Grangea maderaspatana
Grangea maderaspatana · Accepted scientific name
Scientific literature: Very Sparse (1 studies) · ★☆☆☆☆
Grangea maderaspatana is a botanical species that has garnered significant scientific interest due to its potent anticancer activities. The plant contains valuable chemical compounds, most notably the bioactive molecule known as frullanolide. Research has focused on its potential to combat various medical conditions, including arthritis and several forms of cancer such as triple negative breast cancer. Various preparations, including essential oils and methanol extracts, are utilized to isolate its therapeutic components. Specifically, the derivative 7-α-hydroxyfrullanolide (7HF) serves as a key subject in studies exploring the plant's medicinal efficacy.
- Synonyms
- Artemisia Maderaspatana · Cotula Maderaspatana · 10 more
- Common names
- Not available
- Family
- Asteraceae
- Distribution
- Not available
- Plant Parts
- Not available
Classification
Common Names
Grangea maderaspatana is a versatile plant known by a diverse array of regional and common names. In certain areas, it is referred to as Cải đồng, while others may recognize it as Inaolo a limbati. It is also frequently called Lituolo depending on the local dialect or botanical context. Those searching for it in English-speaking regions might encounter it under the name Madras carpet. Furthermore, it is sometimes identified by the name Paprastasis kietenis, reflecting its varied nomenclature across different cultures.
Sources: Catalogue of Life (COL)
Synonyms
Grangea maderaspatana is a botanical subject characterized by a complex web of taxonomic synonyms. Throughout various scientific studies, this plant has been identified under several alternative names, including Artemisia maderaspatana and Cotula maderaspatana. Researchers have also historically referred to it as Cotula sphaeranthus or Ethulia nepalensis depending on the classification system used. Furthermore, the name Grangea adansonii serves as another recognized synonym within its botanical history. Understanding these overlapping designations is essential for ensuring accuracy in botanical research and documentation.
Sources: The World Checklist of Vascular Plants (WCVP)
Taxonomy
Grangea maderaspatana is a distinct member of the kingdom Plantae. This species is classified under the class Equisetopsida and belongs to the diverse order Asterales. Within this botanical hierarchy, it is nested under the family Asteraceae. It further defines its specific identity through its placement within the genus Grangea. Understanding these biological relationships provides essential insight into the plant's evolutionary lineage.
| Rank | Classification |
|---|---|
| Kingdom | Plantae |
| Phylum | Streptophyta |
| Class | Equisetopsida |
| Subclass | Magnoliidae |
| Order | Asterales |
| Family | Asteraceae |
| Genus | Grangea |
Sources: The World Checklist of Vascular Plants (WCVP)
Distribution
Geographic Regions
Grangea maderaspatana is a plant species with a significant presence across various regions of the African continent. Its distribution spans the eastern tropical landscapes of Kenya and Tanzania, showcasing its adaptability to these environments. Furthermore, the species is found within the northeast tropical zones, specifically inhabiting parts of Chad. It also maintains a notable presence in the Horn of Africa, including Ethiopia and Somalia. Together, these locations highlight the wide geographical range this plant occupies throughout East and Northeast Africa.
Sources: The World Checklist of Vascular Plants (WCVP)
Identification
Morphology
Grangea maderaspatana is characterized by its distinct herb growth form. As a self-supporting species, it maintains its structure independently within its natural habitat. This plant typically reaches a maximum height of 0.3 meters. Depending on environmental conditions, its stature can vary between a minimum of 0.1 meters and 0.2 meters. These specific dimensions help define its presence in the local ecosystem.
Sources: Global Inventory of Floras and Traits (GIFT)
Biological Activities
Grangea maderaspatana has demonstrated significant anticancer potential through the isolation of a specific compound known as frullanolide. Research indicates that this compound can effectively target various human breast cancer cell lines, including MCF-7, MDA-MB-468, and MDA-MB-231. By utilizing the MTT assay, studies have confirmed the cytotoxic activity of frullanolide at varying concentrations. Furthermore, the substance works by inducing apoptosis, which is the programmed cell death of cancer cells. These findings suggest that extracts from this plant could offer a promising new approach for developing advanced breast cancer therapies.
Compounds
Grangea maderaspatana serves as a significant botanical source for the isolation and purification of the compound frullanolide. Recent scientific investigations have focused on this specific relationship to explore the compound's potential as a therapeutic agent against breast cancer. Research indicates that frullanolide demonstrates strong anti-cancer activity by inducing apoptosis across various human breast cancer cell lines. Notably, the compound shows high selectivity, exhibiting cytotoxicity toward cancer cells while remaining relatively safe for normal epithelial cells. These findings suggest that the chemical constituents found within Grangea maderaspatana may offer a promising new approach to cancer therapy.
Conditions
Grangea maderaspatana exhibits significant therapeutic potential, including the ability to treat triple negative breast cancer through the action of 7-α-hydroxyfrullanolide. The plant's methanol extract has been shown to treat acetic acid-induced writhing in mice by providing dose-dependent analgesic effects. Furthermore, it serves as an effective anti-inflammatory agent by protecting against carrageenan-induced paw edema. The plant also demonstrates antinociceptive properties by increasing latency in tail flick tests. Finally, Grangea maderaspatana possesses antirheumatic activity, which helps reverse arthritic indices and reduce inflammation in joint models.
Preparations
Grangea maderaspatana is prepared as 7-α-hydroxyfrullanolide (7HF), a compound that has demonstrated significant anti-cancer activity against triple-negative breast cancer cells. This plant is also prepared as an essential oil, which has been found to possess moderate acetylcholinesterase inhibitory activity. Furthermore, the plant is processed into a methanol extract to study its pharmacological properties. Research indicates that the methanol extract of the whole plant exhibits dose-dependent analgesic activity in mice. Additionally, methanol extracts of the species have been identified as having topoisomerase II poison activity in yeast cell-based assays.