Cinchona pubescens

Melanopsidium nigrum · Accepted scientific name

Scientific literature: Very Extensive (274 studies) · ★★★★★

Cinchona pubescens, scientifically known as Melanopsidium nigrum, is a remarkable medicinal shrub native to the Andean forests. Renowned for its alkaloid-rich bark, it serves as a primary source of quinine. This potent botanical is traditionally utilized to treat malaria and various febrile conditions, playing a vital role in pharmacology.

Family
Rubiaceae
Native range
Southern America
Parts used
Stem
Common names
Cinchona Pubescens · Quinine · 4 more
Scientific synonyms
Cinchona Pubescens · Gardenia Ferrea · 2 more

Names and Synonyms

Common Names

Scientific Names

Accepted name

Melanopsidium nigrum

Synonyms

Regional and Traditional Names

Spanish:

  • Cinchona pubescens
  • Cinchona cordifolia var. microcarpa
  • Cinchona cordifolia var peruviana
  • Cinchona cordifolia var. peruviana
  • Cinchona pallescens var ovata
  • Cinchona rugosa
  • Cinchona decurrentifolia
  • Cinchona rufinervis
  • Cinchona ovata
  • Cinchona rosulenta
  • Cinchona cordifolia var. macrocarpa
  • Flor nacional de ecuador
  • Cinchona pelalba
  • Cinchona platyphylla
  • Cinchona succirubra var. conglomerata
  • Cinchona tucujensis
  • Cinchona succirubra
  • Cascarilla
  • Cinchona
  • quino rojo

German:

  • Cinchona pubescens
  • Roter Chinarindenbaum

French:

  • Quinquina rouge
  • Cinchona pubescens
  • quinquina rouge

Sources: Wikidata, Catalogue of Life

Taxonomical Classification

This plant, Melanopsidium nigrum, is classified within the kingdom Plantae and belongs to the phylum Streptophyta. It falls under the class Equisetopsida and the subclass Magnoliidae, specifically within the order Gentianaales. Furthermore, it is a member of the Rubiaceae family and is categorized under the genus Cinchona.

Rank Classification
Kingdom Plantae
Phylum Streptophyta
Class Equisetopsida
Subclass Magnoliidae
Order Gentianales
Family Rubiaceae
Genus Cinchona

Sources: The World Checklist of Vascular Plants (WCVP)

Distribution

This plant is naturally found within specific regions of Brazil. Its geographical presence is primarily concentrated in the Northeast part of the country. Additionally, the species can be located throughout the Southeast region of Brazil. These two distinct areas represent its known native habitats. Therefore, its distribution is limited to these specific Brazilian territories.

Region Area
Brazil Brazil Northeast
Brazil Brazil Southeast

Sources: The World Checklist of Vascular Plants (WCVP)

Botanical Identification

Ecology

The ecology of Melanopsidium nigrum is characterized by its adaptation to specific Brazilian biomes, primarily occurring within the Cerrado (latu sensu) and Restinga ecosystems. This species exhibits a significant vertical distribution across varied landscapes, occupying a broad elevational range that spans from 600 m AMSL to a maximum of 3300 m AMSL. On average, the plant is found at an elevation of approximately 2100 m AMSL, reflecting its ability to thrive in diverse altitudinal gradients within its specialized habitats.

Elevational range max:
3300 m AMSL
Elevational range mean:
2100 m AMSL
Elevational range min:
600 m AMSL
Habitat :
Cerrado (lato sensu), Restinga

Life history

The life history of Melanopsidium nigrum is characterized by its classification as a perennial organism, ensuring its persistence across multiple growing seasons. Structurally, the plant exhibits a phanerophyte life form, specifically categorized under the nanophanerophyte designation, which indicates that its regenerative buds are located on aerial shoots above the ground level. As an evergreen species, it maintains its foliage throughout the year rather than undergoing a seasonal shedding period, contributing to its steady physiological presence in its habitat. This combination of a long-lived lifecycle and persistent aerial growth patterns defines its biological strategy and environmental endurance.

Deciduousness :
evergreen
Life form :
nanophanerophyte
Life form :
phanerophyte
Lifecycle :
perennial

Morphology

The morphology of Melanopsidium nigrum is characterized by its growth form as a woody tree that functions as a self-supporting structure rather than a climber or liana. As a terrestrial plant, it does not exhibit aquatic or semiaquatic tendencies, nor does it function as an epiphyte or a parasite, maintaining an independent biological existence. The plant's stature is significant, with a height that typically ranges from a minimum of 5 meters to a maximum of 12 meters, although some measurements indicate a mean height of 15 meters and a maximum potential of up to 12 meters depending on environmental conditions. Its structural integrity is defined by its woody nature, supporting its development as a robust, self-supporting tree within its natural habitat.

Aquatic :
terrestrial
Climber :
self-supporting
Epiphyte :
terrestrial
Growth form :
tree
Parasite :
independent
Plant height max:
5 m
Plant height max:
12 m
Plant height mean:
15 m
Woodiness :
woody

Physiology

The physiology of Melanopsidium nigrum is characterized by specific metabolic processes and nutrient acquisition strategies that dictate its growth and survival in its natural habitat. Central to its physiological profile is its relationship with soil nutrients, specifically regarding its ability to transform atmospheric gases into usable forms for plant development. Regarding its capacity for nitrogen assimilation through symbiotic relationships, the plant is not a nitrogen fixer, meaning it lacks the specialized root nodules or microbial associations required to convert atmospheric nitrogen into ammonia. Consequently, its physiological processes rely on the uptake of nitrates or ammonium directly from the soil medium to support protein synthesis and enzymatic functions. This dependency on available soil nitrogen influences its metabolic rate and overall biomass production, as its physiological efficiency is strictly tethered to the nutrient availability of its immediate environment.

Nitrogen fixer :
no

Reproduction

The reproduction of Melanopsidium nigrum is characterized by a primarily biotic pollination syndrome, relying on living organisms rather than abiotic factors to facilitate the transfer of pollen. Within this reproductive framework, the plant utilizes an insect-mediated strategy to ensure genetic exchange. Specifically, the pollination process is heavily dependent on bees, which act as the key biological vectors for moving pollen between flowers. This targeted interaction between the plant and its insect pollinators ensures a successful fertilization cycle through these specialized biotic mechanisms.

Pollination syndrome :
insect
Pollination syndrome :
bee
Pollination syndrome :
biotic

Sources: Global Inventory of Floras and Traits (GIFT)

Plant Parts

Melanopsidium nigrum has 1 reported plant parts identified across 1 scientific publications and several other databases that are studied for medicinal purposes. The most consistently reported plant part include stem.

Plant parts reported in Melanopsidium nigrum
Plant part Supporting sources Consensus
Stem 1 supporting sources ★☆☆☆☆

Stem

  1. Lloydia

Chemicals

Melanopsidium nigrum has 48 reported phytochemicals identified across 1 scientific publications and several other databases. The most consistently reported chemicals include Quinine, Quinovic acid, (-)-Epicatechin, 1-Hydroxy-2-hydroxymethylanthraquinone, 2-hydroxy-1,3,4-trimethoxy-anthraquinone.

Chemicals reported in Melanopsidium nigrum
Chemical Supporting sources Consensus
Quinine 2 supporting sources ★☆☆☆☆
Quinovic acid 2 supporting sources ★☆☆☆☆
(-)-Epicatechin 1 supporting sources ★☆☆☆☆
1-Hydroxy-2-hydroxymethylanthraquinone 1 supporting sources ★☆☆☆☆
2-hydroxy-1,3,4-trimethoxy-anthraquinone 1 supporting sources ★☆☆☆☆
3-EPIQUINAMINE 1 supporting sources ★☆☆☆☆
3-alpha,17-beta-Cinchophylline 1 supporting sources ★☆☆☆☆
3-beta,17-beta-Cinchophylline 1 supporting sources ★☆☆☆☆
Alizarin 1 supporting sources ★☆☆☆☆
Alizarin 1-methyl ether 1 supporting sources ★☆☆☆☆

Quinine

  1. Dr. Duke
  2. Journal of ethnopharmacology

Quinovic acid

  1. Dr. Duke
  2. Lloydia

(-)-Epicatechin

  1. Dr. Duke

1-Hydroxy-2-hydroxymethylanthraquinone

  1. Dr. Duke

2-hydroxy-1,3,4-trimethoxy-anthraquinone

  1. Dr. Duke

3-EPIQUINAMINE

  1. Dr. Duke

3-alpha,17-beta-Cinchophylline

  1. Dr. Duke

3-beta,17-beta-Cinchophylline

  1. Dr. Duke

Alizarin

  1. Dr. Duke

Alizarin 1-methyl ether

  1. Dr. Duke

Activities

Melanopsidium nigrum has 198 reported activities identified across 1 scientific publications and several other databases. The most consistently reported activities include Antimalarial, 5-Alpha-Reductase-Inhibitor, 5-Lipoxygenase-Inhibitor, ACE-Inhibitor, Abortifacient.

Activities reported in Melanopsidium nigrum
Activity Supporting sources Consensus
Antimalarial 2 supporting sources ★☆☆☆☆
5-Alpha-Reductase-Inhibitor 1 supporting sources ★☆☆☆☆
5-Lipoxygenase-Inhibitor 1 supporting sources ★☆☆☆☆
ACE-Inhibitor 1 supporting sources ★☆☆☆☆
Abortifacient 1 supporting sources ★☆☆☆☆
Aldose-Reductase-Inhibitor 1 supporting sources ★☆☆☆☆
Allelochemic 1 supporting sources ★☆☆☆☆
Allergenic 1 supporting sources ★☆☆☆☆
Alpha-Glucosidase-Inhibitor 1 supporting sources ★☆☆☆☆
Amebicide 1 supporting sources ★☆☆☆☆

Antimalarial

  1. Dr. Duke
  2. Journal of ethnopharmacology

5-Alpha-Reductase-Inhibitor

  1. Dr. Duke

5-Lipoxygenase-Inhibitor

  1. Dr. Duke

ACE-Inhibitor

  1. Dr. Duke

Abortifacient

  1. Dr. Duke

Aldose-Reductase-Inhibitor

  1. Dr. Duke

Allelochemic

  1. Dr. Duke

Allergenic

  1. Dr. Duke

Alpha-Glucosidase-Inhibitor

  1. Dr. Duke

Amebicide

  1. Dr. Duke

Preparations

Melanopsidium nigrum has 2 reported preparations identified across 1 scientific publications and several other databases. The most consistently reported preparations include stem bark, stem wood.

Preparations reported for Melanopsidium nigrum
Preparation Supporting sources Consensus
Stem bark 1 supporting sources ★☆☆☆☆
Stem wood 1 supporting sources ★☆☆☆☆

Stem bark

  1. Lloydia

Stem wood

  1. Lloydia