10 Possible Side Effects Of Hydrastis Canadensis (Goldenseal)

Hydrastis canadensis has some side effects when used improperly, such as gastrointestinal upset, nausea, and diarrhea.

These side effects can occur due to the high berberine content, which can irritate the digestive system and cause inflammation.

For instance, individuals with stomach ulcers may experience worsened symptoms, leading to increased abdominal pain and discomfort, potentially affecting daily life and productivity.

This article explains in details the 10 most common side effects of Hydrastis canadensis if used imporperly.

1. Suppresses immune response

Hydrastis canadensis causes allergic reactions in some individuals due to the presence of berberine, a bioactive compound found in the plant.

Berberine has been shown to stimulate the immune system, which may trigger an allergic response in people who are sensitive to it.

Additionally, the saponins and alkaloids present in goldenseal can also contribute to allergic reactions, leading to symptoms such as hives, itching, and swelling.

2. Suppresses immune response

Hydrastis canadensis triggers bleeding disorders due to its high concentration of berberine, a natural alkaloid that inhibits platelet aggregation and prolongs bleeding time.

Berberine's ability to thin the blood may lead to excessive bleeding or bruising in some individuals, especially those taking anticoagulant medications or with pre-existing bleeding disorders.

This side effect is thought to occur as berberine interacts with the body's clotting mechanisms, potentially disrupting normal blood coagulation processes.

3. Suppresses immune response

Hydrastis canadensis increases blood pressure by stimulating the sympathetic nervous system and releasing adrenaline, a vasoconstrictor that causes blood vessels to constrict.

This increase in blood pressure may lead to hypertension, particularly in individuals with pre-existing cardiovascular conditions or those who are already taking medications for high blood pressure.

Additionally, the berberine content in goldenseal can also contribute to increased blood pressure by causing vasopressin release, leading to increased peripheral resistance and blood pressure elevation.

4. Suppresses immune response

Hydrastis canadensis reduces kidney function.

The berberine alkaloid present in Hydrastis canadensis may cause a decrease in glomerular filtration rate and reduce the excretion of creatinine in the urine, leading to potential kidney dysfunction.

Additionally, the herb's ability to inhibit cytochrome P450 enzymes may enhance the effects of other medications that affect kidney function, further exacerbating the issue.

5. Suppresses immune response

Hydrastis canadensis interacts with diabetes drugs by altering blood sugar levels.

The berberine content in goldenseal can lower glucose absorption and increase insulin sensitivity, which may lead to hypoglycemia in individuals taking diabetes medications.

This interaction can result in an unintended decrease in blood sugar levels, potentially causing symptoms such as shakiness, dizziness, or confusion.

6. Suppresses immune response

Hydrastis canadensis inhibits vitamin B absorption.

This is due to its berberine content, which has been shown to bind to and reduce the activity of intestinal enzymes involved in vitamin B metabolism. As a result, regular consumption of Hydrastis canadensis may lead to reduced levels of vitamins such as thiamin, riboflavin, and pyridoxine.

This may potentially cause symptoms including fatigue, weakness, and neurological problems if left unchecked.

7. Suppresses immune response

Hydrastis canadensis induces nausea and vomiting.

This side effect is thought to be caused by the plant's bitter compounds, such as berberine, which stimulate the gut and lead to stomach upset. Additionally, the plant's ability to slow down digestion and absorption of nutrients may contribute to nausea and vomiting in some individuals.

These symptoms are usually temporary and may subside once the body adjusts to the herb's effects.

8. Suppresses immune response

Hydrastis canadensis worsens asthma symptoms by releasing histamine and increasing mucus production in the lungs.

This can exacerbate bronchial constriction and wheezing, making it difficult for asthmatics to breathe. Additionally, the plant's alkaloids may trigger an allergic reaction, further irritating the airways and causing respiratory distress.

As a result, individuals with asthma should exercise caution when using Hydrastis canadensis supplements or products.

9. Suppresses immune response

10. Suppresses immune response

Hydrastis canadensis disrupts menstrual cycles due to its ability to stimulate uterine contractions and alter estrogen levels.

The berberine alkaloid present in the plant has been shown to have a direct effect on the uterus, leading to changes in menstrual patterns and potentially causing irregularities or cessation of menstruation.

Additionally, goldenseal's anti-inflammatory properties may also contribute to its effects on hormonal balance, further complicating menstrual cycles.