wild leadwort

Plumbago zeylanica · Accepted scientific name

Scientific literature: Very Extensive (238 studies) · ★★★★★

Wild leadwort, scientifically known as Plumbago zeylanica, is a perennial herb highly valued in traditional Ayurvedic medicine. Renowned for its potent therapeutic properties, it is frequently utilized to treat various ailments, including skin disorders, inflammation, and digestive issues. Its bioactive compounds make it a significant subject in ethnopharmacology.

Family
Plumbaginaceae
Native range
Europe
Parts used
Root · Leaf
Common names
Blister Bush · Bright Eyes · 9 more
Scientific synonyms
Plumbagidium Scandens · Molubda Scandens · 20 more

Names

Common Names

Regional and Traditional Names

Spanish:

  • Aretitos

French:

  • Plumbago sauvage

Scientific Names

Accepted name

Plumbago zeylanica

Synonyms

Taxonomical Classification

This plant, known scientifically as Plumbago zeylanica, belongs to the kingdom Plantae and the phylum Streptophyta. Within the class Equisetopsida and subclass Magnoliidae, it is classified under the order Caryophyllales. Finally, it is a member of the family Plumbaginaceae and the genus Plumbago.

Rank Classification Source
Kingdom Plantae WCVP
Phylum Streptophyta WCVP
Class Equisetopsida WCVP
Subclass Magnoliidae WCVP
Order Caryophyllales WCVP
Family Plumbaginaceae WCVP
Genus Plumbago WCVP

Distribution

This plant exhibits a diverse geographical range that spans several distinct regions across the globe. In Southeastern Europe, its presence can be noted within the country of Italy. Moving toward the Atlantic, it is found in the Macaronesian region, specifically in Cape Verde. The species also extends into West Tropical Africa, where it inhabits the nations of Benin and Burkina. Finally, its distribution continues through West Tropical Africa to include the country of Gambia.

Region Area Source
Southeastern Europe Italy WCVP
Macaronesia Cape Verde WCVP
West Tropical Africa Benin WCVP
West Tropical Africa Burkina WCVP
West Tropical Africa Gambia WCVP
West Tropical Africa Ghana WCVP
West Tropical Africa Guinea-Bissau WCVP
West Tropical Africa Guinea WCVP
West Tropical Africa Ivory Coast WCVP
West Tropical Africa Liberia WCVP

Plant Parts

This plant, Plumbago zeylanica, is a medicinal shrub where various components are utilized for their therapeutic properties. The roots are frequently employed in traditional medicine to treat various ailments, and even a single extracted root can contain potent bioactive compounds. The leaf is also significant, often used in topical applications or decoctions. Furthermore, the Root system provides stability and nutrient absorption, while the slender stem supports the plant's growth and carries its small, fragrant flowers.
Plant Part Sources Consensus
root Phytotherapy research : PTR (and other 18 sources) ★★★★★
leaf 3 Biotech (and other 3 sources) ★★☆☆☆
stem Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 1 sources) ★☆☆☆☆

Chemicals

Plumbago zeylanica has 39 reported phytochemicals identified across 22 scientific publications and several other databases. The most consistently reported chemicals include Plumbagin, Flavonoids, 5-Hydroxy-2-methyl-1,4-naphthoquinone, Phenols, Isoshinanolone.

Chemicals reported in Plumbago zeylanica
Chemical Supporting sources Consensus
Plumbagin 36 supporting sources ★★★★★
Flavonoids 7 supporting sources ★★★★☆
5-Hydroxy-2-methyl-1,4-naphthoquinone 3 supporting sources ★★☆☆☆
Phenols 3 supporting sources ★★☆☆☆
Isoshinanolone 2 supporting sources ★☆☆☆☆
1,4-NAPHTHOQUINONE 1 supporting sources ★☆☆☆☆
4-hydroxybenzaldehyde 1 supporting sources ★☆☆☆☆
AFLATOXIN B1 1 supporting sources ★☆☆☆☆
ARSENIC 1 supporting sources ★☆☆☆☆
BETA-SITOSTEROL 1 supporting sources ★☆☆☆☆

Plumbagin

  1. Journal of pharmacological sciences
  2. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
  3. The Journal of biological chemistry
  4. Redox report : communications in free radical research
  5. Journal of natural medicines
View 31 additional sources
  1. Mutagenesis
  2. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
  3. Heliyon
  4. Bone research
  5. Phytotherapy research : PTR
  6. Food science & nutrition
  7. Acta pharmacologica Sinica
  8. Molecular cancer research : MCR
  9. Biochimica et biophysica acta. Proteins and proteomics
  10. Journal of natural products
  11. Molecular oncology
  12. Analytica chimica acta
  13. PloS one
  14. Journal of neuroimmunology
  15. 3 Biotech
  16. Fitoterapia
  17. Parasitology research
  18. Journal of plant research
  19. Alternative therapies in health and medicine
  20. Folia medica
  21. Hybridoma (2005)
  22. International journal of nanomedicine
  23. Chemical biology & drug design
  24. Indian journal of physiology and pharmacology
  25. Experimental dermatology
  26. Dalton transactions (Cambridge, England : 2003)
  27. RSC advances
  28. BioMed research international
  29. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  30. Indian journal of pharmaceutical sciences
  31. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Flavonoids

  1. Redox report : communications in free radical research
  2. Journal of nanoscience and nanotechnology
  3. Iranian journal of pharmaceutical research : IJPR
  4. Biotechnology journal
  5. Microbiological research
View 2 additional sources
  1. International journal of nanomedicine
  2. Advances in pharmacological sciences

5-Hydroxy-2-methyl-1,4-naphthoquinone

  1. The Journal of biological chemistry
  2. Molecular cancer research : MCR
  3. Analytica chimica acta

Phenols

  1. Journal of nanoscience and nanotechnology
  2. Biotechnology journal
  3. Microbiological research

Isoshinanolone

  1. Fitoterapia
  2. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

1,4-NAPHTHOQUINONE

  1. Molecular oncology

4-hydroxybenzaldehyde

  1. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

AFLATOXIN B1

  1. Microbial ecology

ARSENIC

  1. Analytica chimica acta

BETA-SITOSTEROL

  1. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

Activities

Plumbago zeylanica has 15 reported activities identified across 22 scientific publications and several other databases. The most consistently reported activities include Anticancer, Antioxidant, Hepatoprotective, Antimicrobial, Antidiabetic.

Most Reported Activities

Activity Sources Consensus
Anticancer Journal of nanoscience and nanotechnology (and other 6 sources) ★★★☆☆
Antioxidant Journal of traditional and complementary medicine (and other 6 sources) ★★★☆☆
Hepatoprotective Saudi journal of biological sciences (and other 4 sources) ★★☆☆☆
Antimicrobial Food science & nutrition (and other 3 sources) ★★☆☆☆
Antidiabetic Food science & nutrition (and other 2 sources) ★☆☆☆☆
Cardiotonic Redox report : communications in free radical research (and other 2 sources) ★☆☆☆☆
Neuroprotective Redox report : communications in free radical research (and other 2 sources) ★☆☆☆☆
Antiatherosclerotic Indian journal of physiology and pharmacology (and other 1 sources) ★☆☆☆☆
Anticarcinogenic The Journal of biological chemistry (and other 1 sources) ★☆☆☆☆
Antimalarial Food science & nutrition (and other 1 sources) ★☆☆☆☆

Medicinal Uses

Plumbago zeylanica has 64 reported medicinal uses identified across 22 scientific publications and several other databases. The most consistently reported uses include cancer, inflammation, skin cancer, E. coli, PCa.

Most Reported Uses

Use Sources Consensus
cancer Journal of pharmacological sciences (and other 5 sources) ★★★☆☆
inflammation Journal of traditional and complementary medicine (and other 3 sources) ★★☆☆☆
skin cancer Carcinogenesis (and other 3 sources) ★★☆☆☆
E. coli International journal of nanomedicine (and other 2 sources) ★☆☆☆☆
PCa Cancer research (and other 2 sources) ★☆☆☆☆
anemia Food science & nutrition (and other 2 sources) ★☆☆☆☆
arthritis Food science & nutrition (and other 2 sources) ★☆☆☆☆
breast cancer Bone research (and other 2 sources) ★☆☆☆☆
cardiotonic Redox report : communications in free radical research (and other 2 sources) ★☆☆☆☆
glioma Journal of pharmacological sciences (and other 2 sources) ★☆☆☆☆

Preparations

Preparations Sources Consensus
extracts Iranian journal of pharmaceutical research : IJPR (and other 3 sources) ★★☆☆☆
Plumbagin The Journal of biological chemistry (and other 2 sources) ★☆☆☆☆
plumbagin Bone research (and other 2 sources) ★☆☆☆☆
50% ethanol extract of the root Phytotherapy research : PTR (and other 1 sources) ★☆☆☆☆
80% methanol extract of the root part Journal of ethnopharmacology (and other 1 sources) ★☆☆☆☆
80% methanolic extracts Journal of ethnopharmacology (and other 1 sources) ★☆☆☆☆
90% ethanol extraction Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials (and other 1 sources) ★☆☆☆☆
Alcoholic crude extracts Microbiological research (and other 1 sources) ★☆☆☆☆
Aqueous extracts of leaves Advances in pharmacological sciences (and other 1 sources) ★☆☆☆☆
Aqueous root extract International journal of nanomedicine (and other 1 sources) ★☆☆☆☆