Esfand
Peganum harmala · Accepted scientific name
Scientific literature: Very Extensive (487 studies) · ★★★★★
Esfand, scientifically known as Peganum harmala, is a perennial herb widely recognized in traditional medicine across the Middle East and Central Asia. Renowned for its potent alkaloids, particularly harmine, it is frequently utilized for its antimicrobial, antioxidant, and sedative properties, often featured in ritualistic practices and folk remedies.
- Family
- Nitrariaceae
- Native range
- Europe
- Parts used
- Seed · Root
- Common names
- African-Rue · Syrian-Rue · 6 more
- Scientific synonyms
- Peganon Harmalum · Harmala Peganum
Names
Common Names
- African-rue
- Syrian-rue
- wild rue
- African rue
- Syrian rue
- aspand
- esfand
- harmal peganum
Regional and Traditional Names
Spanish:
- Alharmel
- Matarrocin
- Hármaga
- Alfármega
- Alhármel
- Catarrocín
- Catarrecino
- Ruda-harmel
- Harmel
- Tacarrecín
- Ruda hármala
- Alhargama
- Jamega
- Gamarsa
- Cuentas de burro
- Catarrofin
- Ruda siria
- Alharmega
- Venenera
- Estacarracin
- Catarrofic
- Harmaga blanca
- Armalá
- Alfarma
- Alargama
- Matarrufín
- Alhármaga
- Alhamega
- Matarrocín
- Alárgama
- Ruda-harmala
- Harmaga
- Harmala
- Aljamega
- Ruda borda
- Hármala
- Alhármega
- Harmaga real
- Catarrucín
- Arjamega
- Matarocín
- Estacarracín
- Alharma
- Alfarmega
- Catarrocin
- Tacarrecin
- Ruda harmala
- Armala
- Matarrufin
- Alharmaga
- Catarrucin
- Matarocin
- alharma
- gamarza
German:
- Steppenraute
- Harmalkraute
French:
- Harmal
- Rue de Syrie
- rue sauvage
- Rue de Syrie
- harmal
Scientific Names
Accepted name
Peganum harmalaSynonyms
- Peganon harmalum
- Harmala peganum
Taxonomical Classification
This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta within the class Equisetopsida. As a member of the subclass Magnoliidae and the order Sapindales, it is further categorized into the family Nitrariaceae. Ultimately, it is identified by the genus Peganum, specifically known as Peganum harmala.
| Rank | Classification | Source |
|---|---|---|
| Kingdom | Plantae | WCVP |
| Phylum | Streptophyta | WCVP |
| Class | Equisetopsida | WCVP |
| Subclass | Magnoliidae | WCVP |
| Order | Sapindales | WCVP |
| Family | Nitrariaceae | WCVP |
| Genus | Peganum | WCVP |
Distribution
This plant exhibits a diverse geographical distribution across several European regions. In Middle Europe, it can be found growing in Hungary. Its presence extends into Southwestern Europe, where it inhabits the Baleares islands. Additionally, the species is located within the territories of France and Sardegna. Finally, it is also widely distributed throughout Spain.
| Region | Area | Source |
|---|---|---|
| Middle Europe | Hungary | WCVP |
| Southwestern Europe | Baleares | WCVP |
| Southwestern Europe | France | WCVP |
| Southwestern Europe | Sardegna | WCVP |
| Southwestern Europe | Spain | WCVP |
| Southeastern Europe | Bulgaria | WCVP |
| Southeastern Europe | Greece | WCVP |
| Southeastern Europe | Italy | WCVP |
| Southeastern Europe | Romania | WCVP |
| Southeastern Europe | Türkiye-in-Europe | WCVP |
Plant Parts
This plant, Peganum harmala, is a versatile medicinal herb where various components are utilized for their pharmacological properties. The most potent part is often considered to be the tiny, dark seeds, which contain high concentrations of harmala alkaloids. These seed units are contained within a distinctive, capsule-like fruit that develops as the plant matures. Beneath the surface, the roots can also be harvested for medicinal purposes, while the upright stems provide the structural support necessary to hold the flowers and developing fruit aloft.| Plant Part | Sources | Consensus |
|---|---|---|
| seed | Phytotherapy research : PTR (and other 16 sources) | ★★★★★ |
| root | Saudi journal of biological sciences (and other 4 sources) | ★★☆☆☆ |
| leaf | Saudi journal of biological sciences (and other 3 sources) | ★★☆☆☆ |
| fruit | Avicenna journal of phytomedicine (and other 2 sources) | ★☆☆☆☆ |
| flower | Avicenna journal of phytomedicine (and other 1 sources) | ★☆☆☆☆ |
| stem | PloS one (and other 1 sources) | ★☆☆☆☆ |
Chemicals
Peganum harmala has 84 reported phytochemicals identified across 27 scientific publications and several other databases. The most consistently reported chemicals include HARMINE, harmaline, harmalol, HARMANE, Harmol.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| HARMINE | 23 supporting sources | ★★★★★ |
| harmaline | 20 supporting sources | ★★★★★ |
| harmalol | 8 supporting sources | ★★★★☆ |
| HARMANE | 5 supporting sources | ★★★☆☆ |
| Harmol | 4 supporting sources | ★★☆☆☆ |
| Peganine | 4 supporting sources | ★★☆☆☆ |
| Flavonoids | 3 supporting sources | ★★☆☆☆ |
| Vasicine | 3 supporting sources | ★★☆☆☆ |
| Deoxypeganine | 2 supporting sources | ★☆☆☆☆ |
| Norharmane | 2 supporting sources | ★☆☆☆☆ |
HARMINE
- Dr. Duke
- Avicenna journal of phytomedicine
- European journal of pharmacology
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Journal of chromatographic science
View 18 additional sources
- Viruses
- International immunopharmacology
- Journal of ethnopharmacology
- Scientific reports
- Pathogens (Basel, Switzerland)
- International journal of cancer
- Toxicon : official journal of the International Society on Toxinology
- Phytotherapy research : PTR
- Zeitschrift fur Naturforschung. C, Journal of biosciences
- Yao xue xue bao = Acta pharmaceutica Sinica
- Oncotarget
- Journal of analytical methods in chemistry
- Asian Pacific journal of tropical biomedicine
- Current pharmaceutical design
- Molecules (Basel, Switzerland)
- Archives of pharmacal research
- DNA and cell biology
- Natural product research
harmaline
- Dr. Duke
- Avicenna journal of phytomedicine
- European journal of pharmacology
- Metabolic brain disease
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
View 15 additional sources
- Journal of chromatographic science
- Viruses
- Scientific reports
- Pathogens (Basel, Switzerland)
- Toxicon : official journal of the International Society on Toxinology
- Phytotherapy research : PTR
- Zeitschrift fur Naturforschung. C, Journal of biosciences
- Recent patents on biotechnology
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
- Yao xue xue bao = Acta pharmaceutica Sinica
- Journal of analytical methods in chemistry
- Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
- Annales pharmaceutiques francaises
- Molecules (Basel, Switzerland)
- DNA and cell biology
harmalol
- Dr. Duke
- European journal of pharmacology
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Journal of chromatographic science
- Pathogens (Basel, Switzerland)
View 3 additional sources
- Phytotherapy research : PTR
- DNA and cell biology
- Natural product research
HARMANE
- Journal of chromatographic science
- Pathogens (Basel, Switzerland)
- Neuroscience letters
- Phytotherapy research : PTR
- DNA and cell biology
Harmol
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Pathogens (Basel, Switzerland)
- Phytotherapy research : PTR
- Molecules (Basel, Switzerland)
Peganine
- Dr. Duke
- Avicenna journal of phytomedicine
- Molecules (Basel, Switzerland)
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Flavonoids
- Toxicon : official journal of the International Society on Toxinology
- Combinatorial chemistry & high throughput screening
- Endocrine, metabolic & immune disorders drug targets
Vasicine
- European journal of pharmacology
- Scientific reports
- Journal of analytical methods in chemistry
Deoxypeganine
- Dr. Duke
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Norharmane
- Journal of chromatographic science
- Zeitschrift fur Naturforschung. C, Journal of biosciences
Activities
Peganum harmala has 119 reported activities identified across 27 scientific publications and several other databases. The most consistently reported activities include Antibacterial, Antioxidant, Antidiabetic, Antitumor, Anticancer.
Most Reported Activities
| Activity | Sources | Consensus |
|---|---|---|
| Antibacterial | Dr. Duke (and other 8 sources) | ★★★★☆ |
| Antioxidant | Chemistry & biodiversity (and other 7 sources) | ★★★★☆ |
| Antidiabetic | Dr. Duke (and other 5 sources) | ★★★☆☆ |
| Antitumor | Dr. Duke (and other 5 sources) | ★★★☆☆ |
| Anticancer | International journal of cancer (and other 4 sources) | ★★☆☆☆ |
| Antifungal | Therapie (and other 4 sources) | ★★☆☆☆ |
| Antiviral | Dr. Duke (and other 4 sources) | ★★☆☆☆ |
| Antimicrobial | European journal of pharmacology (and other 3 sources) | ★★☆☆☆ |
| Cytotoxic | Dr. Duke (and other 3 sources) | ★★☆☆☆ |
| Hallucinogenic | Dr. Duke (and other 3 sources) | ★★☆☆☆ |
Medicinal Uses
Peganum harmala has 76 reported medicinal uses identified across 27 scientific publications and several other databases. The most consistently reported uses include inflammation, Staphylococcus aureus, oxidative stress, Alzheimer's disease, Candida albicans.
Most Reported Uses
| Use | Sources | Consensus |
|---|---|---|
| inflammation | Combinatorial chemistry & high throughput screening (and other 4 sources) | ★★☆☆☆ |
| Staphylococcus aureus | Biopolymers (and other 3 sources) | ★★☆☆☆ |
| oxidative stress | Endocrine, metabolic & immune disorders drug targets (and other 3 sources) | ★★☆☆☆ |
| Alzheimer's disease | Metabolic brain disease (and other 2 sources) | ★☆☆☆☆ |
| Candida albicans | Pharmaceutical biology (and other 2 sources) | ★☆☆☆☆ |
| E. coli | Phytotherapy research : PTR (and other 2 sources) | ★☆☆☆☆ |
| Escherichia coli | Biopolymers (and other 2 sources) | ★☆☆☆☆ |
| Leishmania | Annals of medicine and surgery (2012) (and other 2 sources) | ★☆☆☆☆ |
| analgesic | American journal of therapeutics (and other 2 sources) | ★☆☆☆☆ |
| asthma | Phytomedicine : international journal of phytotherapy and phytopharmacology (and other 2 sources) | ★☆☆☆☆ |
Preparations
| Preparations | Sources | Consensus |
|---|---|---|
| seeds | TheScientificWorldJournal (and other 5 sources) | ★★★☆☆ |
| methanolic extracts | Pakistan journal of pharmaceutical sciences (and other 4 sources) | ★★☆☆☆ |
| extract | Iranian journal of basic medical sciences (and other 2 sources) | ★☆☆☆☆ |
| methanol extract | BMC complementary and alternative medicine (and other 2 sources) | ★☆☆☆☆ |
| Crude alkaloids | BMC complementary and alternative medicine (and other 1 sources) | ★☆☆☆☆ |
| Dried ethanol extracts | Phytotherapy research : PTR (and other 1 sources) | ★☆☆☆☆ |
| Extract | Pathogens (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| Extracts from seeds | Pathogens (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| Methanolic extract | Pakistan journal of pharmaceutical sciences (and other 1 sources) | ★☆☆☆☆ |
| Peganum harmala extract | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (and other 1 sources) | ★☆☆☆☆ |