Polygonatum cyrtonema

What's the taxonomical classification of Polygonatum cyrtonema?

Polygonatum cyrtonema belongs to the kingdom Plantae and is classified within the phylum Streptophyta. Within the class Equisetopsida, it falls under the subclass Magnoliidae and is further categorized in the order Asparagales. This plant is a member of the family Asparagaceae, situated specifically within the genus Polygonatum, and is identified by its unique species designation, cyrtonema.

Taxonomic Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Asparagales
Family Asparagaceae
Genus Polygonatum
Species cyrtonema
Evidence Level: ★★★★☆

What are the morphological characteristics of this plant?

Polygonatum cyrtonema has slender, creeping rhizomes that produce erect stems reaching up to 50 centimeters in height with alternate, lanceolate leaves that possess entire margins and acute tips. The leaves are typically dark green and arranged in a single plane along the stem. Small, bell-shaped flowers emerge from the leaf axils in a pendulous fashion, often appearing in small clusters. These blossoms are creamy white or pale greenish-white and hang downward to protect the reproductive organs. Once pollinated, the plant develops small, oblong berries that transition from green to a dark reddish-brown or black color when ripe.

Evidence Level: ★☆☆☆☆

What is the geographical distribution of this plant?

This plant is native to specific regions of East Asia, primarily distributed across parts of China, Japan, and Korea. It thrives within temperate forest ecosystems where moisture and shade are consistent. Within these territories, it is often found growing in shaded woodland areas or along the edges of mountain slopes. The species demonstrates a preference for well-drained soils typical of these eastern mountainous habitats. Its range is relatively localized compared to more cosmopolitan plant species.

Evidence Level: ★☆☆☆☆

How is this plant cultivated?

This plant requires well-drained, humus-rich soil and a location with partial shade to thrive in temperate garden settings.

It is best cultivated by dividing the rhizomes during the dormant season to manage spreading. Consistent moisture is essential for its growth, though the soil must not remain waterlogged to prevent root rot. Once established, the plant is quite hardy and can tolerate various soil types as long as they remain fertile.

Regular mulching helps maintain the necessary cool, moist environment for its root system.

Evidence Level: ★☆☆☆☆

What parts of this plant are used medicinally?

This plant utilizes its rhizome, roots, and tubers for medicinal purposes, while the stem and leaf are generally not employed in traditional remedies. The fleshy rhizome serves as the primary source of bioactive compounds used to treat various ailments. Deeply embedded roots also contribute to the plant's therapeutic profile in herbal medicine. Small tubers found within the underground structure provide additional medicinal value. In contrast, the stem and leaf do not contain the necessary concentrations of healing substances required for treatment.

According to a study published by "Frontiers in plant science", Polygonatum cyrtonema Hua is a medicinal and edible perennial plant used in traditional Chinese medicine. This plant is rich in polysaccharides, which are bioactive compounds involved in multiple plant defense mechanisms. Research investigated the contents of polysaccharides, sucrose, glucose, and fructose across 4 specific tissues including the rhizome, stem, leaf, and flower. Polysaccharides were found to be mainly accumulated in the rhizomes, leaves, and flowers. The study also provided information regarding valuable genes involved in the tolerance to abiotic stresses in Polygonatum cyrtonema Hua.

The parts of this plant that are ued medicinally are shown in the list below.

  • Rhizome
  • Roots
  • Stem
  • Leaf
  • Tuber
Evidence Level: ★★★☆☆

What traditional systems uses this plant?

This plant, Polygonatum cyrtonema, is utilized in Traditional Chinese Medicine as a tonic herb known as Yu Zhu to nourish Yin and moisten the lungs. Historical practitioners primarily used the dried rhizomes to treat conditions characterized by dryness, such as chronic coughs and constipation. The herb is frequently incorporated into decoctions designed to replenish fluids and strengthen the stomach. Beyond its role in respiratory health, it has been applied to support kidney function and address deficiencies in essence. These traditional applications emphasize the plant's ability to balance internal moisture levels within the body.

According to a study published by "PloS one", Polygonatum cyrtonema is a perennial plant that has long been used in traditional Chinese medicine for food and medicine. The medicinal part of the plant is the rhizome, though the aerial parts are typically used in cosmetics, food storage, and animal feed. Research shows that the polysaccharide content in the whole rhizome (PCR) is 10.47%, which is higher than the 3.65% in PCS, 5.99% in PCL, and 4.76% in PCF. Additionally, the topping of the aerial part increased the rhizome weight gain coefficient to 3.43 and the total saponin content to 37.60 mg/g. In vitro hypoglycemic results showed that PCS, PCL, and PCF had inhibitory activities on α-amylase and α-glucosidase of 66.25% and 52.81%, which were close to the rhizome activities of 67.96% and 52.22%.

The hystorical systems that uses this plant are shown in the list below.

  • Traditional Chinese Medicine
Evidence Level: ★★★☆☆

What are the pharmacological activities of Polygonatum cyrtonema?

This plant has anti-diabetic, anti-inflammatory, anti-oxidant, immunomodulatory, and hypoglycemic pharmacological activities. Its hypoglycemic properties allow it to effectively lower blood glucose levels in various biological models. Through its anti-diabetic mechanisms, it helps manage systemic metabolic dysregulation. The plant also serves as a potent anti-inflammatory agent by reducing swelling and irritation in tissues. Additionally, its anti-oxidant and immunomodulatory effects protect cells from oxidative stress and regulate immune system responses.

According to a study published by "Journal of ethnopharmacology", Polygonatum cyrtonema is one of the species used to derive Huangjing. While the study identifies that the genus Polygonatum contains 71 species, it notes that at least 37 species and 1 variety have been utilized as traditional medicine and functional food. The pharmacological effects of the genus, which includes P. cyrtonema, include anti-aging, anti-diabetic, anti-fatigue, and anticancer effects. Specific confirmed pharmacological effects for the genus include anti-osteoporosis, neuroprotective, immunomodulatory, anti-diabetic, and anti-fatigue effects. These effects are mostly attributed to polysaccharides, saponins, and lectins.

The primary pharmacological activities of this plant are shown in the list below.

  • anti-diabetic
  • anti-inflammatory
  • anti-oxidant
  • immunomodulatory
  • hypoglycemic
Evidence Level: ★★★☆☆

What medicinal compounds this plant contains?

This plant contains the medicinal compounds (25S)-pratioside D1, Polygonatum cyrtonema polysaccharides (PCPs), iso-ophiopogonanone B, sarasapogenin, and various steroidal saponins. These specific bioactive molecules are responsible for the diverse pharmacological activities associated with the species. For instance, the steroidal saponins and sarasapogenin contribute to its traditional use in various health treatments. Furthermore, the unique polysaccharides known as PCPs play a significant role in its biological efficacy. Research continues to investigate how these distinct chemical constituents interact to produce therapeutic effects.

According to a study published by "Frontiers in plant science", Polygonatum cyrtonema is a medicinal and edible herb rich in polysaccharides, steroidal saponins, and flavonoids. Metabolome analysis showed that iso-ophiopogonanone B, (25S)-pratioside D1, disporopsin, and isodiosgenin-Glc-Glc were significantly upregulated in the stem and leaf compared with the rhizome. Most saccharides, including arabinose, cellobiose, maltoteatraose, and panose, showed the opposite trend regarding their accumulation. Additionally, 4-hydroxymandelonitrile was found to have a relatively good inhibitory effect on α-glucosidase, indicating a potential role in hypoglycemic functions. Candidate genes involved in the accumulation of these substances include PcSQLE, PcCYP71A1, PcSUS, PcFK, and PcMYB102.

The primary medicinal compounds of this plant are shown in the list below.

  • Polygonatum cyrtonema polysaccharides (PCPs)
  • iso-ophiopogonanone B
  • isodiosgenin-Glc-Glc
  • sarasapogenin
  • steroidal saponins
Evidence Level: ★★★☆☆

What health conditions is this plant used for?

This plant is used for treating Qi deficiency, Yin deficiency, Splen deficiency, Kidney deficiency, and Lung dryness. It acts as a tonic to nourish the body's essential fluids and vital energies. By addressing Kidney deficiency, it helps strengthen the foundational essence of the organism. The herb also targets Splen deficiency to improve digestive functions and overall nutrient absorption. Furthermore, it helps moisten the respiratory system to relieve symptoms associated with Lung dryness.

According to a study published by "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica", Polygonatum cyrtonema is one of 3 plant varieties of medicinal PR recorded in the Chinese Pharmacopoeia. This medicinal plant is used to tonify Qi and nourish Yin, while also helping to strengthen the spleen and kidney. It exhibits a wide range of pharmacological effects including anti-oxidation, anti-osteoporosis, and anti-tumor effects. The chemical components of this plant mainly include polysaccharides, steroidal saponins, flavonoids, phenylpropanoids, and alkaloids.

The main health conditions this plant is used for are shown in the list below.

  • Qi deficiency
  • Yin deficiency
  • spleen deficiency
  • spleen weakness
  • weakness of the stomach and intestines
Evidence Level: ★★★☆☆

What are the herbal preparations of this plant?

This plant is used to create medicinal herbal preparations such as Polygonati rhizoma decoction, infusion, tea, and wine. These various forms are prepared by processing the dried rhizomes to extract specific bioactive compounds. A decoction involves boiling the root in water to ensure a concentrated liquid extract. For milder applications, the plant is steeped as an infusion or consumed as a soothing tea. Additionally, the rhizomes can be macerated in alcohol to produce a medicinal wine.

According to a study published by "Frontiers in plant science", the rhizome of Polygonatum cyrtonema Hua is used as a traditional and classic dual-purpose material in both food and medicine. The rhizome of this plant is divided into five distinct types, which include the "Jitou"-type, atypical "Jitou"-type, "Jiang"-type, "Cylinder"-type, and "Baiji"-type. Researchers analyzed nutritional and medicinal component data along with antioxidant capacity using DPPH and ABTS tests to evaluate the quality of these different types. The results indicated that the comprehensive quality of the BJPR and JTPR types was better, regardless of their specific nutritional or medicinal values. These findings can be used to recommend future breeding efforts to produce Polygonatum cyrtonema with improved nutritional and medicinal qualities.

The main herbal preparations of this plant are shown in the list below.

  • Polygonati rhizoma
  • decoction
  • infusion
  • tea
  • wine
Evidence Level: ★★★☆☆

What side effects this plant can have?

This plant can cause hypoglycemia, oxidative stress, cell damage, disrupted bacterial and fungal communities, and reduced microbial diversity. Consumption of its components may lead to dangerously low blood sugar levels in sensitive individuals. The chemical constituents are also capable of triggering oxidative stress, which subsequently results in significant cell damage. Furthermore, the plant's compounds can alter the natural balance of the microbiome by disrupting bacterial and fungal communities. This disruption ultimately leads to a state of reduced microbial diversity within the body.

According to a study published by "Frontiers in plant science", Polygonatum cyrtonema is a medicinal and edible herb containing polysaccharides, steroidal saponins, and flavonoids. The plant contains 4-hydroxymandelonitrile, which has a relatively good inhibitory effect on alpha-glucosidase. This specific component may play a role in hypoglycemic functions. These findings regarding the main active substances relate to pathological and biological regulation.

The main side effects this plant can have are shown in the list below.

  • hypoglycemia
  • oxidative stress
  • cell damage
  • disrupted bacterial and fungal communities
  • reduced microbial diversity
Evidence Level: ★★★☆☆

What herbs are paired with Polygonatum cyrtonema?

This plant, Polygonatum cyrtonema, is traditionally paired with herbs such as Rehmannia glutinosa, Panax ginseng, and Astragalus membranaceus to balance its tonifying properties.

These combinations are frequently utilized in traditional Chinese medicine to nourish Yin and strengthen the body's vital energy. Rehmannia is often included to enhance the moistening effect on the kidneys and lungs. Adding ginseng or astragalus helps to boost the overall qi and counteract any potential depletion.

Together, these herb pairings aim to create a synergistic effect that supports systemic recovery and long-term vitality.

Evidence Level: ★☆☆☆☆