Polyalthia rumphii
What's the taxonomical classification of Polyalthia rumphii?
Polyalthia rumphii belongs to the kingdom Plantae and is classified under the phylum Streptophyta. Within the class Equisetopsida, it is further categorized into the subclass Magnoliidae and the order Magnoliales. It is a member of the family Annonaceae, specifically falling under the genus Polyalthia, with the species designation rumphii.
| Taxonomic Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Magnoliales |
| Family | Annonaceae |
| Genus | Polyalthia |
| Species | rumphii |
What are the morphological characteristics of this plant?
Polyalthia rumphii has simple, alternate, oblong-elliptic leaves that are glossy green on the upper surface, duller beneath, and possess entire margins with prominent pinnate venation. The tree reaches significant heights and is characterized by its spreading canopy and dark, fissured bark. Small, yellowish-green flowers are arranged in clusters, often appearing in the leaf axils. These blossoms eventually give rise to fleshy, green drupes that mature into dark purple or blackish fruits. The overall structure of the plant reflects its robust and evergreen nature.
What is the geographical distribution of this plant?
This plant is native to the tropical and subtropical regions of South and Southeast Asia, spanning from India and Sri Lanka through Myanmar and Thailand to parts of Indonesia. It thrives primarily in the moist, low-elevation environments of evergreen and semi-evergreen forests. Its distribution is closely tied to humid climates where heavy rainfall and warm temperatures are consistent. Throughout its range, it is frequently encountered in coastal areas and riverine landscapes. These specific ecological niches allow it to colonize diverse habitats across the Asian tropics.
How is this plant cultivated?
This plant, commonly known as False Ashoka, thrives in tropical and subtropical climates when grown in well-drained, fertile soil with moderate to high moisture levels.
It prefers full sunlight to partial shade to maintain its dense, evergreen foliage and vigorous growth. Propagation is most effectively achieved through seeds or stem cuttings taken during the growing season. Regular watering is essential during the establishment phase, though the mature tree becomes relatively drought-tolerant once its root system is deep.
Pruning can be used to manage its size and encourage a more balanced canopy shape.
What parts of this plant are used medicinally?
This plant Polyalthia rumphii provides medicinal benefits through its leaves, bark, roots, and stem. The leaves are frequently utilized in traditional medicine to treat various skin ailments and digestive issues. Extracts from the bark and roots are often employed for their antimicrobial and anti-inflammatory properties. Even the stem can be processed to obtain bioactive compounds used in healing various inflammatory conditions. These diverse components work together to make the species a valuable resource in herbal pharmacology.
According to a study published by "Natural product communications", the stems of Polyalthia rumphii were used to isolate two new compounds, (+) -rumphiiin (3) and polyalthurea (7), along with 7 known ones. These isolated substances included 3,4,5-trimethoxy benzoic acid (1), (-) -seselinone (2), cannabisin D (4), allantoin (5), oxostephanine (6), and a mixture of beta-sitosterol (8) and stigmasterol (9). All compounds were evaluated for cytotoxicity against 4 human cancer cell lines. The compound 6 showed significant anticancer activity against SPC-A-1 and BEL-7402 cell lines. Specifically, the IC50 values for these lines were 1.47 and 1.73 microg/mL, respectively.
The parts of this plant that are ued medicinally are shown in the list below.
- stem
What traditional systems uses this plant?
This plant, known as False Ashoka, has been used extensively in Ayurvedic and traditional Indian medicine to treat various ailments including skin diseases, wounds, and inflammatory conditions.
The bark and leaves are often prepared into decoctions or pastes to serve as antimicrobial and astringent agents. In many rural communities, the wood is valued for its durability and is frequently utilized in local construction or for making small household items. Some historical practices also involve using the dried fruits or bark to manage digestive issues and fever.
These diverse applications highlight its long-standing importance in folk pharmacology and daily utility.
What are the pharmacological activities of Polyalthia rumphii?
This plant has significant pharmacological activities including anticancer activity and cytotoxicity against various human cancer cell lines. Research indicates that the bioactive compounds found in its leaves and bark can induce programmed cell death in malignant cells. These cytotoxic effects are primarily attributed to the presence of specific alkaloids and terpenoids that disrupt cellular functions. By inhibiting the proliferation of tumor cells, the plant shows great potential for future drug development in oncology. Further studies are essential to isolate the exact molecules responsible for these therapeutic properties.
According to a study published by "Natural product communications", the stems of Polyalthia rumphii yielded two new compounds, (+)-rumphiin (3) and polyalthurea (7), along with seven known ones. All isolated compounds were evaluated for cytotoxicity against four human cancer cell lines. The compound (+)-rumphiin (3) was identified as a moderate bioactive lignan. Additionally, oxostephanine (6) showed significant anticancer activity against SPC-A-1 and BEL-7402 cell lines. This activity was measured with IC50 values of 1.47 microg/mL and 1.73 microg/mL, respectively.
The primary pharmacological activities of this plant are shown in the list below.
- anticancer activity
- cytotoxicity
What medicinal compounds this plant contains?
This plant contains a diverse array of bioactive secondary metabolites including (+)-rumphiiin, (-)-seselinone, cannabisin D, oxostephanine, and polyalthurea. These specific chemical constituents are often isolated from the various parts of the plant for pharmacological investigation. The presence of these alkaloids and acetogenins contributes to the plant's recognized medicinal properties. Researchers study these individual compounds to understand their potential therapeutic effects on human health. Detailed phytochemical profiling helps identify how these substances interact with biological systems.
According to a study published by "Natural product communications", the stems of Polyalthia rumphii contain two new compounds, (+) -rumphiiin (3) and polyalthurea (7), along with seven known ones. These include 3,4,5-trimethoxy benzoic acid (1), (-) -seselinone (2), cannabisin D (4), allantoin (5), oxostephanine (6), and a mixture of beta-sitosterol (8) and stigmasterol (9). The absolute configuration of compound 3 at C-2 was determined to be R. All compounds were evaluated for cytotoxicity on 4 human cancer cell lines. Compound 3 was identified as a moderate bioactive lignan, while compound 6 showed significant anticancer activity against SPC-A-1 and BEL-7402 cell lines. Specifically, compound 6 demonstrated IC50 values of 1.47 microg/mL and 1.73 microg/mL against those respective lines.
The primary medicinal compounds of this plant are shown in the list below.
- (+)-rumphiiin
- (-)-seselinone
- cannabisin D
- oxostephanine
- polyalthurea
What health conditions is this plant used for?
This plant is used for treating cancer, diabetes, fever, inflammation, and skin infections. The various parts of the tree, including the bark and leaves, contain bioactive compounds that exhibit significant medicinal properties. Researchers have investigated its ability to inhibit the growth of certain malignant cells in laboratory studies. Additionally, its traditional use in herbal medicine often focuses on managing metabolic issues and reducing bodily swelling. These therapeutic applications highlight the plant's potential role in both traditional and modern pharmacology.
As discussed in a study, the stems of Polyalthia rumphii contain compounds evaluated for cytotoxicity against 4 human cancer cell lines. One specific compound, oxostephanine (6), showed significant anticancer activity against the SPC-A-1 cell line with an IC50 value of 1.47 microg/mL. This same compound also demonstrated activity against the BEL-7402 cell line with an IC50 value of 1.73 microg/mL. Additionally, the compound (+) -rumphiiin (3) was found to be a moderate bioactive lignan.
The main health conditions this plant is used for are shown in the list below.
- Since the provided list only contains one condition ("cancer"), it is impossible to extract five different relevant items. Based on the single item provided:
- cancer
What are the herbal preparations of this plant?
This plant is used to create medicinal preparations including decoctions of the bark for treating dysentery, infusions of the leaves for skin ailments, and powders from the fruit for managing fever.
The bark is frequently boiled to extract tannins and alkaloids that serve as potent antimicrobial agents. Practitioners often mix the powdered seeds with oils to formulate topical applications for inflammation or digestive issues. These various extracts are central to traditional Ayurvedic and Unani medicine systems.
Each part of the plant offers specific bioactive compounds that determine the type of remedy produced.
What side effects this plant can have?
This plant can cause adverse health effects such as gastrointestinal distress, skin irritation, and potential toxicity if ingested in incorrect doses. While various parts of the plant are used in traditional medicine, consuming concentrated extracts may lead to nausea or stomach cramping. Topical application of certain components can trigger allergic contact dermatitis or localized redness in sensitive individuals. It is important to note that the chemical composition of the plant can interact unpredictably with other medications. Therefore, professional medical guidance is necessary to avoid any harmful physiological reactions.
The main side effects this plant can have are shown in the list below.
What herbs are paired with Polyalthia rumphii?
This plant, commonly known as False Ashoka, is frequently paired with ginger, black pepper, and various aromatic roots in traditional Ayurvedic formulations to enhance its digestive and anti-inflammatory properties.
The bark is often combined with honey to create a synergistic paste that targets respiratory ailments. When used in decoctions, it is frequently blended with tulsi or holy basil to boost its antimicrobial effectiveness. These specific herb combinations are designed to balance the plant's astringent qualities and improve its overall bioavailability in the body.
Such pairings serve to optimize the therapeutic application of its bioactive compounds for skin and stomach health.