has been traditionally used to treat pain and has been found to exhibit analgesic activity, providing relief from pain and discomfort associated with various conditions.
• Hepatoprotective: Psoralea corylifolia has been reported to exhibit hepatoprotective activity, protecting the liver from damage and alleviating symptoms associated with liver disease.
• Anticancer: Studies have demonstrated that Psoralea corylifolia exhibits anticancer activity, inhibiting the growth of cancer cells and inducing apoptosis, although further research is required to confirm its efficacy as a cancer treatment.

What are the major healing constituents of Psoralea corylifolia?

The healing constituents of Psoralea corylifolia are psoralen, which is a furanocoumarin responsible for its phototoxic and therapeutic properties, particularly in the treatment of psoriasis and vitiligo due to its ability to penetrate the skin and react with UV light.

Additionally, the plant contains saponins, which exhibit anti-inflammatory and antioxidant activities by inhibiting the production of pro-inflammatory cytokines and scavenging free radicals. Flavonoids present in Psoralea corylifolia have been shown to possess anti-cancer properties by inducing apoptosis and inhibiting the proliferation of cancer cells. Coumarins, such as scopoletin and umbelliferone, also found in the plant, have anti-inflammatory and antioxidant effects, while phenolic acids, including caffeic acid and ferulic acid, exhibit antimicrobial and antioxidant activities by inhibiting the growth of microorganisms and scavenging free radicals.

These bioactive compounds contribute to the medicinal properties of Psoralea corylifolia, making it a valuable herb in traditional medicine.

The following illustration give a summary of the major healing consitutents of Psoralea corylifolia.

The list below provides more details on what are the major healing constituents of Psoralea corylifolia and why they are important for health.

• Psoralen: Psoralen is a furanocoumarin with phototoxic and photosensitizing properties, causing skin darkening and hyperpigmentation upon exposure to ultraviolet light.
• Saponins: Saponins are triterpenoid glycosides present in Psoralea corylifolia, exhibiting hemolytic, antifungal, and anti-inflammatory properties
• Flavonoids: Found in Psoralea corylifolia, Flavonoids are water-soluble, plant-derived compounds possessing antioxidant, anti-inflammatory, and antimicrobial properties.
• Coumarins: Coumarins are a class of organic compounds with anticoagulant, antimicrobial, and antioxidant properties
• Phenolic acids: Phenolic acids found in Psoralea corylifolia have antioxidant, anti-inflammatory, and antimicrobial properties.
• Benzofuran: Benzofuran is a lignan constituent of Psoralea corylifolia, exhibiting antioxidant and anti-inflammatory properties.
• Lignans: Lignans are a type of constituent in Psoralea corylifolia that possess antioxidant, anti-inflammatory and estrogenic properties.
• Isopsoralen: Isopsoralen is a furanocoumarin constituent of Psoralea corylifolia, exhibiting phototoxic, spasmolytic, and vasodilatory properties.
• Triterpenoids: Triterpenoids, found in Psoralea corylifolia, exhibit anti-inflammatory, antioxidant, and hepatoprotective properties.
• Isoimperatorin: Isoimperatorin is a furanocoumarin constituent of Psoralea corylifolia, exhibiting antioxidant, anti-inflammatory, and hepatoprotective properties.

The table that follows estimates the relative concentrations of the main medicinal constituents contained in Psoralea corylifolia and lists the most relevant medicinal properties of each constituent based on the corresponding concentrations.

What are the most used parts of Psoralea corylifolia in medicine?

The most used parts of Psoralea corylifolia for medicinal purposes are seeds, roots, and leaves.

The seeds are rich in isopsoralen, a furocoumarin responsible for their phototoxic properties, and are traditionally used to treat vitiligo and psoriasis due to their ability to stimulate melanin production and inhibit melanocyte proliferation. The roots contain psoralen and isosporalen, which exhibit anti-inflammatory and antioxidant properties, and are used to treat various conditions including rheumatism and fever. The leaves are a source of flavonoids such as kaempferol and quercetin, which possess antioxidant and anti-inflammatory activities, and are used to treat conditions like fever and skin diseases.

These bioactive compounds are responsible for the medicinal properties of Psoralea corylifolia, including anti-inflammatory, antioxidant, and phototoxic effects.

The following illustration give a summary of the most used parts of Psoralea corylifolia in medicine.

The list below provides more details on what are the most used parts of Psoralea corylifolia in medicine and why.

• Seeds: The seeds of this plant are rich in isopsoralen and psoralen, which possess potent antioxidant, anti-inflammatory, and immunomodulatory properties, conferring anti-arthritic, anti-diabetic, and anti-cancer benefits, as well as protecting against neurodegenerative diseases and cardiovascular disorders.
• Roots: The roots of this plant are primarily composed of isopsoralen, psoralen, and isomangiferin, which exhibit significant anti-inflammatory, antimicrobial, and antifungal activities, leading to therapeutic effects on various conditions, including fever reduction, wound healing, and the treatment of skin and soft tissue infections.
• Leaves: The leaves of this plant contain a diverse array of bioactive compounds, including isopsoralen, psoralen, and isomangiferin, which display pronounced anti-inflammatory, antioxidant, and immunomodulatory properties, resulting in potential therapeutic applications for the management of conditions such as arthritis, diabetes, and certain types of cancer.

The table that follows gives a more complete list of healing constituents found in each part of Psoralea corylifolia mentioned above.

What are the most common medicinal preparations of Psoralea corylifolia?

The most common herbal preparation of Psoralea corylifolia for medicinal purposes are tinctures, which are used to treat a variety of health issues, including skin conditions and reproductive problems.

Capsules are another preparation, providing a standardized and convenient dosage of the plant's active compounds, often used to enhance fertility and reduce symptoms of menopause. Decoctions, which involve boiling the plant material in water, are traditionally used to treat kidney stones and reduce inflammation. Salves, topical preparations made from the plant's extract, are applied directly to the skin to treat skin conditions such as eczema and psoriasis.

Tea, a liquid infusion of the plant's leaves, is consumed to treat respiratory issues, including bronchitis and asthma.

The following illustration give a summary of the most common medicinal preparations of Psoralea corylifolia.

The list below provides more details on what are the most common medicinal preparations of Psoralea corylifolia and what are their main uses.

• Tincture: Tincture made from this plant is a medicinal preparation used to treat skin diseases such as leucoderma and vitiligo, and also to enhance fertility in males.
• Capsule: Capsule made from this plant is used to treat hypogonadism, osteoporosis, and skin diseases such as vitiligo and psoriasis due to its anti-inflammatory and antioxidant properties.
• Decoction: Decoction made from this plant is used for treating leucoderma, skin diseases and scorpion stings, and also used as a diuretic and to treat kidney stones.
• Salve: Salve made from this plant is used to treat skin conditions such as eczema, psoriasis, and vitiligo, as well as to reduce inflammation and promote wound healing.
• Tea: Tea made from this plant is used to treat hyperlipidemia, osteoporosis, and erectile dysfunction by lowering cholesterol levels, increasing bone density, and improving erectile function.

The table that follows shows what are the most used parts of Psoralea corylifolia for each medicinal preparation.

Tincture

Psoralea corylifolia tincture is widely used to treat a range of conditions including psoriasis, infertility, arthritis, hypertension, asthma, osteoporosis, hyperlipidemia, diabetes and menopause.

It's a common preparation, often found in traditional medicine. Common effects include improved skin health and reduced inflammation. The tincture is typically made from the seeds and roots of the Psoralea corylifolia plant.

Due to the high lignans and coumarins content in the plant, it's difficult to produce a high-quality preparation, as the process requires careful extraction to preserve the active compounds.

Below you find an image of Psoralea corylifolia tincture.

Below you find a 5-step quick procedure to make effective medicinal Psoralea corylifolia tincture.

1. Harvest and dry the seeds and roots of Psoralea corylifolia in a clean, dark environment.
2. Combine the dried seeds and roots in a ratio of 1:1 and grind them into a fine powder using a mortar and pestle.
3. Mix the powder with 80% vodka in a clean glass container, making sure the plant material is completely submerged.
4. Allow the mixture to steep in a cool, dark place for 2-6 weeks, shaking the container occasionally, to facilitate extraction.
5. Strain the mixture through a cheesecloth or coffee filter into another container, discarding the solids and reserving the liquid tincture.

Capsule

Psoralea corylifolia capsule is a widely used herbal preparation that treats various conditions including hypothyroidism, hyperlipidemia, osteoporosis, asthma, menopause, infertility, diabetes, arthritis, impotence, and skin allergy.

It's one of the most common used herbal remedies, often found in traditional medicine systems. Common side effects of Psoralea corylifolia capsule include photosensitivity and gastrointestinal disturbances. The capsule is made from the seeds, roots, and flowers of the Psoralea corylifolia plant.

The preparation process is moderately complex, requiring careful drying and extraction of the plant's bioactive compounds.

Below you find a 5-step quick procedure to make effective medicinal Psoralea corylifolia capsule.

1. Collect and dry the seeds, roots, and flowers of Psoralea corylifolia.
2. Grind the dried seeds, roots, and flowers into a fine powder.
3. Mix the powder of seeds, roots, and flowers in a specific proportion.
4. Fill empty gelatin capsules with the prepared mixture.
5. Seal the capsules tightly and label them for identification and storage.

Decoction

Psoralea corylifolia decoction is used to treat various conditions including fungal infections, skin infections, psoriasis, eczema, alopecia, hyperlipidemia, arthritis, hypertension, diabetes and skin cancer.

It is a commonly used preparation in traditional medicine. Its common effect is the increase of follicular growth and the stimulation of hair growth. This preparation is made from the seeds and roots of the Psoralea corylifolia plant.

Preparation of the decoction is moderately difficult, requiring a specific ratio of plant material to water and a controlled temperature for a set period of time.

Below you find a 5-step quick procedure to make effective medicinal Psoralea corylifolia decoction.

1. Gather dried Psoralea corylifolia seeds and roots according to requirement.
2. Clean and wash the dried seeds and roots thoroughly to remove any impurities.
3. Combine the seeds and roots in a saucepan and pour sufficient water to cover them.
4. Boil the mixture over medium heat, then reduce the heat to low and let it simmer for an adequate period.
5. Strain the decoction and discard the solids, allowing it to cool before use.

Salve

Psoralea corylifolia salve is a herbal preparation used to treat eczema, psoriasis, alopecia, ringworm, tinea, scabies, pruritus, and acne.

It is a common treatment in traditional medicine due to its widespread use. The preparation has anti-inflammatory effects, reducing redness and itching associated with these conditions.

Psoralea corylifolia salve is typically made from the seeds and roots of the Psoralea corylifolia plant, which are combined in a process that can be challenging and time-consuming to prepare.

Below you find an image of Psoralea corylifolia salve.

Below you find a 5-step quick procedure to make effective medicinal Psoralea corylifolia salve.

1. Harvest the seeds and roots of the Psoralea corylifolia plant and clean them thoroughly.
2. Dry the seeds and roots in a low-temperature oven or through air drying to preserve their potency.
3. Combine the dried seeds and roots with a carrier oil such as olive or coconut oil in a clean glass jar.
4. Steep the mixture in the sun or through gentle heat to allow the active compounds to infuse into the oil.
5. Strain the infused oil and mix it with a natural wax such as beeswax to create a solid salve.

Tea

Psoralea corylifolia tea is a widely used herbal preparation that has been employed to treat various conditions including eczema, psoriasis, alopecia, acne, hyperlipidemia, osteoporosis and diabetes.

It is a very common herbal remedy due to its widespread availability and ease of access. This preparation often causes diuresis, a common effect where the body increases urine production. The tea is typically made from the seeds and roots of the Psoralea corylifolia plant, which are steeped in hot water to release their bioactive compounds.

Preparing Psoralea corylifolia tea is relatively simple, requiring only the addition of the plant material to boiling water and allowing it to steep before straining and consumption.

Below you find an image of Psoralea corylifolia tea.

Below you find a 5-step quick procedure to make effective medicinal Psoralea corylifolia tea.

1. Gather and clean the Psoralea corylifolia seeds and roots.
2. Dry the seeds and roots thoroughly in a cool, dark place for several days.
3. Combine the dried seeds and roots in a bowl, and grind them into a fine powder using a mortar and pestle.
4. Steep one teaspoon of the ground seed and root mixture in a cup of boiling water for 5-7 minutes.
5. Strain the liquid and serve the Psoralea corylifolia herbal tea hot or chilled.

What are the possible side effects of Psoralea corylifolia if used improperly?

The possible side effects of improperly using Psoralea corylifolia are nauseate, vomiting can occur, abdominal pain may arise due to liver toxicity.

Diarrhea and allergic reactions can also be triggered, the latter manifesting as itching and potentially life-threatening anaphylaxis. In some cases, hypotension can be caused by the plant's ability to lower blood pressure excessively.

This can further lead to headache, fatigue, and in rare instances, a skin rash may develop, typically associated with contact dermatitis.

The most common side effects Psoralea corylifolia gives people when used improperly are listed below, along with a brief explanation.

• Nauseate: Ingestion of Psoralea corylifolia causes gastrointestinal irritation leading to vomiting.
• Vomit: Administration of Psoralea corylifolia extracts induces nausea and vomiting in some individuals.
• Abdominal Pain: Severe abdominal pain occurs due to gastrointestinal irritation caused by Psoralea corylifolia's coumarins.
• Diarrhea: Psoralea corylifolia causes gastrointestinal irritation leading to loose stools and increased frequency of bowel movements.
• Allergic Reaction: Psoralea corylifolia causes an immune system response resulting in symptoms such as hives, itching, and swelling.
• Itching: Psoralea corylifolia causes contact dermatitis, resulting in intense itching.
• Hypotension: Psoralea corylifolia extracts cause a decrease in blood pressure
• Headache: Psoralea corylifolia contains coumarins, which can cause headache due to vasodilation.
• Fatigue: Psoralea corylifolia contains coumarin, which can cause decreased energy levels and physical exhaustion.
• Skin Rash: Psoralea corylifolia causes contact dermatitis, leading to skin rash and irritation.

What are the precautions to take before using Psoralea corylifolia medicinally?

The precautions to take before using Psoralea corylifolia medicinally are to consult a qualified practitioner to ensure safe administration, as it can interact with various medications and have adverse effects.

Follow recommended dosages, as excessive consumption can lead to liver damage and other complications. Monitoring blood sugar levels is essential, as Psoralea corylifolia may lower blood sugar levels and interact with diabetes medications. Avoid using this plant in pregnancy and breastfeeding, as it may cause adverse effects on the fetus or infant.

Additionally, report any allergic reactions, be cautious with potential interactions with other medications, monitor thyroid function, avoid using it in individuals with certain medical conditions, and store it safely out of reach to prevent accidental ingestion.

The most important precautions you must take before using Psoralea corylifolia for medicinal purposes are listed below, along with a brief explanation.

• Consult A Qualified Practitioner: Use under the guidance of a qualified practitioner due to potential interactions with medications and health conditions.
• Follow Recommended Dosages: Adhere strictly to prescribed dosages to avoid toxicity and adverse effects.
• Monitor Blood Sugar Levels: Concomitant use with antidiabetic drugs requires careful monitoring of blood glucose levels due to potential hypoglycemic effect.
• Watch For Liver Damage: Prolonged use of Psoralea corylifolia can cause hepatotoxicity and liver damage.
• Avoid In Pregnancy And Breastfeeding: Psoralea corylifolia may cause uterine stimulation and has estrogenic effects, potentially leading to miscarriage, premature labor, or other pregnancy complications.
• Report Allergic Reactions: Allergic reactions, including dermatitis, hives, and asthma, have been reported in individuals taking Psoralea corylifolia extracts.
• Be Cautious With Interactions: Psoralea corylifolia interacts with warfarin, increasing risk of bleeding.
• Monitor Thyroid Function: Psoralea corylifolia may inhibit thyroid peroxidase, necessitating thyroid function monitoring.
• Avoid In Certain Medical Conditions: Contraindicated in patients with kidney or liver disease, or those taking certain medications, including warfarin, due to increased risk of toxicity and adverse effects.
• Store Safely Out Of Reach: Keep out of the reach of children to prevent accidental ingestion.

Are there scientific studies that prove the medical effectiveness of Psoralea corylifolia?

Yes, there are several scientific studies that prove the medicianl effectiveness of Psoralea corylifolia. Here are some studies that are worthy of notice.

According to a study published by "Fitoterapia", Psoralea corylifolia seed extract has been found to stimulate the immune system in mice, leading to enhanced natural killer cell activity and antibody production. This stimulation of the immune system also inhibits the growth of EAC ascitic tumours. Furthermore, the extract promotes antibody-dependent cellular cytotoxicity and complement-mediated cytotoxicity during tumour development.

In another study published by "Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials", the processing of Psoralea corylifolia by Lei-Gong method increases the content of its effective composition, psoralen, and isopsoralen. This improvement in content enhances its biological activity, suggesting a potential increase in its therapeutic benefits. Furthermore, the processing also raises the levels of microelements such as Mn, Ca, Mg, and Fe, but has a minimal effect on the microelement Cu.

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