Fallopia multiflora

Pleuropterus multiflorus · Accepted scientific name

Scientific literature: Very Extensive (760 studies) · ★★★★★

Fallopia multiflora, scientifically known as Pleuropterus multiflorus, is a perennial herb native to East Asia, highly revered in traditional medicine. Commonly called Japanese knotweed, its nutrient-rich rhizomes contain potent compounds like resveratrol, offering significant antioxidant and anti-inflammatory benefits used to support circulation, longevity, and overall metabolic health.

Family
Polygonaceae
Native range
Asia-Temperate
Parts used
Root · Leaf
Common names
Not available
Scientific synonyms
Reynoutria Multiflora · Fallopia Multiflora · 10 more

Names and Synonyms

Scientific Names

Accepted name

Pleuropterus multiflorus

Synonyms

Sources: Wikidata

Taxonomical Classification

This plant belongs to the kingdom Plantae within the phylum Streptophyta and the class Equisetopsida. It is further classified under the subclass Magnoliidae and the order Caryophyllales. Finally, it is a member of the family Polygonaceae and falls under the genus Pleuropterus.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Caryophyllales
Family Polygonaceae
Genus Pleuropterus

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant exhibits a broad geographical distribution across several distinct regions. In the Caucasus, it can be found specifically within the Transcaucasus area. Its presence in China is widespread, spanning from the North-Central regions to the Southeast. Furthermore, the species is documented in the South-Central parts of China. Finally, its range extends southward to include the island of Hainan.

Region Area
Caucasus Transcaucasus
China China South-Central
China Hainan
China China North-Central
China China Southeast
Eastern Asia Japan
Eastern Asia Korea
Eastern Asia Taiwan
Indo-China Thailand
Indo-China Vietnam

Sources: The World Checklist of Vascular Plants (WCVP)

Plant Parts

Pleuropterus multiflorus has 4 reported plant parts identified across 19 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include root, leaf, rhizome, stem.

Plant parts reported in Pleuropterus multiflorus
Plant part Supporting sources Consensus
Root 14 supporting sources ★★★★★
Leaf 3 supporting sources ★★☆☆☆
Rhizome 1 supporting sources ★☆☆☆☆
Stem 1 supporting sources ★☆☆☆☆

Root

  1. Applied biosciences
  2. Molecules (Basel, Switzerland)
  3. Planta medica
  4. Journal of ethnopharmacology
  5. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
View 9 additional sources
  1. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  2. Pharmacognosy magazine
  3. Frontiers in plant science
  4. Frontiers of medicine
  5. The American journal of Chinese medicine
  6. Heliyon
  7. Plants (Basel, Switzerland)
  8. Journal of chromatography. A
  9. Journal of natural products

Leaf

  1. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  2. Heliyon
  3. Planta medica

Rhizome

  1. Oxidative medicine and cellular longevity

Stem

  1. Planta medica

Chemicals

Pleuropterus multiflorus has 125 reported phytochemicals identified across 19 scientific publications and several other databases. The most consistently reported chemicals include emodin, Physcion, Anthraquinones, Gallic acid, Flavonoids.

Chemicals reported in Pleuropterus multiflorus
Chemical Supporting sources Consensus
emodin 19 supporting sources ★★★★★
Physcion 11 supporting sources ★★★★★
Anthraquinones 7 supporting sources ★★★★☆
Gallic acid 5 supporting sources ★★★☆☆
Flavonoids 4 supporting sources ★★☆☆☆
Rhein 4 supporting sources ★★☆☆☆
TSG 4 supporting sources ★★☆☆☆
ANTHRAQUINONE 3 supporting sources ★★☆☆☆
Stilbenes 3 supporting sources ★★☆☆☆
ARSENIC 2 supporting sources ★☆☆☆☆

emodin

  1. Dr. Duke
  2. Phytotherapy research : PTR
  3. Journal of ethnopharmacology
  4. Planta medica
  5. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
View 14 additional sources
  1. Frontiers in plant science
  2. Pharmaceutical biology
  3. Acta pharmacologica Sinica
  4. Frontiers in pharmacology
  5. Journal of acupuncture and meridian studies
  6. Biological & pharmaceutical bulletin
  7. Molecules (Basel, Switzerland)
  8. Protoplasma
  9. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  10. Phytomedicine : international journal of phytotherapy and phytopharmacology
  11. Chemical research in toxicology
  12. The American journal of Chinese medicine
  13. Plants (Basel, Switzerland)
  14. Journal of chromatography. A

Physcion

  1. Dr. Duke
  2. Chemical research in toxicology
  3. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  4. Frontiers in plant science
  5. Frontiers in pharmacology
View 6 additional sources
  1. Biological & pharmaceutical bulletin
  2. Journal of AOAC International
  3. Protoplasma
  4. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  5. The American journal of Chinese medicine
  6. Journal of ethnopharmacology

Anthraquinones

  1. Dr. Duke
  2. Journal of ethnopharmacology
  3. Journal of pharmaceutical and biomedical analysis
  4. Scientific data
  5. Journal of AOAC International
View 2 additional sources
  1. Protoplasma
  2. Frontiers in plant science

Gallic acid

  1. Dr. Duke
  2. Frontiers in pharmacology
  3. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  4. Molecules (Basel, Switzerland)
  5. Journal of chromatography. A

Flavonoids

  1. Applied microbiology and biotechnology
  2. Frontiers in plant science
  3. Heliyon
  4. Planta medica

Rhein

  1. Dr. Duke
  2. Toxicology letters
  3. Pharmacognosy magazine
  4. Journal of chromatography. A

TSG

  1. Journal of ethnopharmacology
  2. BioMed research international
  3. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  4. Plants (Basel, Switzerland)

ANTHRAQUINONE

  1. Journal of ethnopharmacology
  2. Pharmacognosy magazine
  3. Journal of acupuncture and meridian studies

Stilbenes

  1. Applied microbiology and biotechnology
  2. Frontiers in plant science
  3. Heliyon

ARSENIC

  1. Dr. Duke
  2. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials

Activities

Pleuropterus multiflorus has 454 reported activities identified across 19 scientific publications and several other databases. The most consistently reported activities include Anticancer, Antioxidant, Estrogenic, Hepatoprotective, Antimicrobial.

Activities reported in Pleuropterus multiflorus
Activity Supporting sources Consensus
Anticancer 5 supporting sources ★★★☆☆
Antioxidant 5 supporting sources ★★★☆☆
Estrogenic 4 supporting sources ★★☆☆☆
Hepatoprotective 4 supporting sources ★★☆☆☆
Antimicrobial 3 supporting sources ★★☆☆☆
Neuroprotective 3 supporting sources ★★☆☆☆
Antiinflammatory 2 supporting sources ★☆☆☆☆
Antiosteoporotic 2 supporting sources ★☆☆☆☆
Antiviral 2 supporting sources ★☆☆☆☆
Cardioprotective 2 supporting sources ★☆☆☆☆

Anticancer

  1. Dr. Duke
  2. Phytotherapy research : PTR
  3. Journal of ethnopharmacology
  4. International journal of molecular medicine
  5. Archiv der Pharmazie

Antioxidant

  1. Dr. Duke
  2. Phytotherapy research : PTR
  3. Journal of ethnopharmacology
  4. Protoplasma
  5. Neurochemistry international

Estrogenic

  1. Dr. Duke
  2. Environmental toxicology and pharmacology
  3. Journal of ethnopharmacology
  4. Phytotherapy research : PTR

Hepatoprotective

  1. Dr. Duke
  2. Phytotherapy research : PTR
  3. Scientific data
  4. Archiv der Pharmazie

Antimicrobial

  1. Phytotherapy research : PTR
  2. Journal of ethnopharmacology
  3. Archiv der Pharmazie

Neuroprotective

  1. Dr. Duke
  2. Phytomedicine : international journal of phytotherapy and phytopharmacology
  3. Archiv der Pharmazie

Antiinflammatory

  1. Dr. Duke
  2. Phytotherapy research : PTR

Antiosteoporotic

  1. Dr. Duke
  2. Journal of ethnopharmacology

Antiviral

  1. Dr. Duke
  2. Archiv der Pharmazie

Cardioprotective

  1. Dr. Duke
  2. Archiv der Pharmazie

Conditions

Pleuropterus multiflorus has 2 reported investigations on conditions identified across 19 scientific publications and several other databases. The most consistently reported conditions include amnesia, lung cancer.

Conditions investigated for Pleuropterus multiflorus
Condition Supporting sources Consensus
Amnesia 1 supporting sources ★☆☆☆☆
Lung cancer 1 supporting sources ★☆☆☆☆

Amnesia

  1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Lung cancer

  1. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Preparations

Pleuropterus multiflorus has 44 reported preparations identified across 19 scientific publications and several other databases. The most consistently reported preparations include Polygonum multiflorum extract, hairy roots, 70% EtOH extracts, Fresh (raw) Heshouwu, Heshouwu.

Preparations reported for Pleuropterus multiflorus
Preparation Supporting sources Consensus
Polygonum multiflorum extract 2 supporting sources ★☆☆☆☆
Hairy roots 2 supporting sources ★☆☆☆☆
70% etoh extracts 1 supporting sources ★☆☆☆☆
Fresh (raw) heshouwu 1 supporting sources ★☆☆☆☆
Heshouwu 1 supporting sources ★☆☆☆☆
Meoh extract of the dried root tubers 1 supporting sources ★☆☆☆☆
Pmc-12 1 supporting sources ★☆☆☆☆
Pme 1 supporting sources ★☆☆☆☆
Rhizome extract 1 supporting sources ★☆☆☆☆
Zishen yutai pill 1 supporting sources ★☆☆☆☆

Polygonum multiflorum extract

  1. Journal of chromatography. A
  2. Drug development and industrial pharmacy

Hairy roots

  1. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  2. Pharmacognosy magazine

70% etoh extracts

  1. Journal of ethnopharmacology

Fresh (raw) heshouwu

  1. Journal of ethnopharmacology

Heshouwu

  1. Frontiers of medicine

Meoh extract of the dried root tubers

  1. Journal of natural products

Pmc-12

  1. Neuroscience letters

Pme

  1. Plants (Basel, Switzerland)

Rhizome extract

  1. Oxidative medicine and cellular longevity

Zishen yutai pill

  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica