American ginseng

Panax quinquefolius · Accepted scientific name

Scientific literature: Very Extensive (1270 studies) · ★★★★★

American ginseng, scientifically known as Panax quinquefolius, is a perennial herb native to eastern North America. Highly valued in traditional medicine, this adaptogen is renowned for its ability to reduce stress, enhance cognitive function, and bolster the immune system, making it a cornerstone of holistic wellness and herbal therapy.

Family
Araliaceae
Native range
Northern America
Parts used
Root · Flower
Common names
American Ginseng · Five-Leaved Ginseng · 5 more
Scientific synonyms
Aralia Quinquefolia · Ginseng Quinquefolium · 6 more

Names

Common Names

Regional and Traditional Names

Spanish:

  • Panax americanus var. elatus
  • Panax quinuefolius var americanus
  • Panax americanus
  • Panax quinquefolius var obovatus
  • Panax cuneatus
  • Panax americanus var elatus
  • Panax quinuefolius var. obovatus
  • Panax quinquefolius var americanus
  • Panax quinquefolius var. americanus
  • Panax quinquefolius var. obovatus
  • Panax americanus var. obovatus
  • Ginseng americano
  • Panax americanus var obovatus
  • Panax quinuefolius var. americanus
  • Panax quinuefolius var obovatus
  • Aralia quinquefolia
  • ginseng americano

German:

  • amerikanischer Ginseng
  • kanadischer Ginseng

French:

  • Ginseng américain
  • Ginseng à cinq folioles
  • Ginseng americain
  • ginseng à cinq folioles
  • grand ginseng
  • panace à cinq folioles
  • ginseng d'Amérique
  • Ginseng Américain

Scientific Names

Accepted name

Panax quinquefolius

Synonyms

Taxonomical Classification

This plant belongs to the kingdom Plantae and the phylum Streptophyta, falling within the class Equisetopsida and subclass Magnoliidae. It is categorized under the order Apiales and the family Araliaceae. Finally, its scientific classification is completed within the genus Panax.

Rank Classification Source
Kingdom Plantae WCVP
Phylum Streptophyta WCVP
Class Equisetopsida WCVP
Subclass Magnoliidae WCVP
Order Apiales WCVP
Family Araliaceae WCVP
Genus Panax WCVP

Distribution

This plant, known as American ginseng, is found across several specific regions in North America. In Eastern Canada, its range includes the provinces of Ontario and Québec. Moving southward, the species extends into the North-Central United States. Within this region, it can be located in the state of Illinois. Furthermore, its geographical distribution continues through Iowa and Kansas.

Region Area Source
Eastern Canada Ontario WCVP
Eastern Canada Québec WCVP
North-Central U.S.A. Illinois WCVP
North-Central U.S.A. Iowa WCVP
North-Central U.S.A. Kansas WCVP
North-Central U.S.A. Minnesota WCVP
North-Central U.S.A. Missouri WCVP
North-Central U.S.A. Nebraska WCVP
North-Central U.S.A. Oklahoma WCVP
North-Central U.S.A. South Dakota WCVP

Plant Parts

This plant, known commonly as American ginseng, exhibits a distinct morphology where each part contributes to its botanical profile. The leaves are palmately compound, typically consisting of three to five leaflets that spread out from a central point. Emerging from the center of these leaves are the flowers, which are small, greenish-white, and arranged in umbels. Supporting the plant is a sturdy stem that rises above the ground to hold the foliage and blooms. Most importantly, the medicinal value is concentrated in the roots, specifically the fleshy, perennial root system that develops underground over many years, forming the characteristic branched structure used in traditional medicine.
Plant Part Sources Consensus
root Journal of ginseng research (and other 6 sources) ★★★☆☆
flower Journal of ginseng research (and other 5 sources) ★★★☆☆
leaf Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 5 sources) ★★★☆☆
fruit Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 2 sources) ★☆☆☆☆
stem Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 1 sources) ★☆☆☆☆

Chemicals

Panax quinquefolius has 282 reported phytochemicals identified across 19 scientific publications and several other databases. The most consistently reported chemicals include Ginsenosides, RB1, RE, GINSENOSIDE, RG1.

Chemicals reported in Panax quinquefolius
Chemical Supporting sources Consensus
Ginsenosides 32 supporting sources ★★★★★
RB1 10 supporting sources ★★★★★
RE 9 supporting sources ★★★★☆
GINSENOSIDE 8 supporting sources ★★★★☆
RG1 7 supporting sources ★★★★☆
Saponins 6 supporting sources ★★★☆☆
RC 5 supporting sources ★★★☆☆
RD 5 supporting sources ★★★☆☆
Rg3 5 supporting sources ★★★☆☆
SAPONIN 4 supporting sources ★★☆☆☆

Ginsenosides

  1. Dr. Duke
  2. Phytomedicine : international journal of phytotherapy and phytopharmacology
  3. BMC genomics
  4. Current protein & peptide science
  5. Molecular biology reports
View 27 additional sources
  1. Analytica chimica acta
  2. Journal of chromatography. A
  3. Rapid communications in mass spectrometry : RCM
  4. Plant physiology and biochemistry : PPB
  5. Chemistry & biodiversity
  6. Journal of plant biology = Singmul Hakhoe chi
  7. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  8. SpringerPlus
  9. Journal of advanced research
  10. Analytical chemistry
  11. Analytical and bioanalytical chemistry
  12. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  13. Die Pharmazie
  14. Foods (Basel, Switzerland)
  15. Medicinal research reviews
  16. BMC plant biology
  17. Plant cell reports
  18. Drugs
  19. Molecules (Basel, Switzerland)
  20. Fitoterapia
  21. Journal of AOAC International
  22. Physiologia plantarum
  23. Journal of ethnopharmacology
  24. Journal of ginseng research
  25. Journal of pharmaceutical and biomedical analysis
  26. Food research international (Ottawa, Ont.)
  27. Molecular and cellular biochemistry

RB1

  1. Plant physiology and biochemistry : PPB
  2. Journal of the science of food and agriculture
  3. SpringerPlus
  4. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  5. BioMed research international
View 5 additional sources
  1. Phytochemistry
  2. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  3. Journal of separation science
  4. Plant cell reports
  5. Molecules (Basel, Switzerland)

RE

  1. Phytochemistry
  2. The American journal of Chinese medicine
  3. Journal of ethnopharmacology
  4. Natural product research
  5. BioMed research international
View 4 additional sources
  1. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  2. Journal of separation science
  3. Molecules (Basel, Switzerland)
  4. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

GINSENOSIDE

  1. International journal of molecular sciences
  2. Journal of the science of food and agriculture
  3. Phytochemistry
  4. Journal of chromatography. A
  5. Analytical and bioanalytical chemistry
View 3 additional sources
  1. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  2. Food & function
  3. Applied microbiology and biotechnology

RG1

  1. Journal of AOAC International
  2. Phytochemistry
  3. The American journal of Chinese medicine
  4. Journal of ethnopharmacology
  5. Natural product research
View 2 additional sources
  1. BioMed research international
  2. Molecules (Basel, Switzerland)

Saponins

  1. Dr. Duke
  2. Current protein & peptide science
  3. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  4. Frontiers in plant science
  5. International journal of molecular sciences
View 1 additional sources
  1. Japanese journal of pharmacology

RC

  1. BioMed research international
  2. Phytochemistry
  3. Journal of separation science
  4. Applied microbiology and biotechnology
  5. Molecules (Basel, Switzerland)

RD

  1. Plant physiology and biochemistry : PPB
  2. BioMed research international
  3. Journal of separation science
  4. Molecules (Basel, Switzerland)
  5. Phytochemistry

Rg3

  1. Plant physiology and biochemistry : PPB
  2. SpringerPlus
  3. Phytochemistry
  4. Journal of separation science
  5. Applied microbiology and biotechnology

SAPONIN

  1. Dr. Duke
  2. Journal of ethnopharmacology
  3. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
  4. Applied microbiology and biotechnology

Activities

Panax quinquefolius has 661 reported activities identified across 19 scientific publications and several other databases. The most consistently reported activities include Antidiabetic, Antioxidant, Antitumor, Adaptogenic, Anxiolytic.

Most Reported Activities

Activity Sources Consensus
Antidiabetic Dr. Duke (and other 3 sources) ★★☆☆☆
Antioxidant Dr. Duke (and other 3 sources) ★★☆☆☆
Antitumor Dr. Duke (and other 3 sources) ★★☆☆☆
Adaptogenic Dr. Duke (and other 2 sources) ★☆☆☆☆
Anxiolytic Dr. Duke (and other 2 sources) ★☆☆☆☆
Cardioprotective Dr. Duke (and other 2 sources) ★☆☆☆☆
Hepatoprotective Dr. Duke (and other 2 sources) ★☆☆☆☆
Immunostimulant Dr. Duke (and other 2 sources) ★☆☆☆☆
Neuroprotective Dr. Duke (and other 2 sources) ★☆☆☆☆
11B-HSD-Inhibitor Dr. Duke (and other 1 sources) ★☆☆☆☆

Medicinal Uses

Panax quinquefolius has 43 reported medicinal uses identified across 19 scientific publications and several other databases. The most consistently reported uses include antidiabetic, breast cancer, cancer, Alzheimer disease, DNA damage.

Most Reported Uses

Use Sources Consensus
antidiabetic Molecules (Basel, Switzerland) (and other 2 sources) ★☆☆☆☆
breast cancer Annals of surgical oncology (and other 2 sources) ★☆☆☆☆
cancer Yao xue xue bao = Acta pharmaceutica Sinica (and other 2 sources) ★☆☆☆☆
Alzheimer disease Regulatory toxicology and pharmacology : RTP (and other 1 sources) ★☆☆☆☆
DNA damage Phytomedicine : international journal of phytotherapy and phytopharmacology (and other 1 sources) ★☆☆☆☆
Insulin Resistance Biomedical chromatography : BMC (and other 1 sources) ★☆☆☆☆
LDL cholesterol Atherosclerosis (and other 1 sources) ★☆☆☆☆
Lung Adenocarcinoma Molecules (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
antioxidants Molecules (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
anxiolytic effects Journal of chromatography. A (and other 1 sources) ★☆☆☆☆

Preparations

Preparations Sources Consensus
American ginseng Phytomedicine : international journal of phytotherapy and phytopharmacology (and other 1 sources) ★☆☆☆☆
Cold FX The American journal of Chinese medicine (and other 1 sources) ★☆☆☆☆
North American ginseng extract Molecular and cellular biochemistry (and other 1 sources) ★☆☆☆☆
PQS Journal of agricultural and food chemistry (and other 1 sources) ★☆☆☆☆
dietary supplements Molecules (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
energy drinks Molecules (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
extracts Molecules (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
ginseng methanolic extracts Analytical chemistry (and other 1 sources) ★☆☆☆☆
nutraceuticals Molecules (Basel, Switzerland) (and other 1 sources) ★☆☆☆☆
polysaccharides Journal of immunology research (and other 1 sources) ★☆☆☆☆