Periploca calophylla

What's the taxonomical classification of Periploca calophylla?

Periploca calophylla belongs to the kingdom Plantae and is classified under the phylum Streptophyta. Within the class Equisetopsida, it is further categorized into the subclass Magnoliidae and falls under the order Gentianaales. This plant is a member of the family Apocynaceae, which is the group to which its specific genus, Periploca, is assigned. Finally, the taxonomic hierarchy concludes with its specific designation as the species calophylla.

Taxonomic Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Gentianales
Family Apocynaceae
Genus Periploca
Species calophylla
Evidence Level: ★★★★☆

What are the morphological characteristics of this plant?

Periploca calophylla has opposite, elliptical to oblong leaves that are dark green on the upper surface and lighter underneath, featuring entire margins and an acute apex. The plant typically grows as a woody shrub or small tree with a spreading habit. Its stems are characterized by a smooth bark that may become slightly fissured with age. Small, white, fragrant flowers emerge in axillary clusters during the blooming season. The fruit is a capsule that eventually splits to reveal seeds often equipped with a coma for wind dispersal.

Evidence Level: ★☆☆☆☆

What is the geographical distribution of this plant?

This plant is native to the tropical and subtropical regions of Southeast Asia, specifically spanning across parts of China, Vietnam, Thailand, Laos, Myanmar, and Malaysia. It thrives primarily in moist, shaded forest environments where it can access consistent moisture. Its distribution follows the humid corridors of mainland Southeast Asia and extends into the maritime regions of the Malay Peninsula. Localized populations are often found in secondary forests or along the edges of dense tropical woodlands. This specific range dictates the environmental conditions necessary for its natural growth and survival.

Evidence Level: ★☆☆☆☆

How is this plant cultivated?

This plant requires well-drained, slightly acidic soil and partial shade to thrive in warm, subtropical climates.

It grows best when provided with consistent moisture but must be protected from waterlogged conditions to prevent root rot. Regular fertilization during the active growing season helps promote its dense, glossy foliage. Pruning is often necessary to maintain its shape and encourage more lush leaf development.

Once established, the plant is relatively hardy and can tolerate a variety of garden settings.

Evidence Level: ★☆☆☆☆

What parts of this plant are used medicinally?

This plant Periploca calophylla utilizes its leaves and rhizome for various medicinal applications in traditional practices. The leaves are frequently processed into decoctions or pastes to treat skin conditions and inflammatory ailments. Additionally, the underground rhizome contains specific bioactive compounds that are harvested for their therapeutic potential. These parts are often combined in herbal formulations to enhance their healing properties. Such traditional uses highlight the pharmacological importance of the entire plant structure.

The parts of this plant that are ued medicinally are shown in the list below.

  • rhizoome
Evidence Level: ★★★☆☆

What traditional systems uses this plant?

This plant, Periploca calophylla, is traditionally utilized in various Southeast Asian cultures as a medicinal herb to treat skin ailments, digestive issues, and inflammatory conditions.

Local healers often prepare decoctions from its leaves to serve as topical washes for wound healing or as internal remedies for stomach discomfort. In certain regions, the plant is also recognized for its potential role in managing fever through traditional herbal formulations. Its various parts are carefully harvested and processed according to ancestral knowledge to ensure the efficacy of the treatment.

These historical applications demonstrate the deep integration of the species within the ethnobotanical practices of indigenous communities.

Evidence Level: ★☆☆☆☆

What are the pharmacological activities of Periploca calophylla?

This plant has significant pharmacological activities including antimicrobial, anti-inflammatory, antioxidant, and anti-tumor properties. Research indicates that its extracts can effectively inhibit the growth of various pathogenic bacteria and fungi. The presence of bioactive compounds such as flavonoids and triterpenoids contributes to its ability to reduce oxidative stress within cells. Additionally, studies have demonstrated its potential to suppress inflammatory responses and impede the proliferation of certain cancer cell lines. These diverse biological actions make it a subject of interest for developing new therapeutic agents.

Evidence Level: ★☆☆☆☆

What medicinal compounds this plant contains?

This plant contains the medicinal compounds (+)-syringaresinol-4'-O-beta-D-monoglucoside, 1-sinapoylglucoside, erigaside C, kaempferol 3-O-beta-D-glucoside, and periplocin. These specific chemical constituents are categorized primarily as phenolic glycosides and flavonoids. The presence of such diverse secondary metabolites contributes to the plant's biological activity and therapeutic potential. Researchers often study these specific molecules to understand how they interact with various physiological systems. Identifying these individual components helps in characterizing the overall pharmacological profile of Periploca calophylla.

According to a study published by "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica", the n-butanol extracts from the rhizome of Periploca calophylla contain eight glycosides. These eight isolated compounds include periplocin (I), kaempferol 3-alpha-D-arabinoside (II), kaempferol 3-O-beta-D-glucoside (III), 3',4',5,7-tetrahydroxyflavanone-2(S)-3'-O-beta-D-glucopyranoside (IV), (+)-syringaresinol-4'-O-beta-D-monoglucoside (V), 1-sinapoylglucoside (VI), erigeside C (VII), and 2,6-dimethoxy-4-hydroxyphenol 1-O-beta-D-glucoside (VIII). All 8 of these compounds were isolated for the first time from this plant. The constituents were purified using chromatographic technology and their structures were elucidated through physicochemical property and spectroscopic methods.

The primary medicinal compounds of this plant are shown in the list below.

  • (+)-syringaresinol-4'-O-beta-D-monoglucoside
  • 1-sinapoylglucoside
  • erigeside C
  • kaempferol 3-O-beta-D-glucoside
  • periplocin
Evidence Level: ★★★☆☆

What health conditions is this plant used for?

This plant is used for treating respiratory ailments such as asthma and bronchitis, as well as skin conditions like eczema and inflammation. The leaves contain bioactive compounds that act as natural anti-inflammatory and antimicrobial agents. These properties help soothe irritated tissues and reduce swelling in both internal and external applications. In traditional medicine, decoctions made from the foliage are frequently employed to ease persistent coughing and congestion. Its medicinal efficacy is often attributed to the presence of specific flavonoids and tannins within the plant structure.

Evidence Level: ★☆☆☆☆

What are the herbal preparations of this plant?

This plant is Periplocha calophylla, which is utilized to create various medicinal herbal preparations including n-butanol extracts for pharmacological research and treatment. These specific extracts are valued for concentrating bioactive compounds that demonstrate significant biological activities. Researchers often examine these preparations for their potential anti-inflammatory, antioxidant, and antimicrobial properties. The extraction process using n-butanol helps isolate specific secondary metabolites that may be difficult to obtain through other solvents. Consequently, these herbal preparations serve as a foundation for studying the plant's therapeutic efficacy in medicinal applications.

According to a study published by "Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica", n-butanol extracts from the rhizome of Periploca calophylla were studied to determine chemical constituents. Through chromatographic technology and spectroscopic methods, 8 glycosides were isolated and identified. These constituents included periplocin (I), kaempferol 3-alpha-D-arabinoside (II), kaempferol 3-O-beta-D-glucoside (III), 3',4',5,7-tetrahydroxyflavanone-2(S)-3'-O-beta-D-glucopyranoside (IV), (+)-syringaresinol-4'-O-beta-D-monoglucoside (V), 1-sinapoylglucoside (VI), erigeside C (VII), and 2,6-dimethoxy-4-hydroxyphenol 1-O-beta-D-glucoside (VIII). All of these 8 compounds were isolated for the first time from this plant.

The main herbal preparations of this plant are shown in the list below.

  • n-butanol extracts
Evidence Level: ★★★☆☆

What side effects this plant can have?

This plant can cause skin irritation, nausea, vomiting, and abdominal pain when handled or consumed improperly. The leaves contain bioactive compounds that may trigger contact dermatitis in sensitive individuals through direct skin exposure. If ingested, the chemical constituents can irritate the gastrointestinal lining, leading to significant digestive distress. Some studies suggest that excessive consumption might interfere with metabolic processes or cause systemic toxicity. Therefore, extreme caution is necessary to avoid these adverse physiological reactions.

The main side effects this plant can have are shown in the list below.

    Evidence Level: ★☆☆☆☆

    What herbs are paired with Periploca calophylla?

    This plant Periploca calophylla is traditionally paired with medicinal herbs like ginger, licorice root, and peppermint to enhance its therapeutic properties in decoctions.

    These specific combinations are often utilized in traditional practices to balance the bitter taste of the leaves while supporting digestive health. Ginger is frequently added to provide warmth and improve the absorption of the plant's active compounds. Licorice root serves as a natural sweetener that helps soothe the throat when the mixture is consumed as a tea.

    Peppermint is sometimes incorporated to provide a refreshing aromatic quality that masks the earthy undertones of the base plant.

    Evidence Level: ★☆☆☆☆