Eupatorium Perfoliatum Uses, Benefits, And Remedies

Eupatorium perfoliatum, commonly known as boneset, is a flowering plant native to North America, known for its use in traditional herbal medicine.
This herb is valued for its ability to reduce fever, alleviate muscle pain, and support the immune system.
The bioactive constituents in boneset include compounds such as alkaloids, flavonoids, and sesquiterpene lactones, which contribute to its therapeutic effects.
Herbal preparations such as infusions, tinctures, and topical salves can be made from boneset to harness its healing properties.
This page analize the most important medicinal aspects of Eupatorium perfoliatum.
- Health Benefits
- Bioactive Constituents
- Medicinal Parts
- Herbal Preparations
- Side Effects of eupatorium perfoliatum
Health Benefits
Eupatorium perfoliatum relieves joint pain by reducing inflammation and promoting the healing of connective tissues, making it a valuable herb for individuals suffering from arthritis or other inflammatory joint conditions.
Its anti-inflammatory properties are attributed to the presence of compounds such as flavonoids and sesquiterpenes, which help suppress the production of pro-inflammatory cytokines in the body. Additionally, this herb supports the immune system by enhancing the body's natural defenses and regulating immune responses, which can be beneficial for those with chronic inflammatory disorders. Eupatorium perfoliatum also helps reduce muscle spasms by relaxing muscle fibers and improving circulation, which can alleviate discomfort associated with muscle tension and cramps.
Overall, its multifaceted health benefits make it a promising natural remedy for a range of conditions related to inflammation, pain, and immune support.
The 9 best health benefits of Eupatorium perfoliatum are shown in the image below.

The list below give a brief description of the 9 best health benefits of Eupatorium perfoliatum.
- Relieves Joint Pain: Eupatorium perfoliatum may help alleviate joint pain due to its anti-inflammatory properties, which can reduce swelling and discomfort in the joints.
- Reduces Inflammation: This herb contains compounds that have anti-inflammatory effects, helping to reduce inflammation in the body and alleviate related symptoms.
- Supports Immune System: Eupatorium perfoliatum may enhance immune function by stimulating the body's natural defenses and promoting the production of immune cells.
- Reduces Muscle Spasms: The herb's sedative and antispasmodic properties may help relax muscle tissues and reduce muscle spasms and cramps.
- Reduces Fever Symptoms: Eupatorium perfoliatum has been traditionally used to lower body temperature and reduce symptoms associated with fever.
- Treats Respiratory Issues: It may help ease respiratory conditions such as coughs and congestion by acting as a mild expectorant and bronchodilator.
- Calms Nervous System: The herb is known for its calming effects on the nervous system, helping to reduce anxiety and promote relaxation.
- Treats Sinus Infections: Eupatorium perfoliatum may help alleviate symptoms of sinus infections by reducing inflammation and clearing nasal passages.
- Reduces Stress Levels: It has adaptogenic properties that help the body manage stress, promoting a sense of calm and balance in the body.
Bioactive Constituents
Eupatorium perfoliatum flavonoids, including compounds like quercetin, are known for their potent antioxidant and anti-inflammatory properties.
These flavonoids help neutralize free radicals in the body, reducing oxidative stress and supporting overall cellular health. Quercetin, one of the most prominent flavonoids in Eupatorium perfoliatum, has been studied for its ability to modulate immune responses and may aid in the management of inflammatory conditions.
In addition to flavonoids, the herb contains tannins, which contribute to its astringent properties and may support digestive health by reducing inflammation in the gastrointestinal tract. Phenolic acids, another group of bioactive compounds present in Eupatorium perfoliatum, further enhance its antioxidant profile and may play a role in protecting against chronic diseases.
Together, these medicinal constituents make Eupatorium perfoliatum a valuable herb in traditional and modern herbal medicine for its diverse therapeutic potential.
The 13 best bioactive constituents of Eupatorium perfoliatum are shown in the image below.

The list below give a brief description of the 9 best bioactive constituents of Eupatorium perfoliatum.
- Flavonoids: A group of plant-derived compounds known for their antioxidant properties and potential anti-inflammatory effects.
- Quercetin: A flavonoid with strong antioxidant and anti-inflammatory properties, often used for its health benefits.
- Tannins: A class of polyphenolic compounds that have astringent properties and are known for their antioxidant and antimicrobial effects.
- Phenolic Acids: Organic acids with antioxidant properties that help neutralize free radicals and reduce inflammation.
- Isorhapontigenin: A flavone with potential anti-inflammatory and antioxidant properties, often found in various plants.
- Chlorogenic Acid: A compound known for its antioxidant and anti-inflammatory properties, and its role in metabolism.
- Caffeic Acid: A phenolic acid with antioxidant properties and potential anti-inflammatory and antimicrobial effects.
- Rosmarinic Acid: A polyphenolic compound known for its antioxidant and anti-inflammatory properties, often found in herbs like rosemary.
- Luteolin: A flavone with antioxidant, anti-inflammatory, and neuroprotective properties.
- Apigenin: A flavone with antioxidant and anti-inflammatory properties, and potential benefits for cognitive function.
- Kaempferol: A flavonoid with antioxidant and anti-inflammatory properties, and potential cardiovascular benefits.
- Terpenoids: A diverse group of organic compounds with various biological activities, including antioxidant and anti-inflammatory effects.
- Quinic Acid: A compound with antioxidant properties and potential anti-inflammatory and antimicrobial effects.
Medicinal Parts
Eupatorium perfoliatum leaf has been traditionally used in herbal medicine for its purported anti-inflammatory and analgesic properties.
The leaves contain various bioactive compounds, including flavonoids and sesquiterpene lactones, which may contribute to its therapeutic effects. In traditional Chinese medicine, the leaves are often used to treat conditions such as fever, rheumatism, and skin infections. The leaf's ability to promote sweating is believed to aid in reducing body temperature and detoxifying the body.
Additionally, the leaf has been studied for its potential antimicrobial and antiviral activities, making it a valuable component in natural remedies.
The 2 best medicinal parts of Eupatorium perfoliatum are shown in the image below.

The list below give a brief description of the 2 best medicinal parts of Eupatorium perfoliatum.
Herbal Preparations
Eupatorium perfoliatum tinctures are commonly used to harness the herb's anti-inflammatory and analgesic properties, often prepared by soaking the dried plant in alcohol to extract its active compounds.
These tinctures are typically used externally for muscle pain, joint inflammation, and skin conditions, though internal use should be carefully monitored due to potential toxicity. In addition to tinctures, Eupatorium perfoliatum can be made into teas by steeping the dried herb in hot water, offering a mild digestive aid and potential support for respiratory health.
Decoctions, which involve boiling the herb for a longer period, are used for more potent internal applications, while capsules provide a convenient and standardized form for daily supplementation. The herb is also used in the preparation of oils and creams, which can be applied topically to soothe muscle aches and reduce skin irritation. Ointments and liniments made from Eupatorium perfoliatum are valued for their ability to alleviate pain and inflammation, while poultices made from fresh or dried leaves can be applied directly to wounds or inflamed areas.
Each preparation method allows for tailored use, depending on the desired therapeutic effect and the specific condition being addressed.
The 10 best herbal preparations of Eupatorium perfoliatum are shown in the image below.

The list below give a brief description of the 10 best herbal preparations of Eupatorium perfoliatum.
- Tinctures: Eupatorium perfoliatum tinctures are used to support the immune system and alleviate symptoms of colds and flu due to their antiviral and anti-inflammatory properties.
- Teas: Eupatorium perfoliatum teas are traditionally used to relieve fever, chills, and respiratory congestion, often employed in treating colds and flu.
- Decoctions: Eupatorium perfoliatum decoctions are used to address digestive issues and promote detoxification, leveraging the herb's cleansing properties.
- Capsules: Eupatorium perfoliatum capsules provide a convenient form for supporting respiratory health and immune function, often used during seasonal changes.
- Oils: Eupatorium perfoliatum oils are applied topically to reduce inflammation and soothe skin irritations, benefiting conditions like eczema and psoriasis.
- Creams: Eupatorium perfoliatum creams are used to relieve muscle pain, joint inflammation, and skin conditions due to their anti-inflammatory and soothing effects.
- Mucillages: Eupatorium perfoliatum mucillages are used to support digestive health and soothe the lining of the stomach and intestines.
- Oinments: Eupatorium perfoliatum ointments are applied to treat skin conditions, wounds, and inflammatory disorders due to their healing and soothing properties.
- Liniments: Eupatorium perfoliatum liniments are used to relieve muscle aches, joint pain, and inflammatory conditions when applied topically.
- Poultices: Eupatorium perfoliatum poultices are used to treat wounds, infections, and inflammatory skin conditions by applying a paste of the herb to the affected area.
Side Effects of eupatorium perfoliatum
Eupatorium perfoliatum causes skin irritation, which may manifest as redness, itching, or a burning sensation upon contact with the plant's leaves or oils.
This herb can also trigger allergic reactions in sensitive individuals, leading to symptoms such as hives, swelling, or even anaphylaxis in severe cases. Additionally, it may induce skin rash, particularly in those with pre-existing dermatological conditions or heightened sensitivity to plant-based compounds.
Some users report nausea and dizziness after ingesting or applying the herb, suggesting potential gastrointestinal and neurological side effects. Furthermore, Eupatorium perfoliatum can cause eye and throat irritation, dry mouth, blurred vision, and even nosebleeds, highlighting the need for caution when using this herb, especially in its raw or concentrated forms.
These health effects underscore the importance of proper preparation and consultation with a healthcare professional before using Eupatorium perfoliatum for medicinal purposes.
The 11 most common side effects of Eupatorium perfoliatum are shown in the image below.

The list below give a brief description of the 11 most common side effects of Eupatorium perfoliatum.
- Causes Skin Irritation: Prolonged contact with Eupatorium perfoliatum may cause redness, itching, or a burning sensation on the skin.
- Triggers Allergic Reactions: Some individuals may experience allergic responses such as hives, swelling, or difficulty breathing upon exposure to the herb.
- Triggers Skin Rash: Skin contact with the herb can lead to a rash characterized by red, itchy, or raised bumps on the skin.
- Leads To Nausea: Ingesting Eupatorium perfoliatum may cause feelings of nausea or an upset stomach in some individuals.
- Induces Dizziness: The herb may cause dizziness or lightheadedness, especially when consumed in large amounts or by sensitive individuals.
- Causes Eye Irritation: Contact with the herb can lead to eye irritation, including redness, itching, or a burning sensation.
- Induces Throat Irritation: Inhaling or ingesting the herb may cause throat irritation, leading to a sore or scratchy sensation.
- Causes Fatigue: Eupatorium perfoliatum may cause fatigue or a general sense of tiredness in some users.
- Induces Dry Mouth: Consuming the herb may result in a dry mouth or reduced saliva production.
- Causes Blurred Vision: In some cases, the herb may lead to blurred vision or visual disturbances.
- Triggers Nosebleeds: Exposure to the herb may cause nosebleeds or irritation of the nasal passages.