By Leen Randell
Updated: Oct 20, 2024
What to know about Melissa officinalis before using it medicinally
Melissa officinalis, commonly known as sweet melissa, is a herb that has been traditionally used to treat a range of health conditions, including anxiety, insomnia, and digestive issues such as irritable bowel syndrome (IBS) and stomach ulcers.
The main health benefits associated with Melissa officinalis include its anti-inflammatory, antioxidant, and antimicrobial properties, which contribute to its therapeutic potential. The herb is also known for its calming and relaxing effects, which have been attributed to its anxiolytic and sedative properties. The main bioactive compounds found in Melissa officinalis include limonene, linalool, and rosmarinic acid, which are responsible for its medicinal properties.
People often prepare Melissa officinalis as a tea or tincture to take advantage of its therapeutic benefits, which can be used to soothe the nervous system and promote relaxation.
Featured Study:
According to a study published by "Oxidative medicine and cellular longevity", Melissa officinalis has been reported to have numerous beneficial properties, including antioxidant, antimicrobial, antitumour, antiviral, antiallergic, anti-inflammatory, and flatulence inhibiting effects, which can be attributed to its bioactive compounds such as terpenoids, alcohols, rosmarinic acid, and phenolic antioxidants. These properties can help in various health-promoting effects, making it a potential nutraceutical application. Overall, the study suggests that Melissa officinalis has a significant potential in providing numerous health benefits and is a subject of great interest in research.
The following article explains in detail what are the medicinal uses of Melissa officinalis, its health benefits, therapeutic properties, bioactive compounds, used parts, and herbal preparation. It also warns you about the potential side effects of this plant and what precautions to take before using it for medicinal purposes.
ARTICLE SUMMARY: The table below summarizes the most crucial information about Melissa officinalis provided in the article below, which is useful if you are in a hurry and don't have time to dig deep into the very detailed content that follows.
| Medicinal Aspect | Summary |
|---|---|
| Uses | Anxiety, Stress, Digestive issues, Insomnia, Hypertension, Inflammation, Diarrhea, Menstrual cramps, Nausea, Gastroesophageal reflux disease |
| Benefits | Reduces anxiety, Relieves stress, Fights insomnia, Treats ulcers, Relieves dyspepsia, Lowers cholesterol, Improves digestion, Boosts immunity, Fights infections, Reduces inflammation |
| Properties | Antimicrobial, Antioxidant, Anti-inflammatory, Anxiolytic, Antispasmodic, Antihistaminic, Analgesic |
| Constituents | Rosmarinic acid, Luteolin, Apigenin, Quercetin, Naringenin, Kaempferol, Caffeic acid, Chlorogenic acid, Tannins, Volatile oils |
| Parts | Leaves, Flowers |
| Preparations | Tincture, Essential oil, Salve, Tea, Capsule, Suppository |
| Side Effects | Develop, Experience, Induce, Manifest, Occur, Prolong, Rebound, Rebound anxiety, Relapse, Trigger |
| Precaution | Use in moderation, Pregnancy and breastfeeding warning, Allergic reactions risk, Interactions with medications, Kidney and liver function monitoring, Dosage adjustments necessary, Contraindicated in certain medical conditions, Increased risk of sedation, Combination with sedatives and tranquilizers, Long-term use potential |
BONUS CHEATSHEET: The cheatsheet below illustrates the most important medicinal aspects of Melissa officinalis. Feel free to download it, print it, and reference it when you need a quick reminder.
- What are the main medicinal uses of Melissa officinalis?
- Modern Western Medicine
- Traditional Chinese Medicine
- Ayurvedic Medicine
- Unani Medicine
- Homeopathic Medicine
- What are the primary health benefits of Melissa officinalis?
- Circulatory System
- Digestive System
- Endocrine System
- Integumentary System
- Lymphatic System
- Musculoskeletal System
- Nervous System
- Reproductive System
- Respiratory System
- Urinary System
- What are the dominant therapeutic properties of Melissa officinalis?
- What are the major healing constituents of Melissa officinalis?
- What are the most used parts of Melissa officinalis in medicine?
- What are the most common medicinal preparations of Melissa officinalis?
- What are the possible side effects of Melissa officinalis if used improperly?
- What are the precautions to take before using Melissa officinalis medicinally?
- Are there scientific studies that prove the medical effectiveness of Melissa officinalis?
- Related herbs to Melissa officinalis?
What are the main medicinal uses of Melissa officinalis?
The main medicinal uses of Melissa officinalis are relief from anxiety, which is attributed to the anxiolytic effects of rosmarinic acid, a phenolic dimer that has been shown to reduce stress and anxiety.
The plant has also been used to alleviate digestive issues, such as diarrhea, due to its high content of apigenin and luteolin, flavonoids that have been demonstrated to have anti-inflammatory properties and improve gut health. Additionally, Melissa officinalis is used to treat respiratory issues, including fever, which is caused by the presence of essential oils like borneol and camphor, that exhibit antimicrobial and antipyretic properties. Furthermore, the plant's sedative properties, attributed to the presence of rosmarinic acid and apigenin, make it effective in treating sleep disorders and insomnia.
The plant's efficacy in alleviating menopausal symptoms and hiccups can also be attributed to its flavonoid content, which has been shown to have estrogenic and anti-inflammatory properties, respectively.
The following illustration give a summary of the main medicinal uses of Melissa officinalis.
The list below provide more details on why Melissa officinalis is used to alleviate the health conditions mentioned in the illustration above.
- Anxiety: This herb is used for anxiety due to its ability to modulate the activity of the neurotransmitter GABA, which helps to reduce anxiety and promote relaxation. The herb contains compounds that have been shown to have anxiolytic effects in animal studies.
- Stress: The herb is used for stress due to its adaptogenic properties, which allow it to help the body adapt to stress and promote balance in the body. It contains compounds that have been shown to have a positive effect on the body's response to stress in animal studies.
- Digestive Issues: This herb is used for digestive issues due to its ability to relax the muscles in the digestive tract and reduce inflammation. It contains compounds that have been shown to have anti-inflammatory and antispasmodic effects, which can help to alleviate symptoms of digestive issues such as bloating and cramps.
- Insomnia: The herb is used for insomnia due to its ability to promote relaxation and reduce anxiety. It contains compounds that have been shown to have a sedative effect and help to regulate sleep patterns.
- Hypertension: This herb is used for hypertension due to its ability to help lower blood pressure. It contains compounds that have been shown to have a hypotensive effect in animal studies, which can help to reduce the risk of cardiovascular disease.
- Inflammation: The herb is used for inflammation due to its anti-inflammatory properties. It contains compounds that have been shown to have a suppressive effect on the production of pro-inflammatory cytokines, which can help to reduce inflammation and alleviate symptoms of conditions such as arthritis.
- Diarrhea: This herb is used for diarrhea due to its ability to slow down the movement of food through the digestive tract and reduce inflammation. It contains compounds that have been shown to have an antidiarrheal effect and help to alleviate symptoms of diarrhea.
- Menstrual Cramps: The herb is used for menstrual cramps due to its ability to relax the muscles in the uterus and reduce inflammation. It contains compounds that have been shown to have an antispasmodic and anti-inflammatory effect, which can help to alleviate symptoms of menstrual cramps.
- Nausea: This herb is used for nausea due to its ability to reduce inflammation and alleviate symptoms of nausea. It contains compounds that have been shown to have an antiemetic effect and help to alleviate symptoms of nausea and vomiting.
- Gastroesophageal Reflux Disease: The herb is used for gastroesophageal reflux disease due to its ability to reduce inflammation and alleviate symptoms of heartburn and acid reflux. It contains compounds that have been shown to have an antacid and anti-inflammatory effect, which can help to alleviate symptoms of gastroesophageal reflux disease.
The table that follows gives an overview of what are the most common health conditions that are treated with Melissa officinalis, in each of the major medicinal systems.
| Medicinal System | Conditions Treated |
|---|---|
| Modern Western Medicine | Anxiety, Stress, Digestive Issues, Gastroesophageal Reflux Disease, Insomnia, Menstrual Cramps, Hypertension, Sleep Disorders, Inflammation, Nausea, Skin Conditions, Inflammatory Bowel Disease, Menopausal Symptoms, Digestion, Migraines, Respiratory Issues, Wound Healing, Irritable Bowel Syndrome, Immune System Support, Diabetes |
| Traditional Chinese Medicine | Anxiety, Stress, Digestive Issues, Insomnia, Gastroesophageal Reflux Disease, Inflammation, Hypertension, Depression, Asthma, Diabetes, Menstrual Cramps, Sleep Disorders, Migraines, Diarrhea, Nausea, Respiratory Problems, Irritable Bowel Syndrome, Indigestion, Sleep, Gastroenteritis |
| Ayurvedic Medicine | Anxiety, Stress, Digestive Issues, Insomnia, Sleep Disorder, Hypertension, Inflammation, Gastroesophageal Reflux, Digestion, Nausea, Respiratory Issues, Skin Irritation, Cough, Skin Conditions, Fever, Diarrhea, Menopause, Asthma, Hives, Skin Issues |
| Unani Medicine | Anxiety, Hypertension, Digestive Issues, Insomnia, Stress, Diarrhea, Inflammation, Nausea, Respiratory Issues, Gastroesophageal Reflux, Gastritis, Cough, Menstrual Cramps, Hiccups, Respiratory Infections, Digestion, Rheumatism, Skin Conditions, Sleep, Peptic Ulcer |
| Homeopathic Medicine | Anxiety, Stress, Digestive Issues, Insomnia, Menstrual Cramps, Inflammation, Gastroesophageal Reflux, Nausea, Skin Irritations, Hypertension, Hives, Migraines, Digestion, Pain Relief, Menopausal Symptoms, Skin Conditions, Respiratory Issues, Depression, Diarrhea, Sleep Disorders |
Modern Western Medicine
In modern western medicine, Melissa officinalis is used to treat anxiety by reducing symptoms through its anxiolytic properties.
It is also used to alleviate stress by promoting relaxation and reducing cortisol levels. Additionally, Melissa officinalis is used to treat digestive issues such as gastroesophageal reflux disease, insomnia, and menstrual cramps due to its antispasmodic and anti-inflammatory effects. Furthermore, it is used to manage hypertension, sleep disorders, inflammation, nausea, skin conditions, inflammatory bowel disease, menopausal symptoms, digestion, migraines, and respiratory issues through its anti-inflammatory and antioxidant properties.
Its wound-healing properties, immune system support, irritable bowel syndrome management, and potential role in diabetes prevention also make it a valuable treatment option.
Traditional Chinese Medicine
In traditional Chinese medicine, Melissa officinalis is used to treat anxiety, stress, and digestive issues, often manifesting as indigestion and nausea.
The plant's anti-inflammatory properties also make it effective in reducing inflammation, a common symptom of respiratory problems such as asthma and gastroenteritis. Its calming effects are also beneficial for insomnia, while its antispasmodic properties alleviate menstrual cramps and migraines. Additionally, Melissa officinalis is used to treat gastroesophageal reflux disease, hypertension, depression, diabetes, diarrhea, sleep disorders, and irritable bowel syndrome, due to its ability to regulate digestive function and reduce stress.
Furthermore, its sedative properties also aid in sleep and alleviate symptoms of gastroenteritis, a condition often accompanied by diarrhea and nausea.
Ayurvedic Medicine
In ayurvedic medicine, Melissa officinalis is used to treat anxiety, a common condition it addresses through its calming effects on the nervous system.
Melissa officinalis is also employed to alleviate stress, its adaptogenic properties helping the body to cope with internal and external stressors. Additionally, it is used to treat digestive issues, such as gastroesophageal reflux, by soothing the digestive tract and reducing inflammation. Melissa officinalis is further used to treat insomnia and sleep disorder by promoting relaxation and improving sleep quality, as well as hypertension, through its blood pressure lowering properties.
Furthermore, it is used to treat inflammation, nausea, respiratory issues, skin irritation, cough, skin conditions, fever, diarrhea, menopause symptoms, and skin issues, such as hives and asthma, due to its anti-inflammatory and antispasmodic properties.
Unani Medicine
In unani medicine, Melissa officinalis is used to treat anxiety, a common condition that affects millions of people worldwide.
Melissa officinalis is also used to help manage hypertension, a serious health condition that can lead to cardiovascular disease and stroke. Additionally, its anti-inflammatory and antispasmodic properties make it effective in treating digestive issues, such as diarrhea and nausea, as well as inflammation, which can lead to various health problems. It is also used to alleviate insomnia and stress, which are often interconnected with respiratory issues, including cough and respiratory infections.
Furthermore, Melissa officinalis has been found to be beneficial in treating gastritis, peptic ulcer, and gastroesophageal reflux, as well as menstrual cramps, hiccups, and rheumatism, and is also used to improve digestion, reduce inflammation, and alleviate skin conditions, and promote sleep and relief from symptoms of nausea.
Homeopathic Medicine
In homeopathic medicine, Melissa officinalis is used to treat anxiety by modulating the nervous system, alleviate stress through its adaptogenic properties, and ease digestive issues such as irritable bowel syndrome due to its antispasmodic effects.
It is also employed to alleviate insomnia, menstrual cramps, and inflammation caused by its anti-inflammatory and antispasmodic properties. Furthermore, it treats gastroesophageal reflux, nausea, and skin irritations like eczema, while lowering hypertension by mitigating sympathetic nervous system activity. Additionally, Melissa officinalis is used to alleviate hives, migraines, and respiratory issues like bronchitis by its anti-inflammatory and antispasmodic properties.
It also relieves diarrhea, sleep disorders, and menopausal symptoms like hot flashes, and provides pain relief and digestion support, as well as alleviating skin conditions like acne and depression.
What are the primary health benefits of Melissa officinalis?
Melissa officinalis reduces anxiety by modulating the GABAergic system, which has a calming effect on the nervous system, and its rosmarinic acid content also contributes to this effect.
Relieving stress is also a key benefit of Melissa officinalis, as it has been shown to decrease the production of stress hormones like cortisol. Fighting insomnia is another benefit of this plant, which contains compounds that regulate sleep patterns and improve the quality of sleep. Treating ulcers is also a notable benefit of Melissa officinalis, as its ursolic acid content has been proven to reduce the production of gastric acid and heal ulcers.
Additionally, Melissa officinalis lowers cholesterol by inhibiting the activity of HMG-CoA reductase, an enzyme involved in cholesterol production, while also improving digestion, boosting immunity, fighting infections, and reducing inflammation through its antioxidant and anti-inflammatory properties.
The following illustration give a summary of the primary health benefits of Melissa officinalis.
The list below provides more details on why Melissa officinalis offers the health benefits mentioned in the illustration above.
- Reduces Anxiety: This plant has been traditionally used to reduce anxiety due to its ability to interact with the body's GABA receptors, which are responsible for regulating the body's response to stress, thereby promoting a sense of calm and relaxation.
- Relieves Stress: Its high content of rosmarinic acid and other polyphenolic compounds allows this plant to act as a stress reliever by reducing oxidative stress and promoting the body's natural response to stress, thereby helping to alleviate symptoms of stress and anxiety.
- Fights Insomnia: The sedative properties of this plant, particularly due to its high content of citral and other essential oils, help to promote relaxation and reduce restlessness, thereby aiding in the relief of insomnia and promoting a good night's sleep.
- Treats Ulcers: The anti-inflammatory and antioxidant properties of this plant help to reduce inflammation and protect the stomach lining from damage, thereby aiding in the treatment of ulcers and other gastrointestinal issues.
- Relieves Dyspepsia: The antispasmodic properties of this plant help to relax the muscles in the digestive tract, thereby reducing symptoms of dyspepsia such as bloating, gas, and abdominal pain.
- Lowers Cholesterol: The antioxidant and anti-inflammatory properties of this plant help to reduce inflammation in the blood vessels and improve lipid profiles, thereby aiding in the reduction of cholesterol levels and the prevention of cardiovascular disease.
- Improves Digestion: The carminative and antispasmodic properties of this plant help to reduce gas and bloating, and relax the muscles in the digestive tract, thereby improving digestion and alleviating symptoms of indigestion and other gastrointestinal issues.
- Boosts Immunity: The high content of vitamin C and other antioxidants in this plant help to protect the body from oxidative stress and promote the production of white blood cells, thereby boosting the immune system and reducing the risk of illness and disease.
- Fights Infections: The antimicrobial properties of this plant, particularly due to its high content of rosmarinic acid and other polyphenolic compounds, help to fight off infections and promote the healing of wounds and other injuries.
- Reduces Inflammation: The anti-inflammatory properties of this plant, particularly due to its high content of rosmarinic acid and other polyphenolic compounds, help to reduce inflammation and alleviate symptoms of conditions such as arthritis and other inflammatory diseases.
The table that follows gives an overview of what are the primary health benefits of Melissa officinalis for each of the major body system.
| Body System | Health Benefits |
|---|---|
| Circulatory System | Improves Blood Flow, Reduces Blood Pressure, Regulates Heart Rate, Enhances Circulation, Reduces Inflammation, Prevents Blood Clots, Lowers Cholesterol, Reduces Vasoconstriction, Improves Oxygenation, Reduces Atherosclerosis |
| Digestive System | Reduces Inflammation, Relieves Bloating, Calms Digestion, Prevents Diarrhea, Treats Nausea, Cures Ibs, Soothes Irritation, Regulates Bowel, Eases Cramping, Cleansse Gut |
| Endocrine System | Regulates Hormonal, Balances Thyroid, Supports Adrenal, Reduces Insulin, Stabilizes Cortisol, Maintains Ovarian, Enhances Testicular, Relaxes Pituitary, Improves Pancreatic, Increases Estrogen |
| Integumentary System | Soothes Skin, Calms Irritation, Reduces Inflammation, Exfoliates Dead Cells, Protects From Sun, Treats Acne, Relieves Eczema, Heals Wounds, Cures Rashes, Improves Complexion |
| Lymphatic System | Enhances Lymph Flow, Regulates Lymph Function, Reduces Lymph Swelling, Improves Lymph Drainage, Supports Lymph Health, Stimulates Lymph System, Boosts Lymph Defense, Activates Lymph Circulation, Promotes Lymph Detox, Protects Lymph Tissue |
| Musculoskeletal System | Relieves Inflammation, Reduces Joint Pain, Soothes Muscle Cramps, Prevents Muscle Spasms, Reduces Muscle Fatigue, Eases Joint Stiffness, Protects Bone Health, Improves Bone Density, Sustains Muscle Function, Enhances Muscle Strength |
| Nervous System | Reduces Anxiety, Soothes Nerves, Calms Down, Relaxes Muscles, Tones Nervous, Stabilizes Mood, Promotes Relaxation, Relieves Stress, Sedates Nervous, Improves Sleep |
| Reproductive System | Regulates Ovulation, Stimulates Fertility, Improves Hormonal Balance, Relaxes Reproductive Muscles, Enhances Menstrual Flow, Supports Ovum Maturation, Increases Fsh Levels, Decreases Menstrual Cramps, Promotes Endometrial Growth, Regenerates Reproductive Tissues |
| Respiratory System | Relieves Congestion, Eases Breathing, Reduces Inflammation, Fights Infections, Lowers Allergies, Calms Asthma, Soothes Coughs, Prevents Bronchitis, Cures Phlegm, Protects Lungs |
| Urinary System | Prevents Infections, Relieves Burning, Treats Diarrhea, Reduces Inflammation, Fights Bacteria, Cures Utis, Eases Discomfort, Heals Wounds, Relaxes Muscles, Soothes Irritation |
Circulatory System
Melissa officinalis improves blood flow by relaxing smooth muscles in blood vessels, reducing vascular resistance, and increasing nitric oxide production, which is essential for vasodilation.
Reduced blood pressure is also a result of Melissa officinalis due to its diuretic and vasodilatory properties, which decrease peripheral resistance and promote a decrease in blood pressure. The herb's antioxidant and anti-inflammatory properties regulate heart rate by reducing oxidative stress and inflammation in the heart, preventing arrhythmias and cardiac hypertrophy. Enhanced circulation is achieved through Melissa officinalis's ability to reduce vasoconstriction, a condition where blood vessels constrict, thereby improving blood flow and delivery of oxygen and nutrients to tissues.
By reducing inflammation and preventing the formation of blood clots, lowering cholesterol levels, improving oxygenation, reducing atherosclerosis, and preventing the accumulation of lipids in the arterial walls, Melissa officinalis offers comprehensive circulatory system support.
The medicinal benefits of Melissa officinalis on the circulatory system help relieving the health conditions listed below.
- Cardiac arrhythmia
- Hypotension
- Varicose veins
- Poor circulation
- Raynaud's disease
Digestive System
Melissa officinalis reduces inflammation due to its anti-inflammatory and antioxidant properties, which have been found to decrease the production of pro-inflammatory cytokines and increase the production of anti-inflammatory cytokines.
This plant relieves bloating by containing carminative properties, which help to expel gas from the digestive system and alleviate discomfort. Melissa officinalis calms digestion by possessing anti-ulcerogenic properties, which protect the mucous membranes of the stomach and intestines from damage and irritation. The plant prevents diarrhea by exhibiting antimicrobial properties, which inhibit the growth of pathogenic bacteria that can cause gastrointestinal infections.
Melissa officinalis treats nausea and cures IBS by containing anti-spasmodic and anti-inflammatory properties, which ease muscle spasms and reduce inflammation in the digestive tract, while also soothing irritation and regulating bowel movements, easing cramping, and cleansing the gut with its antioxidant and anti-inflammatory properties.
The medicinal benefits of Melissa officinalis on the digestive system help relieving the health conditions listed below.
- Irritable bowel syndrome
- Peptic ulcer
- Indigestion
- Nausea
- Gastritis
- Constipation
- Diarrhea
Endocrine System
Melissa officinalis regulates hormonal balance through its antimicrobial and antioxidant properties, which help to stabilize the endocrine system.
It balances thyroid function by modulating the conversion of T4 to T3, reducing the risk of hypothyroidism and hyperthyroidism. The plant supports adrenal function by reducing oxidative stress and promoting the production of cortisol. Additionally, Melissa officinalis reduces insulin resistance by activating AMP-activated protein kinase, which improves glucose metabolism and reduces the risk of developing type 2 diabetes.
Furthermore, it maintains ovarian health by modulating the hypothalamic-pituitary-gonadal axis, enhances testicular function through its anti-inflammatory properties, relaxes the pituitary gland by reducing stress hormones, improves pancreatic function by stimulating insulin secretion, and increases estrogen levels by modulating the conversion of androgens to estrogens.
The medicinal benefits of Melissa officinalis on the endocrine system help relieving the health conditions listed below.
- Hypothyroidism
- Adrenal fatigue
- Polycystic ovary syndrome
- Insulin resistance
- Hormonal imbalance
- Menopausal symptoms
- Diabetes
Integumentary System
Melissa officinalis soothes skin with its antimicrobial properties that inhibit the growth of pathogenic microorganisms, thereby preventing infections and promoting a healthy skin environment.
Calms irritation caused by its anti-inflammatory compounds, which reduce redness and swelling by inhibiting the production of pro-inflammatory enzymes. The plant's antioxidant properties, such as its phenolic compounds, reduce inflammation and protect the skin from oxidative damage, while its exfoliating properties, attributed to its saponins, help remove dead skin cells, revealing smoother skin. Protects from sun damage due to its antioxidant and photoprotective properties, which neutralize free radicals and prevent UV-induced damage.
The plant's anti-inflammatory and antimicrobial properties also treat acne, relieve eczema, heal wounds, cure rashes, and improve complexion by reducing inflammation, preventing infection, and promoting tissue repair.
The medicinal benefits of Melissa officinalis on the integumentary system help relieving the health conditions listed below.
- Acne
- Eczema
- Psoriasis
- Wound healing
- Sunburn
- Itching
- Skin infections
Lymphatic System
Melissa officinalis enhances lymph flow by increasing the production of nitric oxide, which causes the dilation of lymphatic vessels and promotes the circulation of lymph fluid.
This plant regulates lymph function by modulating the immune response and reducing inflammation in the lymph nodes. The antimicrobial properties of Melissa officinalis reduce lymph swelling by inhibiting the growth of pathogens and toxins that can cause swelling. Improved lymph drainage is achieved through the plant's antioxidant properties, which scavenge free radicals and promote the breakdown of toxic waste in the lymphatic system.
Regular consumption of Melissa officinalis supports lymph health by stimulating the lymph system, boosting its defense against pathogens, activating lymph circulation, promoting lymph detox, and protecting lymph tissue, ultimately maintaining the balance of the lymphatic system.
The medicinal benefits of Melissa officinalis on the lymphatic system help relieving the health conditions listed below.
- Lymphedema
- Edema
- Swelling
- Lymphatic infections
- Fibromyalgia
- Cancer-related swelling
- Varicose veins
- Tendinitis
- Arthritis
Musculoskeletal System
Melissa officinalis relieves inflammation by exerting anti-inflammatory properties, which help reduce joint pain by inhibiting the production of pro-inflammatory cytokines.
It soothes muscle cramps by modulating muscle tone and alleviating spasms, while preventing muscle spasms through its antispasmodic properties. The plant reduces muscle fatigue by countering oxidative stress and enhancing mitochondrial function. Melissa officinalis eases joint stiffness by promoting the repair of damaged connective tissue and protecting bone health through its antioxidant and osteoprotective properties, which improve bone density and sustain muscle function.
By strengthening muscle fibers and enhancing muscle strength, Melissa officinalis supports the musculoskeletal system's ability to function optimally, contributing to overall well-being.
The medicinal benefits of Melissa officinalis on the musculoskeletal system help relieving the health conditions listed below.
- Osteoarthritis
- Muscle spasms
- Sciatica
- Tendinitis
- Bursitis
- Fibromyalgia
Nervous System
Melissa officinalis reduces anxiety through its adaptogenic properties, helping the body adapt to stress by regulating the hypothalamic-pituitary-adrenal axis.
This plant soothes nerves by possessing antioxidant properties, which protect the nervous system from oxidative stress and damage caused by free radicals. Melissa officinalis calms down the nervous system by exhibiting sedative properties, which induce relaxation and reduce muscle tension. The plant tones the nervous system by acting as a nervine tonic, strengthening and stabilizing the nervous system's function.
Melissa officinalis promotes relaxation, relieves stress, sedates nervous activity, and improves sleep due to its calming and anxiolytic effects, resulting from its high content of rosmarinic acid and other bioactive compounds.
The medicinal benefits of Melissa officinalis on the nervous system help relieving the health conditions listed below.
- Anxiety
- Insomnia
- Digestive issues
- Stress
- Migraines
- Hyperactivity
- Adhd
- Fatigue
- Depression
Reproductive System
Melissa officinalis regulates ovulation by modulating the hypothalamic-pituitary-gonadal axis, which is supported by its antioxidant and anti-inflammatory properties.
This plant stimulates fertility in females by enhancing the quality and quantity of oocytes, due to its antioxidant activity. Melissa officinalis improves hormonal balance by modulating the production of sex hormones, including estrogen and progesterone, attributed to its estrogenic activity. Furthermore, it relaxes reproductive muscles by exerting a calming effect on the uterus, a result of its sedative and anti-spasmodic properties, which also enhances menstrual flow.
Additionally, Melissa officinalis supports ovum maturation, increases FSH levels, decreases menstrual cramps, promotes endometrial growth, and regenerates reproductive tissues, all of which are facilitated by its anti-inflammatory, antioxidant, and regenerative properties.
The medicinal benefits of Melissa officinalis on the reproductive system help relieving the health conditions listed below.
- Menorrhagia
- Endometriosis
- Hirsutism
- Polycystic ovary syndrome
- Dysmenorrhea
- Infertility
- Premenstrual syndrome
- Uterine fibroids
Respiratory System
Melissa officinalis relieves congestion due to its expectorant properties, which help to loosen and clear mucus from the airways.
Eases breathing is also facilitated by the plant's anti-inflammatory properties, which reduce swelling in the lungs and airways, thereby improving airflow. Melissa officinalis reduces inflammation through its antioxidant properties, which neutralize free radicals that cause oxidative stress and inflammation in the respiratory system. The plant fights infections with its antimicrobial properties, which inhibit the growth of pathogens that can cause respiratory infections.
Melissa officinalis lowers allergies by modulating the immune response and reducing the production of IgE antibodies, which are responsible for triggering allergic reactions, while also soothing coughs, calming asthma, preventing bronchitis, curing phlegm, and protecting lungs through its anti-inflammatory and expectorant properties.
The medicinal benefits of Melissa officinalis on the respiratory system help relieving the health conditions listed below.
- Asthma
- Allergies
- Bronchitis
- Cough
- Sinusitis
Urinary System
Melissa officinalis prevents infections due to its antimicrobial properties, which inhibit the growth of harmful pathogens and bacteria.
Relieving burning sensations in the urinary system is another benefit of Melissa officinalis, attributed to its soothing and calming effects on the mucous membranes. The plant treats diarrhea by regulating bowel movements and reducing inflammation, thanks to its anti-inflammatory properties, which help to alleviate symptoms and promote healing. Additionally, Melissa officinalis reduces inflammation in the urinary tract, fights bacteria through its antimicrobial action, and cures UTIs by eliminating the underlying infection.
Easing discomfort and relaxing muscles are also benefits of Melissa officinalis, which eases irritation and promotes a sense of calm, while its antioxidant properties heal wounds.
The medicinal benefits of Melissa officinalis on the urinary system help relieving the health conditions listed below.
- Urinary tract infections
- Kidney stones
- Overactive bladder
- Bedwetting
- Urinary incontinence
What are the dominant therapeutic properties of Melissa officinalis?
The therapeutic properties of Melissa officinalis are multifaceted, exhibiting antimicrobial activity against various pathogens, including bacteria and fungi, due to the presence of rosmarinic acid and ursolic acid.
The plant's antioxidant properties are attributed to flavonoids and phenolic acids, which protect against oxidative stress and cell damage. Anti-inflammatory responses are modulated by the sesquiterpene lactones, which inhibit the production of pro-inflammatory cytokines and enzymes. Additionally, Melissa officinalis has anxiolytic effects, likely resulting from the interaction of rosmarinic acid with GABA receptors in the brain, reducing anxiety and stress levels.
The plant's antispasmodic, antihistaminic, and analgesic properties are also present, with the volatile oil linalool contributing to these effects through its action on smooth muscle and nerve endings.
The following illustration give a summary of the dominant therapeutic properties of Melissa officinalis.
The list below provides more details on why Melissa officinalis has the therapeutic properties mentioned in the illustration above.
- Antimicrobial: Melissa officinalis has been shown to exhibit antimicrobial activity against various microorganisms, including bacteria, fungi, and yeast, due to the presence of compounds such as rosmarinic acid, ursolic acid, and caffeic acid, which inhibit the growth of these pathogens and prevent the development of infections.
- Antioxidant: The plant Melissa officinalis contains antioxidant compounds like rosmarinic acid, which scavenge free radicals and reduce oxidative stress, thereby protecting cells from damage and contributing to the prevention of chronic diseases such as cancer, atherosclerosis, and neurodegenerative disorders.
- Anti-Inflammatory: Melissa officinalis has anti-inflammatory properties, attributed to the presence of compounds like rosmarinic acid, which inhibit the production of pro-inflammatory enzymes and cytokines, and reduce inflammation and tissue damage in response to injury or infection.
- Anxiolytic: The essential oil of Melissa officinalis has been found to possess anxiolytic effects, likely due to the presence of linalool and other terpenoids, which interact with the brain's GABA receptors and reduce anxiety and stress levels, promoting relaxation and calmness.
- Antispasmodic: Melissa officinalis has been traditionally used to treat muscle spasms and cramps, and studies have shown that its extracts can relax smooth muscle tissue and reduce spasmodic activity, likely due to the presence of compounds like rosmarinic acid and ursolic acid, which have a direct effect on muscle physiology.
- Antihistaminic: The plant Melissa officinalis has been found to exhibit antihistaminic activity, likely due to the presence of compounds like rosmarinic acid, which inhibit the release of histamine from mast cells and reduce allergic responses, such as itching, sneezing, and runny nose.
- Analgesic: Melissa officinalis has been traditionally used to treat pain and headaches, and studies have shown that its extracts can reduce pain perception and analgesic activity, likely due to the presence of compounds like rosmarinic acid and ursolic acid, which have a direct effect on pain pathways and neurotransmitters.
What are the major healing constituents of Melissa officinalis?
The healing constituents of Melissa officinalis are primarily responsible for its medicinal properties.
The plant contains rosmarinic acid which has been shown to exhibit antioxidant and anti-inflammatory activities by inhibiting the production of pro-inflammatory enzymes and cytokines. Luteolin a flavonoid present in Melissa officinalis has been found to possess anti-inflammatory and antioxidant properties by scavenging free radicals and modulating the activity of various signaling pathways. Additionally the presence of apigenin and quercetin in the plant contribute to its anti-inflammatory and antioxidant activities by inhibiting the production of pro-inflammatory mediators and enzymes.
Furthermore the flavanone naringenin present in Melissa officinalis has been reported to possess antioxidant and anti-inflammatory properties by scavenging free radicals and modulating the activity of various signaling pathways involved in inflammation.
The following illustration give a summary of the major healing consitutents of Melissa officinalis.
The list below provides more details on what are the major healing constituents of Melissa officinalis and why they are important for health.
- Rosmarinic acid: Rosmarinic acid is a polyphenolic compound that exhibits antioxidant, anti-inflammatory and antimicrobial properties.
- Luteolin: A flavonoid compound found in Melissa officinalis, known for its antioxidant, anti-inflammatory, and antimicrobial properties.
- Apigenin: Flavonoid compound found in Melissa officinalis with antioxidant, anti-inflammatory, and antimicrobial properties.
- Quercetin: Flavonoid constituent of Melissa officinalis with antioxidant, anti-inflammatory, and antiviral properties.
- Naringenin: A flavonoid compound found in Melissa officinalis, it has antioxidant, anti-inflammatory, and antimicrobial properties.
- Kaempferol: Kaempferol is a flavonoid with antioxidant, anti-inflammatory and antimicrobial properties
- Caffeic acid: Caffeic acid is a phenolic compound with antioxidant, anti-inflammatory, and antimicrobial properties.
- Chlorogenic acid: A phenolic compound with antioxidant properties, anti-inflammatory activity, and potential neuroprotective effects.
- Tannins: Tannins from Melissa officinalis are astringent, antiseptic, and anti-inflammatory compounds.
- Volatile oils: The volatile oils of Melissa officinalis are composed of citral, geraniol, linalool, and other terpenes.
The table that follows estimates the relative concentrations of the main medicinal constituents contained in Melissa officinalis and lists the most relevant medicinal properties of each constituent based on the corresponding concentrations.
| Constituent | Concentration | Properties |
|---|---|---|
| Rosmarinic acid | HIGH | Antimicrobial, Antioxidant, Anti-inflammatory, Antiviral, Antihistaminic, Antipruritic, Antiseptic |
| Luteolin | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Antibacterial, Antiviral, Neuroprotective, Antihistaminic, Anticancer, Antioxidant, Antiedemic, Anti-hyperlipidemic |
| Apigenin | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Antihistaminic, Analgesic, Antispasmodic, Antibacterial, Antiviral |
| Quercetin | LOW | Antioxidant, Anti-inflammatory, Antimicrobial, Antiviral, Anticancer, Anti-allergic, Anti-histamine, Analgesic |
| Naringenin | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Antiproliferative, Anticancer, Analgesic, Antihistaminic, Antiviral |
| Kaempferol | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Antiviral, Analgesic, Cytoprotective, Anticancer |
| Caffeic acid | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Antiallergic, Analgesic |
| Chlorogenic acid | LOW | Antioxidant, Antimicrobial, Anti-inflammatory, Hypoglycemic, Antioxidant, Cardioprotective |
| Tannins | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Astringent, Anticariogenic, Antiseptic |
| Volatile oils | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Antispasmodic, Sedative, Anticough |
What are the most used parts of Melissa officinalis in medicine?
The most used parts of Melissa officinalis for medicinal purposes are leaves and flowers.
The leaves of Melissa officinalis contain primarily rosmarinic acid, a water-soluble phenolic diterpene, and flavonoids such as luteolin and apigenin, which exhibit antioxidant, anti-inflammatory, and antimicrobial properties. The flowers of Melissa officinalis are rich in essential oils, including linalool, limonene, and geraniol, which possess sedative, anti-anxiety, and antiseptic properties. The leaves are primarily used for their anti-inflammatory, antispasmodic, and antiseptic properties, while the flowers are used for their sedative, anti-anxiety, and antiseptic properties.
The combination of rosmarinic acid, flavonoids, and essential oils in both parts contributes to the medicinal properties of Melissa officinalis, making it a popular herbal remedy for anxiety, insomnia, and digestive issues.
The following illustration give a summary of the most used parts of Melissa officinalis in medicine.
The list below provides more details on what are the most used parts of Melissa officinalis in medicine and why.
- Leaves: The leaves of this plant are rich in rosmarinic acid, a potent antioxidant, and also contain luteolin, apigenin, and caffeic acid, which contribute to its anti-inflammatory, antimicrobial, and antiseptic properties, providing relief from digestive issues, anxiety, and stress, while also exhibiting hepatoprotective and immunomodulatory effects.
- Flowers: The flowers of this plant contain flavonoids, particularly luteolin and apigenin, along with rosmarinic acid and other phenolic compounds, which contribute to its antispasmodic, anti-inflammatory, and antiseptic properties, making it effective in alleviating menstrual cramps, anxiety, and insomnia, while also exhibiting antimicrobial and immunomodulatory effects.
The table that follows gives a more complete list of healing constituents found in each part of Melissa officinalis mentioned above.
| Part | Constituents |
|---|---|
| Leaves | Rosmarinic acid, Nepetalactone, Volatile oils, Limonene, Menthone, Methyl chavicol, Geranial, Linalool, Linalyl acetate, Acidic triterpenes, Phenolic acids, Flavonoids, Saponins |
| Flowers | Rosmarinic acid, Luteolin, Apigenin, Caffeic acid, Volatile oils, Terpenes, Sesquiterpenes, Flavonoids, Phenolic acids, Tannins |
What are the most common medicinal preparations of Melissa officinalis?
The most common herbal preparation of Melissa officinalis for medicinal purposes are tinctures, which are used to treat anxiety and insomnia due to their sedative properties.
Essential oil, extracted from the plant's leaves, is used topically to relieve digestive issues and skin irritations, such as eczema and acne, due to its antispasmodic and anti-inflammatory effects. A salve, made from the essential oil and beeswax, is applied topically to soothe wounds and burns, accelerating the healing process. Melissa officinalis tea is consumed to treat various health conditions, including colds, sore throats, and respiratory problems, due to its expectorant and antiseptic properties.
Capsules, containing dried Melissa officinalis leaves, are taken orally to alleviate symptoms of irritable bowel syndrome, while suppositories are used to treat gastrointestinal issues and infections, such as hemorrhoids and urinary tract infections.
The following illustration give a summary of the most common medicinal preparations of Melissa officinalis.
The list below provides more details on what are the most common medicinal preparations of Melissa officinalis and what are their main uses.
- Tincture: Tincture made from this plant is used to alleviate anxiety, insomnia, and digestive issues, and as a sedative and anti-inflammatory agent.
- Essential Oil: Essential oil made from this plant is used to treat anxiety, insomnia, and digestive issues, as well as to reduce pain and inflammation.
- Salve: Salve made from this plant is used to treat anxiety, insomnia, and digestive issues, and also as a topical anti-inflammatory and antimicrobial agent.
- Tea: Tea made from this plant is used to treat insomnia, anxiety, digestive issues, and to reduce inflammation and pain.
- Capsule: Capsule made from this plant is used to treat anxiety, insomnia, digestive issues, and as a natural anticonvulsant and anti-inflammatory agent.
The table that follows shows what are the most used parts of Melissa officinalis for each medicinal preparation.
| Preparation | Parts |
|---|---|
| Tincture | Leaves, Flowers |
| Essential oil | Leaves, Flowers |
| Salve | Leaves, Flowers |
| Tea | Leaves, Flowers |
| Capsule | Leaves, Flowers |
Tincture
Melissa officinalis tincture is a herbal remedy used to treat a range of health issues including insomnia, anxiety, stress, digestive problems such as irritable bowel syndrome, menstrual cramps, hypertension, and cold sores.
It's a very commonly used preparation due to its widespread availability and effectiveness. One of its most common effects is promoting relaxation and reducing anxiety. Melissa officinalis tincture is typically made from the leaves and flowers of the Melissa officinalis plant.
Its preparation is moderately difficult, requiring precise dosing and extraction methods to ensure optimal potency.
Below you find an image of Melissa officinalis tincture.
Below you find a 5-step quick procedure to make effective medicinal Melissa officinalis tincture.
- Gather fresh Melissa officinalis leaves and flowers from a reputable source.
- Chop the leaves and flowers into small pieces to release their essential oils.
- Combine the chopped herbs with a neutral spirit, such as vodka or glycerin, in a clean glass jar.
- Steep the mixture in a cool, dark place for 2-6 weeks, shaking the jar daily to facilitate extraction.
- Strain the liquid through a cheesecloth or coffee filter into a clean glass bottle, discarding the solids.
Essential Oil
Melissa officinalis essential oil, derived from the leaves and flowers of Melissa officinalis, is commonly used to treat anxiety, stress, digestive issues, sleep disorders, menstrual cramps, inflammation, immune system imbalances, and skin issues.
This oil is widely used in aromatherapy and herbal medicine, due to its widespread availability and popularity. A common effect of Melissa officinalis essential oil is its uplifting and calming properties, which can help reduce feelings of anxiety and stress.
The oil is typically extracted through steam distillation, a process that requires a significant amount of leaves and flowers, making its production somewhat labor-intensive and expensive.
Below you find an image of Melissa officinalis essential oil.
Below you find a 5-step quick procedure to make effective medicinal Melissa officinalis essential oil.
- Gather fresh Melissa officinalis leaves and flowers for distillation.
- Wash the Melissa officinalis leaves and flowers with clean water to remove any impurities.
- Use a steam distillation apparatus to heat the water and release the essential oil from the Melissa officinalis leaves and flowers.
- Collect the distilled essential oil and separate it from the water using a condenser.
- Filter the essential oil through a coffee filter to remove any remaining plant particles and achieve a clear product.
Salve
Melissa officinalis salve is used to treat burns, wounds, fungal infections, herpes, cold sores, and skin irritations.
It's a common preparation used by herbalists and homeopaths due to its widespread availability and established uses. Melissa officinalis salve is often used to calm irritated skin and reduce inflammation. The preparation is typically made with the leaves and flowers of the Melissa officinalis plant, which contain compounds like linalool and linalyl acetate that contribute to its therapeutic effects.
However, making the salve is a challenging process that requires precise measurements and preparation of the plant material, as well as a suitable carrier oil, to ensure the desired consistency and potency.
Below you find an image of Melissa officinalis salve.
Below you find a 5-step quick procedure to make effective medicinal Melissa officinalis salve.
- Gather a sufficient amount of Melissa officinalis leaves and flowers for the recipe.
- Dry the harvested Melissa officinalis leaves and flowers thoroughly, either air-drying or using a dehydrator.
- Infuse the dried Melissa officinalis leaves and flowers in a carrier oil, such as olive or sweet almond oil, in a clean glass jar for several weeks.
- Strain the infused oil through cheesecloth or a coffee filter into a clean glass container, discarding the solids.
- Mix the strained oil with a thickening agent, such as beeswax, and heat the mixture gently until the beeswax is fully incorporated, then let it cool and solidify into a salve.
Tea
Melissa officinalis tea is a herbal preparation used to treat various health issues, including digestive problems, sleep disorders, anxiety, stress, indigestion, inflammation, cough and hiccups.
It's a very common remedy, widely available in stores and online, due to its effectiveness and ease of use. One of its most common effects is promoting relaxation and reducing stress levels, which can be attributed to its bioactive compounds, such as citral and geranial.
The tea is typically made by steeping leaves and flowers of the Melissa officinalis plant in hot water, making it easy to prepare at home.
Below you find an image of Melissa officinalis tea.
Below you find a 5-step quick procedure to make effective medicinal Melissa officinalis tea.
- Gather fresh Melissa officinalis leaves and flowers, either from your garden or a local herbalist.
- Rinse the leaves and flowers with clean water to remove any dirt or debris.
- Combine the leaves and flowers in a heat-resistant cup or teapot.
- Pour boiling water over the leaves and flowers, and let it steep for a few minutes.
- Strain the tea and discard the solids before serving.
Capsule
Melissa officinalis capsule is used to treat insomnia, anxiety, stress, menopause, digestion, indigestion, depression, gastroesophageal reflux, and migraine.
This preparation is widely used due to its effectiveness in alleviating various health issues. Its common effect is to promote relaxation and reduce symptoms of anxiety and stress. The capsule is typically made from the leaves and flowers of the Melissa officinalis plant, which are rich in essential oils, particularly linalool and linalyl acetate.
The preparation process for Melissa officinalis capsule is considered moderately difficult, requiring precise methods to ensure the optimal extraction of active compounds from the plant material.
Below you find a 5-step quick procedure to make effective medicinal Melissa officinalis capsule.
- Harvest Melissa officinalis leaves and flowers from a clean and organic source.
- Clean and dry the harvested leaves and flowers using a dehydrator or air dry method.
- Grind the dried leaves and flowers into a fine powder using a spice grinder or mortar and pestle.
- Fill empty gelatin capsules with the powdered Melissa officinalis mixture.
- Seal the capsules properly to ensure freshness and potency.
What are the possible side effects of Melissa officinalis if used improperly?
The possible side effects of improperly using Melissa officinalis are develop liver toxicity, which can occur in rare cases.
If not used carefully, this herb can experience adverse interactions with certain medications, such as blood thinners and diabetes medications. Improper use of Melissa officinalis can induce excessive sedation, especially when combined with other sedatives. Long-term misuse of this herb may manifest in gastrointestinal problems, including stomach pain and diarrhea.
Prolonged consumption of improperly used Melissa officinalis can rebound, causing anxiety in some individuals, potentially leading to rebound anxiety, which may trigger relapse of the original condition.
The most common side effects Melissa officinalis gives people when used improperly are listed below, along with a brief explanation.
- Develop: Nausea and vomiting occur in individuals consuming excessive amounts of Melissa officinalis extract.
- Experience: Subjective effects such as euphoria, relaxation, and improved mood occur.
- Induce: Hypoglycemia in individuals with diabetes taking hypoglycemic medications.
- Manifest: Hypomania in some individuals.
- Occur: The plant Melissa officinalis can cause allergic reactions in some individuals.
- Prolong: Melissa officinalis prolongs the bleeding time due to its effect on platelet aggregation.
- Rebound: Withdrawal symptoms occur after abruptly stopping or reducing Melissa officinalis consumption.
- Rebound Anxiety: Withdrawal from Melissa officinalis after prolonged use can cause symptoms similar to those experienced during initial anxiety.
- Relapse: Withdrawal symptoms recur after cessation of Melissa officinalis use.
- Trigger: Increased uterine contractions
What are the precautions to take before using Melissa officinalis medicinally?
The precautions to take before using Melissa officinalis medicinally are use in moderation, as excessive consumption can lead to adverse effects.
Pregnancy and breastfeeding women should consult a healthcare provider due to potential risks to the fetus or infant. Allergic reactions risk exists, and individuals should discontinue use if skin irritation, hives, or difficulty breathing occur. Interactions with medications, such as blood thinners and diabetes medications, may occur, requiring monitoring and potential dosage adjustments necessary.
Contraindicated in certain medical conditions, including kidney and liver disease, increased risk of sedation, and combination with sedatives and tranquilizers, may lead to long-term use potential and exacerbate kidney and liver function monitoring.
The most important precautions you must take before using Melissa officinalis for medicinal purposes are listed below, along with a brief explanation.
- Use In Moderation: Excessive consumption of Melissa officinalis may cause liver damage and interact with certain medications, particularly in pregnant women and children.
- Pregnancy And Breastfeeding Warning: Melissa officinalis should be used with caution during pregnancy and breastfeeding due to potential estrogen-like effects.
- Allergic Reactions Risk: Melissa officinalis essential oil causes skin irritation and allergic contact dermatitis in some individuals.
- Interactions With Medications: Melissa officinalis may interact with anticholinergics, antihistamines, sedatives, and other medications, increasing the risk of adverse effects such as drowsiness and confusion.
- Kidney And Liver Function Monitoring: Monitor kidney and liver function in patients taking Melissa officinalis due to potential hepatotoxicity and nephrotoxicity.
- Dosage Adjustments Necessary: Higher doses may cause gastrointestinal upset, and lower doses may be ineffective; adjust accordingly based on individual tolerance and response.
- Contraindicated In Certain Medical Conditions: Avoid using Melissa officinalis in patients with epilepsy due to potential for seizures and in patients with gastroesophageal reflux disease (GERD) due to potential for exacerbating symptoms.
- Increased Risk Of Sedation: Combining Melissa officinalis with sedatives or other central nervous system depressants increases sedative effects.
- Combination With Sedatives And Tranquilizers: Combining Melissa officinalis with sedatives and tranquilizers can enhance their sedative effects and increase the risk of respiratory depression.
- Long-Term Use Potential: Prolonged consumption of Melissa officinalis may lead to tolerance and decreased efficacy.
Are there scientific studies that prove the medical effectiveness of Melissa officinalis?
Yes, there are several scientific studies that prove the medicianl effectiveness of Melissa officinalis. Here are some studies that are worthy of notice.
According to a study published by "Journal of ethnopharmacology", Melissa officinalis has been shown to exhibit numerous positive effects, including anxiolytic, antiviral, and antispasmodic activities, as well as improving mood, cognition, and memory in clinical trials. The mechanisms behind these effects involve AChE inhibitory activity, stimulation of the acetylcholine and GABAA receptors, and inhibition of matrix metalloproteinase-2. As a result, Melissa officinalis has been identified as a potential source for the treatment of a wide range of diseases, particularly anxiety and some other CNS disorders.
In another study published by "Molecules (Basel, Switzerland)", Melissa officinalis has been found to have beneficial effects on skin recovery, including enhanced skin hydration and decreased erythema and transepidermal water loss levels. Additionally, the extract showed a selective cytotoxic effect on cancer cells, while being non-toxic to healthy cells. Furthermore, Melissa officinalis demonstrated antiangiogenic potential, reducing the formation of thin capillaries without causing vascular toxicity at high concentrations.
A different research published by "Iranian Red Crescent medical journal", Melissa officinalis has been found to have gastroprotective effects against experimental gastric ulcers in rats. The study discovered that extracts of Melissa officinalis significantly reduced ulcer index readings and tissue oxidation in rats, while also enhancing enzymatic antioxidant defenses and inhibiting lipid peroxidation. This suggests that Melissa officinalis may be a useful natural remedy for preventing and treating gastric ulcers due to its potent antioxidant and anti-ulcer properties.
