American ginseng
Panax quinquefolius · Accepted scientific name
Scientific literature: Very Extensive (1270 studies) · ★★★★★
American ginseng, scientifically known as Panax quinquefolius, is a perennial herb native to eastern North America. Highly valued in traditional medicine, this adaptogen is renowned for its ability to reduce stress, enhance cognitive function, and bolster the immune system, making it a cornerstone of holistic wellness and herbal therapy.
Names
Common Names
- American ginseng
- five-leaved ginseng
- ginseng
- redberry
- Occidental ginseng
- sang
- sheng
Regional and Traditional Names
Spanish:
- Panax americanus var. elatus
- Panax quinuefolius var americanus
- Panax americanus
- Panax quinquefolius var obovatus
- Panax cuneatus
- Panax americanus var elatus
- Panax quinuefolius var. obovatus
- Panax quinquefolius var americanus
- Panax quinquefolius var. americanus
- Panax quinquefolius var. obovatus
- Panax americanus var. obovatus
- Ginseng americano
- Panax americanus var obovatus
- Panax quinuefolius var. americanus
- Panax quinuefolius var obovatus
- Aralia quinquefolia
- ginseng americano
German:
- amerikanischer Ginseng
- kanadischer Ginseng
French:
- Ginseng américain
- Ginseng à cinq folioles
- Ginseng americain
- ginseng à cinq folioles
- grand ginseng
- panace à cinq folioles
- ginseng d'Amérique
- Ginseng Américain
Scientific Names
Accepted name
Panax quinquefoliusSynonyms
- Aralia quinquefolia
- Ginseng quinquefolium
- Panax americanus
- Panax cuneatus
- Panax quinquefolius var. americanus
- Panax quinquefolius var. obovatus
- Panax americanus var. elatus
- Panax americanus var. obovatus
Taxonomical Classification
This plant belongs to the kingdom Plantae and the phylum Streptophyta, falling within the class Equisetopsida and subclass Magnoliidae. It is categorized under the order Apiales and the family Araliaceae. Finally, its scientific classification is completed within the genus Panax.
| Rank | Classification | Source |
|---|---|---|
| Kingdom | Plantae | WCVP |
| Phylum | Streptophyta | WCVP |
| Class | Equisetopsida | WCVP |
| Subclass | Magnoliidae | WCVP |
| Order | Apiales | WCVP |
| Family | Araliaceae | WCVP |
| Genus | Panax | WCVP |
Distribution
This plant, known as American ginseng, is found across several specific regions in North America. In Eastern Canada, its range includes the provinces of Ontario and Québec. Moving southward, the species extends into the North-Central United States. Within this region, it can be located in the state of Illinois. Furthermore, its geographical distribution continues through Iowa and Kansas.
| Region | Area | Source |
|---|---|---|
| Eastern Canada | Ontario | WCVP |
| Eastern Canada | Québec | WCVP |
| North-Central U.S.A. | Illinois | WCVP |
| North-Central U.S.A. | Iowa | WCVP |
| North-Central U.S.A. | Kansas | WCVP |
| North-Central U.S.A. | Minnesota | WCVP |
| North-Central U.S.A. | Missouri | WCVP |
| North-Central U.S.A. | Nebraska | WCVP |
| North-Central U.S.A. | Oklahoma | WCVP |
| North-Central U.S.A. | South Dakota | WCVP |
Plant Parts
This plant, known commonly as American ginseng, exhibits a distinct morphology where each part contributes to its botanical profile. The leaves are palmately compound, typically consisting of three to five leaflets that spread out from a central point. Emerging from the center of these leaves are the flowers, which are small, greenish-white, and arranged in umbels. Supporting the plant is a sturdy stem that rises above the ground to hold the foliage and blooms. Most importantly, the medicinal value is concentrated in the roots, specifically the fleshy, perennial root system that develops underground over many years, forming the characteristic branched structure used in traditional medicine.| Plant Part | Sources | Consensus |
|---|---|---|
| root | Journal of ginseng research (and other 6 sources) | ★★★☆☆ |
| flower | Journal of ginseng research (and other 5 sources) | ★★★☆☆ |
| leaf | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 5 sources) | ★★★☆☆ |
| fruit | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 2 sources) | ★☆☆☆☆ |
| stem | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (and other 1 sources) | ★☆☆☆☆ |
Chemicals
Panax quinquefolius has 282 reported phytochemicals identified across 19 scientific publications and several other databases. The most consistently reported chemicals include Ginsenosides, RB1, RE, GINSENOSIDE, RG1.
| Chemical | Supporting sources | Consensus |
|---|---|---|
| Ginsenosides | 32 supporting sources | ★★★★★ |
| RB1 | 10 supporting sources | ★★★★★ |
| RE | 9 supporting sources | ★★★★☆ |
| GINSENOSIDE | 8 supporting sources | ★★★★☆ |
| RG1 | 7 supporting sources | ★★★★☆ |
| Saponins | 6 supporting sources | ★★★☆☆ |
| RC | 5 supporting sources | ★★★☆☆ |
| RD | 5 supporting sources | ★★★☆☆ |
| Rg3 | 5 supporting sources | ★★★☆☆ |
| SAPONIN | 4 supporting sources | ★★☆☆☆ |
Ginsenosides
- Dr. Duke
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- BMC genomics
- Current protein & peptide science
- Molecular biology reports
View 27 additional sources
- Analytica chimica acta
- Journal of chromatography. A
- Rapid communications in mass spectrometry : RCM
- Plant physiology and biochemistry : PPB
- Chemistry & biodiversity
- Journal of plant biology = Singmul Hakhoe chi
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- SpringerPlus
- Journal of advanced research
- Analytical chemistry
- Analytical and bioanalytical chemistry
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- Die Pharmazie
- Foods (Basel, Switzerland)
- Medicinal research reviews
- BMC plant biology
- Plant cell reports
- Drugs
- Molecules (Basel, Switzerland)
- Fitoterapia
- Journal of AOAC International
- Physiologia plantarum
- Journal of ethnopharmacology
- Journal of ginseng research
- Journal of pharmaceutical and biomedical analysis
- Food research international (Ottawa, Ont.)
- Molecular and cellular biochemistry
RB1
- Plant physiology and biochemistry : PPB
- Journal of the science of food and agriculture
- SpringerPlus
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- BioMed research international
View 5 additional sources
- Phytochemistry
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Journal of separation science
- Plant cell reports
- Molecules (Basel, Switzerland)
RE
- Phytochemistry
- The American journal of Chinese medicine
- Journal of ethnopharmacology
- Natural product research
- BioMed research international
View 4 additional sources
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Journal of separation science
- Molecules (Basel, Switzerland)
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
GINSENOSIDE
- International journal of molecular sciences
- Journal of the science of food and agriculture
- Phytochemistry
- Journal of chromatography. A
- Analytical and bioanalytical chemistry
View 3 additional sources
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Food & function
- Applied microbiology and biotechnology
RG1
- Journal of AOAC International
- Phytochemistry
- The American journal of Chinese medicine
- Journal of ethnopharmacology
- Natural product research
View 2 additional sources
- BioMed research international
- Molecules (Basel, Switzerland)
Saponins
- Dr. Duke
- Current protein & peptide science
- Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
- Frontiers in plant science
- International journal of molecular sciences
View 1 additional sources
- Japanese journal of pharmacology
RC
- BioMed research international
- Phytochemistry
- Journal of separation science
- Applied microbiology and biotechnology
- Molecules (Basel, Switzerland)
RD
- Plant physiology and biochemistry : PPB
- BioMed research international
- Journal of separation science
- Molecules (Basel, Switzerland)
- Phytochemistry
Rg3
- Plant physiology and biochemistry : PPB
- SpringerPlus
- Phytochemistry
- Journal of separation science
- Applied microbiology and biotechnology
SAPONIN
- Dr. Duke
- Journal of ethnopharmacology
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Applied microbiology and biotechnology
Activities
Panax quinquefolius has 661 reported activities identified across 19 scientific publications and several other databases. The most consistently reported activities include Antidiabetic, Antioxidant, Antitumor, Adaptogenic, Anxiolytic.
Most Reported Activities
| Activity | Sources | Consensus |
|---|---|---|
| Antidiabetic | Dr. Duke (and other 3 sources) | ★★☆☆☆ |
| Antioxidant | Dr. Duke (and other 3 sources) | ★★☆☆☆ |
| Antitumor | Dr. Duke (and other 3 sources) | ★★☆☆☆ |
| Adaptogenic | Dr. Duke (and other 2 sources) | ★☆☆☆☆ |
| Anxiolytic | Dr. Duke (and other 2 sources) | ★☆☆☆☆ |
| Cardioprotective | Dr. Duke (and other 2 sources) | ★☆☆☆☆ |
| Hepatoprotective | Dr. Duke (and other 2 sources) | ★☆☆☆☆ |
| Immunostimulant | Dr. Duke (and other 2 sources) | ★☆☆☆☆ |
| Neuroprotective | Dr. Duke (and other 2 sources) | ★☆☆☆☆ |
| 11B-HSD-Inhibitor | Dr. Duke (and other 1 sources) | ★☆☆☆☆ |
Medicinal Uses
Panax quinquefolius has 43 reported medicinal uses identified across 19 scientific publications and several other databases. The most consistently reported uses include antidiabetic, breast cancer, cancer, Alzheimer disease, DNA damage.
Most Reported Uses
| Use | Sources | Consensus |
|---|---|---|
| antidiabetic | Molecules (Basel, Switzerland) (and other 2 sources) | ★☆☆☆☆ |
| breast cancer | Annals of surgical oncology (and other 2 sources) | ★☆☆☆☆ |
| cancer | Yao xue xue bao = Acta pharmaceutica Sinica (and other 2 sources) | ★☆☆☆☆ |
| Alzheimer disease | Regulatory toxicology and pharmacology : RTP (and other 1 sources) | ★☆☆☆☆ |
| DNA damage | Phytomedicine : international journal of phytotherapy and phytopharmacology (and other 1 sources) | ★☆☆☆☆ |
| Insulin Resistance | Biomedical chromatography : BMC (and other 1 sources) | ★☆☆☆☆ |
| LDL cholesterol | Atherosclerosis (and other 1 sources) | ★☆☆☆☆ |
| Lung Adenocarcinoma | Molecules (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| antioxidants | Molecules (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| anxiolytic effects | Journal of chromatography. A (and other 1 sources) | ★☆☆☆☆ |
Preparations
| Preparations | Sources | Consensus |
|---|---|---|
| American ginseng | Phytomedicine : international journal of phytotherapy and phytopharmacology (and other 1 sources) | ★☆☆☆☆ |
| Cold FX | The American journal of Chinese medicine (and other 1 sources) | ★☆☆☆☆ |
| North American ginseng extract | Molecular and cellular biochemistry (and other 1 sources) | ★☆☆☆☆ |
| PQS | Journal of agricultural and food chemistry (and other 1 sources) | ★☆☆☆☆ |
| dietary supplements | Molecules (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| energy drinks | Molecules (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| extracts | Molecules (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| ginseng methanolic extracts | Analytical chemistry (and other 1 sources) | ★☆☆☆☆ |
| nutraceuticals | Molecules (Basel, Switzerland) (and other 1 sources) | ★☆☆☆☆ |
| polysaccharides | Journal of immunology research (and other 1 sources) | ★☆☆☆☆ |