Grewia bilamellata
Grewia bilamellata · Accepted scientific name
Scientific literature: Very Sparse (1 studies) · ★☆☆☆☆
Grewia bilamellata is a botanical species recognized for its significant medicinal potential in combating malaria. Scientific investigations have focused on its antimalarial activities, specifically targeting the parasite Plasmodium falciparum. The plant contains several bioactive chemical compounds, including bilagrewin, ciwujiatone, daucosterol, and cleomiscosin D. Researchers primarily utilize the leaves and stems to extract these therapeutic properties through various preparations. These medicinal components are commonly derived from processed dried leaves, stems, and twigs.
- Synonyms
- Grewia Parva
- Common names
- Not available
- Family
- Malvaceae
- Distribution
- Not available
- Plant Parts
- Leaf · Stem
Classification
Synonyms
Grewia bilamellata is a plant species that is frequently discussed in botanical literature. Within various taxonomic records, it is noted that this plant is also recognized by the synonym Grewia parva. This dual nomenclature can sometimes cause confusion for researchers studying its specific classification. However, understanding that these two names refer to the same organism is essential for accurate identification. Recognizing these botanical relationships ensures that scientific data remains consistent across different studies.
Sources: The World Checklist of Vascular Plants (WCVP)
Taxonomy
Grewia bilamellata is a distinctive member of the kingdom Plantae. This species is classified under the class Equisetopsida and belongs to the order Malvales. Within this botanical hierarchy, it is a true representative of the family Malvaceae. Furthermore, it is nested specifically within the genus Grewia. Understanding these biological relationships provides essential insight into the plant's evolutionary lineage.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Malvales |
| Family | Malvaceae |
| Genus | Grewia |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
Geographic Regions
Grewia bilamellata is a botanical species with a notable presence across various tropical regions of Asia. Its natural distribution extends through the diverse landscapes of Indo-China, specifically including the territory of Vietnam. Furthermore, the plant is well-established within the Malesia region, stretching across much of Southeast Asia. This widespread range encompasses the islands of the Philippines, showcasing the species' adaptability to different environments. Through these varied locations, the plant maintains a significant ecological footprint across the tropical continent.
Sources: The World Checklist of Vascular Plants (WCVP)
Identification
Biological Activities
Grewia bilamellata has demonstrated significant potential in pharmacological research due to its inherent antimalarial activity. Through bioassay-directed fractionation of its dried leaves, twigs, and stems, researchers successfully isolated twelve distinct compounds. Notably, five of these isolates showed varying degrees of in vitro effectiveness against Plasmodium falciparum. These specific compounds were particularly promising because they exhibited antimalarial properties without causing significant cytotoxicity to human cells. This study highlights the plant as a valuable source of novel triterpenes and lignans for future medicinal development.
Compounds
Grewia bilamellata serves as a rich source of diverse chemical constituents identified through bioassay-directed fractionation. Research into its leaves, twigs, and stems has successfully isolated several notable compounds, including the new neolignan bilagrewin. The plant also contains grewin, a compound that has demonstrated significant in vitro antimalarial activity against Plasmodium falciparum. Furthermore, chemical analysis revealed the presence of ciwujiatone and daucosterol within the plant's profile. These findings, which also include the isolation of icariol A2, highlight the complex phytochemical makeup of this species.
Conditions
Grewia bilamellata contains specific compounds extracted from its dried leaves, twigs, and stems that exhibit antimalarial properties. Through bioassay-directed fractionation, researchers isolated twelve distinct compounds from the plant. Among these, five specific isolates demonstrated varying degrees of in vitro activity against the parasite Plasmodium falciparum. Notably, compounds such as 3alpha,20-lupandiol, grewin, and nitidanin were identified as effective agents in this study. These bioactive substances successfully target the malaria parasite without showing significant cytotoxicity toward human cancer cell lines.
Preparations
Grewia bilamellata is prepared as dried leaves for the isolation of various bioactive compounds. The plant is also prepared as stems to facilitate the study of its antimalarial properties. Additionally, the twigs of Grewia bilamellata are utilized in the fractionation process. These different parts of the plant serve as the primary sources for extracting twelve specific isolates. Through the use of these prepared materials, researchers identified several new triterpenes and lignans.
Parts used
Grewia bilamellata serves as a significant source of bioactive compounds for pharmaceutical research. During the isolation process, scientists utilized various parts of the plant, specifically the leaves and stems, to extract medicinal properties. These dried botanical components provided the raw material necessary to identify twelve distinct chemical isolates. Through bioassay-directed fractionation, researchers discovered that several compounds derived from these parts exhibit antimalarial activity. This study highlights the importance of the leaf and stem structures in producing potential treatments for Plasmodium falciparum.