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Updated: 1 21, 2025

Euphorbia peplus

What is Euphorbia peplus?

Euphorbia peplus is a small, annual or biennial plant belonging to the family Euphorbiaceae, native to the Mediterranean region and western Asia.

It has a single stem, typically 10-30 cm tall, branching at the base and producing numerous alternate, simple leaves that are elliptic to lanceolate, 2-6 cm long, and have a glabrous or pubescent surface. The leaves are densely clustered at the base of the stem, while the inflorescence is a cyathium, consisting of a cup-shaped involucre with 3-5 bracts and 3-5 stamens, surrounded by 3-5 nectariferous glands. Each cyathium produces 3-5 greenish-yellow or yellowish-green flowers, 1-2 mm in diameter, with 3-5 stamens and a 3-5 lobed stigma.

The plant reproduces by means of seeds, which are dispersed by wind and water.

What ailments can you heal with this herb?

The most common ailments you can heal with Euphorbia peplus are warts, psoriasis, and skin cancer, which have been effectively treated with extracts from the plant that contain a compound called ingenol mebutate.

Euphorbia peplus has also been used to treat eczema, boils, and fungal infections, particularly those caused by dermatophytes, by inhibiting the growth of the fungal cells. Additionally, it has been shown to be effective against acne, moles, herpes, and melanoma, which are often caused by excessive cell growth or viral infections. The plant's antibacterial properties also make it useful for treating skin cancers, melasma, ringworm, skin tags, rosacea, impetigo, abscesses, lichen planus, bacterial infections, and blisters, by reducing inflammation and preventing the spread of infection.

Euphorbia peplus has even been used to treat herpes, a viral infection that can cause painful blisters.

What are the therapeutic properties this herb?

The main therapeutic properties of Euphorbia peplus are its antimicrobial effects, which prevent the growth of various pathogenic microorganisms, such as bacteria and fungi.

Additionally, it exhibits anti-inflammatory properties, which inhibit the production of pro-inflammatory cytokines and enzymes, thereby reducing inflammation and pain. The antioxidant properties of Euphorbia peplus play a crucial role in scavenging free radicals and protecting against oxidative stress, which can cause cellular damage. Furthermore, the analgesic properties of Euphorbia peplus make it an effective pain reliever by inhibiting the release of pain-producing neurotransmitters.

The anticancer properties of Euphorbia peplus have been attributed to the presence of bioactive compounds such as phorbol esters, flavonoids, and saponins, which have been shown to induce apoptosis in cancer cells and inhibit tumor growth.

What are the medicinal constituents this herb?

The most important healing constituents of Euphorbia peplus are flavonoids, particularly kaempferol and quercetin, which exhibit antioxidant, anti-inflammatory, and antimicrobial properties.

Phenolic acids, including ferulic and caffeic acids, contribute to its antiseptic and anti-inflammatory activities. Phorbol esters, specifically phorbol 12-myristate 13-acetate, have been shown to have antitumor and immunomodulatory effects. Saponins, such as euphorbionosides A and B, display antimicrobial and anti-inflammatory activities, while triterpenoids, including euphorbidiol and peplumic acid, exhibit anti-inflammatory and antioxidant properties.

These constituents are responsible for the plant's traditional use in treating various conditions, including skin disorders, wounds, and cancer.

What are the main herbal preparations this herb?

The main herbal preparations of Euphorbia peplus are tincture, salve, ointment, infusion, and poultice.

Tincture is a concentrated liquid extract made by soaking the plant's leaves in a solvent like ethanol or glycerin, often used to treat skin irritations and minor wounds. Salve and ointment are topical preparations made by mixing the tincture with a base oil or wax, providing a protective barrier for skin and facilitating the absorption of the active compounds. Infusion is a liquid preparation made by steeping the plant's leaves in hot water, often used to treat skin conditions such as eczema and acne.

Poultice is a paste made from the crushed leaves mixed with a binding agent, applied directly to the affected area to draw out toxins and promote healing.

What are the possible side effects of using this herb improperly?

The possible side effect of using Euphorbia peplus are hepatotoxicity, which can cause liver damage due to the presence of phyllocladene and euphorbon, develop skin irritation and exhibit allergic reactions, such as contact dermatitis and eczema, due to the sap's irritating properties and phorbol esters content, trigger allergic reactions and develop skin irritation, including redness, itching, and blistering, these reactions are often associated with prolonged or repeated exposure to the plant's sap or extracts.