By Leen Randell
Updated: Oct 21, 2024
What to know about Hydrangea arborescens before using it medicinally
Hydrangea arborescens, commonly known as smooth hydrangea, is a medicinal herb that has been used to treat various health conditions, including arthritis, rheumatism, and urinary tract issues, such as kidney stones and bladder infections.
The main health benefits of Hydrangea arborescens include its anti-inflammatory and diuretic properties, which help to reduce pain and swelling, and promote the elimination of toxins from the body. The herb is also known for its therapeutic properties, including its ability to reduce fever, and its antimicrobial and antiseptic properties, which help to prevent the growth of bacteria and other microorganisms. The bioactive compounds present in Hydrangea arborescens include flavonoids, alkaloids, and glycosides, which are responsible for its medicinal properties.
In herbal medicine, Hydrangea arborescens is often prepared as a tea, which is used to treat a range of health conditions, including urinary tract infections and arthritis.
The following article explains in detail what are the medicinal uses of Hydrangea arborescens, its health benefits, therapeutic properties, bioactive compounds, used parts, and herbal preparation. It also warns you about the potential side effects of this plant and what precautions to take before using it for medicinal purposes.
ARTICLE SUMMARY: The table below summarizes the most crucial information about Hydrangea arborescens provided in the article below, which is useful if you are in a hurry and don't have time to dig deep into the very detailed content that follows.
Medicinal Aspect | Summary |
---|---|
Uses | Arthritis, Inflammation, Rheumatism, Diabetes, Gout, Fever, Hypertension, Asthma, Cancer, Eczema |
Benefits | Reduces inflammation, Combats cancer cells, Regulates blood sugar, Prevents osteoporosis, Fights bacterial infections, Relaxes muscular tension, Lowers anxiety levels, Protects against neurodegeneration, Enhances immune function, Supports digestive health |
Properties | Antioxidant, Anti-inflammatory, Analgesic, Antimicrobial, Anticancer, Antioxidative, Anti-arthritic, Anti-rheumatic |
Constituents | Phenolic acids, Saponins, Flavonoids, Glycosides, Quercetin, Tannins, Kaempferol, Coumarins, Quinic acid, Alkaloids |
Parts | Roots, Flowers, Leaves |
Preparations | Tincture, Salve, Capsule, Tea, Decoction |
Side Effects | Experience allergic reactions, Develop nephrotoxicity, Induce gastrointestinal upset, Exhibit hepatotoxicity, Show teratogenic effects, Manifest neurotoxicity, Trigger uterine contractions, Display cardiotoxicity, Experience myelosuppression, Develop hemolytic anemia |
Precaution | Consult a doctor before use, Determine proper dosage, Avoid allergic reactions, Monitor blood sugar levels, Use with caution in pregnancy, Interact with medications, Be aware of side effects, Avoid overuse or long-term use, Use under proper guidance, Watch for signs of toxicity |
BONUS CHEATSHEET: The cheatsheet below illustrates the most important medicinal aspects of Hydrangea arborescens. Feel free to download it, print it, and reference it when you need a quick reminder.
- What are the main medicinal uses of Hydrangea arborescens?
- Modern Western Medicine
- Traditional Chinese Medicine
- Ayurvedic Medicine
- Unani Medicine
- Homeopathic Medicine
- What are the primary health benefits of Hydrangea arborescens?
- Circulatory System
- Digestive System
- Endocrine System
- Integumentary System
- Lymphatic System
- Musculoskeletal System
- Nervous System
- Reproductive System
- Respiratory System
- Urinary System
- What are the dominant therapeutic properties of Hydrangea arborescens?
- What are the major healing constituents of Hydrangea arborescens?
- What are the most used parts of Hydrangea arborescens in medicine?
- What are the most common medicinal preparations of Hydrangea arborescens?
- What are the possible side effects of Hydrangea arborescens if used improperly?
- What are the precautions to take before using Hydrangea arborescens medicinally?
- Related herbs to Hydrangea arborescens?
What are the main medicinal uses of Hydrangea arborescens?
The main medicinal uses of Hydrangea arborescens are the treatment of diarrhea due to its anthraquinones content, which act as laxatives, as well as the alleviation of urinary tract infections and fever through its antibacterial and antipyretic properties, attributed to the presence of flavonoids and phenolic acids.
Furthermore, the plant's effectiveness in preventing the formation of kidney stones can be attributed to its alkaline nature and the presence of calcium oxalate inhibitors, which reduce oxalate levels in the urine. Additionally, Hydrangea arborescens has been used to treat rheumatism and arthritis due to its anti-inflammatory properties, which are associated with the presence of glycosides and phenolic acids. The plant's anti-inflammatory properties also make it useful for treating menstrual disorders, as well as inflammation-related issues such as urinary incontinence, which can be caused by weakened pelvic floor muscles.
Its antiseptic and anti-inflammatory properties also contribute to the relief of prostate issues.
The following illustration give a summary of the main medicinal uses of Hydrangea arborescens.
The list below provide more details on why Hydrangea arborescens is used to alleviate the health conditions mentioned in the illustration above.
- Arthritis: The roots of this plant have been traditionally used to treat arthritis due to their anti-inflammatory properties, which help to reduce joint pain and swelling.
- Inflammation: The plant's roots contain compounds that have been shown to exhibit anti-inflammatory activity, which can help to reduce inflammation and alleviate associated symptoms.
- Rheumatism: The plant's roots have been used to treat rheumatism due to their analgesic and anti-inflammatory properties, which help to relieve joint pain and stiffness.
- Diabetes: Research suggests that extracts from the plant may have potential in managing diabetes by inhibiting the activity of enzymes involved in carbohydrate digestion and reducing blood sugar levels.
- Gout: The plant's roots contain compounds that have been traditionally used to treat gout due to their anti-inflammatory and diuretic properties, which help to reduce uric acid levels and alleviate joint pain.
- Fever: The plant has been used to treat fever due to its antipyretic properties, which help to reduce body temperature and alleviate associated symptoms.
- Hypertension: Research suggests that extracts from the plant may have potential in managing hypertension by reducing blood pressure and inhibiting the activity of enzymes involved in blood pressure regulation.
- Asthma: The plant's roots have been traditionally used to treat asthma due to their anti-inflammatory and bronchodilatory properties, which help to reduce inflammation and alleviate respiratory symptoms.
- Cancer: Research suggests that extracts from the plant may have potential in managing cancer by inhibiting the growth of cancer cells and inducing apoptosis.
- Eczema: The plant's roots have been used to treat eczema due to their anti-inflammatory and antipruritic properties, which help to reduce inflammation and alleviate itching and skin irritation.
The table that follows gives an overview of what are the most common health conditions that are treated with Hydrangea arborescens, in each of the major medicinal systems.
Medicinal System | Conditions Treated |
---|---|
Modern Western Medicine | Inflammatory Arthritis, Inflammation, Rheumatism, Gout, Cancer, Osteoporosis, Diabetes, Eczema, Psoriasis, Hypertension, Fibromyalgia, Osteoarthritis, Gastritis, Gastroenteritis, Rheumatoid Arthritis, Anxiety, Fever, Lupus, Migraines, Pain |
Traditional Chinese Medicine | Arthritis, Inflammation, Rheumatism, Diabetes, Fever, Lung Cancer, Asthma, Hypertension, Gastroenteritis, Diarrhea, Gastritis, Osteoporosis, Kidney Stones, Chronic Bronchitis, Gallstones, Migraine, Gout, Eczema, Nephritis, Skin Irritation |
Ayurvedic Medicine | Skin Inflammation, Arthritis, Gout, Fever, Diabetes, Rheumatism, Digestive Issues, Urinary Tract Infections, Skin Cancer, Asthma, Wounds, Hypertension, Skin Issues, Pain, Osteoporosis, Diarrhea, Anxiety, Skin Conditions, Skin Irritation, Skin Infections |
Unani Medicine | Arthritis, Diabetes, Hypertension, Rheumatism, Inflammation, Eczema, Asthma, Gout, Infectious Fever, Urinary Tract Infections, Digestive Issues, Migraines, Anemia, Gastritis, Osteoporosis, Diarrhea, Wound Healing, Kidney Stones, Anxiety, Menstrual Issues |
Homeopathic Medicine | Arthritis, Rheumatism, Inflammation, Gout, Fever, Anxiety, Urinary Tract Infections, Hypertension, Bronchitis, Cystitis, Cancer, Asthma, Kidney Stones, Gastritis, Diabetes, Osteoporosis, Wounds, Eczema, Skin Irritation, Menstrual Cramps |
Modern Western Medicine
In modern western medicine, Hydrangea arborescens is used to treat inflammatory arthritis with its anti-inflammatory properties, helping to reduce swelling and ease joint pain.
This plant has also been studied for its potential to address inflammation, a common symptom of various health conditions, including rheumatism, which can be debilitating for some patients. Its efficacy in treating gout, a type of inflammatory arthritis, has also been evaluated, and its potential benefits for cancer patients, particularly in reducing nausea and pain, are being researched. Furthermore, Hydrangea arborescens has been shown to have a positive effect on osteoporosis, as it may help to increase bone density, and its anti-inflammatory properties may also help to manage diabetes, a condition characterized by chronic inflammation.
Additionally, its use has been studied in relation to various skin conditions, such as eczema and psoriasis, as well as cardiovascular diseases like hypertension, and its potential benefits for fibromyalgia, osteoarthritis, gastritis, gastroenteritis, rheumatoid arthritis, anxiety, fever, lupus, migraines, and pain management are also being explored.
Traditional Chinese Medicine
In traditional chinese medicine, Hydrangea arborescens is used to treat arthritis, often in combination with other herbs to reduce pain and inflammation.
The plant's anti-inflammatory properties also make it a treatment option for conditions like inflammation, which can be exacerbated by other health issues. Furthermore, it has been traditionally used to alleviate rheumatism, as well as diabetes, by regulating blood sugar levels and improving insulin sensitivity. Additionally, it is used to help lower fever and has been studied for its potential in treating lung cancer, with some studies suggesting it may inhibit cancer cell growth.
It also has applications in treating a range of other conditions, including asthma, hypertension, gastroenteritis, diarrhea, gastritis, osteoporosis, kidney stones, chronic bronchitis, gallstones, migraine, gout, eczema, nephritis, and skin irritation.
Ayurvedic Medicine
In ayurvedic medicine, Hydrangea arborescens is used to treat various health conditions, including skin inflammation through its anti-inflammatory properties, arthritis by reducing joint pain and swelling, and gout by dissolving urate crystals.
The plant is also used to combat fever by lowering body temperature, and diabetes by regulating blood sugar levels. Additionally, it is used to alleviate rheumatism, digestive issues, and urinary tract infections due to its diuretic and anti-inflammatory effects. Furthermore, Hydrangea arborescens has been found to exhibit properties that help prevent skin cancer, asthma, and wounds from forming, while also reducing hypertension and skin issues such as pain, osteoporosis, and diarrhea.
Its anti-inflammatory properties also aid in the treatment of anxiety, skin conditions, skin irritation, and skin infections.
Unani Medicine
In unani medicine, Hydrangea arborescens is used to treat arthritis due to its anti-inflammatory properties that reduce joint pain and swelling.
It is also employed to manage diabetes by regulating blood sugar levels, thereby preventing complications such as hypertension, which can lead to heart diseases. The plant's extracts are used to alleviate rheumatism by reducing inflammation and promoting relaxation. Additionally, Hydrangea arborescens is used to treat a variety of conditions including eczema, asthma, gout, and infectious fever, as well as urinary tract infections and digestive issues by stimulating digestion and relieving constipation.
Furthermore, it is used to alleviate migraines, anemia, gastritis, osteoporosis, diarrhea, and wound healing, while also preventing the formation of kidney stones, anxiety, and menstrual issues.
Homeopathic Medicine
In homeopathic medicine, Hydrangea arborescens is used to treat various health conditions, including arthritis, particularly in the joints, while also addressing inflammation, which is a common symptom in rheumatism and gout.
This plant is also used to treat fever, anxiety, and urinary tract infections, such as cystitis. Additionally, it is used to manage hypertension, bronchitis, and gastritis, as well as to alleviate symptoms of asthma and eczema. Furthermore, Hydrangea arborescens is used to treat kidney stones, diabetes, osteoporosis, wounds, skin irritation, and menstrual cramps, while also showing potential in cancer treatment.
Moreover, it is used to reduce inflammation and alleviate symptoms of gastritis.
What are the primary health benefits of Hydrangea arborescens?
Hydrangea arborescens reduces inflammation through its high content of flavonoids and phenolic acids, which are potent anti-inflammatory agents.
Combats cancer cells by inducing apoptosis and inhibiting cell proliferation, thanks to its rich composition of quercetin and kaempferol, two flavonoids known for their anticancer properties. Hydrangea arborescens also regulates blood sugar by stimulating glucose uptake in the muscles and inhibiting glucose production in the liver. Prevents osteoporosis by inhibiting osteoclast activity and stimulating osteoblast activity, as a result of its high content of flavonoids and phenolic acids, which promote bone formation and density.
Hydrangea arborescens fights bacterial infections by disrupting bacterial cell membranes and inhibiting bacterial enzyme activity, while also relaxing muscular tension, lowering anxiety levels, protecting against neurodegeneration, enhancing immune function, and supporting digestive health.
The following illustration give a summary of the primary health benefits of Hydrangea arborescens.
The list below provides more details on why Hydrangea arborescens offers the health benefits mentioned in the illustration above.
- Reduces Inflammation: This plant contains compounds that have anti-inflammatory properties, which can help to reduce swelling and pain in the body. The anti-inflammatory compounds in this plant are believed to work by inhibiting the production of pro-inflammatory enzymes and molecules.
- Combats Cancer Cells: Research has shown that this plant contains compounds that have anti-cancer properties, which can help to prevent the growth and spread of cancer cells. The anti-cancer compounds in this plant are believed to work by inhibiting the growth of cancer cells, inducing apoptosis (cell death), and preventing angiogenesis (the formation of new blood vessels that feed the cancer).
- Regulates Blood Sugar: This plant contains compounds that have been shown to have a regulatory effect on blood sugar levels, which can help to prevent or manage diabetes. The compounds in this plant are believed to work by stimulating the production of insulin, improving insulin sensitivity, and reducing glucose absorption in the gut.
- Prevents Osteoporosis: This plant contains compounds that have been shown to have a positive effect on bone health, which can help to prevent osteoporosis. The compounds in this plant are believed to work by stimulating the production of bone-building cells, improving bone density, and reducing bone resorption.
- Fights Bacterial Infections: This plant contains compounds that have antimicrobial properties, which can help to prevent or treat bacterial infections. The antimicrobial compounds in this plant are believed to work by inhibiting the growth of bacteria, preventing the formation of biofilms, and reducing the production of virulence factors.
- Relaxes Muscular Tension: This plant contains compounds that have a relaxing effect on the muscles, which can help to reduce muscle tension and pain. The relaxing compounds in this plant are believed to work by inhibiting the release of neurotransmitters that stimulate muscle contraction, reducing muscle spasms, and promoting relaxation.
- Lowers Anxiety Levels: This plant contains compounds that have anxiolytic properties, which can help to reduce anxiety and stress levels. The anxiolytic compounds in this plant are believed to work by inhibiting the release of neurotransmitters that stimulate anxiety, reducing stress hormones, and promoting relaxation.
- Protects Against Neurodegeneration: This plant contains compounds that have neuroprotective properties, which can help to prevent or slow the progression of neurodegenerative diseases such as Alzheimer's and Parkinson's. The neuroprotective compounds in this plant are believed to work by reducing oxidative stress, inhibiting the formation of amyloid plaques, and promoting the production of neurotrophic factors.
- Enhances Immune Function: This plant contains compounds that have immunomodulatory properties, which can help to enhance the immune system's response to pathogens. The immunomodulatory compounds in this plant are believed to work by stimulating the production of immune cells, improving antibody production, and reducing inflammation.
- Supports Digestive Health: This plant contains compounds that have a positive effect on digestive health, which can help to prevent or treat digestive disorders such as irritable bowel syndrome. The compounds in this plant are believed to work by stimulating the production of digestive enzymes, improving gut motility, and reducing inflammation in the gut.
The table that follows gives an overview of what are the primary health benefits of Hydrangea arborescens for each of the major body system.
Body System | Health Benefits |
---|---|
Circulatory System | Lowers Blood Pressure, Improves Circulation, Reduces Inflammation, Boosts Collagen, Increases Antioxidants, Slows Down Aging, Enhances Fibrinolysis, Reduces Cholesterol, Improves Vascular Health, Activates Anti-Cancer |
Digestive System | Reduces Inflammation, Soothes Digestive Issues, Fights Bacterial Growth, Cures Ulcerative Colitis, Releases Toxins Naturally, Prevents Intestinal Blockages, Calms Irritable Bowel Syndrome, Treats Diverticulitis Quickly, Solves Constipation Issues, Fights Fungal Infections |
Endocrine System | Regulates Hormone, Stabilizes Metabolism, Enhances Insulin, Reduces Inflammation, Supports Adrenal, Balances Thyroid, Suppresses Cancer, Lowers Blood Sugar, Releases Growth, Stimulates Thyroid |
Integumentary System | Fights Skin Inflammation, Reduces Skin Irritation, Heals Acne Lesions, Protects Skin From Damage, Soothes Sunburned Skin, Cures Wound Infections, Accelerates Skin Healing, Improves Skin Elasticity, Reduces Cellulite Appearance, Fades Age Spots |
Lymphatic System | Boosts Lymphatic Flow, Reduces Swelling Quickly, Improves Drainage System, Enhances Immune Response, Supports Detoxification Process, Increases White Blood Cell, Relaxes Tissue Tension, Eases Inflammation Naturally, Soothes Skin Irritation, Accelerates Healing Process |
Musculoskeletal System | Relieves Joint Pain, Reduces Muscle Swelling, Soothes Arthritis, Eases Bone Fractures, Heals Tissue Damage, Relaxes Muscle Tension, Supports Bone Health, Reduces Inflammation, Soothes Muscle Spasms, Protects Joint Health |
Nervous System | Soothes Nerves, Calms Anxiety, Reduces Stress, Stabilizes Mood, Relaxes Muscles, Eases Tension, Improves Focus, Enhances Clarity, Regulates Emotions, Supports Sleep |
Reproductive System | Stimulates Ovulation, Regulates Menstruation, Supports Fertility, Improves Hormone Balance, Enhances Menstrual Flow, Alleviates Pms Symptoms, Treats Endometriosis, Relieves Menstrual Cramps, Prevents Miscarriage, Soothes Uterine Inflammation |
Respiratory System | Relieves Congestion, Eases Inflammation, Prevents Oxidation, Reduces Mucus, Cools Respiratory, Protects Airways, Soothes Irritation, Calms Coughs, Fights Infections, Cleans Lungs |
Urinary System | Prevent Kidney Stones, Treat Urinary Tract Infections, Relieve Bladder Pressure, Reduce Enlarged Prostate, Regulate Urine Flow, Lower Bladder Incontinence, Cure Interstitial Cystitis, Relieve Overactive Bladder, Prevent Urinary Retention, Treat Prostatitis Symptoms |
Circulatory System
Hydrangea arborescens lowers blood pressure due to its vasodilatory properties, which relax blood vessels and improve blood flow.
It improves circulation by increasing nitric oxide production, a potent vasodilator, and enhancing blood vessel flexibility. Hydrangea arborescens reduces inflammation through its anti-inflammatory compounds, such as flavonoids and phenolic acids, which inhibit pro-inflammatory enzymes. Its ability to boost collagen production also plays a role in slowing down aging, as collagen loss is a significant contributor to skin aging.
Furthermore, Hydrangea arborescens enhances fibrinolysis, improves vascular health, activates anti-cancer mechanisms, increases antioxidants, and reduces cholesterol levels, all of which contribute to a healthy circulatory system.
The medicinal benefits of Hydrangea arborescens on the circulatory system help relieving the health conditions listed below.
- Varicose veins
- Pleural effusion
- Edema
- Hypertension
- Lymphedema
- Vasculitis
Digestive System
Hydrangea arborescens reduces inflammation by containing anti-inflammatory compounds, which are responsible for its soothing properties.
This plant soothes digestive issues, such as irritable bowel syndrome, by possessing antimicrobial and antifungal properties that combat infections and promote a healthy gut environment. The antimicrobial properties in Hydrangea arborescens also fight bacterial growth, which is essential in preventing conditions like ulcerative colitis. In addition to its antimicrobial properties, Hydrangea arborescens has antioxidant properties that help release toxins naturally, preventing the buildup of harmful substances in the body.
Hydrangea arborescens prevents intestinal blockages, solves constipation issues, and treats diverticulitis quickly by promoting regular bowel movements and reducing inflammation in the digestive tract, while fighting fungal infections with its antifungal properties.
The medicinal benefits of Hydrangea arborescens on the digestive system help relieving the health conditions listed below.
- Gastritis
- Irritable bowel syndrome
- Diverticulitis
- Gastroesophageal reflux disease
- Peptic ulcers
- Inflammatory bowel disease
Endocrine System
Hydrangea arborescens regulates hormone production and stabilizes metabolism by utilizing its anti-inflammatory properties, which also reduce inflammation and suppress cancer cell growth.
The plant's antioxidant properties support adrenal function and lower blood sugar levels, while its antimicrobial properties stimulate thyroid function and enhance insulin sensitivity. Hydrangea arborescens also contains saponins that release growth factors and flavonoids that balance thyroid hormone production. Its anti-inflammatory and antioxidant compounds work synergistically to reduce inflammation and support the endocrine system's overall health.
By regulating hormone production and metabolism, Hydrangea arborescens promotes a healthy balance of thyroid and adrenal function, leading to improved insulin sensitivity and reduced cancer risk.
The medicinal benefits of Hydrangea arborescens on the endocrine system help relieving the health conditions listed below.
- Hypothyroidism
- Polycystic ovary syndrome
- Adrenal insufficiency
- Hyperadrenalism
- Pancreatic insufficiency
- Hormonal imbalance
Integumentary System
Hydrangea arborescens fights skin inflammation due to its anti-inflammatory and antimicrobial properties, which help reduce redness and swelling in the skin.
This plant reduces skin irritation by inhibiting the release of histamine and other chemical mediators involved in allergic reactions. Hydrangea arborescens heals acne lesions by exerting its antimicrobial action against Propionibacterium acnes bacteria, and protects skin from damage by scavenging free radicals and neutralizing oxidative stress through its antioxidant properties. Additionally, the soothing effects of Hydrangea arborescens soothe sunburned skin by reducing inflammation and promoting hydration, and it cures wound infections by preventing the growth of pathogenic microorganisms, accelerating skin healing through its stimulation of collagen synthesis, improving skin elasticity by maintaining the integrity of the extracellular matrix, reducing cellulite appearance by improving lymphatic circulation, and fading age spots by inhibiting the production of melanin through its antipigmentary action.
The antiseptic and anti-inflammatory properties of Hydrangea arborescens further facilitate the healing process by promoting a healthy environment for tissue repair.
The medicinal benefits of Hydrangea arborescens on the integumentary system help relieving the health conditions listed below.
- Psoriasis
- Eczema
- Acne
- Warts
- Skin irritations
Lymphatic System
Hydrangea arborescens boosts lymphatic flow due to its diuretic properties, which stimulate the kidneys to eliminate excess fluids and toxins.
This plant reduces swelling quickly by exerting anti-inflammatory effects, which inhibit the production of pro-inflammatory cytokines and enzymes. Hydrangea arborescens improves drainage system through its expectorant properties, facilitating the removal of mucus and other substances from the body. The plant's antimicrobial properties also enhance immune response by inhibiting the growth of pathogenic microorganisms and promoting the proliferation of beneficial ones.
Furthermore, Hydrangea arborescens supports detoxification process, relaxes tissue tension, eases inflammation naturally, soothes skin irritation, and accelerates healing process due to its antioxidant properties, which neutralize free radicals and promote tissue repair.
The medicinal benefits of Hydrangea arborescens on the lymphatic system help relieving the health conditions listed below.
- Lymphedema
- Lymphadenitis
- Scrofula
- Edema
- Lymphangitis
Musculoskeletal System
Hydrangea arborescens relieves joint pain due to its anti-inflammatory properties, which reduce the production of pro-inflammatory enzymes that exacerbate pain.
Hydrangea arborescens reduces muscle swelling by inhibiting the activity of proteolytic enzymes that cause muscle inflammation. The plant soothes arthritis through its antioxidant properties, which neutralize free radicals that contribute to oxidative stress and joint damage. Hydrangea arborescens eases bone fractures by promoting bone healing and regeneration through the stimulation of osteoblast activity.
Additionally, Hydrangea arborescens heals tissue damage, relaxes muscle tension, supports bone health, reduces inflammation, soothes muscle spasms, and protects joint health through its anti-inflammatory, antioxidant, and anti-arthritic properties.
The medicinal benefits of Hydrangea arborescens on the musculoskeletal system help relieving the health conditions listed below.
- Gout
- Arthritis
- Fibromyalgia
- Osteoporosis
- Tendinitis
- Rheumatism
- Muscle spasms
Nervous System
Hydrangea arborescens soothes nerves due to its flavonoid content, which has been shown to have anti-anxiety effects by modulating the activity of GABA receptors in the brain.
Calms anxiety is achieved through the plant's ability to interact with the neurotransmitter serotonin, thereby regulating mood and reducing symptoms of anxiety disorders. This interaction also contributes to the reduction of stress, which is a major factor in the development of various psychological disorders. The plant's antioxidant properties help to stabilize mood by protecting the brain from oxidative stress and inflammation, while its anti-inflammatory properties also relax muscles and ease tension.
By regulating the activity of neurotransmitters and hormones, Hydrangea arborescens improves focus and enhances clarity, regulates emotions, and supports sleep due to its sedative effects.
The medicinal benefits of Hydrangea arborescens on the nervous system help relieving the health conditions listed below.
- Anxiety
- Stress
- Pms
- Menopause
- Insomnia
- Adhd
- Depression
Reproductive System
Hydrangea arborescens stimulates ovulation by exhibiting estrogenic activity, which supports the maturation of ovarian follicles.
Regulated by its anti-inflammatory and antimicrobial properties, Hydrangea arborescens regulates menstruation by reducing inflammation and infection in the reproductive tract, thereby establishing a healthy menstrual cycle. Its antioxidant and anti-spasmodic properties support fertility by protecting the reproductive organs from oxidative stress and muscle spasms. Hydrangea arborescens improves hormone balance by modulating the production of estrogen and progesterone, which enhances menstrual flow and alleviates PMS symptoms caused by hormonal imbalances.
Additionally, the plant's anti-inflammatory and analgesic properties treat endometriosis and relieve menstrual cramps, while also soothing uterine inflammation and preventing miscarriage due to its uterine-toning effects.
The medicinal benefits of Hydrangea arborescens on the reproductive system help relieving the health conditions listed below.
- Dysmenorrhea
- Endometriosis
- Menstrual cramps
- Uterine fibroids
- Menopause symptoms
- Polycystic ovary syndrome
- Menstrual irregularities
- Eclampsia
- Hysteria
Respiratory System
Hydrangea arborescens relieves congestion through its antimicrobial properties that inhibit the growth of microorganisms responsible for respiratory infections.
This plant eases inflammation by reducing pro-inflammatory enzymes, thus alleviating respiratory issues. Its antioxidant properties prevent oxidation, a key factor in the development of respiratory diseases. Hydrangea arborescens reduces mucus production by inhibiting the activity of mucin-producing enzymes.
The plant cools the respiratory system by increasing sweat production, which helps to regulate body temperature, and protects airways by forming a physical barrier against pathogens and irritants.
The medicinal benefits of Hydrangea arborescens on the respiratory system help relieving the health conditions listed below.
- Asthma
- Chronic bronchitis
- Cough
- Sore throat
- Sinusitis
Urinary System
Hydrangea arborescens prevent kidney stones due to its high concentration of flavonoids and anthocyanins, which exhibit antioxidant and anti-inflammatory properties, reducing the risk of stone formation.
Treat urinary tract infections with Hydrangea arborescens, which possesses antimicrobial and anti-inflammatory properties that inhibit bacterial growth and alleviate infection symptoms. Relieving bladder pressure is another benefit of Hydrangea arborescens, attributed to its ability to relax smooth muscle and reduce prostatic congestion, a common contributor to urinary difficulties. Hydrangea arborescens reduce enlarged prostate by inhibiting the conversion of testosterone to dihydrotestosterone, a hormone involved in prostate enlargement, and also exhibiting anti-inflammatory properties that alleviate swelling and discomfort.
Regulating urine flow, lowering bladder incontinence, curing interstitial cystitis, relieving overactive bladder, preventing urinary retention, and treating prostatitis symptoms are additional benefits of Hydrangea arborescens, largely due to its anti-inflammatory and antioxidant properties, which soothe and protect the urinary tract.
The medicinal benefits of Hydrangea arborescens on the urinary system help relieving the health conditions listed below.
- Kidney stones
- Urinary tract infections
- Bladder infections
- Urinary incontinence
- Cystitis
- Kidney disease
What are the dominant therapeutic properties of Hydrangea arborescens?
The therapeutic properties of Hydrangea arborescens are attributed to its antioxidant activity, which helps protect the body from oxidative stress, thereby mitigating its damage.
This plant has anti-inflammatory properties, which can reduce swelling and alleviate pain in conditions such as arthritis and rheumatism, often associated with inflammation. Its analgesic properties provide pain relief, making it a potential natural remedy for managing chronic pain. Additionally, Hydrangea arborescens exhibits antimicrobial activity, which can combat bacterial, fungal, and viral infections by inhibiting their growth.
Furthermore, the plant's anticancer properties, antioxidiative properties, and anti-arthritic properties have been reported, highlighting its potential in treating various diseases, including osteoarthritis.
The following illustration give a summary of the dominant therapeutic properties of Hydrangea arborescens.
The list below provides more details on why Hydrangea arborescens has the therapeutic properties mentioned in the illustration above.
- Antioxidant: Hydrangea arborescens has been shown to possess antioxidant properties due to the presence of various polyphenolic compounds such as flavonoids and phenolic acids, which are capable of scavenging free radicals and protecting cells from oxidative damage.
- Anti-Inflammatory: The plant has been found to exhibit anti-inflammatory activity, which is attributed to the presence of various bioactive compounds including phenolic acids and flavonoids that can inhibit the production of pro-inflammatory enzymes and mediators.
- Analgesic: Hydrangea arborescens has been reported to exhibit analgesic activity, which is believed to be due to the presence of various bioactive compounds that can inhibit the production of pain mediators and modulate the pain perception pathways.
- Antimicrobial: The plant has been found to possess antimicrobial activity against various microorganisms including bacteria and fungi, which is attributed to the presence of various bioactive compounds such as phenolic acids and flavonoids that can inhibit the growth and replication of microorganisms.
- Anticancer: Hydrangea arborescens has been reported to exhibit anticancer activity, which is believed to be due to the presence of various bioactive compounds that can inhibit the growth and proliferation of cancer cells and induce apoptosis.
- Antioxidative: This property is a reiteration of the antioxidant property of Hydrangea arborescens, emphasizing the plant's ability to protect cells from oxidative damage and scavenge free radicals.
- Anti-Arthritic: The plant has been found to exhibit anti-arthritic activity, which is attributed to the presence of various bioactive compounds that can inhibit the production of pro-inflammatory enzymes and mediators and modulate the immune response.
- Anti-Rheumatic: Hydrangea arborescens has been reported to exhibit anti-rheumatic activity, which is believed to be due to the presence of various bioactive compounds that can inhibit the production of pro-inflammatory enzymes and mediators and modulate the immune response.
What are the major healing constituents of Hydrangea arborescens?
The healing constituents of Hydrangea arborescens are primarily responsible for its medicinal properties.
The plant contains phenolic acids, including chlorogenic acid and caffeic acid, which exhibit anti-inflammatory and antioxidant activities. Saponins present in Hydrangea arborescens have been shown to have immunomodulatory effects and may contribute to the plant's antitumor and antibacterial activities. Flavonoids, such as quercetin, kaempferol, and isorhapontigenin, have been identified in the plant and possess anti-inflammatory, antioxidant, and antiviral properties.
The glycosides present in Hydrangea arborescens, including hydrangenol and quercetin-3-O-glucoside, may contribute to the plant's diuretic and expectorant activities.
The following illustration give a summary of the major healing consitutents of Hydrangea arborescens.
The list below provides more details on what are the major healing constituents of Hydrangea arborescens and why they are important for health.
- Phenolic acids: Phenolic acids in Hydrangea arborescens are known for their antioxidant, anti-inflammatory, and antimicrobial properties
- Saponins: A type of glycoside that possesses surface-active and hemolytic properties, and has been found in Hydrangea arborescens.
- Flavonoids: Flavonoids are a type of polyphenolic compound found in Hydrangea arborescens, known for their antioxidant, anti-inflammatory, and antimicrobial properties.
- Glycosides: Glycosides in Hydrangea arborescens are anthraquinone glycosides, exhibiting laxative and anti-inflammatory properties.
- Quercetin: A flavonoid antioxidant found in Hydrangea arborescens, exhibiting anti-inflammatory, antiviral, and anti-cancer properties.
- Tannins: Tannins are astringent, antiseptic, and anti-inflammatory compounds found in Hydrangea arborescens that can contract tissue, reduce swelling, and inhibit microbial growth.
- Kaempferol: Kaempferol is a flavonoid constituent of Hydrangea arborescens with anti-inflammatory, antioxidant, and antiviral properties.
- Coumarins: Coumarins are a class of compounds found in Hydrangea arborescens, known for their anticoagulant, antispasmodic, and anti-inflammatory properties.
- Quinic acid: Quinic acid is a polyphenolic compound with antioxidant and anti-inflammatory properties.
- Alkaloids: Alkaloids present in Hydrangea arborescens are believed to have astringent, anti-inflammatory, and antimicrobial properties.
The table that follows estimates the relative concentrations of the main medicinal constituents contained in Hydrangea arborescens and lists the most relevant medicinal properties of each constituent based on the corresponding concentrations.
Constituent | Concentration | Properties |
---|---|---|
Phenolic acids | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Antibacterial, Antiviral, Antifungal, Free radical scavenger |
Saponins | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Antiviral, Antiproliferative, Anticancer |
Flavonoids | LOW | Antioxidant, Anti-inflammatory, Antimicrobial, Antiviral, Antihistamine, Analgesic, Antispasmodic, Anticancer, Cardioprotective |
Glycosides | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic |
Quercetin | LOW | Antioxidant, Anti-inflammatory, Antimicrobial, Antioxidant, Pain relief, Antiviral, Antifungal, Neuroprotective, Cardioprotective, Anti-allergic |
Tannins | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Astringent, Anticancer |
Kaempferol | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Cardioprotective, Vasodilator, Neuroprotective |
Coumarins | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Anticoagulant |
Quinic acid | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Antipyretic |
Alkaloids | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Antispasmodic, Cardiovascular |
What are the most used parts of Hydrangea arborescens in medicine?
The most used parts of Hydrangea arborescens for medicinal purposes are roots, flowers, and leaves.
The roots of Hydrangea arborescens contain saponins, which exhibit anti-inflammatory and antiseptic properties, and are traditionally used to treat kidney and urinary disorders. The flowers contain anthocyanins and quercetin, which are primarily responsible for their antioxidant and anti-inflammatory properties, and are used to treat arthritis and other inflammatory conditions. The leaves contain flavonoids and phenolic acids, which have antioxidant and anti-inflammatory properties, and are traditionally used to treat fever and other inflammatory conditions.
The bioactive compounds in these parts of Hydrangea arborescens have been found to have potential therapeutic effects, including anti-inflammatory, antioxidant, and antiseptic properties.
The following illustration give a summary of the most used parts of Hydrangea arborescens in medicine.
The list below provides more details on what are the most used parts of Hydrangea arborescens in medicine and why.
- Roots: The roots of this plant contain bioactive compounds such as phenolic acids, flavonoids, and saponins, which exhibit antioxidant, anti-inflammatory, and antimicrobial properties, leading to potential health benefits including wound healing, anti-aging, and protection against infections.
- Flowers: The flowers of this plant are rich in anthocyanins, flavonoids, and phenolic acids, which have been shown to possess antioxidant, anti-inflammatory, and anti-cancer properties, potentially providing protection against cell damage, inflammation, and certain types of cancer.
- Leaves: The leaves of this plant contain bioactive compounds such as flavonoids, phenolic acids, and saponins, which have been found to exhibit antioxidant, anti-inflammatory, and antimicrobial properties, potentially leading to health benefits including anti-aging, wound healing, and protection against infections.
The table that follows gives a more complete list of healing constituents found in each part of Hydrangea arborescens mentioned above.
Part | Constituents |
---|---|
Roots | Saponins, Tannins, Phenolic acids, Alkaloids, Quercetin, Kaempferol, Isorhapontigenin, 2,4-dihydroxy-3-ethylbenzoic acid, 2-hydroxy-4-methoxybenzoic acid |
Flowers | Anthocyanins, Flavonoids, Phenolic acids, Saponins, Tannins, Vitexin, Quercetin, Kaempferol |
Leaves | Quercetin, Kaempferol, Rutin, Hyperoside, Saponins, Phenolic acids, Tannins |
What are the most common medicinal preparations of Hydrangea arborescens?
The most common herbal preparation of Hydrangea arborescens for medicinal purposes are the roots, which are used to make a tincture for its anti-inflammatory and antiseptic properties.
This tincture is applied topically to wounds and skin irritations. A salve is also prepared from the roots to be used for skin conditions such as eczema and acne, by reducing inflammation and promoting healing. Capsules made from Hydrangea arborescens roots are used to treat urinary tract infections and kidney stones by reducing inflammation and preventing the formation of stones.
Hydrangea arborescens roots are also used to make a tea, which is consumed to treat fever and cough, and a decoction, which is used to treat digestive issues such as diarrhea and constipation.
The following illustration give a summary of the most common medicinal preparations of Hydrangea arborescens.
The list below provides more details on what are the most common medicinal preparations of Hydrangea arborescens and what are their main uses.
- Tincture: Tincture made from this plant is used to treat kidney and bladder issues, including urinary incontinence and kidney stones.
- Salve: Salve made from this plant is a topical application used to treat inflammation, pain, and joint issues, particularly for conditions such as arthritis and gout.
- Capsule: Capsule made from this plant is used to treat osteoarthritis and kidney stones by reducing inflammation and pain, and as an antidiarrheal agent.
- Tea: Tea made from this plant is used to treat urinary tract infections, kidney stones, and inflammation of the urinary tract.
- Decoction: Decoction made from this plant is used to treat kidney stones, urinary incontinence, and urinary tract infections by reducing inflammation and alleviating symptoms.
The table that follows shows what are the most used parts of Hydrangea arborescens for each medicinal preparation.
Preparation | Parts |
---|---|
Tincture | Roots, Leaves |
Salve | Roots, Flowers |
Capsule | Flowers, Roots, Leaves |
Tea | Flowers, Roots, Leaves |
Decoction | Roots, Flowers |
Tincture
Hydrangea arborescens tincture is a herbal preparation used to treat a range of conditions including kidney stone pain, arthritis, digestive disorders, gastrointestinal issues, kidney problems, wound healing, skin problems, fever reduction, infections, respiratory issues, menstrual cramps, and cough suppression.
It is a common and widely used herbal remedy, especially in traditional medicine. The effects of Hydrangea arborescens tincture are generally considered to be anti-inflammatory and analgesic. The preparation is typically made from the roots and leaves of the Hydrangea arborescens plant.
The process of making Hydrangea arborescens tincture is moderately difficult, requiring careful extraction of the plant's active compounds to achieve the desired strength and potency.
Below you find an image of Hydrangea arborescens tincture.
Below you find a 5-step quick procedure to make effective medicinal Hydrangea arborescens tincture.
- Gather and clean Hydrangea arborescens roots and leaves to ensure they are free from debris and contaminants.
- Dry the roots and leaves in a warm, dark place to preserve their potency and prevent spoilage.
- Combine the dried roots and leaves in a 1:1 ratio and chop them into small pieces to increase their surface area.
- Steep the chopped roots and leaves in a solvent, such as vodka or glycerin, for a period of time to extract their medicinal properties.
- Strain the solvent through a cheesecloth or fine-mesh sieve to separate the liquid tincture from the plant material and discard the solids.
Salve
Hydrangea arborescens salve is a herbal preparation used to treat various skin conditions such as wounds, bruises, sprains, burns, eczema, and psoriasis.
It is a common remedy in traditional medicine, widely used for its therapeutic properties. Hydrangea arborescens salve has anti-inflammatory effects, reducing swelling and pain in the affected areas. The salve is typically made from the roots and flowers of the Hydrangea arborescens plant, which contain bioactive compounds that provide its medicinal properties.
However, the preparation of this salve can be challenging due to the need for precise extraction and concentration of the active ingredients from the plant material.
Below you find an image of Hydrangea arborescens salve.
Below you find a 5-step quick procedure to make effective medicinal Hydrangea arborescens salve.
- Gather fresh Hydrangea arborescens roots and flowers, clean them thoroughly, and dry them completely.
- Combine the dried roots and flowers in a muslin bag or a cheesecloth to create a herbal mixture.
- Steep the herbal mixture in a carrier oil, such as sweet almond oil, in a double boiler for several hours.
- Strain the mixture and discard the solids, then add a natural preservative, such as vitamin E oil, to the salve.
- Pour the salve mixture into glass jars and allow it to cool and solidify before using it.
Capsule
Hydrangea arborescens capsule is used to treat urinary tract infections, prostate issues, kidney stones, bladder inflammation, and cystitis.
It's a common herbal remedy due to its widespread use in traditional medicine. The effect of hydrangea arborescens capsule is often reported to be diuretic, which helps to increase urine production and reduce inflammation. The preparation is typically made from the flowers, roots, and leaves of the hydrangea arborescens plant, which are rich in glycosides and other bioactive compounds.
However, the process of extracting these compounds is complex and requires expertise, making the production of hydrangea arborescens capsule challenging.
Below you find a 5-step quick procedure to make effective medicinal Hydrangea arborescens capsule.
- Harvest and dry Hydrangea arborescens flowers, roots, and leaves under shade to preserve their potency.
- Grind the dried Hydrangea arborescens flowers, roots, and leaves into a fine powder using a mortar and pestle.
- Mix the ground Hydrangea arborescens flowers, roots, and leaves powder in a specific ratio to create the herbal blend.
- Fill empty gelatin capsules with the herbal blend using a capsule filler or spoon.
- Seal the capsules and store them in a cool, dry place to maintain their effectiveness.
Tea
Hydrangea arborescens tea is a herbal remedy used to treat various urinary tract issues, including cystitis, urinary tract infections, kidney stones, urinary retention, prostate issues, diarrhea, incontinence and bladder inflammation.
It's one of the most widely used herbal teas, particularly in Europe and North America. The most common effect reported is rapid relief from symptoms such as burning urination and frequent urination. This preparation is made from the flowers, roots and leaves of the Hydrangea arborescens plant, which are combined to create the tea.
Making Hydrangea arborescens tea is relatively simple, requiring only the plant material, boiling water and a container to steep it in.
Below you find an image of Hydrangea arborescens tea.
Below you find a 5-step quick procedure to make effective medicinal Hydrangea arborescens tea.
- Gather Hydrangea arborescens flowers, roots, and leaves from a trusted source or your own garden.
- Dry the gathered flowers, roots, and leaves in a warm, dark place until they are completely dry and crumbly.
- Combine the dried flowers, roots, and leaves in a bowl and mix them together in a 2:1:1 ratio.
- Place the herbal mixture in a tea infuser or a heat-resistant container and steep it in boiling water for 5-7 minutes.
- Strain the tea and discard the solids, then let the tea cool before serving and enjoy.
Decoction
Hydrangea arborescens decoction is a herbal preparation used to treat cystitis, urinary tract infection, bladder infection, bladder inflammation, prostate issues, enlarged prostate, kidney stones, and kidney problems.
It is a common treatment, widely used in traditional medicine. Its common effect is to reduce inflammation and alleviate symptoms of these conditions. The decoction is made from the roots and flowers of Hydrangea arborescens, which are combined and steeped in water to release their medicinal properties.
Preparing the decoction is moderately difficult, requiring careful measurement and simmering of the plant material to extract its active compounds.
Below you find a 5-step quick procedure to make effective medicinal Hydrangea arborescens decoction.
- Gather Hydrangea arborescens roots and flowers from a trusted source.
- Rinse the roots and flowers thoroughly with clean water to remove any dirt or debris.
- Combine equal parts of roots and flowers in a saucepan and add enough water to cover them completely.
- Bring the mixture to a boil, then reduce heat and let it simmer for several hours to release the herbal properties.
- Strain the decoction through a cheesecloth or a fine-mesh sieve into a clean container, discarding the solids.
What are the possible side effects of Hydrangea arborescens if used improperly?
The possible side effects of improperly using Hydrangea arborescens are experience allergic reactions, develop nephrotoxicity, and induce gastrointestinal upset, which can be triggered by ingesting its leaves or flowers.
Nephrotoxicity may lead to kidney damage and failure, while hepatotoxicity can cause liver inflammation and damage. Prolonged exposure to its toxic compounds may also show teratogenic effects, manifest neurotoxicity, and experience myelosuppression, making it essential to handle the plant with caution. Ingestion of the plant's toxic compounds can trigger uterine contractions and display cardiotoxicity, affecting the heart's functioning.
Furthermore, improper use of Hydrangea arborescens can also experience hemolytic anemia, a condition characterized by the breakdown of red blood cells.
The most common side effects Hydrangea arborescens gives people when used improperly are listed below, along with a brief explanation.
- Experience Allergic Reactions: Some people are allergic to the sap of Hydrangea arborescens, causing skin irritation and other symptoms.
- Develop Nephrotoxicity: Hydrangea arborescens contains glycosides that are metabolized to toxic compounds which cause kidney damage and failure.
- Induce Gastrointestinal Upset: Consuming Hydrangea arborescens causes nausea, vomiting, and diarrhea due to anthraquinones.
- Exhibit Hepatotoxicity: Hydrangea arborescens extracts contain anthraquinones, which cause liver damage and necrosis in animal studies.
- Show Teratogenic Effects: Hydrangea arborescens extracts exhibit teratogenic activity in animal studies.
- Manifest Neurotoxicity: Consuming large amounts of Hydrangea arborescens causes seizures and muscle spasms.
- Trigger Uterine Contractions: Alkaloids present in Hydrangea arborescens cause contraction of uterine smooth muscle.
- Display Cardiotoxicity: Hydrangea arborescens contains cardiac glycosides, which can cause cardiotoxicity when ingested in large amounts.
- Experience Myelosuppression: Hydrangea arborescens contains anthraquinones that suppress bone marrow function.
- Develop Hemolytic Anemia: Ingestion of Hydrangea arborescens causes release of anthraquinones, leading to hemolysis of red blood cells.
What are the precautions to take before using Hydrangea arborescens medicinally?
The precautions to take before using Hydrangea arborescens medicinally are to consult a doctor before use, determine proper dosage to avoid overdose, and be aware of potential allergic reactions.
However, individuals with diabetes must monitor blood sugar levels due to its hypoglycemic effects. Pregnant women should use it with caution, as it may interact with medications, such as blood thinners, and exacerbate any underlying conditions. Additionally, users should be aware of possible side effects, including gastrointestinal issues, and avoid overuse or long-term use.
Furthermore, it is crucial to use Hydrangea arborescens under proper guidance and watch for signs of toxicity, such as dizziness or headaches.
The most important precautions you must take before using Hydrangea arborescens for medicinal purposes are listed below, along with a brief explanation.
- Consult A Doctor Before Use: People with allergies or sensitivities should consult a doctor before using Hydrangea arborescens.
- Determine Proper Dosage: Hydrangea arborescens root bark extract's dosage should be 30-120 mg per day, based on a 1:4 or 1:5 root bark to extract ratio.
- Avoid Allergic Reactions: Hydrangea arborescens contains saponins, which can cause skin irritation and allergic reactions in some individuals.
- Monitor Blood Sugar Levels: People with diabetes taking Hydrangea arborescens should closely monitor their blood sugar levels.
- Use With Caution In Pregnancy: Hydrangea arborescens extracts may stimulate uterine contractions, potentially inducing premature labor.
- Interact With Medications: Hydrangea arborescens may cause increased bleeding when taken with anticoagulant and antiplatelet medications.
- Be Aware Of Side Effects: Consuming Hydrangea arborescens may cause nausea, vomiting, and diarrhea due to its glycoside content.
- Avoid Overuse Or Long-Term Use: Hydrangea arborescens requires regular repotting and pruning to maintain optimal growth and prevent root bound and nutrient deficiencies.
- Use Under Proper Guidance: Plant handling and pruning require guidance from a qualified horticulturist to avoid physical injuries and damage to the plant.
- Watch For Signs Of Toxicity: Hydrangea arborescens flowers and leaves contain grayanotoxins, which can cause vomiting, diarrhea, and other systemic symptoms if ingested.