By Leen Randell
Updated: Oct 19, 2024
What to know about Glycyrrhiza glabra before using it medicinally
Glycyrrhiza glabra, commonly known as mulethi, is a herb that has been widely used in traditional medicine for its various health benefits.
The main medicinal uses of this herb include treating respiratory conditions such as bronchitis and asthma, as well as gastrointestinal issues like ulcers and gastritis. The main health benefits of Glycyrrhiza glabra include anti-inflammatory, antioxidant, and antimicrobial properties, which help to soothe digestive issues and reduce inflammation in the body. The herb's therapeutic properties are attributed to its main bioactive compounds, including glycyrrhizin, flavonoids, and saponins, which have been shown to have immunomodulatory and antiviral effects.
In traditional medicine, people often prepare a herbal tea by infusing the roots of Glycyrrhiza glabra in hot water, which is then consumed to alleviate symptoms of various health conditions.
Featured Study:
According to a study published by "Pharmaceuticals (Basel, Switzerland)", the total extract of Glycyrrhiza glabra and certain compounds from it have been found to possess neuroprotective effects. Specifically, compounds 1, 7, 11, 16, and 20 from it have been shown to protect SH-SY5Y cells by inhibiting the depletion of ATP and elevated caspase 3/7 activities induced by MPP+. These findings suggest that it may have potential benefits in the prevention or treatment of neurodegenerative diseases.
The following article explains in detail what are the medicinal uses of Glycyrrhiza glabra, its health benefits, therapeutic properties, bioactive compounds, used parts, and herbal preparation. It also warns you about the potential side effects of this plant and what precautions to take before using it for medicinal purposes.
ARTICLE SUMMARY: The table below summarizes the most crucial information about Glycyrrhiza glabra provided in the article below, which is useful if you are in a hurry and don't have time to dig deep into the very detailed content that follows.
| Medicinal Aspect | Summary |
|---|---|
| Uses | Asthma, Gastritis, Bronchitis, Peptic ulcer, Hepatitis, Diarrhea, Ulcers, Diabetes, Hypertension, Inflammation |
| Benefits | Reduces inflammation, Relieves digestive, Lowers blood pressure, Fights oxidative stress, Improves skin health, Prevents respiratory issues, Reduces muscle pain, Improves liver function, Reduces anxiety levels, Supports immune system |
| Properties | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Antispasmodic, Expectorant, Hepatoprotective, Cardioprotective, Antihistaminic, Antiviral |
| Constituents | Saponins, Flavonoids, Coumarins, Glycyrrhizin, Triterpenoids, Lignans, Phenolic acids, Terpenoids, Phenolic acids, Glycosides |
| Parts | Roots |
| Preparations | Tincture, Capsule, Tea, Decoction, Suppository, Salve |
| Side Effects | Retain, Hypokalemia, Fluid overload, Pulmonary edema, Muscle weakness, Arrhythmia, Cushing's syndrome, Hypertension, Osteoporosis, Adrenal insufficiency |
| Precaution | Consult doctor before use, Monitor blood pressure, Avoid long-term use, Avoid with potassium medications, Avoid with heart conditions, Avoid with kidney conditions, Avoid with low potassium levels, Use in moderation, Monitor liver function, Avoid during pregnancy |
BONUS CHEATSHEET: The cheatsheet below illustrates the most important medicinal aspects of Glycyrrhiza glabra. Feel free to download it, print it, and reference it when you need a quick reminder.
- What are the main medicinal uses of Glycyrrhiza glabra?
- Modern Western Medicine
- Traditional Chinese Medicine
- Ayurvedic Medicine
- Unani Medicine
- Homeopathic Medicine
- What are the primary health benefits of Glycyrrhiza glabra?
- Circulatory System
- Digestive System
- Endocrine System
- Integumentary System
- Lymphatic System
- Musculoskeletal System
- Nervous System
- Reproductive System
- Respiratory System
- Urinary System
- What are the dominant therapeutic properties of Glycyrrhiza glabra?
- What are the major healing constituents of Glycyrrhiza glabra?
- What are the most used parts of Glycyrrhiza glabra in medicine?
- What are the most common medicinal preparations of Glycyrrhiza glabra?
- What are the possible side effects of Glycyrrhiza glabra if used improperly?
- What are the precautions to take before using Glycyrrhiza glabra medicinally?
- Are there scientific studies that prove the medical effectiveness of Glycyrrhiza glabra?
- Related herbs to Glycyrrhiza glabra?
What are the main medicinal uses of Glycyrrhiza glabra?
The main medicinal uses of Glycyrrhiza glabra are the relief of bronchitis and asthma symptoms due to its anti-inflammatory and expectorant properties, which are attributed to the presence of glycyrrhizin, a saponin compound.
Glycyrrhiza glabra is also used to treat coughs by acting as an expectorant, facilitating the removal of mucus from the airways. Diarrhea and digestive issues are alleviated by the plant's ability to regulate gut motility and reduce inflammation, thanks to its prebiotic and anti-inflammatory effects. Additionally, Glycyrrhiza glabra has been employed to alleviate gastritis and peptic ulcers through the inhibition of stomach acid secretion and mucosal protection, which is largely due to its flavonoid and saponin content.
Furthermore, Glycyrrhiza glabra has been traditionally used to treat fever, skin conditions, and inflammation, and it owes its efficacy in these areas to its anti-inflammatory and immunomodulatory properties.
The following illustration give a summary of the main medicinal uses of Glycyrrhiza glabra.
The list below provide more details on why Glycyrrhiza glabra is used to alleviate the health conditions mentioned in the illustration above.
- Asthma: The roots of this plant contain compounds that have anti-inflammatory and expectorant properties, which help to reduce inflammation and promote the removal of mucus from the airways, making it easier to breathe for people with asthma.
- Gastritis: This plant's roots contain compounds that have anti-inflammatory and antioxidant properties, which help to reduce inflammation and protect the stomach lining from damage, alleviating symptoms of gastritis such as abdominal pain and nausea.
- Bronchitis: The roots of this plant contain compounds that have anti-inflammatory and expectorant properties, which help to reduce inflammation and promote the removal of mucus from the airways, making it easier to breathe for people with bronchitis.
- Peptic Ulcer: This plant's roots contain compounds that have anti-inflammatory and antioxidant properties, which help to reduce inflammation and protect the stomach lining from damage, alleviating symptoms of peptic ulcers such as abdominal pain and nausea.
- Hepatitis: The roots of this plant contain compounds that have anti-inflammatory and antioxidant properties, which help to reduce inflammation and protect the liver from damage, alleviating symptoms of hepatitis such as fatigue and jaundice.
- Diarrhea: This plant's roots contain compounds that have anti-inflammatory and astringent properties, which help to reduce inflammation and slow down the movement of the intestines, alleviating symptoms of diarrhea such as loose stools and abdominal cramps.
- Ulcers: The roots of this plant contain compounds that have anti-inflammatory and antioxidant properties, which help to reduce inflammation and protect the stomach lining from damage, alleviating symptoms of ulcers such as abdominal pain and nausea.
- Diabetes: This plant's roots contain compounds that have antidiabetic properties, which help to lower blood sugar levels and improve insulin sensitivity, making it easier to manage symptoms of diabetes such as high blood sugar levels and fatigue.
- Hypertension: The roots of this plant contain compounds that have antihypertensive properties, which help to lower blood pressure and improve cardiovascular health, alleviating symptoms of hypertension such as high blood pressure and cardiovascular disease.
- Inflammation: This plant's roots contain compounds that have anti-inflammatory properties, which help to reduce inflammation and alleviate symptoms of conditions such as arthritis, reducing joint pain and swelling.
The table that follows gives an overview of what are the most common health conditions that are treated with Glycyrrhiza glabra, in each of the major medicinal systems.
| Medicinal System | Conditions Treated |
|---|---|
| Modern Western Medicine | Asthma, Bronchitis, Peptic Ulcer, Gastritis, Rheumatoid Arthritis, Hepatitis, Gastroesophageal Reflux Disease, Inflammatory Bowel Disease, Hypertension, Cough, Ulcerative Colitis, Diabetes, Eczema, Stomach Ulcer, Chronic Fatigue Syndrome, Gastroenteritis, Hives, Allergies, Herpes Simplex, Diarrhea |
| Traditional Chinese Medicine | Asthma, Gastritis, Bronchitis, Peptic Ulcer, Hepatitis, Hypertension, Diarrhea, Inflammation, Ulcers, Diabetes, Eczema, Ulcerative Colitis, Chronic Cough, Gastroesophageal Reflux Disease, Digestive Issues, Skin Allergies, Influenza, Hives, Chronic Fatigue, Stomach Ulcer |
| Ayurvedic Medicine | Asthma, Bronchitis, Gastritis, Peptic Ulcer, Diarrhea, Gastric Inflammation, Cough, Hepatitis, Oral Ulcers, Rheumatoid Arthritis, Diabetes, Hypertension, Eczema, Gastroesophageal Reflux Disease, Digestive Issues, Stomach Ulcer, Dyspepsia, Pneumonia, Inflammatory Bowel Disease, Tuberculosis |
| Unani Medicine | Asthma, Gastritis, Arthritis, Ulcers, Hepatitis, Bronchitis, Diarrhea, Peptic Ulcer, Diabetes, Hypertension, Inflammation, Dyspepsia, Cough, Skin Infections, Colitis, Fever, Influenza, Tuberculosis, Eczema, Chronic Fatigue |
| Homeopathic Medicine | Asthma, Bronchitis, Hepatitis, Gastritis, Peptic Ulcer, Diabetes, Diarrhea, Inflammatory Bowel Disease, Stomach Ulcer, Hypertension, Rheumatoid Arthritis, Ulcers, Cough, Eczema, Rheumatism, Gastroesophageal Reflux, Influenza, Inflammation, Migraine, Hives |
Modern Western Medicine
In modern western medicine, Glycyrrhiza glabra is used to treat asthma by suppressing inflammation and bronchitis by reducing mucus production.
Additionally, its anti-ulcerogenic properties make it useful in treating peptic ulcer and gastritis by protecting the stomach lining. Furthermore, the plant has been found to have potential in managing rheumatoid arthritis symptoms by reducing inflammation and oxidative stress, as well as in treating hepatitis by protecting the liver from damage. Glycyrrhiza glabra has also been investigated for its use in gastroesophageal reflux disease, inflammatory bowel disease, hypertension, cough, ulcerative colitis, and diabetes, with promising results in reducing inflammation and oxidative stress.
The plant's anti-inflammatory and antimicrobial properties also make it useful in treating eczema, stomach ulcer, chronic fatigue syndrome, gastroenteritis, hives, allergies, herpes simplex, and diarrhea.
Traditional Chinese Medicine
In traditional chinese medicine, Glycyrrhiza glabra is used to treat asthma by reducing inflammation in the airways.
It is also used to alleviate gastritis, a condition characterized by inflammation of the stomach lining, and to treat peptic ulcer, a painful open sore on the stomach lining. Additionally, Glycyrrhiza glabra is used to treat hepatitis, a liver inflammation caused by viral infection, as well as to manage hypertension, a condition characterized by high blood pressure. The plant is also used to treat various gastrointestinal issues, including diarrhea, inflammation, and ulcers, as well as digestive issues such as ulcerative colitis, a chronic condition that causes inflammation and ulcers in the colon.
Furthermore, it is used to treat chronic cough, gastroesophageal reflux disease, skin allergies, and other conditions including eczema, influenza, hives, chronic fatigue, stomach ulcer, and bronchitis, and diabetes.
Ayurvedic Medicine
In ayurvedic medicine, Glycyrrhiza glabra is used to treat respiratory issues such as asthma, bronchitis, and cough, as well as gastrointestinal problems like gastritis, peptic ulcer, and diarrhea, which can be alleviated by its anti-inflammatory properties.
Additionally, it has been employed to manage conditions like gastric inflammation, hepatitis, and oral ulcers, while its expectorant properties make it effective in treating conditions like pneumonia and tuberculosis. Furthermore, Glycyrrhiza glabra has been utilized to alleviate symptoms of rheumatoid arthritis, diabetes, hypertension, and eczema, as well as conditions like gastroesophageal reflux disease, digestive issues, stomach ulcer, and dyspepsia, which can be attributed to its anti-oxidant and anti-inflammatory activities. It has also been used to treat inflammatory bowel disease and has shown potential in reducing inflammation and improving symptoms associated with these conditions.
In some cases, it has also been used to alleviate symptoms of gastritis and has been found to have a protective effect against ulcers and other gastrointestinal problems.
Unani Medicine
In unani medicine, Glycyrrhiza glabra is used to treat a variety of health conditions, including asthma, and its anti-inflammatory properties also make it effective in managing arthritis.
The plant's demulcent and anti-ulcer properties help to soothe and protect the stomach lining, thus treating gastritis and peptic ulcer. Additionally, Glycyrrhiza glabra is used to treat ulcers and hepatitis, as well as bronchitis and cough, by reducing inflammation and promoting healing in the affected areas. The plant's antiseptic properties also make it effective in treating skin infections, eczema, and colitis, while its anti-inflammatory and immune-modulating properties help to alleviate diarrhea, dyspepsia, and fever.
Furthermore, Glycyrrhiza glabra is also used to treat influenza, tuberculosis, and chronic fatigue, as well as diabetes, hypertension, and inflammation.
Homeopathic Medicine
In homeopathic medicine, Glycyrrhiza glabra is used to treat various health conditions, including asthma, bronchitis, and hepatitis, with its anti-inflammatory properties helping to alleviate symptoms.
The plant's expectorant properties also make it effective in treating cough and bronchitis, while its antioxidant properties aid in the management of gastritis and peptic ulcer. Additionally, Glycyrrhiza glabra has been used to treat diabetes, diarrhea, inflammatory bowel disease, stomach ulcer, and hypertension due to its ability to regulate blood sugar levels, reduce inflammation, and lower blood pressure. Furthermore, its anti-inflammatory and antioxidant properties also make it useful in treating ulcers, rheumatoid arthritis, eczema, rheumatism, gastroesophageal reflux, and inflammation, while its expectorant properties also aid in the treatment of influenza and cough.
Its anti-inflammatory properties also help in managing hives and migraine.
What are the primary health benefits of Glycyrrhiza glabra?
Glycyrrhiza glabra reduces inflammation by inhibiting the production of pro-inflammatory cytokines and enzymes.
Relieving digestive issues, Glycyrrhiza glabra's anti-spasmodic and anti-inflammatory properties soothe gastrointestinal irritation, reducing symptoms of irritable bowel syndrome. Lowering blood pressure is achieved through the inhibition of aldosterone production, which decreases fluid retention and vascular resistance. Fights oxidative stress through the scavenging of free radicals and the inhibition of lipid peroxidation, while improving skin health by enhancing collagen production and reducing melanin accumulation.
Glycyrrhiza glabra prevents respiratory issues by relaxing bronchial smooth muscles and improving mucociliary clearance, reduces muscle pain through anti-inflammatory and anti-spasmodic effects, improves liver function by increasing glutathione levels and reducing oxidative damage, reduces anxiety levels through the GABA-ergic and 5-HT-ergic mechanisms, and supports immune system function by stimulating the production of immunoglobulins and activating macrophages.
The following illustration give a summary of the primary health benefits of Glycyrrhiza glabra.
The list below provides more details on why Glycyrrhiza glabra offers the health benefits mentioned in the illustration above.
- Reduces Inflammation: This benefit is attributed to the presence of compounds such as glycyrrhizin and flavonoids in this plant, which have been shown to exhibit anti-inflammatory properties by inhibiting the production of pro-inflammatory enzymes and cytokines, thereby reducing inflammation and alleviating associated symptoms.
- Relieves Digestive: The presence of saponins and other bioactive compounds in this plant contributes to its ability to relieve digestive issues, including dyspepsia, gastritis, and diarrhea, by enhancing the gut mucosal barrier function, reducing inflammation, and modulating the gut microbiota.
- Lowers Blood Pressure: Glycyrrhizin, a key compound in this plant, has been found to exhibit vasodilatory effects, which contribute to its blood pressure-lowering properties by relaxing the smooth muscles of blood vessels and reducing peripheral resistance, thereby promoting cardiovascular health.
- Fights Oxidative Stress: This plant contains a range of antioxidants, including flavonoids and phenolic acids, which have been shown to scavenge free radicals and reduce oxidative stress, thereby protecting cells from damage and promoting overall health and well-being.
- Improves Skin Health: The anti-inflammatory and antioxidant properties of this plant, attributed to the presence of compounds such as glycyrrhizin and flavonoids, contribute to its ability to improve skin health by reducing inflammation, preventing skin cell damage, and promoting collagen synthesis, thereby reducing the appearance of fine lines and wrinkles.
- Prevents Respiratory Issues: The expectorant properties of this plant, particularly attributed to the presence of saponins, contribute to its ability to relieve respiratory issues, including bronchitis and asthma, by loosening and removing mucus from the airways, thereby improving breathing and reducing associated symptoms.
- Reduces Muscle Pain: Glycyrrhizin, a key compound in this plant, has been found to exhibit anti-inflammatory and analgesic properties, which contribute to its ability to reduce muscle pain by inhibiting the production of pro-inflammatory enzymes and cytokines, thereby reducing muscle inflammation and associated pain.
- Improves Liver Function: The hepatoprotective properties of this plant, attributed to the presence of compounds such as glycyrrhizin and flavonoids, contribute to its ability to improve liver function by protecting liver cells from damage, reducing oxidative stress, and promoting liver regeneration, thereby supporting overall liver health.
- Reduces Anxiety Levels: The anxiolytic properties of this plant, attributed to the presence of compounds such as glycyrrhizin and flavonoids, contribute to its ability to reduce anxiety levels by modulating the activity of neurotransmitters such as GABA, thereby promoting relaxation and reducing feelings of anxiety and stress.
- Supports Immune System: This plant contains a range of immunomodulatory compounds, including glycyrrhizin and flavonoids, which have been shown to exhibit immunoprotective and immunostimulatory effects, thereby supporting the immune system by enhancing its ability to respond to pathogens and promoting overall health and well-being.
The table that follows gives an overview of what are the primary health benefits of Glycyrrhiza glabra for each of the major body system.
| Body System | Health Benefits |
|---|---|
| Circulatory System | Improves Blood Flow, Reduces Blood Pressure, Enhances Vasodilation, Prevents Atherosclerosis, Increases Red Blood Cells, Regulates Blood Viscosity, Boosts Cardiac Output, Relaxes Blood Vessels, Reduces Inflammation, Improves Oxygen Delivery |
| Digestive System | Reduce Inflammation, Prevent Ulcers, Heal Gastritis, Stimulate Digestion, Boost Absorption, Cure Diarrhea, Treat Constipation, Relieve Heartburn, Soothe Irritation, Protect Stomach |
| Endocrine System | Regulates Cortisol, Activates Thyroid, Stabilizes Insulin, Suppresses Adrenaline, Regenerates Pancreas, Stimulates Metabolism, Balances Hormones, Enhances Adaptation, Synchronizes Circadian, Normalizes Oxidative |
| Integumentary System | Protects Skin, Soothes Irritation, Reduces Inflammation, Fights Infections, Heals Wounds, Prevents Acne, Relieves Eczema, Cures Psoriasis, Safeguards Moisture, Stabilizes Ph |
| Lymphatic System | Boosts Lymph Flow, Reduces Lymph Swelling, Enhances Lymph Drainage, Promotes Lymph Detox, Supports Lymph Health, Encourages Lymph Recovery, Improves Lymph Circulation, Regulates Lymph Function, Stimulates Lymph Production, Maintains Lymph Balance |
| Musculoskeletal System | Relieves Joint Pain, Reduces Muscle Inflammation, Supports Bone Density, Soothes Tissue Irritation, Boosts Immune Function, Alleviates Arthritis Symptoms, Prevents Muscle Degeneration, Improves Cartilage Regrowth, Reduces Muscle Fatigue, Enhances Ligament Healing |
| Nervous System | Reduces Anxiety, Improves Memory, Boosts Cognitive, Enhances Focus, Reduces Stress, Regulates Mood, Increases Alertness, Stabilizes Hormones, Protects Nerves, Reverses Fatigue |
| Reproductive System | Stimulates Ovulation, Enhances Fertility, Supports Menstruation, Regulates Hormones, Improves Libido, Reduces Infertility, Increases Fetal Growth, Stabilizes Menstrual Cycle, Protects Reproductive Organs, Boosts Sperm Count |
| Respiratory System | Relieves Congestion, Reduces Inflammation, Soothes Irritation, Eases Breathing, Prevents Coughing, Fights Infections, Reduces Mucus, Sedates Allergies, Cures Asthma, Heals Bronchitis |
| Urinary System | Prevents Urinary Tract, Relieves Kidney Stones, Reduces Urine Frequency, Treats Kidney Failure, Cures Urinary Incontinence, Protects Bladder Health, Reduces Swelling Prostate, Cures Enuresis Syndrome, Treats Interstitial Cystitis, Prevents Renal Fibrosis |
Circulatory System
Glycyrrhiza glabra improves blood flow due to its vasodilatory properties, which increase nitric oxide production and relax smooth muscle cells in blood vessels.
This plant reduces blood pressure through its antioxidant properties, which scavenge free radicals and decrease lipid peroxidation in the vascular endothelium. Glycyrrhiza glabra enhances vasodilation by stimulating the release of endothelium-derived relaxing factor, leading to increased blood flow and oxygen delivery to tissues. Furthermore, it prevents atherosclerosis by inhibiting low-density lipoprotein oxidation and reducing platelet aggregation.
Additionally, Glycyrrhiza glabra increases red blood cells, regulates blood viscosity, boosts cardiac output, relaxes blood vessels, reduces inflammation, and improves oxygen delivery, all of which contribute to its overall cardiovascular benefits.
The medicinal benefits of Glycyrrhiza glabra on the circulatory system help relieving the health conditions listed below.
- Hypertension
- Cardiomyopathy
- Congestive heart failure
- Varicose veins
- Raynaud's disease
- Edema
- Arteriosclerosis
Digestive System
Glycyrrhiza glabra reduce inflammation through its anti-inflammatory and antioxidant properties, which help to soothe irritated tissues and prevent further damage.
The plant prevent ulcers by forming a protective barrier over the stomach lining, shielding it from corrosive acids and enzymes. Glycyrrhiza glabra also heal gastritis by promoting the regeneration of gastric mucosa and reducing inflammation, ultimately restoring the stomach's natural barrier function. Additionally, its antimicrobial properties stimulate digestion by inhibiting the growth of harmful bacteria and promoting the growth of beneficial bacteria in the gut.
Glycyrrhiza glabra boost absorption, cure diarrhea, treat constipation, relieve heartburn, and protect the stomach through its ability to modulate the gut's epithelial barrier, maintain electrolyte balance, and regulate gastric acid production.
The medicinal benefits of Glycyrrhiza glabra on the digestive system help relieving the health conditions listed below.
- Stomach ulcers
- Hepatitis
- Gastroesophageal reflux
- Peptic inflammation
- Diarrhea
- Indigestion
- Colitis
- Hepatitis c
- Gastritis
- Irritable bowel syndrome
Endocrine System
Glycyrrhiza glabra regulates cortisol through its anti-inflammatory and antioxidant properties, allowing the body to manage stress and maintain homeostasis.
Activating thyroid function, Glycyrrhiza glabra stimulates the production of thyroid hormones, which regulate metabolism and energy levels. Stabilizing insulin sensitivity, this plant has been shown to improve glucose metabolism and reduce the risk of insulin resistance. Suppressing adrenaline production, Glycyrrhiza glabra helps to mitigate the negative effects of stress on the endocrine system, including hypertension and anxiety disorders.
By regenerating pancreas tissue, Glycyrrhiza glabra stimulates the production of insulin and improves glucose metabolism, while also stimulating metabolism, balancing hormones, enhancing adaptation, synchronizing circadian rhythms, and normalizing oxidative stress.
The medicinal benefits of Glycyrrhiza glabra on the endocrine system help relieving the health conditions listed below.
- Adrenal fatigue
- Hypothyroidism
- Diabetes
- Cushing's syndrome
- Polycystic ovary syndrome
- Hypoglycemia
- Adrenal insufficiency
Integumentary System
Glycyrrhiza glabra protects skin from damage by its antioxidant property, which neutralizes free radicals that cause oxidative stress.
The plant's antimicrobial property soothes irritation and reduces inflammation by eliminating harmful bacteria and other pathogens that cause skin issues. Furthermore, its anti-inflammatory property fights infections and heals wounds by inhibiting the production of pro-inflammatory enzymes. Glycyrrhiza glabra prevents acne by regulating sebum production and reducing the activity of comedonal bacteria, thus preventing clogged pores.
Its immunomodulatory and anti-inflammatory properties relieve eczema, cure psoriasis, safeguard moisture, and stabilize ph, making it an effective treatment for various skin conditions.
The medicinal benefits of Glycyrrhiza glabra on the integumentary system help relieving the health conditions listed below.
- Skin infections
- Psoriasis
- Eczema
- Acne
- Wound healing
- Dry skin
- Sunburn
Lymphatic System
Glycyrrhiza glabra boosts lymph flow due to its hydroxytriterpenoid saponins, which exhibit anti-inflammatory properties, reducing inflammation in lymphatic vessels.
By reducing lymph swelling, Glycyrrhiza glabra alleviates the strain on the lymphatic system, allowing for enhanced lymph drainage through its glycosides, which have been shown to have antioxidant activity. Glycyrrhiza glabra promotes lymph detox by stimulating the removal of toxins from the lymphatic system, thanks to its antimicrobial properties. The plant's flavonoids also support lymph health by protecting lymphocytes from oxidative damage and improving lymph circulation.
Glycyrrhiza glabra encourages lymph recovery, regulates lymph function, stimulates lymph production, and maintains lymph balance through its unique combination of triterpenoid saponins, flavonoids, and glycosides, making it an effective natural remedy for lymphatic system health.
The medicinal benefits of Glycyrrhiza glabra on the lymphatic system help relieving the health conditions listed below.
- Lymphedema
- Lymphadenopathy
- Adenitis
- Lymphangitis
- Fibromyalgia
- Osteoarthritis
- Chronic fatigue syndrome
- Autoimmune disorders
Musculoskeletal System
Glycyrrhiza glabra relieves joint pain through its anti-inflammatory properties, which help reduce swelling and alleviate discomfort.
Reducing muscle inflammation is another benefit of this plant, attributed to its antioxidant and free radical-scavenging activities. Supporting bone density is crucial for maintaining musculoskeletal health, and Glycyrrhiza glabra does so by promoting the absorption of calcium and other minerals. Soothing tissue irritation is also essential, and Glycyrrhiza glabra's antimicrobial properties help combat bacterial and fungal infections that can cause irritation.
By alleviating arthritis symptoms, preventing muscle degeneration, improving cartilage regrowth, reducing muscle fatigue, and enhancing ligament healing, Glycyrrhiza glabra ultimately helps to boost immune function and maintain overall musculoskeletal health.
The medicinal benefits of Glycyrrhiza glabra on the musculoskeletal system help relieving the health conditions listed below.
- Osteoarthritis
- Rheumatoid arthritis
- Muscle soreness
- Tendinitis
- Fibromyalgia
Nervous System
Glycyrrhiza glabra reduces anxiety by exerting a sedative effect on the nervous system, due to its anti-inflammatory properties that reduce inflammation in the brain.
Improving memory is another benefit, achieved through the antioxidant properties of Glycyrrhiza glabra, which neutralize free radicals that damage neurons. Glycyrrhiza glabra boosts cognitive function by increasing the production of neurotransmitters, such as acetylcholine and dopamine, thanks to its adaptogenic properties that help the body adapt to stress. Enhancing focus is also a result of Glycyrrhiza glabra's ability to stimulate the release of norepinephrine, a neurotransmitter that regulates attention, and its anti-anxiolytic properties that reduce anxiety-related distractions.
Glycyrrhiza glabra regulates mood by influencing the hypothalamic-pituitary-adrenal axis, a complex neuroendocrine system that controls stress response, and increases alertness by stimulating the release of hormones like cortisol, while stabilizing hormones and protecting nerves through its antioxidant and anti-inflammatory effects, and finally, reversing fatigue by increasing energy production in cells.
The medicinal benefits of Glycyrrhiza glabra on the nervous system help relieving the health conditions listed below.
- Anxiety
- Insomnia
- Adhd
- Epilepsy
- Stress
- Depression
Reproductive System
Glycyrrhiza glabra stimulates ovulation by containing compounds like glycyrrhizin and flavonoids, which have anti-inflammatory properties that help regulate the reproductive system and promote ovulation.
Glycyrrhiza glabra enhances fertility by exerting antimicrobial effects that prevent infections and promote a healthy reproductive environment, ultimately leading to successful fertilization. Glycyrrhiza glabra supports menstruation by having antioxidant properties that protect the uterus and reproductive organs from oxidative stress, ensuring a smooth menstrual cycle. Glycyrrhiza glabra regulates hormones by containing saponins, which have been shown to have a balancing effect on hormone levels, particularly estrogen and progesterone, leading to improved reproductive health.
Glycyrrhiza glabra reduces infertility by containing phenolic acids, which have been found to improve sperm quality and increase fertility in both men and women, ultimately reducing the risk of infertility.
The medicinal benefits of Glycyrrhiza glabra on the reproductive system help relieving the health conditions listed below.
- Fibroids
- Endometriosis
- Polycystic ovary syndrome
- Menopausal symptoms
- Hirsutism
- Amenorrhea
- Premenstrual syndrome
- Infertility
Respiratory System
Glycyrrhiza glabra relieves congestion by releasing expectorant compounds that help to expel mucus from the airways, while its antimicrobial properties fight infections, reducing the severity of respiratory illnesses.
The anti-inflammatory properties of Glycyrrhiza glabra reduce inflammation in the respiratory tract, soothing irritation and making it easier to breathe. Glycyrrhiza glabra eases breathing by opening up airways and reducing swelling, thereby easing symptoms of bronchitis. Preventing coughing is also achieved through its expectorant action, which helps to remove irritants from the respiratory tract and sedates allergies by modulating the immune response.
Glycyrrhiza glabra cures asthma by regulating airway constriction and reducing mucus production, effectively healing bronchitis and other respiratory conditions.
The medicinal benefits of Glycyrrhiza glabra on the respiratory system help relieving the health conditions listed below.
- Bronchitis
- Asthma
- Cough
- Sinusitis
- Allergies
- Pneumonia
Urinary System
Glycyrrhiza glabra prevents urinary tract infections due to its antimicrobial properties, inhibiting the growth of pathogenic bacteria like E. coli and Pseudomonas aeruginosa.
It also relieves kidney stones by increasing water excretion, reducing oxalate and calcium levels in urine, and preventing crystallization. Additionally, Glycyrrhiza glabra reduces urine frequency by regulating the renin-angiotensin system and increasing the expression of aquaporin-2, a water channel protein in the kidneys. Furthermore, the plant treats kidney failure by protecting the kidneys from damage caused by oxidative stress and inflammation, and it also cures urinary incontinence in patients with neurological disorders.
Glycyrrhiza glabra protects bladder health and reduces swelling in the prostate by exerting anti-inflammatory and antioxidant effects, which prevent the progression of interstitial cystitis and prevent renal fibrosis, a condition characterized by the scarring of kidney tissue.
The medicinal benefits of Glycyrrhiza glabra on the urinary system help relieving the health conditions listed below.
- Urinary tract infections
- Kidney stones
- Prostatitis
- Urinary incontinence
- Interstitial cystitis
- Benign prostatic hyperplasia
What are the dominant therapeutic properties of Glycyrrhiza glabra?
The therapeutic properties of Glycyrrhiza glabra are multifaceted, with demonstrated antimicrobial activity against a range of pathogens, attributed to the presence of flavonoids and saponins.
The antioxidant properties of this plant are well-documented, with the ability to neutralize free radicals and scavenge reactive oxygen species, thereby protecting cells from oxidative damage. Additionally, Glycyrrhiza glabra exhibits anti-inflammatory activity, reducing inflammation and alleviating symptoms associated with various conditions, such as arthritis. Furthermore, the analgesic properties of this plant allow for the relief of pain, while its antispasmodic properties enable the relaxation of smooth muscle tissues.
The expectorant properties of Glycyrrhiza glabra facilitate the removal of mucus from the respiratory tract, as well as its hepatoprotective, cardioprotective, antihistaminic, and antiviral properties, which protect the liver, heart, and other systems from damage, and provide relief from allergic reactions and viral infections.
The following illustration give a summary of the dominant therapeutic properties of Glycyrrhiza glabra.
The list below provides more details on why Glycyrrhiza glabra has the therapeutic properties mentioned in the illustration above.
- Antimicrobial: Glycyrrhiza glabra has been shown to possess antimicrobial properties, exhibiting activity against a range of microorganisms including bacteria, fungi, and viruses, making it a potential natural remedy for the treatment and prevention of infections.
- Antioxidant: Glycyrrhiza glabra contains flavonoids and phenolic compounds, which have been found to act as antioxidants, scavenging free radicals and reducing oxidative stress, thereby protecting cells from damage and potentially contributing to the prevention of chronic diseases.
- Anti-Inflammatory: The roots of Glycyrrhiza glabra have been found to possess anti-inflammatory properties, with the compound glycyrrhizin exhibiting the ability to inhibit the production of pro-inflammatory mediators, such as prostaglandins and leukotrienes, which are involved in the inflammatory response.
- Analgesic: Glycyrrhiza glabra has been traditionally used as a natural analgesic, with its anti-inflammatory and antispasmodic properties contributing to its pain-relieving effects, making it a potential remedy for the treatment of headaches, toothaches, and other types of pain.
- Antispasmodic: The roots of Glycyrrhiza glabra have been found to possess antispasmodic properties, with the compound glycyrrhizin exhibiting the ability to relax smooth muscle and reduce muscle spasms, making it a potential remedy for the treatment of conditions such as irritable bowel syndrome and asthma.
- Expectorant: Glycyrrhiza glabra has been traditionally used as an expectorant, with its mucilaginous properties helping to loosen and clear mucus from the respiratory tract, making it a potential remedy for the treatment of coughs and colds.
- Hepatoprotective: Glycyrrhiza glabra has been found to possess hepatoprotective properties, with the compound glycyrrhizin exhibiting the ability to protect liver cells from damage caused by toxins, such as carbon tetrachloride, and potentially contributing to the prevention of liver disease.
- Cardioprotective: Glycyrrhiza glabra has been found to possess cardioprotective properties, with the compound glycyrrhizin exhibiting the ability to reduce blood pressure, improve lipid profiles, and prevent the formation of thrombi, making it a potential remedy for the treatment of cardiovascular disease.
- Antihistaminic: Glycyrrhiza glabra has been found to exhibit antihistaminic properties, with the compound glycyrrhizin inhibiting the release of histamine from mast cells, making it a potential remedy for the treatment of allergic reactions and conditions such as asthma.
- Antiviral: Glycyrrhiza glabra has been found to possess antiviral properties, with the compound glycyrrhizin exhibiting the ability to inhibit the replication of viruses such as herpes simplex and HIV, making it a potential remedy for the treatment of viral infections.
What are the major healing constituents of Glycyrrhiza glabra?
The healing constituents of Glycyrrhiza glabra are saponins, flavonoids, coumarins, glycyrrhizin, and triterpenoids, which contribute to its medicinal properties.
Saponins exhibit anti-inflammatory activity by inhibiting the production of pro-inflammatory cytokines, while flavonoids demonstrate antioxidant, anti-inflammatory, and antimicrobial effects due to their ability to scavenge free radicals and modulate signaling pathways. Glycyrrhizin, a triterpenoid saponin, has been shown to have anti-inflammatory, antimicrobial, and immunomodulatory effects by inhibiting the production of pro-inflammatory cytokines and inducing apoptosis in cancer cells. Coumarins in Glycyrrhiza glabra have been reported to possess antioxidant, anti-inflammatory, and antimicrobial activities, and may also contribute to its anti-cancer properties.
The combination of these constituents in Glycyrrhiza glabra is thought to be responsible for its diverse range of medicinal applications.
The following illustration give a summary of the major healing consitutents of Glycyrrhiza glabra.
The list below provides more details on what are the major healing constituents of Glycyrrhiza glabra and why they are important for health.
- Saponins: Saponins are a type of triterpenoid glycoside that exhibit hemolytic and foaming properties.
- Flavonoids: Flavonoids are flavonoid glycosides with antioxidant, anti-inflammatory, and antimicrobial properties.
- Coumarins: Coumarins are a class of medicinal constituents found in Glycyrrhiza glabra with anticoagulant, anti-inflammatory, and antioxidant properties.
- Glycyrrhizin: Glycyrrhizin is a triterpenoid saponin with anti-inflammatory, anti-viral, and anti-bacterial properties, and the ability to inhibit 11-beta-hydroxysteroid dehydrogenase, affecting cortisol and aldosterone levels.
- Triterpenoids: A type of steroid that exhibits anti-inflammatory, antimicrobial, and antioxidant properties, as well as inhibiting the activity of certain enzymes.
- Lignans: Lignans are glycosidic compounds found in Glycyrrhiza glabra that have antioxidant, anti-inflammatory, and antimicrobial properties.
- Phenolic acids: Phenolic acids in Glycyrrhiza glabra are tannins with astringent, anti-inflammatory, and antimicrobial properties.
- Terpenoids: Glycyrrhiza glabra terpenoids have anti-inflammatory, antimicrobial, and antioxidant properties.
- Phenolic Acids: Phenolic Acids are a type of bioactive compound found in Glycyrrhiza glabra, characterized by their antioxidant, anti-inflammatory, and antimicrobial properties.
- Glycosides: Glycosides are the primary medicinal constituents of Glycyrrhiza glabra, known for their anti-inflammatory, antiviral, and hepatoprotective properties, as well as their ability to exhibit immunomodulatory, antioxidant, and antibacterial activities.
The table that follows estimates the relative concentrations of the main medicinal constituents contained in Glycyrrhiza glabra and lists the most relevant medicinal properties of each constituent based on the corresponding concentrations.
| Constituent | Concentration | Properties |
|---|---|---|
| Saponins | HIGH | Antimicrobial, Antioxidant, Anti-inflammatory, Hepatoprotective, Immunomodulatory, Cardioprotective, Neuroprotective |
| Flavonoids | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Cardioprotective, Vasodilatory, Antidiabetic, Anticancer |
| Coumarins | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic |
| Glycyrrhizin | HIGH | Anti-inflammatory, Antioxidant, Analgesic, Anticancer, Antiviral, Antimicrobial, Antibacterial, Antiulcer, Hepatoprotective, Immunomodulatory, Cardioprotective |
| Triterpenoids | HIGH | Antimicrobial, Antioxidant, Anti-inflammatory, Analgesic, Anti-ulcer, Hormone-regulating, Cardioprotective, Neuroprotective, Immunomodulatory, Antiviral |
| Lignans | LOW | Antioxidant, Anti-inflammatory, Antimicrobial, Antiviral, Antifungal, Anticancer, Cardio protective |
| Phenolic acids | LOW | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Antihistamine, Antiviral, Analgesic, Antispasmodic, Antihypertensive |
| Terpenoids | MEDIUM | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Antiviral, Antifungal, Immunomodulatory |
| Phenolic Acids | HIGH | Antimicrobial, Antioxidant, Anti-inflammatory, Anticancer, Antiviral, Analgesic, Papain-inhibiting, Cytoprotective |
| Glycosides | HIGH | Antimicrobial, Anti-inflammatory, Antioxidant, Anticancer, Antiviral, Analgesic, Immunomodulatory, Hepatoprotective, Cardioprotective |
What are the most used parts of Glycyrrhiza glabra in medicine?
The most used parts of Glycyrrhiza glabra for medicinal purposes are its roots.
The roots contain a high concentration of triterpenoid saponins, particularly glycyrrhizin, which is responsible for their bioactivity. The primary medicinal properties of these roots include anti-inflammatory, anti-ulcerogenic, and adrenal-suppressing activities, making them useful in treating conditions such as rheumatism and peptic ulcers. The saponins in the roots also exhibit immunomodulatory and antioxidant effects, contributing to their overall therapeutic potential.
The bioactive compounds in the roots of Glycyrrhiza glabra are responsible for their traditional use in traditional medicine to alleviate various ailments and promote general well-being.
The following illustration give a summary of the most used parts of Glycyrrhiza glabra in medicine.
The list below provides more details on what are the most used parts of Glycyrrhiza glabra in medicine and why.
- Roots: The roots of this plant contain major bioactive compounds such as glycyrrhizin, flavonoids, and triterpenoids, which exhibit anti-inflammatory, antioxidant, and immunomodulatory properties, conferring primary health benefits including the relief of cough and sore throat, reduction of inflammation and pain, and enhancement of liver and kidney function.
The table that follows gives a more complete list of healing constituents found in each part of Glycyrrhiza glabra mentioned above.
| Part | Constituents |
|---|---|
| Roots | Glycyrrhizin, Saponins, Flavonoids, Coumarins, Phenolic acids, Asperuloside, Liquiritin, Liquiritigenin, Isoflavones |
What are the most common medicinal preparations of Glycyrrhiza glabra?
The most common herbal preparation of Glycyrrhiza glabra for medicinal purposes are tinctures, which are concentrated extracts used to treat digestive issues and inflammation.
Glycyrrhiza glabra capsules are often used as dietary supplements to reduce stress and improve liver function. In addition, tea made from the roots of this plant is traditionally consumed to soothe coughs and relieve respiratory problems. A decoction of Glycyrrhiza glabra is sometimes used as a topical treatment for skin conditions, such as eczema, due to its anti-inflammatory properties.
Suppositories and salves are also prepared from this plant to treat gastrointestinal issues and skin irritations, respectively.
The following illustration give a summary of the most common medicinal preparations of Glycyrrhiza glabra.
The list below provides more details on what are the most common medicinal preparations of Glycyrrhiza glabra and what are their main uses.
- Tincture: Tincture made from this plant is used to treat digestive issues, such as heartburn and stomach ulcers, to reduce inflammation and as an expectorant to relieve coughs.
- Capsule: Capsule made from this plant is used for anti-inflammatory, antacid, and immunomodulatory effects to treat conditions such as gastritis, peptic ulcers, and bronchitis
- Tea: Tea made from this plant is used to treat respiratory and gastrointestinal issues, and to support liver function, due to its anti-inflammatory and antiviral properties, and its ability to stimulate bile production.
- Decoction: Decoction made from this plant is used for its anti-inflammatory and expectorant properties to treat respiratory and digestive issues, including bronchitis, coughs, and peptic ulcers.
- Salve: Salve made from this plant is used to treat skin conditions such as eczema and psoriasis, and also for wound healing and anti-inflammatory purposes, including sore throat and digestive issues.
The table that follows shows what are the most used parts of Glycyrrhiza glabra for each medicinal preparation.
| Preparation | Parts |
|---|---|
| Tincture | Roots |
| Capsule | Roots |
| Tea | Roots |
| Decoction | Roots |
| Salve | Roots |
Tincture
Glycyrrhiza glabra tincture is widely used to treat various health conditions, including bronchitis, digestive issues, asthma, skin allergies, hepatitis, urinary tract infections and thyroid problems.
It's a very common herbal preparation, found in many households and used by practitioners of traditional medicine. One of the most common effects of using Glycyrrhiza glabra tincture is the relief of inflammation and pain. This preparation is made from the roots of the licorice plant, which are rich in glycyrrhizin and other bioactive compounds.
The process of making tincture from these roots is moderately difficult and requires some expertise, but the end result is a highly effective and versatile treatment option.
Below you find an image of Glycyrrhiza glabra tincture.
Below you find a 5-step quick procedure to make effective medicinal Glycyrrhiza glabra tincture.
- Harvest and clean the roots of the Glycyrrhiza glabra plant.
- Dry the cleaned roots in a warm, well-ventilated area or using a food dehydrator.
- Cut the dried roots into small pieces and place them in a clean glass jar.
- Add a solvent such as ethanol or glycerin to the jar, covering the roots completely.
- Steep the mixture in a cool, dark place for several weeks, shaking the jar daily to facilitate extraction.
Capsule
Glycyrrhiza glabra capsule is used to treat inflammation, stress, allergies, skin conditions, anxiety, digestive issues, asthma, hypertension, eczema and hiccups.
It's a very common herbal preparation widely used in traditional medicine. Its anti-inflammatory effects are well-documented, causing a reduction in swelling and pain in affected areas. The capsule is made from the roots of the Glycyrrhiza glabra plant, which are rich in glycyrrhizin, a compound responsible for its medicinal properties.
The process of extracting glycyrrhizin from the roots is moderately difficult, requiring careful harvesting and processing to ensure optimal potency.
Below you find a 5-step quick procedure to make effective medicinal Glycyrrhiza glabra capsule.
- Harvest mature roots of Glycyrrhiza glabra from a trusted source, ensuring they are free from contamination and impurities.
- Clean and wash the roots under cold running water to remove any dirt or debris.
- Dry the roots in a well-ventilated area or using a dehydrator at a low temperature to prevent degradation.
- Grind the dried roots into a fine powder using a mortar and pestle or a grinding machine.
- Fill vegetable capsules with the powdered root and seal them to produce the final herbal product.
Tea
Glycyrrhiza glabra tea is widely used to treat anxiety, inflammation, stress, gastritis, rheumatism, digestive issues, fatigue, bronchitis, hepatitis, skin issues and allergies.
This preparation is extremely common, used by millions worldwide. It has a well-documented effect of lowering cortisol levels, which is a direct result of its anti-inflammatory properties. Glycyrrhiza glabra tea is made from the roots of the Glycyrrhiza glabra plant, which contain the active compound glycyrrhizin.
The preparation is relatively simple to make, requiring only the roots, water and sometimes honey or lemon to taste.
Below you find an image of Glycyrrhiza glabra tea.
Below you find a 5-step quick procedure to make effective medicinal Glycyrrhiza glabra tea.
- Gather dried Glycyrrhiza glabra roots from a trusted supplier.
- Rinse the roots in cold water to remove any impurities.
- Place 1-2 teaspoons of the Glycyrrhiza glabra roots in a tea infuser or a heat-resistant cup.
- Pour boiling water over the roots and let it steep for 5-7 minutes.
- Strain the tea and serve hot or let it cool down before consumption.
Decoction
Glycyrrhiza glabra decoction is a traditional herbal remedy used to treat various conditions, including chronic bronchitis, peptic ulcer, asthma, liver disease, gastritis, skin conditions, hepatitis, and digestive issues.
This preparation is commonly used worldwide due to its effectiveness in alleviating symptoms associated with these conditions. A common effect of Glycyrrhiza glabra decoction is its anti-inflammatory properties, which help reduce swelling and alleviate pain. The decoction is made from the roots of the Glycyrrhiza glabra plant, which are rich in glycyrrhizin, a compound responsible for its medicinal properties.
Moderately difficult to prepare, the decoction requires careful measurement of the roots and simmering in water to release the active ingredients, making it a viable option for those seeking natural remedies.
Below you find a 5-step quick procedure to make effective medicinal Glycyrrhiza glabra decoction.
- Gather and clean the roots of Glycyrrhiza glabra.
- Chop the cleaned roots into small pieces to increase their surface area.
- Combine the chopped roots with enough water in a saucepan to cover them completely.
- Bring the water to a boil and then reduce the heat to a simmer for 10-15 minutes.
- Strain the decoction through a cheesecloth or a fine-mesh sieve into a clean container.
Salve
Glycyrrhiza glabra salve is a topical herbal remedy used to treat various skin conditions, including eczema, psoriasis, rashes, alopecia, acne, burns, wounds, and insect bites.
This preparation is commonly used due to its widespread availability and effectiveness. The common effect of Glycyrrhiza glabra salve is its anti-inflammatory and antiseptic properties, which help soothe and protect affected skin. The salve is made from the roots of the Glycyrrhiza glabra plant, which contain glycyrrhizin, a compound responsible for its medicinal properties.
Moderately difficult to prepare, Glycyrrhiza glabra salve requires some experience in herbalism to extract the active ingredients from the roots and combine them with a carrier oil or wax to create a topical application.
Below you find an image of Glycyrrhiza glabra salve.
Below you find a 5-step quick procedure to make effective medicinal Glycyrrhiza glabra salve.
- Gather and dry a sufficient quantity of Glycyrrhiza glabra roots.
- Grind the dried roots into a fine powder using a mortar and pestle.
- Combine the ground roots with a carrier oil such as olive or coconut oil in a clean glass jar.
- Heat the mixture in a double boiler or a microwave-safe bowl for a few minutes to facilitate infusion.
- Strain the infused oil through a cheesecloth or a coffee filter into a clean glass container, then add beeswax and heat until melted to create a solid salve.
What are the possible side effects of Glycyrrhiza glabra if used improperly?
The possible side effects of improperly using Glycyrrhiza glabra are retain of potassium, hypokalemia which can lead to life-threatening complications such as fluid overload, pulmonary edema, and muscle weakness, which can further cause arrhythmia.
The prolonged use of the plant can also lead to Cushing's syndrome due to its similar structure to cortisol, resulting in hypertension.
Additionally, long-term consumption may cause osteoporosis due to the displacement of other minerals in the body, ultimately leading to adrenal insufficiency.
The most common side effects Glycyrrhiza glabra gives people when used improperly are listed below, along with a brief explanation.
- Retain: Glycyrrhiza glabra retains sodium and water in the body, increasing blood volume and blood pressure.
- Hypokalemia: Prolonged consumption of Glycyrrhiza glabra causes excessive potassium excretion in urine, leading to decreased serum potassium levels.
- Fluid Overload: Prolonged consumption of Glycyrrhiza glabra can lead to increased potassium excretion and water retention, resulting in sodium retention and subsequent fluid overload, often mimicking congestive heart failure.
- Pulmonary Edema: Glycyrrhiza glabra-induced pulmonary edema results from sodium retention, potassium loss, and water retention, leading to fluid accumulation in the lungs.
- Muscle Weakness: Prolonged consumption of Glycyrrhiza glabra can lead to a deficiency of aldosterone, resulting in muscle weakness due to low potassium levels and high sodium levels.
- Arrhythmia: Glycyrrhiza glabra can cause low potassium levels, which can lead to arrhythmia.
- Cushing'S Syndrome: Prolonged consumption of Glycyrrhiza glabra can lead to the accumulation of glycyrrhetic acid, which inhibits the enzyme 11-beta-hydroxysteroid dehydrogenase, resulting in an increase of cortisol levels and symptoms of Cushing's Syndrome.
- Hypertension: Glycyrrhiza glabra extracts cause increased aldosterone levels leading to sodium retention and hypertension.
- Osteoporosis: Glycyrrhizin from Glycyrrhiza glabra impairs osteoclast differentiation and function, leading to decreased bone resorption and potentially resulting in osteoporosis.
- Adrenal Insufficiency: Prolonged glycyrrhizinic acid consumption leads to decreased aldosterone production, causing sodium retention and potassium excretion.
What are the precautions to take before using Glycyrrhiza glabra medicinally?
The most important precautions you must take before using Glycyrrhiza glabra for medicinal purposes are listed below, along with a brief explanation.
- Consult Doctor Before Use: Glycyrrhiza glabra may interact with certain medications and worsen conditions like hypertension, heart failure, and potassium deficiency.
- Monitor Blood Pressure: High doses of Glycyrrhiza glabra may cause potassium deficiency, which can lead to hypertension.
- Avoid Long-Term Use: Long-term use of Glycyrrhiza glabra can lead to increased levels of aldosterone, which can result in hypokalemia and other electrolyte imbalances.
- Avoid With Potassium Medications: Concurrent use with potassium supplements or medications can increase potassium levels, potentially leading to hyperkalemia.
- Avoid With Heart Conditions: Glycyrrhiza glabra may exacerbate heart failure and hypertension due to its licorice root component, which can increase potassium levels and worsen cardiac function.
- Avoid With Kidney Conditions: Glycyrrhiza glabra can exacerbate pre-existing kidney conditions due to its licorice root content, which inhibits 11-beta-hydroxysteroid dehydrogenase, leading to increased aldosterone levels and reduced potassium levels, causing fluid retention and electrolyte imbalance.
- Avoid With Low Potassium Levels: Glycyrrhizin can cause potassium loss, exacerbating hypokalemia.
- Use In Moderation: Excessive consumption may lead to potassium deficiency and other adverse effects.
- Monitor Liver Function: Glycyrrhizin, a compound in Glycyrrhiza glabra, can cause liver damage and elevated liver enzymes in some individuals.
- Avoid During Pregnancy: High levels of glycyrrhizin, a compound in Glycyrrhiza glabra, can cause preterm labor and low birth weight.
Are there scientific studies that prove the medical effectiveness of Glycyrrhiza glabra?
Yes, there are several scientific studies that prove the medicianl effectiveness of Glycyrrhiza glabra. Here are some studies that are worthy of notice.
According to a study published by "Biomolecules", Glycyrrhiza glabra has been found to exhibit various pharmacological activities, including antioxidant, antifungal, anticarcinogenic, anti-inflammatory, and cytotoxic properties. Additionally, extracts of Glycyrrhiza glabra have been shown to have antimicrobial effects against pathogenic bacteria, viruses, and parasites, such as Plasmodium falciparum. These properties suggest that Glycyrrhiza glabra may be effective in treating a range of diseases and conditions, including infections and certain types of cancer.
In another study published by Pakistan Journal of Pharmaceutical Sciences, Glycyrrhiza glabra has been found to possess various medicinal properties, including anti-inflammatory, spasmolytic, laxative, anti-depressive, anti-ulcer, and anti-diabetic effects. The plant's major active constituent, glycyrrhizin, is widely used in herbal preparations for treating liver complaints, showcasing its effectiveness in maintaining liver health. By utilizing Glycyrrhiza glabra in medicinal preparations, individuals can potentially alleviate a range of health issues and improve their overall well-being.
A different research published by "Lloydia", the research conducted on Glycyrrhiza glabra has revealed several positive effects, including its anti-inflammatory properties which can help alleviate conditions such as arthritis. Additionally, the study found that Glycyrrhiza glabra has been shown to exhibit antioxidant and hepatoprotective effects, suggesting its potential use in protecting the liver from damage. Furthermore, the study's findings suggest that Glycyrrhiza glabra may also possess immunomodulatory properties, which can help regulate the immune system.
