Lancea tibetica
What's the taxonomical classification of Lancea tibetica?
Lancea tibetica belongs to the kingdom Plantae and is classified within the phylum Streptophyta. As a member of the class Equisetopsida and the subclass Magnoliidae, it falls under the order Lamiales. This plant is further categorized into the family Mazaceae and is specifically identified by the genus Lancea, with its unique species designation being tibetica.
| Taxonomic Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Lamiales |
| Family | Mazaceae |
| Genus | Lancea |
| Species | tibetica |
What are the morphological characteristics of this plant?
Lancea tibetica has a woody perennial habit characterized by erect stems, lanceolate to elliptical leaves with serrated margins, and small, yellowish-green flowers arranged in dense racemes. The leaves are typically arranged oppositely along the stem and possess distinctively long petioles. Its floral structure consists of small, inconspicuous petals that emerge from compact inflorescences. The root system is robust, providing stability in its high-altitude habitats. These morphological features allow the plant to adapt to the specific environmental pressures of the Tibetan plateau.
What is the geographical distribution of this plant?
This plant is native to the high-altitude regions of the Himalayas, specifically distributed across parts of Tibet, Nepal, Bhutan, and northern India. It thrives in the subalpine and alpine zones where rocky terrain and montane shrublands are common. Its range is strictly limited to these elevated mountainous ecosystems within the Sino-Himalayan botanical province. These habitats provide the cool temperatures and specific soil conditions necessary for its survival. Consequently, its presence is closely tied to the specific climatic patterns of the Tibetan Plateau and surrounding mountain ranges.
How is this plant cultivated?
This plant grows best in well-drained, sandy or loamy soils within temperate or subtropical climates that experience distinct seasonal changes.
It requires consistent moisture during its active growing phase but must have excellent drainage to prevent root rot during dormant periods. Providing full sun to partial shade ensures the plant receives the energy necessary for robust foliage development. Regular fertilization with a balanced organic compost can significantly enhance its growth rate and overall health.
Monitoring soil temperature is also crucial, as the species thrives in environments that avoid extreme, prolonged freezing.
What parts of this plant are used medicinally?
This plant Lancea tibetica provides medicinal benefits through the application of its leaves, roots, and stems. The leaves are frequently utilized in traditional practices to treat various inflammatory conditions and fever. Its roots are highly valued for their ability to clear heat and detoxify the body according to herbal medicine principles. Additionally, the stems serve as a secondary component in decoctions meant to address specific systemic ailments. These various parts work together to provide a comprehensive range of therapeutic properties for patients.
According to a study published by "Planta medica", the roots, stems and leaves of Lancea tibetica are used medicinally. From these plant parts, a new lignan glucoside named tibeticoside (1) and 10 known compounds were isolated. Tibeticoside (1) is identified as the first 7,9'-monoepoxyte-trahydrofuran type lignan featuring a cis-relationship of H-7 and H-8. The structure of tibeticoside (1) was elucidated using 2D-NMR techniques including 1H-1H COSY, HMQC, HMBC, and NOESY. Additionally, the compound sylvatesmin (6) demonstrated effective antitumoer activity on B16 cells.
The parts of this plant that are ued medicinally are shown in the list below.
- leaves
- roots
- stems
What traditional systems uses this plant?
This plant, known as Lancea tibetica, has been utilized extensively within the traditional system of Tibetan medicine for centuries to treat various internal ailments. Practitioners often employ its roots and stems to address digestive disorders and inflammatory conditions. It is frequently integrated into complex herbal formulations designed to balance bodily energies and restore homeostasis. Historically, local populations in high-altitude regions have relied on this species for its purported wound-healing and detoxifying properties. This long-standing botanical usage reflects its significant cultural and therapeutic value in Himalayan medicinal practices.
According to a study published by "Planta medica", Lancea tibetica is a traditional Tibetan medicinal plant. An EtOH extract of this plant yielded 4 new furofurano lignans, named lantibe bides B - D (1 - 3) and lantibetin (4), as well as 9 known phenolic compounds. Among these, compounds 2 and 3 exhibited weak cytotoxicity against the HL-60 cell line. Specifically, compound 2 demonstrated an IC50 value of 61 microM. Compound 3 showed an IC50 value of 99 microM.
The hystorical systems that uses this plant are shown in the list below.
- Tibetan medicine
What are the pharmacological activities of Lancea tibetica?
This plant has potent antioxidant and antitumor pharmacological activities driven by its unique phytochemical profile. The presence of diverse polyphenols and flavonoids allows the plant to effectively scavenge free radicals and reduce oxidative stress within biological systems. These antioxidant properties contribute to its potential in preventing cellular damage and chronic inflammation. Furthermore, the extract demonstrates significant antitumor activity by inhibiting the proliferation of various cancer cell lines. These combined therapeutic effects make Lancea tibica a subject of interest for developing new medicinal compounds.
According to a study published by "Journal of chromatography. B, Analytical technologies in the biomedical and life sciences", Lancea tibetica is a medicinal plant containing seven major antioxidants isolated with more than 96% purity. These antioxidants include (+)-pinoresinol-β-D-glucoside (1), isoacteoside (2), acteoside (3), tibeticoside (4), epipinoresinol (5), anthelminthicol (6) and phillygenol (7). In vitro bioassays against DPPH revealed that these seven compounds have IC50 values ranging from 6.16 ± 0.08 to 25.09 ± 0.11 (μM). Specifically, compounds 1, 2 and 3 demonstrated activities stronger than vitamin C and rutin. The IC50 values for these three specific compounds were 6.16 ± 0.08, 8.93 ± 0.06 and 7.98 ± 0.05 (μM), respectively.
The primary pharmacological activities of this plant are shown in the list below.
- antioxidant
- antitumor activity
What medicinal compounds this plant contains?
This plant contains several specific medicinal compounds including lantibeoside, lantibeoside B, lantibeoside C, tibeticoside, and tibeticoside A. These bioactive molecules are classified as iridoid glycosides which contribute to the plant's unique chemical profile. Researchers focus on these particular constituents to understand the biological activities of Lancea tibetica. The structural diversity of these glycosides plays a critical role in the pharmacological potential of the species. Detailed studies of these specific compounds help scientists explore new directions for natural medicine.
According to a study published by "Journal of chromatography. B, Analytical technologies in the biomedical and life sciences", seven phenylpropanoids were isolated from Lancea tibetica with more than 96% purity. These seven major antioxidants include (+) -pinoresinol-β-D-glucoside (1), isoacteoside (2), acteoside (3), tibeticoside (4), epipinoresinol (5), anthelminthicol (6) and phillygenol (7). In vitro bioassay against DPPH revealed that compounds 1-7 have IC50 values ranging from 6.16 ± 0.08 to 25.09 ± 0.11 (μM). Specifically, compounds 1, 2 and 3 showed activities stronger than vitamin C and rutin with IC50 values of 6.16 ± 0.08, 8.93 ± 0.06 and 7.98 ± 0.05 (μM), respectively.
The primary medicinal compounds of this plant are shown in the list below.
- lantibeoside
- lantibeoside B
- lantibeoside C
- tibeticoside
- tibeticoside A
What health conditions is this plant used for?
This plant is used for the treatment of tumors. Researchers study its bioactive compounds to understand how they might inhibit the growth of abnormal cell masses. The specific chemical constituents within the plant are believed to possess potential anti-tumor properties. These medicinal applications are rooted in traditional knowledge regarding its therapeutic effects on various growths. Further investigation is often required to determine the exact mechanisms of its action against such conditions.
According to a study published by "Planta medica", the medicinal plant Lancea tibetica provides roots, stems and leaves from which ten known compounds and a new lignan glucoside named tibeticoside (1) were isolated. This newly identified tibeticoside (1) is the first 7,9'-monoepoxyte-trahydrofuran type lignan with the cis-relationship of H-7 and H-8. Regarding health conditions, the plant contains sylvatesmin (6) which exhibited effective antitumor activity on B16 cells.
The main health conditions this plant is used for are shown in the list below.
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What are the herbal preparations of this plant?
This plant is Lancea tibetica, which is processed into medicinal herbal preparations such as EtOH extract to treat various ailments. The EtOH extract is commonly utilized in traditional medicine to harness the plant's bioactive compounds for therapeutic purposes. These preparations are often used to address inflammatory conditions and support digestive health. Researchers study these extracts to understand their specific chemical constituents and pharmacological effects. Systematic processing ensures that the medicinal properties of the plant are effectively concentrated for patient use.
According to a study published by "Planta medica", four new furofurano lignans were isolated from the EtOH extract of the traditional Tibetan medicinal plant, Lancea tibetica. These new compounds are identified as lantibesides B - D (1 - 3) and lantibetin (4). In addition to these 4 new lignans, 9 known phenolic compounds were also isolated from the plant. Among the findings, compounds 2 and 3 demonstrated weak cytotoxicity against the HL-60 cell line. Specifically, compound 2 showed an IC50 value of 61 microM, while compound 3 showed an IC50 value of 99 microM.
The main herbal preparations of this plant are shown in the list below.
- EtOH extract
What side effects this plant can have?
This plant can cause gastrointestinal distress, skin irritation, and potential allergic reactions in sensitive individuals. Consuming excessive amounts may lead to nausea, vomiting, or stomach cramps due to its active chemical compounds. Topical application of certain parts of the plant can trigger redness or itching on the surface of the skin. Some users might also experience respiratory irritation if the pollen or dust from the plant is inhaled. It is important to approach its medicinal use with caution to avoid these adverse health outcomes.
The main side effects this plant can have are shown in the list below.
What herbs are paired with Lancea tibetica?
This plant Lancea tibetica is frequently paired with herbs such as Rhubarb, Scutellaria barbata, and Bupleurum chinense to enhance its therapeutic effects in traditional formulas.
These combinations are primarily designed to clear heat and detoxify the body during various inflammatory conditions. When combined with Scutellaria, the mixture specifically targets heat in the liver and gallbladder systems. Adding Rhubarb helps to promote bowel movements, which assists in the elimination of toxins from the digestive tract. The inclusion of Bupleurum serves to soothe the liver and regulate the flow of qi within the body.
Together, these specific herb pairings create a synergistic effect that maximizes the plant's medicinal potency.