wild leadwort
Plumbago zeylanica · Accepted scientific name
Scientific literature: Very Extensive (238 studies) · ★★★★★
Wild leadwort, scientifically known as Plumbago zeylanica, is a perennial herb highly valued in traditional Ayurvedic medicine. Renowned for its potent therapeutic properties, it is frequently utilized to treat various ailments, including skin disorders, inflammation, and digestive issues. Its bioactive compounds make it a significant subject in ethnopharmacology.
Names
Common Names
- Blister Bush
- Bright Eyes
- Eyebright
- Toothwort
- Ceylon leadwort
- doctorbush
- plumbago
- wild plumbago
- White Flowered Leadwort
- Wild white plumbago
- wild leadwort
Regional and Traditional Names
Spanish:
- Aretitos
French:
- Plumbago sauvage
Scientific Names
Accepted name
Plumbago zeylanicaSynonyms
- Plumbagidium scandens
- Molubda scandens
- Findlaya alba
- Plumbago scandens var. densiflora
- Thela alba
- Plumbago littoralis
- Plumbago zeylanica var. oxypetala
- Plumbago zeylanica var. glaucescens
- Plumbago viscosa
- Plumbago canescens
- Plumbago toxicaria
- Plumbago maximowiczii
- Plumbago mexicana
- Plumbago occidentalis
- Plumbago juncea
- Plumbago scandens
- Plumbago sarmentosa
- Plumbago flaccida
- Plumbago floridana
- Plumbago lactea
- Plumbago americana
- Plumbago scandens var. erecta
Taxonomical Classification
This plant, known scientifically as Plumbago zeylanica, belongs to the kingdom Plantae and the phylum Streptophyta. Within the class Equisetopsida and subclass Magnoliidae, it is classified under the order Caryophyllales. Finally, it is a member of the family Plumbaginaceae and the genus Plumbago.
| Rank | Classification | Source |
|---|---|---|
| Kingdom | Plantae | WCVP |
| Phylum | Streptophyta | WCVP |
| Class | Equisetopsida | WCVP |
| Subclass | Magnoliidae | WCVP |
| Order | Caryophyllales | WCVP |
| Family | Plumbaginaceae | WCVP |
| Genus | Plumbago | WCVP |
Distribution
This plant exhibits a diverse geographical range that spans several distinct regions across the globe. In Southeastern Europe, its presence can be noted within the country of Italy. Moving toward the Atlantic, it is found in the Macaronesian region, specifically in Cape Verde. The species also extends into West Tropical Africa, where it inhabits the nations of Benin and Burkina. Finally, its distribution continues through West Tropical Africa to include the country of Gambia.
| Region | Area | Source |
|---|---|---|
| Southeastern Europe | Italy | WCVP |
| Macaronesia | Cape Verde | WCVP |
| West Tropical Africa | Benin | WCVP |
| West Tropical Africa | Burkina | WCVP |
| West Tropical Africa | Gambia | WCVP |
| West Tropical Africa | Ghana | WCVP |
| West Tropical Africa | Guinea-Bissau | WCVP |
| West Tropical Africa | Guinea | WCVP |
| West Tropical Africa | Ivory Coast | WCVP |
| West Tropical Africa | Liberia | WCVP |
Plant Parts
This plant, Plumbago zeylanica, is a medicinal shrub where various components are utilized for their therapeutic properties. The roots are frequently employed in traditional medicine to treat various ailments, and even a single extracted root can contain potent bioactive compounds. The leaf is also significant, often used in topical applications or decoctions. Furthermore, the Root system provides stability and nutrient absorption, while the slender stem supports the plant's growth and carries its small, fragrant flowers.| Plant Part | Sources | Consensus |
|---|---|---|
| root | Phytotherapy research : PTR (and other 18 sources) | ★★★★★ |
| leaf | 3 Biotech (and other 3 sources) | ★★☆☆☆ |
| stem | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 1 sources) | ★☆☆☆☆ |
Chemicals
Plumbago zeylanica has 39 reported phytochemicals identified across 22 scientific publications and several other databases. The most consistently reported chemicals include Plumbagin, Flavonoids, 5-Hydroxy-2-methyl-1,4-naphthoquinone, Phenols, Isoshinanolone.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| Plumbagin | 36 supporting sources | ★★★★★ |
| Flavonoids | 7 supporting sources | ★★★★☆ |
| 5-Hydroxy-2-methyl-1,4-naphthoquinone | 3 supporting sources | ★★☆☆☆ |
| Phenols | 3 supporting sources | ★★☆☆☆ |
| Isoshinanolone | 2 supporting sources | ★☆☆☆☆ |
| 1,4-NAPHTHOQUINONE | 1 supporting sources | ★☆☆☆☆ |
| 4-hydroxybenzaldehyde | 1 supporting sources | ★☆☆☆☆ |
| AFLATOXIN B1 | 1 supporting sources | ★☆☆☆☆ |
| ARSENIC | 1 supporting sources | ★☆☆☆☆ |
| BETA-SITOSTEROL | 1 supporting sources | ★☆☆☆☆ |
Plumbagin
- Journal of pharmacological sciences
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- The Journal of biological chemistry
- Redox report : communications in free radical research
- Journal of natural medicines
View 31 additional sources
- Mutagenesis
- Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
- Heliyon
- Bone research
- Phytotherapy research : PTR
- Food science & nutrition
- Acta pharmacologica Sinica
- Molecular cancer research : MCR
- Biochimica et biophysica acta. Proteins and proteomics
- Journal of natural products
- Molecular oncology
- Analytica chimica acta
- PloS one
- Journal of neuroimmunology
- 3 Biotech
- Fitoterapia
- Parasitology research
- Journal of plant research
- Alternative therapies in health and medicine
- Folia medica
- Hybridoma (2005)
- International journal of nanomedicine
- Chemical biology & drug design
- Indian journal of physiology and pharmacology
- Experimental dermatology
- Dalton transactions (Cambridge, England : 2003)
- RSC advances
- BioMed research international
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Indian journal of pharmaceutical sciences
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
Flavonoids
- Redox report : communications in free radical research
- Journal of nanoscience and nanotechnology
- Iranian journal of pharmaceutical research : IJPR
- Biotechnology journal
- Microbiological research
View 2 additional sources
- International journal of nanomedicine
- Advances in pharmacological sciences
5-Hydroxy-2-methyl-1,4-naphthoquinone
- The Journal of biological chemistry
- Molecular cancer research : MCR
- Analytica chimica acta
Phenols
- Journal of nanoscience and nanotechnology
- Biotechnology journal
- Microbiological research
Isoshinanolone
- Fitoterapia
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
1,4-NAPHTHOQUINONE
- Molecular oncology
4-hydroxybenzaldehyde
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
AFLATOXIN B1
- Microbial ecology
ARSENIC
- Analytica chimica acta
BETA-SITOSTEROL
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
Activities
Plumbago zeylanica has 15 reported activities identified across 22 scientific publications and several other databases. The most consistently reported activities include Anticancer, Antioxidant, Hepatoprotective, Antimicrobial, Antidiabetic.
Most Reported Activities
| Activity | Sources | Consensus |
|---|---|---|
| Anticancer | Journal of nanoscience and nanotechnology (and other 6 sources) | ★★★☆☆ |
| Antioxidant | Journal of traditional and complementary medicine (and other 6 sources) | ★★★☆☆ |
| Hepatoprotective | Saudi journal of biological sciences (and other 4 sources) | ★★☆☆☆ |
| Antimicrobial | Food science & nutrition (and other 3 sources) | ★★☆☆☆ |
| Antidiabetic | Food science & nutrition (and other 2 sources) | ★☆☆☆☆ |
| Cardiotonic | Redox report : communications in free radical research (and other 2 sources) | ★☆☆☆☆ |
| Neuroprotective | Redox report : communications in free radical research (and other 2 sources) | ★☆☆☆☆ |
| Antiatherosclerotic | Indian journal of physiology and pharmacology (and other 1 sources) | ★☆☆☆☆ |
| Anticarcinogenic | The Journal of biological chemistry (and other 1 sources) | ★☆☆☆☆ |
| Antimalarial | Food science & nutrition (and other 1 sources) | ★☆☆☆☆ |
Medicinal Uses
Plumbago zeylanica has 64 reported medicinal uses identified across 22 scientific publications and several other databases. The most consistently reported uses include cancer, inflammation, skin cancer, E. coli, PCa.
Most Reported Uses
| Use | Sources | Consensus |
|---|---|---|
| cancer | Journal of pharmacological sciences (and other 5 sources) | ★★★☆☆ |
| inflammation | Journal of traditional and complementary medicine (and other 3 sources) | ★★☆☆☆ |
| skin cancer | Carcinogenesis (and other 3 sources) | ★★☆☆☆ |
| E. coli | International journal of nanomedicine (and other 2 sources) | ★☆☆☆☆ |
| PCa | Cancer research (and other 2 sources) | ★☆☆☆☆ |
| anemia | Food science & nutrition (and other 2 sources) | ★☆☆☆☆ |
| arthritis | Food science & nutrition (and other 2 sources) | ★☆☆☆☆ |
| breast cancer | Bone research (and other 2 sources) | ★☆☆☆☆ |
| cardiotonic | Redox report : communications in free radical research (and other 2 sources) | ★☆☆☆☆ |
| glioma | Journal of pharmacological sciences (and other 2 sources) | ★☆☆☆☆ |
Preparations
| Preparations | Sources | Consensus |
|---|---|---|
| extracts | Iranian journal of pharmaceutical research : IJPR (and other 3 sources) | ★★☆☆☆ |
| Plumbagin | The Journal of biological chemistry (and other 2 sources) | ★☆☆☆☆ |
| plumbagin | Bone research (and other 2 sources) | ★☆☆☆☆ |
| 50% ethanol extract of the root | Phytotherapy research : PTR (and other 1 sources) | ★☆☆☆☆ |
| 80% methanol extract of the root part | Journal of ethnopharmacology (and other 1 sources) | ★☆☆☆☆ |
| 80% methanolic extracts | Journal of ethnopharmacology (and other 1 sources) | ★☆☆☆☆ |
| 90% ethanol extraction | Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (and other 1 sources) | ★☆☆☆☆ |
| Alcoholic crude extracts | Microbiological research (and other 1 sources) | ★☆☆☆☆ |
| Aqueous extracts of leaves | Advances in pharmacological sciences (and other 1 sources) | ★☆☆☆☆ |
| Aqueous root extract | International journal of nanomedicine (and other 1 sources) | ★☆☆☆☆ |