hop

Humulus lupulus · Accepted scientific name

Scientific literature: Very Extensive (1328 studies) · ★★★★★

Hop, scientifically known as Humulus lupulus, is a climbing herbaceous perennial essential to brewing. Beyond flavoring beer, it possesses significant medicinal properties. Rich in essential oils and bitter acids, it acts as a natural sedative, aids sleep, reduces anxiety, and offers antioxidant benefits, making it a versatile botanical remedy.

Family
Cannabaceae
Native range
Europe
Parts used
Flower · Leaf
Common names
Hop · Hops · 2 more
Scientific synonyms
Lupulus Humulus · Humulus Lupulus Var. Silvestris · 6 more

Names

Common Names

Regional and Traditional Names

Spanish:

  • Betiguera
  • H. lupulus
  • Retigueras
  • Canamiza
  • Lupulo bravo
  • Lúpulo
  • Hombrecillos
  • Esparragos de sortijilla
  • Espárrago de soguilla
  • Espárrago de río
  • Lupiera
  • Pina fofa
  • Zaramancon
  • Esparrago de rio
  • Espárrago de ortiga
  • Zaramangón
  • Zaramangon
  • Humulus lupulus var lupulus
  • Espárragos de sortijilla
  • Espárragos de ortiga
  • Hombrecillo
  • Cuerpo de hombre
  • Esparrago de ortiga
  • Pimienta blanquizca
  • Flor de hombre
  • Lupulus scandens
  • Lupulo
  • Lúpulo bravo
  • Esparrago de río
  • Espárrago de rio
  • Ombrecillo
  • Zaramancón
  • Esparragos de culebra
  • Esparrago de soguilla
  • Esparragos de zarza
  • Humulus lupulus var. lupulus
  • Cañamiza
  • H lupulus
  • Lupina
  • Lupo
  • Esparragos de ortiga
  • Piña fofa
  • lúpulo

German:

  • Echter Hopfen
  • Gewöhnlicher Hopfen
  • Humulus lupus
  • Hopfen
  • Hopfen
  • Gewöhnlicher Hopfen

French:

  • houblon
  • Houblons
  • Houblon grimpant
  • Houblon
  • houblon
  • houblon commun

Scientific Names

Accepted name

Humulus lupulus

Synonyms

Taxonomical Classification

This plant, known scientifically as Humulus lupulus, belongs to the kingdom Plantae and the phylum Streptophyta. Within the class Equisetopsida and subclass Magnoliidae, it is categorized under the order Rosales and the family Cannabaceae. Ultimately, its taxonomic identity is defined by the genus Humulus.

Rank Classification Source
Kingdom Plantae WCVP
Phylum Streptophyta WCVP
Class Equisetopsida WCVP
Subclass Magnoliidae WCVP
Order Rosales WCVP
Family Cannabaceae WCVP
Genus Humulus WCVP

Distribution

This plant, known as Humulus lupulus, is widely distributed across several regions in Northern Europe. In the southern reaches of this area, it can be found growing in Denmark. Moving further north, the species is also established in the landscapes of Norway and Finland. The plant's range extends westward to include the islands of Great Britain and Ireland. Together, these locations highlight the specific northern territories where the species thrives.

Region Area Source
Northern Europe Denmark WCVP
Northern Europe Finland WCVP
Northern Europe Great Britain WCVP
Northern Europe Ireland WCVP
Northern Europe Norway WCVP
Northern Europe Sweden WCVP
Middle Europe Austria WCVP
Middle Europe Belgium WCVP
Middle Europe Czechia-Slovakia WCVP
Middle Europe Germany WCVP

Plant Parts

This plant, Humulus lupulus, is a climbing perennial known for its complex structural components used in various medicinal and traditional applications. The botanical structure features distinct leaves that are deeply lobed, often serving as the primary site for gathering leaf extracts for their chemical properties. During its flowering stage, the plant produces a specialized inflorescence which typically develops into dense, resinous hop cones. These cone-like structures are found on the female plants and are the most commercially and medicinally significant parts of the species, often growing in clusters that can be described as part of the plant's reproductive racemes.
Plant Part Sources Consensus
flower Planta medica (and other 2 sources) ★☆☆☆☆
leaf Molecules (Basel, Switzerland) (and other 2 sources) ★☆☆☆☆

Chemicals

Humulus lupulus has 310 reported phytochemicals identified across 4 scientific publications and several other databases. The most consistently reported chemicals include Xanthohumol, 8-Prenylnaringenin, Isoxanthohumol, polyphenols, 6-Prenylnaringenin.

Chemicals reported in Humulus lupulus
Chemical Supporting sources Consensus
Xanthohumol 19 supporting sources ★★★★★
8-Prenylnaringenin 12 supporting sources ★★★★★
Isoxanthohumol 8 supporting sources ★★★★☆
polyphenols 5 supporting sources ★★★☆☆
6-Prenylnaringenin 4 supporting sources ★★☆☆☆
CHLOROGENIC ACID 3 supporting sources ★★☆☆☆
Flavonoids 3 supporting sources ★★☆☆☆
Lupulone 3 supporting sources ★★☆☆☆
MYRCENE 3 supporting sources ★★☆☆☆
RUTIN 3 supporting sources ★★☆☆☆

Xanthohumol

  1. Dr. Duke
  2. Pharmaceutical patent analyst
  3. Plants (Basel, Switzerland)
  4. Foods (Basel, Switzerland)
  5. Journal of natural products
View 14 additional sources
  1. Cancer prevention research (Philadelphia, Pa.)
  2. PloS one
  3. The Journal of clinical endocrinology and metabolism
  4. Bulletin of experimental biology and medicine
  5. Molecular nutrition & food research
  6. Chemico-biological interactions
  7. Pharmaceuticals (Basel, Switzerland)
  8. Chemical research in toxicology
  9. Planta medica
  10. Molecules (Basel, Switzerland)
  11. Journal of agricultural and food chemistry
  12. International journal of molecular sciences
  13. Biomedical chromatography : BMC
  14. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

8-Prenylnaringenin

  1. Planta medica
  2. Journal of natural products
  3. Cancer prevention research (Philadelphia, Pa.)
  4. PloS one
  5. The Journal of clinical endocrinology and metabolism
View 7 additional sources
  1. Drug metabolism and disposition: the biological fate of chemicals
  2. Molecular nutrition & food research
  3. The Journal of steroid biochemistry and molecular biology
  4. Chemical research in toxicology
  5. International journal of molecular sciences
  6. Biomedical chromatography : BMC
  7. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Isoxanthohumol

  1. Dr. Duke
  2. Journal of natural products
  3. The Journal of clinical endocrinology and metabolism
  4. Bulletin of experimental biology and medicine
  5. Planta medica
View 3 additional sources
  1. Biomedical chromatography : BMC
  2. International journal of molecular sciences
  3. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

polyphenols

  1. Food chemistry
  2. Plants (Basel, Switzerland)
  3. Foods (Basel, Switzerland)
  4. Fitoterapia
  5. Bioscience, biotechnology, and biochemistry

6-Prenylnaringenin

  1. Journal of natural products
  2. The Journal of clinical endocrinology and metabolism
  3. Planta medica
  4. Biomedical chromatography : BMC

CHLOROGENIC ACID

  1. Dr. Duke
  2. Foods (Basel, Switzerland)
  3. Molecules (Basel, Switzerland)

Flavonoids

  1. Foods (Basel, Switzerland)
  2. Molecules (Basel, Switzerland)
  3. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

Lupulone

  1. Dr. Duke
  2. Foods (Basel, Switzerland)
  3. Journal of natural products

MYRCENE

  1. Dr. Duke
  2. Pharmaceuticals (Basel, Switzerland)
  3. Plant biology (Stuttgart, Germany)

RUTIN

  1. Dr. Duke
  2. Fitoterapia
  3. Pharmaceuticals (Basel, Switzerland)

Activities

Humulus lupulus has 731 reported activities identified across 4 scientific publications and several other databases. The most consistently reported activities include Antioxidant, Estrogenic, Anticancer, Antimicrobial, Sedative.

Most Reported Activities

Activity Sources Consensus
Antioxidant Dr. Duke (and other 7 sources) ★★★★☆
Estrogenic Dr. Duke (and other 6 sources) ★★★☆☆
Anticancer Dr. Duke (and other 4 sources) ★★☆☆☆
Antimicrobial Pharmaceutical patent analyst (and other 4 sources) ★★☆☆☆
Sedative Dr. Duke (and other 4 sources) ★★☆☆☆
Antibacterial Dr. Duke (and other 3 sources) ★★☆☆☆
Anticarcinogenic Dr. Duke (and other 3 sources) ★★☆☆☆
Antiproliferative Dr. Duke (and other 3 sources) ★★☆☆☆
Antiviral Dr. Duke (and other 3 sources) ★★☆☆☆
Analgesic Dr. Duke (and other 2 sources) ★☆☆☆☆

Medicinal Uses

Humulus lupulus has 49 reported medicinal uses identified across 4 scientific publications and several other databases. The most consistently reported uses include anxiety, depression, cancer, inflammation, insomnia.

Most Reported Uses

Use Sources Consensus
anxiety Phytomedicine : international journal of phytotherapy and phytopharmacology (and other 8 sources) ★★★★☆
depression Phytomedicine : international journal of phytotherapy and phytopharmacology (and other 5 sources) ★★★☆☆
cancer Journal of mass spectrometry : JMS (and other 3 sources) ★★☆☆☆
inflammation International journal of molecular sciences (and other 3 sources) ★★☆☆☆
insomnia Revista de enfermeria (Barcelona, Spain) (and other 3 sources) ★★☆☆☆
cardiovascular disease Pharmaceutical patent analyst (and other 2 sources) ★☆☆☆☆
diabetes mellitus Journal of natural products (and other 2 sources) ★☆☆☆☆
hot flashes European review for medical and pharmacological sciences (and other 2 sources) ★☆☆☆☆
obesity Pharmaceutical patent analyst (and other 2 sources) ★☆☆☆☆
primary insomnia Indian journal of pharmacology (and other 2 sources) ★☆☆☆☆

Preparations

Preparations Sources Consensus
ethanol extracts Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan (and other 2 sources) ★☆☆☆☆
extracts Analytical and bioanalytical chemistry (and other 2 sources) ★☆☆☆☆
plant extracts Antibiotics (Basel, Switzerland) (and other 2 sources) ★☆☆☆☆
aqueous extract Fitoterapia (and other 1 sources) ★☆☆☆☆
aqueous-methanolic extract (1:1; v/v) Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences (and other 1 sources) ★☆☆☆☆
brewing Journal of biomedicine & biotechnology (and other 1 sources) ★☆☆☆☆
extract Biomedical chromatography : BMC (and other 1 sources) ★☆☆☆☆
herbal extracts Current pharmaceutical design (and other 1 sources) ★☆☆☆☆
hop cone extract Platelets (and other 1 sources) ★☆☆☆☆
hops extract Avicenna journal of phytomedicine (and other 1 sources) ★☆☆☆☆