Medicinal Herbs

Phyllanthus niruri · Accepted scientific name

Scientific literature: Very Extensive (498 studies) · ★★★★★

Medicinal Herbs, scientifically known as Phyllanthus niruri, is a versatile plant widely revered in traditional Ayurvedic medicine. Often called "stonebreaker," it is celebrated for its potent hepatoprotective and diuretic properties. This small herb plays a vital role in supporting liver health and managing kidney stones through its bioactive compounds.

Family
Phyllanthaceae
Native range
Northern America
Parts used
Leaf
Common names
Stone Breaker Tea
Scientific synonyms
Nymphanthus Niruri · Diasperus Niruri

Names and Synonyms

Common Names

Scientific Names

Accepted name

Phyllanthus niruri

Synonyms

Regional and Traditional Names

Spanish:

  • Phyllanthus rosellus
  • Phyllanthus lathyroides
  • Phyllanthus humilis
  • Chanca piedra
  • Nymphanthus niruri
  • Niruris indica
  • Phyllanthus kirganella
  • Phyllanthus chlorophaeus
  • Quebra pedra
  • Phyllanthus filiformis
  • Diasperus lathyroides
  • Diasperus rosellus
  • Phyllanthus lathyroides var. commutatus
  • Niruris annua
  • Phyllanthus carolinianus
  • Phyllanthus amarus
  • chancapiedra
  • quinina criolla
  • Barbasquillo
  • Dormilona
  • Rompe piedras

German:

  • Niruri
  • Steinbrecher

French:

  • derrière dos
  • quinine créole

Sources: Wikidata, Catalogue of Life

Taxonomical Classification

This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta and the class Equisetopsida. Within the subclass Magnoliidae, it is further categorized under the order Malpighiales and the family Phyllanthaceae. Finally, it is identified by the genus Phyllanthus.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Malpighiales
Family Phyllanthaceae
Genus Phyllanthus

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant exhibits a widespread distribution across several key regions in North America. In the United States, its presence is specifically noted within the state of Texas in the South-Central region. Moving into Mexico, it can be found throughout the diverse landscapes of Mexico Central. The species also extends into the coastal and inland areas of Mexico Gulf. Finally, its range reaches the varied terrains of Mexico Northwest, completing its regional footprint.

Region Area
South-Central U.S.A. Texas
Mexico Mexico Central
Mexico Mexico Northeast
Mexico Mexico Gulf
Mexico Mexico Northwest
Mexico Mexico Southwest
Mexico Mexico Southeast
Central America Belize
Central America Costa Rica
Central America Honduras

Sources: The World Checklist of Vascular Plants (WCVP)

Botanical Identification

Ecology

The ecology of Phyllanthus niruri is characterized by remarkable adaptability across diverse and varied environments, ranging from coastal ecosystems to high-altitude terrains. It thrives in a wide array of habitats, including anthropogenic areas, Caatinga (strictu sensu), Campinarana, Campo de Várzea, Campo Limpo, Cerrado (lato sensu), Floresta Ombrófila (pluvial forest), and Restinga. This environmental plasticity is further reflected in its significant altitudinal distribution, which spans from sea level up to a maximum elevation of 3000 m AMSL. With an average elevational range of approximately 1880 m AMSL, the species demonstrates a robust capacity to occupy both lowland tropical regions and much higher montane zones.

Elevational range max:
3000 m AMSL
Elevational range mean:
1880 m AMSL
Elevational range min:
0 m AMSL
Habitat :
Área Antrópica, Caatinga (stricto sensu), Campinarana, Campo de Várzea, Campo Limpo, Cerrado (lato sensu), Floresta Ombrófila (= Floresta Pluvial), Restinga

Life history

The life history of Phyllanthus niruri is characterized by an annual lifecycle, completing its entire biological process from germination to seed production within a single growing season. As a therophyte, the plant adopts a strategy of surviving unfavorable environmental conditions through highly resilient seeds rather than persistent vegetative structures, allowing it to rapidly colonize disturbed areas or seasonal habitats. This life form is further classified under the therophyte category, signifying that the individual plant dies at the end of the season, leaving behind seeds that remain dormant until the next period of favorable moisture and temperature.

Life form :
therophyte
Lifecycle :
annual

Morphology

The morphology of Phyllanthus niruri is characterized by its classification as a non-woody herb and specifically a forb. It functions as a self-supporting plant, lacking the climbing mechanisms of a liana or vine, and grows as an independent organism rather than a parasite or epiphyte. The plant is strictly terrestrial in its habitat and does not exhibit aquatic or semiaquatic tendencies. In terms of stature, it is a relatively small species with a mean plant height of approximately 0.3 m, though it can reach a maximum height of about 0.457 m.

Aquatic :
terrestrial
Climber :
self-supporting
Epiphyte :
terrestrial
Growth form :
herb
Growth form :
forb
Parasite :
independent
Plant height max:
0.457200914 m
Plant height mean:
0.3 m
Woodiness :
non-woody

Physiology

The physiology of Phyllanthus niruri is characterized by a non-succulent growth habit, as it lacks the specialized parenchyma tissues required for significant water storage within its stems or leaves, necessitating a consistent moisture environment to maintain turgor pressure. It does not function as a nitrogen fixer, meaning it lacks the symbiotic relationship with rhizobia or actinomycetes required to convert atmospheric nitrogen into bioavailable forms, relying instead on the uptake of nitrates and ammonium from the soil through its root system. The plant's metabolic processes are centered around the synthesis of diverse secondary metabolites, such as lignans, flavonoids, and tannins, which are produced through complex biochemical pathways to serve as defense mechanisms. Its photosynthetic efficiency is driven by standard C3 pathways, utilizing chlorophyll to convert solar energy into chemical energy, while its transpiration rates are regulated by stomatal movement to balance gas exchange with water loss in its typical tropical or subtropical habitats.

Nitrogen fixer :
no
Succulence :
no

Reproduction

The reproduction of Phyllanthus niruri is characterized by a broad and flexible flowering period that can span nearly the entire year, typically beginning in September and concluding in October, though the specific timing remains highly variable. Regarding its seed dispersal mechanisms, the plant utilizes an autochorous syndrome, meaning it relies on internal mechanisms for seed dispersal rather than external agents. This autochorous trait is consistently observed across its reproductive cycles, facilitating the spread of its progeny through self-dispersal methods.

Dispersal syndrome :
autochorous
Flowering time :
Sep
Flowering time :
Oct

Sources: Global Inventory of Floras and Traits (GIFT)

Plant Parts

Phyllanthus niruri has 1 reported plant parts identified across 7 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include leaf.

Plant parts reported in Phyllanthus niruri
Plant part Supporting sources Consensus
Leaf 7 supporting sources ★★★★☆

Leaf

  1. Pharmaceutical biology
  2. Natural product research
  3. BMC complementary and alternative medicine
  4. Journal of ethnopharmacology
  5. Interdisciplinary toxicology
View 2 additional sources
  1. Iranian journal of veterinary research
  2. Journal of clinical and diagnostic research : JCDR

Chemicals

Phyllanthus niruri has 77 reported phytochemicals identified across 7 scientific publications and several other databases. The most consistently reported chemicals include Gallic acid, Flavonoids, Hypophyllanthin, Phyllanthin, ellagic acid.

Chemicals reported in Phyllanthus niruri
Chemical Supporting sources Consensus
Gallic acid 5 supporting sources ★★★☆☆
Flavonoids 4 supporting sources ★★☆☆☆
Hypophyllanthin 4 supporting sources ★★☆☆☆
Phyllanthin 4 supporting sources ★★☆☆☆
ellagic acid 4 supporting sources ★★☆☆☆
Brevifolin carboxylic acid 3 supporting sources ★★☆☆☆
Lignans 3 supporting sources ★★☆☆☆
Tannins 3 supporting sources ★★☆☆☆
quercetin 3 supporting sources ★★☆☆☆
Astragalin 2 supporting sources ★☆☆☆☆

Gallic acid

  1. Molecules (Basel, Switzerland)
  2. Natural product research
  3. BMC complementary and alternative medicine
  4. Phytotherapy research : PTR
  5. Journal of natural products

Flavonoids

  1. PloS one
  2. Current pharmaceutical design
  3. The Journal of pharmacy and pharmacology
  4. Antibiotics (Basel, Switzerland)

Hypophyllanthin

  1. Molecules (Basel, Switzerland)
  2. Natural product research
  3. Journal of ethnopharmacology
  4. Environmental monitoring and assessment

Phyllanthin

  1. Dr. Duke
  2. Tropical life sciences research
  3. Journal of ethnopharmacology
  4. Environmental monitoring and assessment

ellagic acid

  1. Chemical & pharmaceutical bulletin
  2. Natural product research
  3. Phytotherapy research : PTR
  4. Journal of pharmaceutical analysis

Brevifolin carboxylic acid

  1. Dr. Duke
  2. Chemical & pharmaceutical bulletin
  3. Natural product research

Lignans

  1. Current pharmaceutical design
  2. The Journal of pharmacy and pharmacology
  3. Planta medica

Tannins

  1. Current pharmaceutical design
  2. The Journal of pharmacy and pharmacology
  3. Antibiotics (Basel, Switzerland)

quercetin

  1. Dr. Duke
  2. Molecules (Basel, Switzerland)
  3. Journal of pharmaceutical analysis

Astragalin

  1. Dr. Duke
  2. Natural product research

Activities

Phyllanthus niruri has 265 reported activities identified across 7 scientific publications and several other databases. The most consistently reported activities include Hepatoprotective, Antiviral, Antibacterial, Antidiabetic, Antioxidant.

Activities reported in Phyllanthus niruri
Activity Supporting sources Consensus
Hepatoprotective 6 supporting sources ★★★☆☆
Antiviral 5 supporting sources ★★★☆☆
Antibacterial 4 supporting sources ★★☆☆☆
Antidiabetic 4 supporting sources ★★☆☆☆
Antioxidant 4 supporting sources ★★☆☆☆
Anticancer 3 supporting sources ★★☆☆☆
Immunostimulant 3 supporting sources ★★☆☆☆
Analgesic 2 supporting sources ★☆☆☆☆
Antihepatotoxic 2 supporting sources ★☆☆☆☆
Antispasmodic 2 supporting sources ★☆☆☆☆

Hepatoprotective

  1. Dr. Duke
  2. Chemistry & biodiversity
  3. Current pharmaceutical design
  4. Indian journal of physiology and pharmacology
  5. Asian Pacific journal of cancer prevention : APJCP
View 1 additional sources
  1. Vegetos (Bareilly, India)

Antiviral

  1. Dr. Duke
  2. Current pharmaceutical design
  3. BioMed research international
  4. Asian Pacific journal of cancer prevention : APJCP
  5. Applied microbiology and biotechnology

Antibacterial

  1. Dr. Duke
  2. Environmental pollution (Barking, Essex : 1987)
  3. Current pharmaceutical design
  4. Asian Pacific journal of cancer prevention : APJCP

Antidiabetic

  1. Dr. Duke
  2. Journal of pharmaceutical and biomedical analysis
  3. Current pharmaceutical design
  4. Asian Pacific journal of cancer prevention : APJCP

Antioxidant

  1. Dr. Duke
  2. Molecules (Basel, Switzerland)
  3. Chemistry & biodiversity
  4. BMC complementary medicine and therapies

Anticancer

  1. Dr. Duke
  2. Evidence-based complementary and alternative medicine : eCAM
  3. Current pharmaceutical design

Immunostimulant

  1. Dr. Duke
  2. Journal of toxicology
  3. Iranian journal of veterinary research

Analgesic

  1. Dr. Duke
  2. Asian Pacific journal of cancer prevention : APJCP

Antihepatotoxic

  1. Dr. Duke
  2. Journal of ethnopharmacology

Antispasmodic

  1. Dr. Duke
  2. Asian Pacific journal of cancer prevention : APJCP

Medicinal Uses

Phyllanthus niruri has 54 reported medicinal uses identified across 7 scientific publications and several other databases. The most consistently reported uses include kidney stones, malaria, Helicobacter pylori, Plasmodium falciparum, chronic hepatitis B.

Most Reported Uses

Use Sources Consensus
kidney stones Pharmaceutical biology (and other 4 sources) ★★☆☆☆
malaria Pharmaceutical biology (and other 4 sources) ★★☆☆☆
Helicobacter pylori Phytotherapy research : PTR (and other 2 sources) ★☆☆☆☆
Plasmodium falciparum Parasitology research (and other 2 sources) ★☆☆☆☆
chronic hepatitis B Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 2 sources) ★☆☆☆☆
hypertension Biological trace element research (and other 2 sources) ★☆☆☆☆
inflammation Plants (Basel, Switzerland) (and other 2 sources) ★☆☆☆☆
jaundice Biological trace element research (and other 2 sources) ★☆☆☆☆
obesity Journal of pharmaceutical and biomedical analysis (and other 2 sources) ★☆☆☆☆
ovarian cancer BMC complementary and alternative medicine (and other 2 sources) ★☆☆☆☆

Preparations

Preparations Sources Consensus
aqueous leaf extract Pharmaceutical biology (and other 3 sources) ★★☆☆☆
aqueous extract Natural product research (and other 2 sources) ★☆☆☆☆
2% aqueous KOH Journal of natural products (and other 1 sources) ★☆☆☆☆
70% ethanolic extract Chemical & pharmaceutical bulletin (and other 1 sources) ★☆☆☆☆
A dry extract Experimental biology and medicine (Maywood, N.J.) (and other 1 sources) ★☆☆☆☆
AgNPs Applied microbiology and biotechnology (and other 1 sources) ★☆☆☆☆
Aqueous extraction Journal of natural products (and other 1 sources) ★☆☆☆☆
HP-1 Human & experimental toxicology (and other 1 sources) ★☆☆☆☆
Isoamyl alcohol fractions Journal of ethnopharmacology (and other 1 sources) ★☆☆☆☆
Phyllanthus niruri extract Journal of pharmaceutical and biomedical analysis (and other 1 sources) ★☆☆☆☆