Esfand

Peganum harmala · Accepted scientific name

Scientific literature: Very Extensive (487 studies) · ★★★★★

Esfand, scientifically known as Peganum harmala, is a perennial herb widely recognized in traditional medicine across the Middle East and Central Asia. Renowned for its potent alkaloids, particularly harmine, it is frequently utilized for its antimicrobial, antioxidant, and sedative properties, often featured in ritualistic practices and folk remedies.

Family
Nitrariaceae
Native range
Europe
Parts used
Seed · Root
Common names
African-Rue · Syrian-Rue · 6 more
Scientific synonyms
Peganon Harmalum · Harmala Peganum

Names

Common Names

Regional and Traditional Names

Spanish:

  • Alharmel
  • Matarrocin
  • Hármaga
  • Alfármega
  • Alhármel
  • Catarrocín
  • Catarrecino
  • Ruda-harmel
  • Harmel
  • Tacarrecín
  • Ruda hármala
  • Alhargama
  • Jamega
  • Gamarsa
  • Cuentas de burro
  • Catarrofin
  • Ruda siria
  • Alharmega
  • Venenera
  • Estacarracin
  • Catarrofic
  • Harmaga blanca
  • Armalá
  • Alfarma
  • Alargama
  • Matarrufín
  • Alhármaga
  • Alhamega
  • Matarrocín
  • Alárgama
  • Ruda-harmala
  • Harmaga
  • Harmala
  • Aljamega
  • Ruda borda
  • Hármala
  • Alhármega
  • Harmaga real
  • Catarrucín
  • Arjamega
  • Matarocín
  • Estacarracín
  • Alharma
  • Alfarmega
  • Catarrocin
  • Tacarrecin
  • Ruda harmala
  • Armala
  • Matarrufin
  • Alharmaga
  • Catarrucin
  • Matarocin
  • alharma
  • gamarza

German:

  • Steppenraute
  • Harmalkraute

French:

  • Harmal
  • Rue de Syrie
  • rue sauvage
  • Rue de Syrie
  • harmal

Scientific Names

Accepted name

Peganum harmala

Synonyms

Taxonomical Classification

This plant belongs to the kingdom Plantae and is classified under the phylum Streptophyta within the class Equisetopsida. As a member of the subclass Magnoliidae and the order Sapindales, it is further categorized into the family Nitrariaceae. Ultimately, it is identified by the genus Peganum, specifically known as Peganum harmala.

Rank Classification Source
Kingdom Plantae WCVP
Phylum Streptophyta WCVP
Class Equisetopsida WCVP
Subclass Magnoliidae WCVP
Order Sapindales WCVP
Family Nitrariaceae WCVP
Genus Peganum WCVP

Distribution

This plant exhibits a diverse geographical distribution across several European regions. In Middle Europe, it can be found growing in Hungary. Its presence extends into Southwestern Europe, where it inhabits the Baleares islands. Additionally, the species is located within the territories of France and Sardegna. Finally, it is also widely distributed throughout Spain.

Region Area Source
Middle Europe Hungary WCVP
Southwestern Europe Baleares WCVP
Southwestern Europe France WCVP
Southwestern Europe Sardegna WCVP
Southwestern Europe Spain WCVP
Southeastern Europe Bulgaria WCVP
Southeastern Europe Greece WCVP
Southeastern Europe Italy WCVP
Southeastern Europe Romania WCVP
Southeastern Europe Türkiye-in-Europe WCVP

Plant Parts

This plant, Peganum harmala, is a versatile medicinal herb where various components are utilized for their pharmacological properties. The most potent part is often considered to be the tiny, dark seeds, which contain high concentrations of harmala alkaloids. These seed units are contained within a distinctive, capsule-like fruit that develops as the plant matures. Beneath the surface, the roots can also be harvested for medicinal purposes, while the upright stems provide the structural support necessary to hold the flowers and developing fruit aloft.
Plant Part Sources Consensus
seed Phytotherapy research : PTR (and other 16 sources) ★★★★★
root Saudi journal of biological sciences (and other 4 sources) ★★☆☆☆
leaf Saudi journal of biological sciences (and other 3 sources) ★★☆☆☆
fruit Avicenna journal of phytomedicine (and other 2 sources) ★☆☆☆☆
flower Avicenna journal of phytomedicine (and other 1 sources) ★☆☆☆☆
stem PloS one (and other 1 sources) ★☆☆☆☆

Chemicals

Peganum harmala has 84 reported phytochemicals identified across 27 scientific publications and several other databases. The most consistently reported chemicals include HARMINE, harmaline, harmalol, HARMANE, Harmol.

Chemicals reported in Peganum harmala
Chemical Supporting sources Consensus
HARMINE 23 supporting sources ★★★★★
harmaline 20 supporting sources ★★★★★
harmalol 8 supporting sources ★★★★☆
HARMANE 5 supporting sources ★★★☆☆
Harmol 4 supporting sources ★★☆☆☆
Peganine 4 supporting sources ★★☆☆☆
Flavonoids 3 supporting sources ★★☆☆☆
Vasicine 3 supporting sources ★★☆☆☆
Deoxypeganine 2 supporting sources ★☆☆☆☆
Norharmane 2 supporting sources ★☆☆☆☆

HARMINE

  1. Dr. Duke
  2. Avicenna journal of phytomedicine
  3. European journal of pharmacology
  4. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  5. Journal of chromatographic science
View 18 additional sources
  1. Viruses
  2. International immunopharmacology
  3. Journal of ethnopharmacology
  4. Scientific reports
  5. Pathogens (Basel, Switzerland)
  6. International journal of cancer
  7. Toxicon : official journal of the International Society on Toxinology
  8. Phytotherapy research : PTR
  9. Zeitschrift fur Naturforschung. C, Journal of biosciences
  10. Yao xue xue bao = Acta pharmaceutica Sinica
  11. Oncotarget
  12. Journal of analytical methods in chemistry
  13. Asian Pacific journal of tropical biomedicine
  14. Current pharmaceutical design
  15. Molecules (Basel, Switzerland)
  16. Archives of pharmacal research
  17. DNA and cell biology
  18. Natural product research

harmaline

  1. Dr. Duke
  2. Avicenna journal of phytomedicine
  3. European journal of pharmacology
  4. Metabolic brain disease
  5. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
View 15 additional sources
  1. Journal of chromatographic science
  2. Viruses
  3. Scientific reports
  4. Pathogens (Basel, Switzerland)
  5. Toxicon : official journal of the International Society on Toxinology
  6. Phytotherapy research : PTR
  7. Zeitschrift fur Naturforschung. C, Journal of biosciences
  8. Recent patents on biotechnology
  9. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
  10. Yao xue xue bao = Acta pharmaceutica Sinica
  11. Journal of analytical methods in chemistry
  12. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
  13. Annales pharmaceutiques francaises
  14. Molecules (Basel, Switzerland)
  15. DNA and cell biology

harmalol

  1. Dr. Duke
  2. European journal of pharmacology
  3. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  4. Journal of chromatographic science
  5. Pathogens (Basel, Switzerland)
View 3 additional sources
  1. Phytotherapy research : PTR
  2. DNA and cell biology
  3. Natural product research

HARMANE

  1. Journal of chromatographic science
  2. Pathogens (Basel, Switzerland)
  3. Neuroscience letters
  4. Phytotherapy research : PTR
  5. DNA and cell biology

Harmol

  1. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  2. Pathogens (Basel, Switzerland)
  3. Phytotherapy research : PTR
  4. Molecules (Basel, Switzerland)

Peganine

  1. Dr. Duke
  2. Avicenna journal of phytomedicine
  3. Molecules (Basel, Switzerland)
  4. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Flavonoids

  1. Toxicon : official journal of the International Society on Toxinology
  2. Combinatorial chemistry & high throughput screening
  3. Endocrine, metabolic & immune disorders drug targets

Vasicine

  1. European journal of pharmacology
  2. Scientific reports
  3. Journal of analytical methods in chemistry

Deoxypeganine

  1. Dr. Duke
  2. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Norharmane

  1. Journal of chromatographic science
  2. Zeitschrift fur Naturforschung. C, Journal of biosciences

Activities

Peganum harmala has 119 reported activities identified across 27 scientific publications and several other databases. The most consistently reported activities include Antibacterial, Antioxidant, Antidiabetic, Antitumor, Anticancer.

Most Reported Activities

Activity Sources Consensus
Antibacterial Dr. Duke (and other 8 sources) ★★★★☆
Antioxidant Chemistry & biodiversity (and other 7 sources) ★★★★☆
Antidiabetic Dr. Duke (and other 5 sources) ★★★☆☆
Antitumor Dr. Duke (and other 5 sources) ★★★☆☆
Anticancer International journal of cancer (and other 4 sources) ★★☆☆☆
Antifungal Therapie (and other 4 sources) ★★☆☆☆
Antiviral Dr. Duke (and other 4 sources) ★★☆☆☆
Antimicrobial European journal of pharmacology (and other 3 sources) ★★☆☆☆
Cytotoxic Dr. Duke (and other 3 sources) ★★☆☆☆
Hallucinogenic Dr. Duke (and other 3 sources) ★★☆☆☆

Medicinal Uses

Peganum harmala has 76 reported medicinal uses identified across 27 scientific publications and several other databases. The most consistently reported uses include inflammation, Staphylococcus aureus, oxidative stress, Alzheimer's disease, Candida albicans.

Most Reported Uses

Use Sources Consensus
inflammation Combinatorial chemistry & high throughput screening (and other 4 sources) ★★☆☆☆
Staphylococcus aureus Biopolymers (and other 3 sources) ★★☆☆☆
oxidative stress Endocrine, metabolic & immune disorders drug targets (and other 3 sources) ★★☆☆☆
Alzheimer's disease Metabolic brain disease (and other 2 sources) ★☆☆☆☆
Candida albicans Pharmaceutical biology (and other 2 sources) ★☆☆☆☆
E. coli Phytotherapy research : PTR (and other 2 sources) ★☆☆☆☆
Escherichia coli Biopolymers (and other 2 sources) ★☆☆☆☆
Leishmania Annals of medicine and surgery (2012) (and other 2 sources) ★☆☆☆☆
analgesic American journal of therapeutics (and other 2 sources) ★☆☆☆☆
asthma Phytomedicine : international journal of phytotherapy and phytopharmacology (and other 2 sources) ★☆☆☆☆

Preparations

Preparations Sources Consensus
seeds TheScientificWorldJournal (and other 5 sources) ★★★☆☆
methanolic extracts Pakistan journal of pharmaceutical sciences (and other 4 sources) ★★☆☆☆
extract Iranian journal of basic medical sciences (and other 2 sources) ★☆☆☆☆
methanol extract BMC complementary and alternative medicine (and other 2 sources) ★☆☆☆☆
Crude alkaloids BMC complementary and alternative medicine (and other 1 sources) ★☆☆☆☆
Dried ethanol extracts Phytotherapy research : PTR (and other 1 sources) ★☆☆☆☆
Extract Pathogens (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
Extracts from seeds Pathogens (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
Methanolic extract Pakistan journal of pharmaceutical sciences (and other 1 sources) ★☆☆☆☆
Peganum harmala extract Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (and other 1 sources) ★☆☆☆☆